Protein A Resin Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

The report covers Global Protein-A Resin Market Growth and it is segmented By Product Type (Agarose-based Protein, Glass or Silica-based Protein, Organic Polymer-based Protein), Application (Antibody Purification, Immunoprecipitation), End User (Pharmaceutical and Biopharmaceutical Companies, Research Laboratories, Others), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market size and forecast values are provided in terms of (USD) for all the above segments.

Protein A Resin Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

Protein A Resins Market Size

Global Protein A Resin Market Summary
Study Period 2019 - 2030
Base Year For Estimation 2024
Market Size (2025) USD 1.27 Billion
Market Size (2030) USD 1.93 Billion
CAGR (2025 - 2030) 8.69 %
Fastest Growing Market Asia Pacific
Largest Market North America

Major Players

Global Protein A Resin Market Major Players

*Disclaimer: Major Players sorted in no particular order

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Protein A Resins Market Analysis

The Global Protein A Resin Market size is estimated at USD 1.27 billion in 2025, and is expected to reach USD 1.93 billion by 2030, at a CAGR of 8.69% during the forecast period (2025-2030).

The Protein A Resin industry is experiencing significant transformation driven by technological advancements in purification processes and manufacturing capabilities. Major industry players are actively expanding their production facilities to meet growing market demands, as evidenced by Purolite's announcement in November 2023 to construct a new plant in the Quzhou Industrial Park, with operations expected to commence in 2026. The focus on technological innovation has led to the development of advanced resins with improved binding capacities and enhanced purification processes, such as Purolite's Praesto Jetted A50 HipH technology showcased in August 2023, which demonstrates exceptional performance capabilities in protein purification resin.


The market landscape is being reshaped by strategic collaborations and partnerships among key industry players. In February 2024, Purolite and Repligen Corporation launched Praesto CH1, a groundbreaking 70-micron agarose-based affinity chromatography resin designed specifically for specialized monoclonal antibodies and recombinant antibody fragments. This trend of strategic partnerships is further exemplified by AGC Biologics' collaborative agreement with WL Gore & Associates in December 2022 for Protein A affinity purification technology, highlighting the industry's move toward more integrated solutions.


The biopharmaceutical manufacturing sector is witnessing a significant shift toward more efficient and scalable purification processes. According to the Society of Biological Engineering Journal's February 2023 report, the industry is increasingly focusing on reusable Protein A Resins across multiple products in GMP facilities, leading to substantial cost reductions and improved operational efficiency. This trend is particularly evident in the development of next-generation purification technologies that offer higher binding capacities and improved flow rates.


The market is experiencing a notable evolution in application scope, particularly in specialized therapeutic areas. Recent developments include the adaptation of chromatography resin for purifying novel antibody formats and bispecific antibodies. According to BioPharm International's January 2024 report, innovations in resin technology are specifically addressing challenges in purifying specialized monoclonal antibodies and antibody fragments, offering solutions for previously unmet purification challenges. These advancements are enabling more efficient production of complex therapeutic proteins while maintaining high purity standards.

Segment Analysis: By Product

Agarose-based Protein Segment in Global Protein A Resin Market

The agarose-based protein segment dominates the global protein A resin market, commanding approximately 58% of the market share in 2024. This segment's leadership position is attributed to the wide applications of agarose-based protein in research studies and drug discovery, particularly in the purification of antibodies such as monoclonal and polyclonal antibodies from different fluids, including culture media, serum, ascites fluid, or hybridoma supernatants. The segment is also experiencing the fastest growth trajectory, projected to grow at nearly 9% from 2024 to 2029, driven by strategic initiatives taken by market players. For instance, in February 2024, Purolite and Repligen Corporation launched Praesto CH1, a new 70μm agarose-based affinity chromatography resin designed to purify specialized monoclonal antibodies. The segment's growth is further supported by its extensive application in downstream processes of antibodies and monoclonal antibody products as a cost-effective method in the industry.

Market Analysis of Global Protein A Resin Market: Chart for By Product

Remaining Segments in Product Segmentation

The glass or silica-based protein and organic polymer-based protein segments complete the market landscape, each offering unique advantages for specific applications. Glass or silica-based proteins are valued for their availability in various pore sizes and particle diameters, good mechanical strength under HPLC system conditions, and compatibility with applications spanning from target purification to pharmaceutical analysis. Meanwhile, organic polymer-based proteins, characterized by their partial hydrophobicity and monodisperse particles, serve specialized needs in protein purification resin and ligand coupling applications. Both segments continue to evolve with technological advancements and expanding applications in the biopharmaceutical industry, contributing to the overall market growth through their distinct capabilities and use cases.

Segment Analysis: By Application

Antibody Purification Segment in Protein A Resin Market

The Antibody Purification segment dominates the global protein A resin market, commanding approximately 60% of the market share in 2024. This significant market position is primarily driven by the increasing initiatives taken by market players on the development of advanced protein A resin for antibody purification, coupled with rising investments in antibody-related therapeutics by pharmaceutical companies. The segment's growth is further bolstered by substantial government support and funding initiatives for research and development in antibody purification technologies. For instance, in March 2024, Epsilogen and Lonza completed the Good Manufacturing Practice (GMP) manufacturing of MOv18 IgE, a new IgE antibody drug candidate, demonstrating the continued innovation and development in antibody purification processes. Additionally, the rising demand for monoclonal antibodies in various therapeutic applications, particularly in oncology and autoimmune diseases, has significantly contributed to the segment's market dominance.

Immunoprecipitation Segment in Protein A Resin Market

The Immunoprecipitation segment is projected to exhibit the fastest growth in the protein A resin market, with an anticipated CAGR of approximately 9% during the forecast period 2024-2029. This accelerated growth is attributed to the increasing focus on research and development by pharmaceutical and biotechnology companies related to antigens and proteins for different therapeutics. The segment's expansion is further supported by the wide applications of immunoprecipitation in research, particularly in identifying protein activation status, determining post-translational protein modifications, and studying protein-protein interactions. For instance, in September 2023, the Southampton Research Team received significant funding of GBP 2.25 million from Cancer Research UK for research focused on improving immunotherapy treatments and developing more effective anti-cancer antibodies, highlighting the growing investment in immunoprecipitation techniques. The segment's growth is also driven by the rising adoption of chromatography resin in academic and research laboratories for various biomolecule isolation applications.

Segment Analysis: By End User

Pharmaceutical & Biopharmaceutical Companies Segment in Protein A Resin Market

The Pharmaceutical & Biopharmaceutical Companies segment dominates the global protein A resin market, commanding approximately 66% of the market share in 2024. This segment's leadership position is driven by the rapid growth of pharmaceutical and biotechnology industries worldwide, coupled with their increasing focus on research and development activities. The segment is also expected to maintain the highest growth rate of around 9% during 2024-2029, primarily due to the rising investments in antibody development and expanding manufacturing capabilities. For instance, in April 2024, Merck invested approximately EUR 300 million for developing a new research center in Darmstadt, Germany, dedicated to providing research solutions for manufacturing antibodies and mRNA applications. Similarly, in March 2024, AGC Biologics planned to construct a new manufacturing facility at Yokohama Technical Center in Japan, offering manufacturing services for mammalian-based protein biologics such as antibodies. The strategic initiatives taken by protein A resin market players to serve the increasing needs of pharmaceutical and biopharmaceutical companies further strengthen this segment's market position.

Academic Institutes and Research Laboratories Segment in Protein A Resin Market

The Academic Institutes and Research Laboratories segment plays a crucial role in the protein A resin market, driven by increasing grants and funding support from governments for innovative therapeutics and drug discovery. This segment encompasses end users such as academic institutes, research centers, contract development and manufacturing organizations (CDMOs), contract manufacturing organizations (CMOs), and other research laboratories. The segment's growth is supported by various government initiatives and research grants. For instance, in April 2024, the Washington University School of Medicine in St. Louis received a USD 6.2 million grant from the National Institute of Health for developing gene therapy focused on producing super antibodies to HIV. Additionally, in October 2023, the Texas Therapeutics Institute at UTHealth Houston expanded its drug discovery capabilities in the TMC3 Collaborative Building, focusing on antibody-drug resistance mechanisms, biomarkers for therapeutic antibodies, and antibody drug discovery targeting human diseases. These developments, coupled with increasing collaborative agreements between academic institutions and market players, continue to drive the segment's growth in the protein A resin market.

Global Protein A Resin Market Geography Segment Analysis

Protein A Resin Market in North America

The North American protein A resin market demonstrates robust growth driven by rising investments in antibody development, technological advancements, and increasing research and development expenditure on pharmaceutical and biological research. The United States leads the regional market, followed by Canada and Mexico, with a strong presence of major biopharmaceutical companies and research institutions. The region benefits from advanced healthcare infrastructure, substantial funding for biomedical research, and a growing focus on developing novel therapeutic antibodies. Strategic initiatives by key market players, including facility expansions and new product launches, further strengthen North America's position in the global protein A resin landscape.

Market Analysis of Global Protein A Resin Market: Forecasted Growth Rate by Region

Protein A Resin Market in United States

The United States dominates the North American protein A resin market, holding approximately 89% share in 2024. The country's market leadership is attributed to its extensive biopharmaceutical research and development activities, particularly in monoclonal antibody purification. According to recent data, there were 1,248 clinical studies reported for monoclonal antibodies in the United States as of March 2024, indicating a robust biopharmaceutical development pipeline. The country's market is further strengthened by continuous technological advancements in protein A resin technology, such as improved binding capacities and enhanced purification processes, making them more attractive to biopharmaceutical companies.

Protein A Resin Market in Canada

Canada emerges as the fastest-growing market in North America, with a projected growth rate of approximately 8% during 2024-2029. The country's growth is driven by increasing company developments to expand offerings in the biopharmaceutical sector and rising research and development activities. The Canadian government's substantial investments in antibody-based facilities and infrastructure development have created a favorable environment for market expansion. The country's focus on clinical trials and research activities around monoclonal antibodies, with 224 clinical trials recorded as of March 2024, demonstrates its commitment to advancing in this sector.

Protein A Resin Market in Europe

The European protein A resin market showcases significant growth potential, supported by extensive research infrastructure and a strong presence of pharmaceutical companies. The region encompasses key markets including Germany, United Kingdom, France, Italy, and Spain, each contributing substantially to the overall market development. The European market benefits from increasing investments in biotechnology research, growing demand for monoclonal antibodies, and continuous technological innovations in chromatography resin techniques. The presence of major research institutions and biopharmaceutical companies across these countries further strengthens the regional market dynamics.

Protein A Resin Market in Germany

Germany stands as the largest market in Europe, commanding approximately 21% of the regional market share in 2024. The country's leading position is supported by significant investments in drug discovery and development, particularly in monoclonal antibody research. The presence of major pharmaceutical companies and research institutions, coupled with advanced manufacturing capabilities, contributes to Germany's market dominance. The country's focus on research and development is evident through various collaborations between pharmaceutical companies and research institutions for developing novel monoclonal antibody therapeutics.

Protein A Resin Market in France

France emerges as the fastest-growing market in Europe, with an expected growth rate of approximately 10% from 2024-2029. The country's market is driven by rising government and public funding for research investment, coupled with increasing drug discovery and research and development activities by market players for biologics, including monoclonal antibodies. The presence of 229 clinical trials for monoclonal antibodies as of March 2024 demonstrates France's strong commitment to advancing in the biopharmaceutical sector. The country's focus on immunotherapy research and strategic collaborations in the biopharmaceutical industry further accelerates market growth.

Protein A Resin Market in Asia-Pacific

The Asia-Pacific protein A resin market demonstrates dynamic growth potential, encompassing diverse markets including China, Japan, India, Australia, and South Korea. The region's market expansion is driven by increasing investments in biotechnology research, growing demand for biosimilar monoclonal antibodies, and rising focus on healthcare infrastructure development. The establishment of new manufacturing facilities, coupled with strategic initiatives by key market players, contributes to the region's growing significance in the global protein A resin landscape.

Protein A Resin Market in China

China emerges as the dominant force in the Asia-Pacific protein A resin market, driven by the presence of over 60 pharmaceutical companies involved in antibody development. The country's leadership is attributed to its growing focus on biosimilar antibody development, government initiatives promoting the usage of copy monoclonal antibodies, and strategic establishment of new manufacturing facilities. The country's commitment to expanding its biopharmaceutical capabilities and increasing adoption of affinity chromatography resin in various applications strengthens its market position.

Protein A Resin Market in India

India represents the fastest-growing market in the Asia-Pacific region, driven by increasing development of therapeutic antibodies and growing usage of antibodies in various applications. The country's market growth is supported by government initiatives in developing new antibodies, establishment of new manufacturing facilities, and rising investments in research and development. The expansion of bioproduction capabilities and focus on developing customized solutions for the pharmaceutical industry further accelerates India's market growth trajectory.

Protein A Resin Market in Middle East & Africa

The Middle East & Africa protein A resin market shows promising growth potential, with GCC countries and South Africa as key contributors. The region's market development is driven by increased biopharmaceutical manufacturing, growing demand for monoclonal antibodies, and advancements in healthcare infrastructure. Among the countries in this region, GCC emerges as the largest market, benefiting from substantial investments in healthcare infrastructure and rising focus on biotechnology research. South Africa demonstrates the fastest growth potential, supported by increasing grants and funds for innovative therapeutics and drug discovery activities.

Protein A Resin Market in South America

The South American protein A resin market, primarily led by Brazil and Argentina, shows steady growth potential driven by increasing investments in biotechnology research and rising demand for protein-based therapeutics. The region's market development is supported by growing research and development activities, rising collaboration initiatives for antibody development, and increasing focus on healthcare infrastructure development. Brazil emerges as both the largest and fastest-growing market in the region, supported by continuous research and development of antibodies and government initiatives to produce immunoglobulins.

Protein A Resins Industry Overview

Top Companies in Protein A Resin Market

The protein A resin market features prominent players like Danaher Corporation, Merck KGaA, Thermo Fisher Scientific, Bio-Rad Laboratories, and Tosoh Bioscience leading the innovation landscape. Companies are increasingly focusing on developing specialized resins with enhanced binding capacity and specificity, particularly for emerging applications like bispecific antibodies and gene therapies. Strategic partnerships and collaborations have become commonplace, exemplified by agreements between Purolite and Repligen Corporation for developing high-performance ligands. Manufacturing capacity expansion remains a key priority, with companies establishing new facilities across different regions to meet growing demand. The industry witnesses continuous product launches featuring improved technologies like optimized high-flow agarose base matrices and genetically engineered protein A-derived ligands, demonstrating the sector's commitment to advancing purification capabilities.

Market Dominated by Global Life Science Leaders

The chromatography resin market structure is characterized by the strong presence of large multinational life science and biotechnology conglomerates who leverage their extensive research capabilities and global distribution networks. These established players maintain their market positions through comprehensive product portfolios spanning different types of resins, including agarose-based, glass or silica-based, and organic polymer-based variants. The market shows significant consolidation with major players actively pursuing strategic acquisitions to strengthen their technological capabilities and expand geographical presence, particularly in emerging markets.


The competitive dynamics are shaped by the presence of both diversified life science companies and specialized resin manufacturers, creating a multi-tiered competitive landscape. While global leaders like Danaher and Merck command significant market share through their established brands and extensive distribution networks, specialized players carve out niches through focused innovation in specific applications or technologies. The industry has witnessed several strategic mergers and acquisitions, particularly aimed at expanding manufacturing capabilities and accessing new geographical markets, indicating a trend toward further consolidation.

Innovation and Scale Drive Market Success

Success in the protein A resin market increasingly depends on companies' ability to develop innovative products that address specific purification challenges while maintaining cost-effectiveness. Incumbent players are focusing on expanding their manufacturing capabilities, investing in research and development for next-generation resins, and strengthening their distribution networks to maintain market leadership. Companies are also emphasizing the development of application-specific solutions, particularly for emerging therapeutic areas like cell and gene therapy, while maintaining strong relationships with key pharmaceutical and biotechnology customers through comprehensive technical support and service offerings.


For new entrants and smaller players, success lies in identifying and serving specific market niches, developing innovative technologies that address unmet needs, and establishing strategic partnerships with larger companies for manufacturing and distribution. The affinity chromatography resin market's growth potential is influenced by the increasing adoption of biological therapeutics and the expanding biopharmaceutical industry, though companies must navigate challenges including high development costs and stringent regulatory requirements. Building strong intellectual property portfolios and maintaining product quality standards remain crucial for long-term success, while the ability to offer competitive pricing without compromising performance becomes increasingly important in winning market share.

Protein A Resins Market Leaders

  1. Bio-Rad Laboratories, Inc.

  2. Thermofisher Scientific, Inc.

  3. Merck KGaA

  4. Agarose Bead Technologies

  5. Danaher Corporation (Cytiva)

  6. *Disclaimer: Major Players sorted in no particular order
Global Protein A Resin Market Concentration
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Protein A Resins Market News

  • February 2024: Purolite, an Ecolab company, and Repligen Corporation reported the commercial launch of Praesto CH1, a new 70 μm (micron) agarose-based affinity resin designed to purify specialized mAbs such as bispecifics and recombinant antibody fragments.
  • January 2024: Dutch Oxitope and Norwegian Arxx reported a merger to form Calluna Pharma Inc. to develop monoclonal antibody therapies for inflammatory and fibrotic diseases. The newly formed company raised USD 80.4 million (EUR 75 million) in Series A financing for the clinical stage lead program, CAL101, which is a monoclonal antibody that neutralizes the bioactivity of S100A4. CAL101 under Phase 1 for fibrosis and inflammation indications.

Protein A Resins Market Report - Table of Contents

1. INTRODUCTION

  • 1.1 Study Assumptions and Market Definition
  • 1.2 Scope of the Study

2. RESEARCH METHODOLOGY

3. EXECUTIVE SUMMARY

4. MARKET DYNAMICS

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Increasing Demand for Antibodies
    • 4.2.2 Increasing Number of Drug Discoveries and R&D Activities
  • 4.3 Market Restraints
    • 4.3.1 High Cost Associated With Protein A Resin
  • 4.4 Porter's Five Forces Analysis
    • 4.4.1 Threat of New Entrants
    • 4.4.2 Bargaining Power of Buyers/Consumers
    • 4.4.3 Bargaining Power of Suppliers
    • 4.4.4 Threat of Substitute Products
    • 4.4.5 Intensity of Competitive Rivalry

5. MARKET SEGMENTATION (Market Size - Value in USD)

  • 5.1 By Product
    • 5.1.1 Agarose -based Protein
    • 5.1.2 Glass or Silica-based Protein
    • 5.1.3 Organic Polymer-based Protein
  • 5.2 By Application
    • 5.2.1 Antibody Purification
    • 5.2.2 Immunoprecipitation
  • 5.3 By End User
    • 5.3.1 Pharmaceutical and Biopharmaceutical Companies
    • 5.3.2 Research Laboratories
    • 5.3.3 Other End Users
  • 5.4 Geography
    • 5.4.1 North America
    • 5.4.1.1 United States
    • 5.4.1.2 Canada
    • 5.4.1.3 Mexico
    • 5.4.2 Europe
    • 5.4.2.1 Germany
    • 5.4.2.2 United Kingdom
    • 5.4.2.3 France
    • 5.4.2.4 Italy
    • 5.4.2.5 Spain
    • 5.4.2.6 Rest of Europe
    • 5.4.3 Asia-Pacific
    • 5.4.3.1 China
    • 5.4.3.2 Japan
    • 5.4.3.3 India
    • 5.4.3.4 Australia
    • 5.4.3.5 South Korea
    • 5.4.3.6 Rest of Asia-Pacific
    • 5.4.4 Middle East and Africa
    • 5.4.4.1 GCC
    • 5.4.4.2 South Africa
    • 5.4.4.3 Rest of Middle East and Africa
    • 5.4.5 South America
    • 5.4.5.1 Brazil
    • 5.4.5.2 Argentina
    • 5.4.5.3 Rest of South America

6. COMPETITIVE LANDSCAPE

  • 6.1 Company Profiles
    • 6.1.1 Agarose Beads Technologies
    • 6.1.2 Bio-Rad Laboratories, Inc.
    • 6.1.3 Abcam Limited
    • 6.1.4 Danaher Corporation (Cytiva)
    • 6.1.5 Genscript Corporation
    • 6.1.6 Merck KGaA
    • 6.1.7 Axplora
    • 6.1.8 Ecolab Inc. (Purolite Lifesciences)
    • 6.1.9 Repligen Corporation
    • 6.1.10 Thermofisher Scientific Inc.
    • 6.1.11 Tosoh Bioscience LLC
    • 6.1.12 Kaneka Corporation
    • 6.1.13 JSR Life Sciences
  • *List Not Exhaustive

7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Subject to Availability
**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments
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Protein A Resins Industry Segmentation

As per the scope of the report, protein A resin is an affinity chromatography medium designed for easy, one-step purification of classes, subclasses, and fragments of immunoglobulins from biological fluids and cell culture media. 

The Protein A Resin market is segmented by product type, application, end user, and geography. By product type, the market is segmented into agarose-based protein, glass or silica-based protein, and organic polymer-based protein. By application, the market is segmented into antibody purification and immunoprecipitation. By end user, the market is segmented into pharmaceutical and biopharmaceutical companies, research laboratories, and others. By geography, the market is segmented into North America, Europe, Asia-Pacific, the Middle East and Africa, and South America. The report also covers the estimated market sizes and trends for 17 countries across major regions globally. The report offers the values (USD) for all the above segments.

By Product Agarose -based Protein
Glass or Silica-based Protein
Organic Polymer-based Protein
By Application Antibody Purification
Immunoprecipitation
By End User Pharmaceutical and Biopharmaceutical Companies
Research Laboratories
Other End Users
Geography North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East and Africa GCC
South Africa
Rest of Middle East and Africa
South America Brazil
Argentina
Rest of South America
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Protein A Resins Market Research FAQs

How big is the Global Protein A Resin Market?

The Global Protein A Resin Market size is expected to reach USD 1.27 billion in 2025 and grow at a CAGR of 8.69% to reach USD 1.93 billion by 2030.

What is the current Global Protein A Resin Market size?

In 2025, the Global Protein A Resin Market size is expected to reach USD 1.27 billion.

Who are the key players in Global Protein A Resin Market?

Bio-Rad Laboratories, Inc., Thermofisher Scientific, Inc., Merck KGaA, Agarose Bead Technologies and Danaher Corporation (Cytiva) are the major companies operating in the Global Protein A Resin Market.

Which is the fastest growing region in Global Protein A Resin Market?

Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).

Which region has the biggest share in Global Protein A Resin Market?

In 2025, the North America accounts for the largest market share in Global Protein A Resin Market.

What years does this Global Protein A Resin Market cover, and what was the market size in 2024?

In 2024, the Global Protein A Resin Market size was estimated at USD 1.16 billion. The report covers the Global Protein A Resin Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Global Protein A Resin Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.

Global Protein A Resin Market Research

Mordor Intelligence provides a comprehensive analysis of the protein a resin industry. We leverage our extensive experience in chromatography resin research and consulting. Our latest report offers detailed insights into bioprocess chromatography applications. It focuses particularly on monoclonal antibody purification and recombinant protein purification technologies. The analysis covers emerging trends in affinity chromatography resin development and implementation. This information is available in an easy-to-read report PDF for immediate download.

This detailed study offers stakeholders crucial information about protein purification resin technologies. It explores their applications in biopharmaceutical purification processes. The report examines key developments in the chromatography resin industry, providing valuable insights for manufacturers, researchers, and industry professionals. Our analysis encompasses the entire value chain of protein a resin market dynamics. It offers a comprehensive understanding of chromatography resin market trends and future growth opportunities in the affinity chromatography resin market.