Protein Purification And Isolation Market Size
| Study Period | 2019 - 2030 |
| Market Size (2025) | USD 10.72 Billion |
| Market Size (2030) | USD 17.74 Billion |
| CAGR (2025 - 2030) | 10.60% |
| Fastest Growing Market | Asia-Pacific |
| Largest Market | North America |
| Market Concentration | High |
Major Players*Disclaimer: Major Players sorted in no particular order |
Protein Purification And Isolation Market Analysis
The Protein Purification And Isolation Market size is estimated at USD 10.72 billion in 2025, and is expected to reach USD 17.74 billion by 2030, at a CAGR of 10.6% during the forecast period (2025-2030).
Increasing investment in pharmaceutical and biotechnological research and development and the rising need for more accurate and rapid purification kits drive market growth. For instance, as per the journal published by Pharma Statistics in April 2023, many key drug companies reinvested 19.2% of prescription drug sales profit into new drug development. Modern drug discovery uses libraries of purified proteins. The proteins used in the initial steps of drug discovery should be highly purified ones, and structural features of proteins must be preserved because protein function is highly dependent on tertiary structure. Thus, protein purification is an essential step for drug discovery and development. Therefore, such facts are anticipated to propel the demand for protein purification and isolation procedures, positively impacting the market growth over the forecast period.
Furthermore, the product launches by the key players to meet the rising need for more accurate and rapid purification kits may also help the market to grow. For instance, in March 2023, Gyros Protein Technologies AB launched three service offerings to support developing and manufacturing peptide-based drugs. The new services are based on the Company's PurePep EasyClean (PEC) orthogonal peptide purification technology. Two existing PEC kit types support the services: Starter Kits and High Throughput Kits. Similarly, in May 2023, 10x Genomics Inc. commercially launched the new Visium CytAssist Gene and Protein Expression product to expand the breadth of the Visium CystAssist spatial analysis capabilities. Thus, owing to such instances, considerable market growth is expected over the forecast period.
However, the high cost of purification instruments and the lack of skilled professionals will likely impede the market growth over the forecast period.
Protein Purification And Isolation Market Trends
Ultrafiltration Segment is Expected to Witness Growth Over the Forecast Period
Ultrafiltration is the process of separating extremely small particles and dissolved molecules from liquids. The primary basis for separation is the size of the molecules, although the permeability of the filter can be affected by the sample's chemical, molecular, or electrostatic properties. To be separated by ultrafiltration, molecules must differ in size by at least an order of magnitude and have a molecular weight between 1 kDa and 1000 kDa. Ultrafiltration membranes can be used to clean the filtrate or collect the retentate. Ultrafiltration is typically used to separate proteins from buffer components for buffer exchange, concentration, or desalting.
The advantages of ultrafiltration and the wide application of ultrafiltration for protein purification and isolation are significant drivers for segment growth over the forecast period. For instance, according to the NCBI study published in January 2022, proteins could be beneficial in their concentrated products or isolates, of which membrane filtration methods such as ultrafiltration include application in a wide range of protein sources. Furthermore, the advantages of ultrafiltration technology, such as the high product throughput and ability to generate rapid results, also boost the use of ultrafiltration.
Moreover, traditional techniques such as chromatography require complex instrumentation support to run efficiently and yield low throughput of product at an extremely high cost, owing to which ultrafiltration technique is becoming more popular as it overcomes such disadvantages. Thus, such advantages and the increasing use of ultrafiltration are expected to propel the segment growth.
Furthermore, product launches by key players are also expected to contribute to the segment's growth. For instance, in March 2023, DuPont launched the next generation of multi-capillary PES In-Out Ultrafiltration (UF) membrane, DuPont Multibore PRO. Thus, considerable segment growth is anticipated over the forecast period due to such factors.
In conclusion, the ultrafiltration market is expected to experience significant growth due to its advantages over traditional methods, increasing applications in protein purification, and continuous innovations by key industry players.
North America is Expected to Witness Considerable Growth Over the Forecast Period
North America is expected to grow considerably in the protein purification and isolation market over the forecast period. The growth is due to increasing research work and rising investments in R&D by the public and private sectors. For instance, according to the data provided by the Organization for Economic Co-operation and Development in November 2022, the research and development expenditure by the biotechnology industries in Canada was USD 651 million in 2022.
Additionally, increasing government initiatives such as high investments in developing various biotechnology research is expected to boost North America's market's growth. For instance, according to the article published by the Government of Canada in August 2022, the Government of Canada invested more than USD 2.2 billion over seven years to boost biomanufacturing. This investment of USD 250.0 million over four years, starting in 2022-2023, was to create a tri-agency administered by the Social Sciences and Humanities Research Council (SSHRC) on behalf of three federal research funding agencies. Thus, such high investments are expected to accelerate drug development and research work in the North American region. Thereby, considerable market growth is expected over the forecast period.
Key product launches, high concentration of market players or manufacturer's presence, acquisition and & partnerships among significant players, and increased investments by biopharmaceutical companies in R&D in the United States are some of the factors driving the growth of the protein purification and isolation market in the country. For instance, according to the NCBI article published in June 2022, the investments in research development by pharmaceutical companies in the United States represented a record more than USD 133.0 billion, an increase from more than 44% in the past 5 years.
Similarly, in July 2021, the National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBP) received two grants totaling USD 153.0 million from the National Institute of Standards and Technology (NIST) of the United States Department of Commerce. Thus, biopharmaceutical companies' increasing research and development expenditures are expected to drive market growth in the United States. Furthermore, product launches in the United States may also help the market to grow. For instance, in June 2022, Bio-Rad Laboratories, Inc. launched the EconoFit Low-Pressure Prepacked Chromatography Column Packs to support resin screening experiments in developing protein purification workflows. Thus, considerable market growth is expected over the forecast period due to such factors.
In conclusion, North America's protein purification and isolation market is on a robust growth trajectory, driven by significant investments in R&D, government initiatives, and strategic industry activities. This dynamic environment is expected to foster innovation and expansion in the market throughout the forecast period.
Protein Purification And Isolation Industry Overview
The protein purification and isolation market is fragmented in nature due to the presence of several companies operating globally as well as regionally. The competitive landscape includes an analysis of a few international as well as local companies that hold the market shares and are well known, including Thermo Fisher Scientific Inc., Merck KGaA, QIAGEN, Bio-Rad Laboratories, Inc., Agilent Technologies, Inc., Promega Corporation, and Danaher Corporation (Cytiva) among others.
Protein Purification And Isolation Market Leaders
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Thermo Fischer Scientific Inc.
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Merck KGaA
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QIAGEN
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Bio-Rad Laboratories, Inc.
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Promega Corporation
- *Disclaimer: Major Players sorted in no particular order
Protein Purification And Isolation Market News
- January 2024: FUJIFILM Wako Pure Chemical Corporation has unveiled its latest offerings: the MassivEV EV Purification Column PS and the MassivEV Purification Buffer Set. These products are meticulously crafted to facilitate the meticulous purification of extracellular vesicles (EVs), catering specifically to the burgeoning exosome research field.
- May 2024: CD Bioparticles launched its new Functional Agarose Particles designed for a variety of applications in the field of bioconjugation, isolation, and purification of biomacromolecules. These particles are ideal for researchers working in areas such as protein purification, antibody production, and nucleic acid isolation.
Protein Purification And Isolation Industry Segmentation
As per the report's scope, protein purification can be defined as a series of steps performed to obtain and study the desired protein from a complex mixture. Protein purification is vital for characterizing the required protein's function, structure, and interactions. The protein isolation aims to safely and efficiently separate the required protein from a mixture. Protein is isolated from samples of mammals, insects, plants, yeasts, or bacteria. The protein purification and isolation market is segmented by Product (Instruments and Consumables), by Technology (Precipitation, Ultrafiltration, Chromatography, Electrophoresis, and Western Blotting), by End User (Academic and Research Institutes, Pharmaceutical and Biotechnological Companies, Contract Research Organizations (CROs), and Hospitals) and Geography (North America, Europe, Asia-Pacific, Middle East, and Africa, and South America). The report also covers the estimated market sizes and trends for 17 countries across major regions globally. The report offers the value (in USD) for the above segments.
| By Product | Instruments | ||
| Consumables | Kits | ||
| Reagents | |||
| Columns | |||
| Other Products | |||
| By Technology | Precipitaion | ||
| Ultrafiltration | |||
| Chromatography | Ion Exchange Chromatography | ||
| Size Exclusion Chromatography | |||
| Reversed Phase Chromatography | |||
| Other Technologies | |||
| Electrophoresis | Gel electrophoresis | ||
| Capillary electrophoresis | |||
| Isoelectric focusing | |||
| Western Blotting | |||
| Other Technologies | |||
| By End-User | Academic and Research Institutes | ||
| Pharmaceutical and Biotechnological Companies | |||
| Contract Research Organizations (CROs) | |||
| Hospitals | |||
| Geography | North America | United States | |
| Canada | |||
| Mexico | |||
| Europe | Germany | ||
| United Kingdom | |||
| France | |||
| Italy | |||
| Spain | |||
| Rest of Europe | |||
| Asia-Pacific | China | ||
| Japan | |||
| India | |||
| Australia | |||
| South Korea | |||
| Rest of Asia-Pacific | |||
| Middle East and Africa | GCC | ||
| South Africa | |||
| Rest of Middle East and Africa | |||
| South America | Brazil | ||
| Argentina | |||
| Rest of South America | |||
| Instruments | |
| Consumables | Kits |
| Reagents | |
| Columns | |
| Other Products |
| Precipitaion | |
| Ultrafiltration | |
| Chromatography | Ion Exchange Chromatography |
| Size Exclusion Chromatography | |
| Reversed Phase Chromatography | |
| Other Technologies | |
| Electrophoresis | Gel electrophoresis |
| Capillary electrophoresis | |
| Isoelectric focusing | |
| Western Blotting | |
| Other Technologies |
| Academic and Research Institutes |
| Pharmaceutical and Biotechnological Companies |
| Contract Research Organizations (CROs) |
| Hospitals |
| North America | United States |
| Canada | |
| Mexico | |
| Europe | Germany |
| United Kingdom | |
| France | |
| Italy | |
| Spain | |
| Rest of Europe | |
| Asia-Pacific | China |
| Japan | |
| India | |
| Australia | |
| South Korea | |
| Rest of Asia-Pacific | |
| Middle East and Africa | GCC |
| South Africa | |
| Rest of Middle East and Africa | |
| South America | Brazil |
| Argentina | |
| Rest of South America |
Protein Purification & Isolation Market Research FAQs
How big is the Protein Purification And Isolation Market?
The Protein Purification And Isolation Market size is expected to reach USD 10.72 billion in 2025 and grow at a CAGR of 10.60% to reach USD 17.74 billion by 2030.
What is the current Protein Purification And Isolation Market size?
In 2025, the Protein Purification And Isolation Market size is expected to reach USD 10.72 billion.
Who are the key players in Protein Purification And Isolation Market?
Thermo Fischer Scientific Inc., Merck KGaA, QIAGEN, Bio-Rad Laboratories, Inc. and Promega Corporation are the major companies operating in the Protein Purification And Isolation Market.
Which is the fastest growing region in Protein Purification And Isolation Market?
Asia-Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).
Which region has the biggest share in Protein Purification And Isolation Market?
In 2025, the North America accounts for the largest market share in Protein Purification And Isolation Market.
What years does this Protein Purification And Isolation Market cover, and what was the market size in 2024?
In 2024, the Protein Purification And Isolation Market size was estimated at USD 9.58 billion. The report covers the Protein Purification And Isolation Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Protein Purification And Isolation Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.
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Global Protein Purification and Isolation Industry Report
Statistics for the 2025 Protein Purification And Isolation market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Protein Purification And Isolation analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.
