Protein A Resin Market- Growth, Trends, and Forecasts (2023 - 2028)

The Protein A Resin market is segmented By Product Type (Agarose-based Protein, Glass or Silica-based Protein, Organic Polymer-based Protein), Application (Antibody Purification, Immunoprecipitation), End User (Pharmaceutical & Biopharmaceutical Companies, Research Laboratories, Others), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (in USD million) for the above segments.

Protein A-Resin Industry Overview

Market Snapshot
Study Period: 2018 - 2028
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 8.5 %

Major Players


*Disclaimer: Major Players sorted in no particular order


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Protein A-Resin Market Analysis

The protein A resin market is expected to register a CAGR of around 8.5% over the forecast period.

The emergence of the COVID-19 pandemic hurt the world economy and the healthcare system. The lockdown all over the globe has affected the supply chain of pharmaceuticals, medical devices, and biotechnological products. On the other hand, research and development have come into focus. All the government agencies and healthcare players have come forward to support the development of diagnostics and treatment methods for COVID-19. The development of therapeutic and preventive strategies requires an accurate understanding of the role that proteins play in the SARS-CoV-2 infection process and progression of COVID-19. But, due to the temporary shutdown of research institutes and less manpower available, it was difficult to perform research activities at a normal pace during the first wave of coronavirus. However, with the advancement in time, the situation gradually improved, and it is expected to improve during the study period further. This will drive the studied market growth.

 The growth of the protein A resin market is majorly attributed to the increasing burden of chronic diseases across the globe and the demand for therapeutics for antibodies. For instance, the study “Protein analysis of extracellular vesicles (EV) to monitor and predict therapeutic response in metastatic breast cancer,” published in May 2021, used a rapid, sensitive, and low-cost thermophoretic aptasensor (TAS) to profile cancer-associated protein profiles of plasma EVs without the interference of soluble proteins. This demonstrated that protein analysis has a high accuracy of 91.1 % for discrimination of metastatic breast cancer, non-metastatic breast cancer, and healthy donors (HD). Thus, studies highlighting technological innovation for identifying cancer will drive market growth.

Additionally, according to the study “Proteomic analysis of human immunodeficiency virus and periodontitis,” published in February 2021, proteomic analysis is one of the leading approaches with increasing significance in clinical applications that is associated with the development of high-performance instruments that allow for the identification of disease-specific biomarkers and rapid protein profiling of the analyzed samples for large-scale analysis of complex biological samples. Therefore, with the implementation of proteomics for infectious disease therapeutics, the cell-free protein expression market is expected to grow during the study period.

Thus, the high prevalence of chronic and infectious diseases further increases the demand for efficient identification of the diseases and the development of novel and effective treatment methods, thereby resulting in increased use of protein A resins, which contributes to the growth of the market studied.

Protein A-Resin Industry Segments

Protein A Resin is used to analyze the contaminant product and thus purifies it. The Protein A Resin market is segmented By Product Type (Agarose-based Protein, Glass or Silica-based Protein, Organic Polymer-based Protein), Application (Antibody Purification, Immunoprecipitation), End User (Pharmaceutical & Biopharmaceutical Companies, Research Laboratories, Others), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (in USD million) for the above segments.

By Product
Agarose -based Protein
Glass or Silica-based Protein
Organic Polymer-based Protein
By Application
Antibody Purification
By End User
Pharmaceutical & Biopharmaceutical Companies
Research Laboratories
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle East & Africa
South Africa
Rest of Middle East & Africa
South America
Rest of South America

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Protein A-Resin Market Trends

This section covers the major market trends shaping the Protein A-Resin Market according to our research experts:

Pharmaceutical and Biopharmaceutical Companies are Expected to Dominate the End User Segment

In any drug discovery and development activity carried out in pharma companies, proteins are the principal target, and thus, protein analysis has a very important role in drug discovery and development. The common application of protein analysis involves target identification and evaluation, identification of efficacy and toxicity biomarkers from readily accessible biological fluids, and investigations into mechanisms of drug action or toxicity, among others, which in turn is expected to grow significantly due to a large number of ongoing drug discovery projects initiated by pharmaceutical companies around the world.

Additionally, chromatography is widely used across these companies in which protein A resin is commonly used. A rise in government funding in pharmaceutical research and development, technological advancements in the area of analytical instruments, increasing life science R&D expenditure, progressing drug discovery, and an increase in the adoption of chromatography are the key factors driving the growth of the protein A resins market in the pharmaceutical and biotechnology industry. For instance, in February 2020, Shimadzu Corporation, in partnership with the Enabling Technologies Consortium (ETC), announced the release of the NexeraPreparative Supercritical Fluid Chromatography System, “NexeraUC Prep”. This next-generation prep SFC system provides the pharmaceutical industry with reliable, high-performance semi-prep purification involving protein A resin. Each NexeraUC Prep is configurable to user specifications to perform the desired purification function optimally, including chiral or achiral purifications, single injections, stacked injections, and fraction collections from several microliters to liters. As the above-mentioned chromatography system is associated with protein A resin, the market studied is expected to grow with such developments. 

Hence, the factors such as product launches and strategic initiatives by market players such as rising investments, the launch of new companies, partnerships, and others are expected to contribute significantly to the segment growth.


North America is Expected to Hold a Significant Share in the Market and Expected to do Same in the Forecast Period

The market for protein A resin in the North American region is expected to experience lucrative growth during the study period owing to the factors such as the rising burden of infectious diseases, technological advancements in the studied market, and increasing research and development expenditure on pharmaceutical, and biological research. In addition, the product launches and strategic initiatives by key market players will also contribute to the market growth.

In the North American region, the United States is believed to dominate the market. As per the HIV Government factsheet published in May 2021, in the United States, approximately 1.2 million people are infected with HIV. About a third of them are unaware of it and require testing. In the United States, an estimated 34,800 new HIV infections occurred in 2019, with 36,801 people receiving an HIV diagnosis. The increasing burden of HIV across the country is believed to propel market growth as protein A resins are being widely used for the immunoprecipitation of proteins.

The product launches, partnerships, and mergers and acquisitions will help the companies in expanding their product offering and geographical footprints, thereby contributing to the lucrative growth of the market. In March 2022, Sengenics launched an autoantibody profiling service – the ‘Pan-Autoimmune Protein Array 1.0’ for efficient identification and quantitation of autoantibody disease biomarker signatures. It is a protein microarray-based, multiplexed immunoassay which utilizes Sengenics’ KREX protein folding technology and optimized computational analysis.

Hence, owing to the above-mentioned factors, the market studied is expected to witness strong growth in the North America region.

Protein A Resin Market - Growth Rate by Region

Protein A-Resin Market Competitor Analysis

Protein A resin market is moderately competitive with a presence of mostly global companies. Companies are taking the initiative to grow their presence in the Protein A Resin market. Key players that are expected to be dominant in the Protein A Resin market are Thermofisher Scientific Inc., GE Healthcare, Merck KGaA, Agarose Beads Technologies, Bio-Rad Laboratories, Inc., Expedeon Ltd., Genscript Corporation, Novasep, Purolite Lifescience, and Repligen

Protein A-Resin Market Top Players

  1. GE Healthcare

  2. Bio-Rad Laboratories, Inc.

  3. Thermofisher Scientific, Inc.

  4. Merck KGaA

  5. Agarose Bead Technologies

*Disclaimer: Major Players sorted in no particular order

Protein A Resin Market Concentration.png

Protein A-Resin Market Recent Developments

  • In June 2022, Navigo Proteins GmbH, a premier protein engineering company and developer of affinity ligands for custom chromatography solutions, announced the successful development of an affinity resin for the capture of an undesired contaminant from the baculovirus insect cell expression system, namely the glycoprotein gp64.
  • In March 2020, Avantor, Inc., a leading global provider of mission-critical products and services to customers in the life sciences, advanced technologies, and applied materials industries, announced a new recombinant Protein A affinity chromatography resin used to purify antibodies during mAbs production.

Protein A-Resin Market Report - Table of Contents


    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increasing Demand for Antibodies

      2. 4.2.2 Increasing Number of Drug Discoveries and R&D Activities

    3. 4.3 Market Restraints

      1. 4.3.1 High Cost Associated With Protein A Resin

    4. 4.4 Porter's Five Force Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION (Market Size - Value in USD million)

    1. 5.1 By Product

      1. 5.1.1 Agarose -based Protein

      2. 5.1.2 Glass or Silica-based Protein

      3. 5.1.3 Organic Polymer-based Protein

    2. 5.2 By Application

      1. 5.2.1 Antibody Purification

      2. 5.2.2 Immunoprecipitation

    3. 5.3 By End User

      1. 5.3.1 Pharmaceutical & Biopharmaceutical Companies

      2. 5.3.2 Research Laboratories

      3. 5.3.3 Others

    4. 5.4 Geography

      1. 5.4.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.4.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.4.4 Middle East & Africa

        1. GCC

        2. South Africa

        3. Rest of Middle East & Africa

      5. 5.4.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 Agarose Beads Technologies

      2. 6.1.2 Bio-Rad Laboratories, Inc.

      3. 6.1.3 Expedeon Ltd.

      4. 6.1.4 GE Healthcare

      5. 6.1.5 Genscript Corporation

      6. 6.1.6 Merck KGaA

      7. 6.1.7 Novasep

      8. 6.1.8 Purolite Lifescience

      9. 6.1.9 Repligen

      10. 6.1.10 Thermofisher Scientific Inc.

    2. *List Not Exhaustive

**Subject to Availability
**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments
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Protein A-Resin Market Research FAQs

The Global Protein A Resin Market is studied from 2018 - 2028.

The Global Protein A Resin Market is growing at a CAGR of 8.5% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2018 - 2028.

North America holds highest share in 2021.

GE Healthcare, Bio-Rad Laboratories, Inc., Thermofisher Scientific, Inc., Merck KGaA, Agarose Bead Technologies are the major companies operating in Global Protein A Resin Market.

Global Protein A Resin Industry Reports

In-depth industry statistics and market share insights of the Global Protein A Resin sector for 2020, 2021, and 2022. The Global Protein A Resin research report provides a comprehensive outlook of the market size and an industry growth forecast for 2023 to 2028. Available to download is a free sample file of the Global Protein A Resin report PDF.

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