Protein Purification and Isolation Market Size & Share Analysis - Growth Trends & Forecasts (2024 - 2029)

The Protein Purification and Isolation Market is Segmented by Product (Instruments and Consumables), by Technology (Precipitation, Ultrafiltration, Chromatography, Electrophoresis, Western Blotting, and Others), by End User (Academic and Research Institutes, Pharmaceutical and Biotechnological Companies, Contract Research Organizations (CROs), and Hospitals) and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The Report Offers the Value (in USD) for the Above Segments.

Protein Purification And Isolation Market Size

Protein Purification And Isolation Market Summary
Study Period 2019 - 2029
Market Size (2024) USD 9.69 Billion
Market Size (2028) USD 16.18 Billion
CAGR (2024 - 2029) 10.60 %
Fastest Growing Market Asia-Pacific
Largest Market North America

Major Players

Protein Purification And Isolation Market Major Players

*Disclaimer: Major Players sorted in no particular order

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Protein Purification And Isolation Market Analysis

The Protein Purification And Isolation Market size is estimated at USD 9.69 billion in 2024, and is expected to reach USD 16.18 billion by 2028, growing at a CAGR of 10.60% during the forecast period (2024-2028).

The outbreak of the pandemic impacted the protein purification and isolation market. The demand for protein purification and isolation procedures drastically increased as it was used to analyze and research severe acute respiratory syndrome coronavirus (SARS-CoV-2). For instance, according to an NCBI study published in September 2021, there was a strong global demand for diagnostic and serological supplies, as countries needed to establish their technologies for producing high-quality biomolecules. The two major viral antigens used to diagnose SARS-CoV-2 are the structural proteins spike (S) protein and nucleocapsid (N) protein. Thus, the demand for protein purification and isolation increased during the pandemic as it was one of the initial and essential steps needed to proceed with further diagnosis and research work. Therefore, the market witnessed healthy growth during the pandemic. In addition, protein purification and isolation are also essential for vaccine manufacturing and are utilized for COVID-19 vaccine preparation. Thus, the market is expected to continue the upward trend over the forecast period.

Increasing investment in pharmaceutical and biotechnological research and development and the rising need for more accurate and rapid purification kits drive market growth. For instance, as per the journal published by Pharma Statistics in April 2023, many key drug companies reinvested 19.2% of prescription drug sales profit into new drug development. Modern drug discovery uses libraries of purified proteins. The proteins used in the initial steps of drug discovery should be highly purified ones, and structural features of proteins must be preserved because protein function is highly dependent on tertiary structure. Thus, protein purification is an essential step for drug discovery and development. Therefore, such facts are anticipated to propel the demand for protein purification and isolation procedures, positively impacting the market growth over the forecast period.

Furthermore, the product launches by the key players to meet the rising need for more accurate and rapid purification kits may also help the market to grow. For instance, in March 2023, Gyros Protein Technologies AB launched three service offerings to support developing and manufacturing peptide-based drugs. The new services are based on the Company's PurePep EasyClean (PEC) orthogonal peptide purification technology. Two existing PEC kit types support the services: Starter Kits and High Throughput Kits. Similarly, in May 2023, 10x Genomics Inc. commercially launched the new Visium CytAssist Gene and Protein Expression product to expand the breadth of the Visium CystAssist spatial analysis capabilities. Thus, owing to such instances, considerable market growth is expected over the forecast period.

However, the high cost of purification instruments and the lack of skilled professionals will likely impede the market growth over the forecast period.

Protein Purification And Isolation Market Trends

Ultrafiltration Segment is Expected to Witness Growth Over the Forecast Period

Ultrafiltration is the process of separating extremely small particles and dissolved molecules from liquids. The primary basis for separation is the size of the molecules, although the permeability of the filter can be affected by the sample's chemical, molecular, or electrostatic properties. To be separated by ultrafiltration, molecules must differ in size by at least an order of magnitude and have a molecular weight between 1 kDa and 1000 kDa. Ultrafiltration membranes can be used to clean the filtrate or collect the retentate. Ultrafiltration is typically used to separate proteins from buffer components for buffer exchange, concentration, or desalting.

The advantages of ultrafiltration and the wide application of ultrafiltration for protein purification and isolation are significant drivers for segment growth over the forecast period. For instance, according to the NCBI study published in January 2021, proteins could be beneficial in their concentrated products or isolates, of which membrane filtration methods such as ultrafiltration include application in a wide range of protein sources. Furthermore, the advantages of ultrafiltration technology, such as the high product throughput and ability to generate rapid results, also boost the use of ultrafiltration. Moreover, traditional techniques such as chromatography require complex instrumentation support to run efficiently and yield low throughput of product at an extremely high cost, owing to which ultrafiltration technique is becoming more popular as it overcomes such disadvantages. Thus, such advantages and the increasing use of ultrafiltration are expected to propel the segment growth.

Furthermore, product launches by key players are also expected to contribute to the segment's growth. For instance, in March 2023, DuPont launched the next generation of multi-capillary PES In-Out Ultrafiltration (UF) membrane, DuPont Multibore PRO. Thus, considerable segment growth is anticipated over the forecast period due to such factors.

Protein Purification And Isolation Market: Estimated and Projected Biopharmaceutical Research and Development Spending (in million), Global, 2022-2024

North America is Expected to Witness Considerable Growth Over the Forecast Period

North America is expected to grow considerably in the protein purification and isolation market over the forecast period. The growth is due to increasing research work and rising investments in R&D by the public and private sectors. For instance, according to the data provided by the Organization for Economic Co-operation and Development in November 2022, the research and development expenditure by the biotechnology industries in Canada was USD 651 million in 2022. Additionally, increasing government initiatives such as high investments in developing various biotechnology research is expected to boost North America's market's growth. For instance, according to the article published by the Government of Canada in August 2022, the Government of Canada invested more than USD 2.2 billion over seven years to boost biomanufacturing. This investment of USD 250.0 million over four years, starting in 2022-2023, was to create a tri-agency administered by the Social Sciences and Humanities Research Council (SSHRC) on behalf of three federal research funding agencies. Thus, such high investments are expected to accelerate drug development and research work in the North American region. Thereby, considerable market growth is expected over the forecast period.

Key product launches, high concentration of market players or manufacturer's presence, acquisition and & partnerships among significant players, and increased investments by biopharmaceutical companies in R&D in the United States are some of the factors driving the growth of the protein purification and isolation market in the country. For instance, according to the NCBI article published in June 2022, the investments in research development by pharmaceutical companies in the United States represented a record more than USD 133.0 billion, an increase from more than 44% in the past 5 years. Similarly, in July 2021, the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBP) received two grants totaling USD 153.0 million from the National Institute of Standards and Technology (NIST) of the United States Department of Commerce. Thus, biopharmaceutical companies' increasing research and development expenditures are expected to drive market growth in the United States. Furthermore, product launches in the United States may also help the market to grow. For instance, in June 2022, Bio-Rad Laboratories, Inc. launched the EconoFit Low-Pressure Prepacked Chromatography Column Packs to support resin screening experiments in developing protein purification workflows. Thus, considerable market growth is expected over the forecast period due to such factors.

Protein Purification And Isolation Market: Protein Purification and Isolation Market - Growth Rate by Region

Protein Purification And Isolation Industry Overview

The protein purification and isolation market is fragmented in nature due to the presence of several companies operating globally as well as regionally. The competitive landscape includes an analysis of a few international as well as local companies that hold the market shares and are well known, including Thermo Fisher Scientific Inc., Merck KGaA, QIAGEN, Bio-Rad Laboratories, Inc., Agilent Technologies, Inc., Promega Corporation, and Danaher Corporation (Cytiva) among others.

Protein Purification And Isolation Market Leaders

  1. Thermo Fischer Scientific Inc.

  2. Merck KGaA

  3. QIAGEN

  4. Bio-Rad Laboratories, Inc.

  5. Promega Corporation

*Disclaimer: Major Players sorted in no particular order

Protein Purification And Isolation Market Concentration
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Protein Purification And Isolation Market News

  • July 2022: Bio-Rad laboratories launched its EconoFitlow-pressure prepacked chromatography column packs. The EconoFitcolumns were designed for resin screening, allowing customers to develop protein purification workflows to select the optimal chemistry for different targets. The columns offered various resins in a prepacked format, including mixed-mode, cation, and anion exchange resin columns and a pack designed for polyhistidine protein purification.
  • June 2022: PerkinElmer, Inc. launched the GC 2400 Platform, an advanced, automated gas chromatography headspace sampler and other solution designed to help lab teams simplify lab operations, drive precise results, and perform more flexible monitoring.

Protein Purification & Isolation Market Report - Table of Contents

  1. 1. INTRODUCTION

    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study

  2. 2. RESEARCH METHODOLOGY

  3. 3. EXECUTIVE SUMMARY

  4. 4. MARKET DYNAMICS

    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increasing in investment in Pharmaceutical and Biotechnological Research and Development

      2. 4.2.2 Growing Need for More Accurate and Rapid Purification Kits

      3. 4.2.3 Increasing Drug Discovery and Development and Technological Advancements

    3. 4.3 Market Restraints

      1. 4.3.1 High cost of Purification Instruments and Lack of Skilled Professionals

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Bargaining Power of Buyers/Consumers

      2. 4.4.2 Bargaining Power of Suppliers

      3. 4.4.3 Threat of New Entrants

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION (Market Size by Value - USD)

    1. 5.1 By Product

      1. 5.1.1 Instruments

      2. 5.1.2 Consumables

        1. 5.1.2.1 Kits

        2. 5.1.2.2 Reagents

        3. 5.1.2.3 Columns

        4. 5.1.2.4 Other Products

    2. 5.2 By Technology

      1. 5.2.1 Precipitaion

      2. 5.2.2 Ultrafiltration

      3. 5.2.3 Chromatography

        1. 5.2.3.1 Ion Exchange Chromatography

        2. 5.2.3.2 Size Exclusion Chromatography

        3. 5.2.3.3 Reversed Phase Chromatography

        4. 5.2.3.4 Other Technologies

      4. 5.2.4 Electrophoresis

        1. 5.2.4.1 Gel electrophoresis

        2. 5.2.4.2 Capillary electrophoresis

        3. 5.2.4.3 Isoelectric focusing

      5. 5.2.5 Western Blotting

      6. 5.2.6 Other Technologies

    3. 5.3 By End-User

      1. 5.3.1 Academic and Research Institutes

      2. 5.3.2 Pharmaceutical and Biotechnological Companies

      3. 5.3.3 Contract Research Organizations (CROs)

      4. 5.3.4 Hospitals

    4. 5.4 Geography

      1. 5.4.1 North America

        1. 5.4.1.1 United States

        2. 5.4.1.2 Canada

        3. 5.4.1.3 Mexico

      2. 5.4.2 Europe

        1. 5.4.2.1 Germany

        2. 5.4.2.2 United Kingdom

        3. 5.4.2.3 France

        4. 5.4.2.4 Italy

        5. 5.4.2.5 Spain

        6. 5.4.2.6 Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. 5.4.3.1 China

        2. 5.4.3.2 Japan

        3. 5.4.3.3 India

        4. 5.4.3.4 Australia

        5. 5.4.3.5 South Korea

        6. 5.4.3.6 Rest of Asia-Pacific

      4. 5.4.4 Middle East and Africa

        1. 5.4.4.1 GCC

        2. 5.4.4.2 South Africa

        3. 5.4.4.3 Rest of Middle East and Africa

      5. 5.4.5 South America

        1. 5.4.5.1 Brazil

        2. 5.4.5.2 Argentina

        3. 5.4.5.3 Rest of South America

  6. 6. COMPETITIVE LANDSCAPE

    1. 6.1 Company Profiles

      1. 6.1.1 Thermo Fisher Scientific Inc.

      2. 6.1.2 Merck KGaA

      3. 6.1.3 QIAGEN

      4. 6.1.4 Bio-Rad Laboratories, Inc.

      5. 6.1.5 Agilent Technologies, Inc.

      6. 6.1.6 Promega Corporation

      7. 6.1.7 Danaher Corporation (Cytiva)

      8. 6.1.8 Norgen Biotek Corp.

      9. 6.1.9 Abcam plc

      10. 6.1.10 Purolite

    2. *List Not Exhaustive
  7. 7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Subject to Availability
**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments
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Protein Purification And Isolation Industry Segmentation

As per the report's scope, protein purification can be defined as a series of steps performed to obtain and study the desired protein from a complex mixture. Protein purification is vital for characterizing the required protein's function, structure, and interactions. The protein isolation aims to safely and efficiently separate the required protein from a mixture. Protein is isolated from samples of mammals, insects, plants, yeasts, or bacteria. The protein purification and isolation market is segmented by Product (Instruments and Consumables), by Technology (Precipitation, Ultrafiltration, Chromatography, Electrophoresis, and Western Blotting), by End User (Academic and Research Institutes, Pharmaceutical and Biotechnological Companies, Contract Research Organizations (CROs), and Hospitals) and Geography (North America, Europe, Asia-Pacific, Middle East, and Africa, and South America). The report also covers the estimated market sizes and trends for 17 countries across major regions globally. The report offers the value (in USD) for the above segments.

By Product
Instruments
Consumables
Kits
Reagents
Columns
Other Products
By Technology
Precipitaion
Ultrafiltration
Chromatography
Ion Exchange Chromatography
Size Exclusion Chromatography
Reversed Phase Chromatography
Other Technologies
Electrophoresis
Gel electrophoresis
Capillary electrophoresis
Isoelectric focusing
Western Blotting
Other Technologies
By End-User
Academic and Research Institutes
Pharmaceutical and Biotechnological Companies
Contract Research Organizations (CROs)
Hospitals
Geography
North America
United States
Canada
Mexico
Europe
Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific
China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East and Africa
GCC
South Africa
Rest of Middle East and Africa
South America
Brazil
Argentina
Rest of South America
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Protein Purification & Isolation Market Research FAQs

The Protein Purification And Isolation Market size is expected to reach USD 9.69 billion in 2024 and grow at a CAGR of 10.60% to reach USD 16.18 billion by 2028.

In 2024, the Protein Purification And Isolation Market size is expected to reach USD 9.69 billion.

Thermo Fischer Scientific Inc., Merck KGaA, QIAGEN, Bio-Rad Laboratories, Inc. and Promega Corporation are the major companies operating in the Protein Purification And Isolation Market.

Asia-Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).

In 2024, the North America accounts for the largest market share in Protein Purification And Isolation Market.

In 2023, the Protein Purification And Isolation Market size was estimated at USD 8.66 billion. The report covers the Protein Purification And Isolation Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Protein Purification And Isolation Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.

Global Protein Purification and Isolation Industry Report

Statistics for the 2024 Protein Purification And Isolation market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Protein Purification And Isolation analysis includes a market forecast outlook to for 2024 to 2029 and historical overview. Get a sample of this industry analysis as a free report PDF download.

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Protein Purification and Isolation Market Size & Share Analysis - Growth Trends & Forecasts (2024 - 2029)