Ligases Enzyme Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

Ligases Enzyme Market is Segmented by Source (Microorganisms (Bacteria, Virus, and Other Microorganisms), Animals, and Plants), Application (Polymerase Chain Reaction, Cloning, Mutation Detection, Next-generation Sequencing, and Drug Target), End User (Diagnostic Centers and Hospitals, and Research Institutes), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America).

Ligases Enzyme Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

Ligases Enzyme Market Size

Ligases Enzyme Market Summary
Study Period 2019 - 2030
Base Year For Estimation 2024
Forecast Data Period 2025 - 2030
Historical Data Period 2019 - 2023
CAGR 5.50 %
Fastest Growing Market Asia Pacific
Largest Market North America

Major Players

Ligases Enzyme Market Major Players

*Disclaimer: Major Players sorted in no particular order

Compare market size and growth of Ligases Enzyme Market with other markets in Healthcare Industry

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Ligases Enzyme Market Analysis

The Ligases Enzyme Market is expected to register a CAGR of 5.5% during the forecast period.

The COVID-19 pandemic had a notable effect on the ligases enzyme market during the pandemic period. There were many research studies providing insight into the applications of ligases enzyme for identifying potential targets of therapeutic strategies against COVID-19 that significantly impacted the market's growth. For instance, the NCBI article published in April 2021 mentioned that HECT family members of E3 ligases were likely novel biomarkers for COVID-19, as well as new possible targets of therapeutic strategy easily tested in clinical trials. Such studies proving the potential benefits of ligase enzymes in the therapeutic usage against COVID-19 significantly impacted the market's growth. In addition, the demand for the ligases enzyme is expected to remain intact due to the applications in various studies of mutant strains of COVID-19, thereby boosting the market's growth over the forecast period.

The growth of the ligase enzyme market may be attributed to the increasing prevalence of various infectious diseases and genetic birth disorders due to its potential diagnostic and therapeutic properties. For instance, as per the WHO data published in 2022, an estimated 10.6 million tuberculosis cases were recorded globally in 2021. Thus, the high prevalence rate of people with tuberculosis surges the demand for effective and early diagnosis, thereby driving the ligases enzyme market. Also, another WHO data published in 2022 found that between January 24 and February 6, 2022, approximately 12,368 people tested positive for influenza viruses, with 8,423 (68.1%) being categorized as influenza A and 3,945 (31.9%), as influenza B. There were nearly 2,483 (93.6%) influenza A viruses and 171 (6.4%) influenza A(H1N1) pdm09 subtypes (H3N2). Such incidences of infectious diseases globally are expected to drive the demand for ligases enzyme, thereby contributing to the growth of the market. Similarly, the advent of ligases as therapeutic interventions for cancer is also expected to be one of the crucial driving factors of the market. For instance, an NCBI research study published in March 2022 stated that small ubiquitin-like modifier (SUMO) relation is a reversible post-translational modification that plays an essential role in numerous aspects of cell physiology, including cell cycle regulation, DNA damage repair, and protein trafficking and turnover, both of which are crucial for cell homeostasis. Thus, such research studies proving the effective therapeutic benefits of ligase enzymes for cancer are also expected to boost the market's growth.

However, the risk of the high sensitivity of the enzyme is expected to hinder the market growth.

Ligases Enzyme Industry Overview

The Ligases Enzyme Market is moderately competitive and consists of global as well as local players. Due to technological advancements, small and mid-sized companies focus on market penetration to grab market share. Some companies currently present in the market are ArcticZymes, New England Biolabs, Promega Corporation, QIAGEN, and Takara Bio Inc.

Ligases Enzyme Market Leaders

  1. Becton, Dickinson and Company

  2. Agilent Technologies

  3. Merck KGaA

  4. Thermo Fisher Scientific

  5. ArcticZymes Technologies

  6. *Disclaimer: Major Players sorted in no particular order
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Ligases Enzyme Market News

  •  June 2022: Nurix Therapeutics initiated an ongoing phase 1 trial to examine NX-2127, an immunomodulatory oral BTK inhibitor. NX-2127 exploits the normal cellular protein degradation mechanism, the E3 ligase-medicated ubiquitin-proteasome pathway, to elicit BTK degradation.
  •  January 2022: ArcticZymes Technologies launched the ArcticZymes R2DTM Ligase. The enzyme can synthesize applications for possible therapeutic uses, next-generation sequencing (NGS), molecular diagnostics (MDx), and other emerging technologies.

Ligases Enzyme Market Report - Table of Contents

1. INTRODUCTION

  • 1.1 Study Assumptions and Market Definition
  • 1.2 Scope of the Study

2. RESEARCH METHODOLOGY

3. EXECUTIVE SUMMARY

4. MARKET DYNAMICS

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Increase in Prevalence of Birth Genetic Disorders and Infectious Diseases
    • 4.2.2 Advent in Ligases as Therapeutic Interventions of Cancer
    • 4.2.3 Rising Research Activities for Sequencing Applications
  • 4.3 Market Restraints
    • 4.3.1 Risk of High Sensitivity of the Enzyme
  • 4.4 Porter's Five Forces Analysis
    • 4.4.1 Threat of New Entrants
    • 4.4.2 Bargaining Power of Buyers/Consumers
    • 4.4.3 Bargaining Power of Suppliers
    • 4.4.4 Threat of Substitute Products
    • 4.4.5 Intensity of Competitive Rivalry

5. MARKET SEGMENTATION (Market Size by Value - USD million)

  • 5.1 By Source
    • 5.1.1 Microorganisms
    • 5.1.1.1 Bacteria
    • 5.1.1.2 Virus
    • 5.1.1.3 Other Microorganisms
    • 5.1.2 Animal
    • 5.1.3 Plant
  • 5.2 By Application
    • 5.2.1 Polymerase Chain Reaction
    • 5.2.2 Cloning
    • 5.2.3 Mutation Detection
    • 5.2.4 Next-generation Sequencing
    • 5.2.5 Drug Target
  • 5.3 By End User
    • 5.3.1 Diagnostic Centers and Hospitals
    • 5.3.2 Research Institutes
  • 5.4 Geography
    • 5.4.1 North America
    • 5.4.1.1 United States
    • 5.4.1.2 Canada
    • 5.4.1.3 Mexico
    • 5.4.2 Europe
    • 5.4.2.1 Germany
    • 5.4.2.2 United Kingdom
    • 5.4.2.3 France
    • 5.4.2.4 Italy
    • 5.4.2.5 Spain
    • 5.4.2.6 Rest of Europe
    • 5.4.3 Asia-Pacific
    • 5.4.3.1 China
    • 5.4.3.2 Japan
    • 5.4.3.3 India
    • 5.4.3.4 Australia
    • 5.4.3.5 South Korea
    • 5.4.3.6 Rest of Asia-Pacific
    • 5.4.4 Middle East and Africa
    • 5.4.4.1 GCC
    • 5.4.4.2 South Africa
    • 5.4.4.3 Rest of Middle East and Africa
    • 5.4.5 South America
    • 5.4.5.1 Brazil
    • 5.4.5.2 Argentina
    • 5.4.5.3 Rest of South America

6. COMPETITIVE LANDSCAPE

  • 6.1 Company Profiles
    • 6.1.1 Agilent Technologies Inc.
    • 6.1.2 ArcticZymes Technologies
    • 6.1.3 Becton, Dickinson and Company
    • 6.1.4 Creative Enzymes
    • 6.1.5 Merck KGaA
    • 6.1.6 New England Biolabs
    • 6.1.7 Oxford Nanopore Technologies
    • 6.1.8 Promega Corporation
    • 6.1.9 QIAGEN
    • 6.1.10 R&D Systems, Inc
    • 6.1.11 Takara Bio Inc.
    • 6.1.12 Thermo Fisher Scientific
  • *List Not Exhaustive

7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Subject to Availability
**Competitive Landscape Covers- Business Overview, Financials, Products and Strategies and Recent Developments
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Ligases Enzyme Industry Segmentation

As per the scope of the report, ligases are specific types of enzymes that speed up the joining of two large molecules, such as DNA. These enzymes are extensively used in cloning, mutation detection, gene synthesis, and next-generation sequencing. Ligase enzymes are also used for correcting dysfunctions and a lack of DNA ligases in humans. 

The Ligases Enzyme Market is Segmented by Source (Microorganisms (Bacteria, Viruses, and Other Microorganisms), Animals, and Plants), Application (Polymerase Chain Reaction, Cloning, Mutation Detection, Next-generation Sequencing, and Drug Target), End User (Diagnostic Centers and Hospitals, and Research Institutes), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (USD million) for the above segments.

By Source Microorganisms Bacteria
Virus
Other Microorganisms
Animal
Plant
By Application Polymerase Chain Reaction
Cloning
Mutation Detection
Next-generation Sequencing
Drug Target
By End User Diagnostic Centers and Hospitals
Research Institutes
Geography North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East and Africa GCC
South Africa
Rest of Middle East and Africa
South America Brazil
Argentina
Rest of South America
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Ligases Enzyme Market Research FAQs

What is the current Ligases Enzyme Market size?

The Ligases Enzyme Market is projected to register a CAGR of 5.5% during the forecast period (2025-2030)

Who are the key players in Ligases Enzyme Market?

Becton, Dickinson and Company, Agilent Technologies, Merck KGaA, Thermo Fisher Scientific and ArcticZymes Technologies are the major companies operating in the Ligases Enzyme Market.

Which is the fastest growing region in Ligases Enzyme Market?

Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).

Which region has the biggest share in Ligases Enzyme Market?

In 2025, the North America accounts for the largest market share in Ligases Enzyme Market.

What years does this Ligases Enzyme Market cover?

The report covers the Ligases Enzyme Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Ligases Enzyme Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.

Ligases Enzyme Industry Report

Statistics for the 2025 Ligases Enzyme market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Ligases Enzyme analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.