Ligases Enzyme Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Ligases Enzyme Market is segmented by Source (Microorganisms, Animals, and Plants), Application (Polymerase Chain Reaction, Cloning, Mutation Detection, Next-generation Sequencing, and Drug Target), End User (Diagnostic Centers and Hospitals and Research Institutes), and Geography.

Market Snapshot

Study Period: 2018 - 2026
Base Year: 2021
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 5.5 %

Need a report that reflects how COVID-19 has impacted this market and its growth?

Market Overview

The ligases enzyme market is anticipated to record a CAGR of nearly 5.5% during the forecast period. An increase in R&D investments to develop ligases as targets for therapeutic intervention of cancer is anticipated to drive the market over the forecast period. Post-translational modification of protein is important for maintaining the physiological function. Dysregulation of protein ubiquitination will induce cancer. Ligases and deubiquitinases regulate protein ubiquitination to control the function and stability of protein, thereby developing inhibitors for the prevention of target disease. This results in a growing need for ligases in disease treatment, thereby propelling the market growth.

Furthermore, an increase in the incidence of birth genetic disorders and infectious diseases is expected to drive the market growth as ligases find application in the detection of birth mutations and infectious diseases. For example, as per the World Health Organization, in the United States, sickle cell anemia affects around 72,000 people, most of whose ancestors come from Africa. About 2 million Americans, or 1 in 12 African Americans, carry the sickle cell allele. Rise in research activities for sequencing applications and involvement of ligase enzymes in protein engineering are considered to be the key factors contributing to market growth.

However, high sensitivity of the enzyme to factors, such as DNA concentration, ligase concentration, temperature, and buffer composition , limits its adoption, which may hinder the growth of the ligase enzyme market.

Scope of the Report

As per the scope of the report, enzymes are biological catalysts that accelerate the speed of chemical reactions, especially the ones that occur within the body of an organism. Ligases are a specific type of enzymes that speed up the joining of two large molecules, such as DNA. These enzymes are extensively used in cloning, mutation detection, gene synthesis, and next-generation sequencing. Ligases enzymes are also used for correcting dysfunctions and a lack of DNA ligases in humans. The ligases enzyme market is segmented by source, application, end user, and geography.

By Source
Other Microorganisms
By Application
Polymerase Chain Reaction
Mutation Detection
Next-generation Sequencing
Drug Target
By End User
Diagnostic Centers and Hospitals
Research Institutes
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle East & Africa
South Africa
Rest of Middle East & Africa
South America
Rest of South America

Report scope can be customized per your requirements. Click here.

Key Market Trends

Polymerase Chain Reaction Segment Dominates the Market and is Expected to Continue the Same during the Forecast Period

  • Polymerase chain reaction (PCR) is expected to dominate of the ligases enzyme market through the forecast period. PCR involves a thermostable ligase to join two probes or other molecules together. This technology has wide-ranging applications in both basic and diagnostic research, such as human genetic testing, forensic sciences, pathogen detection, and infectious disease testing, which act as a high impact rendering factor for this segment’s growth. High prevalence of target diseases and rapid technological advancements, such as the development of high performance and superior qPCR and dPCR systems that demand the high need of ligases, are expected to be the key factors driving the growth.

North America Dominates the Market and is Expected to Continue the Same during the Forecast Period

North America is a prominent market due to the well-established end-user industries, such as molecular biology laboratories, research institutes, and pharmaceuticals companies. High scope for R&D activities in major countries is driving regional growth. The US government has heavily invested in R&D to promote the production of ligases as therapeutics for various genetic disorders, which is expected to propel the regional market over the forecast period.

Asia-Pacific is anticipated to witness lucrative growth over the forecast period. The target population comprising individuals with genetic disorders, such as sickle cell anemia and hemophilia, is on the rise in this region. This provides avenues for players in this vertical to carry out research and develop a novel treatment with regards to disease treatment, thereby, increasing product penetration in the regional verticals.


Competitive Landscape

The ligases enzyme market is moderately competitive and consists of the global as well as local players. Due to the technological advancements, small and mid-sized companies are focusing on market penetration to grab the market share. Some of the companies that are currently present in the market are ArcticZymes, New England Biolabs, Promega Corporation, QIAGEN, and Takara Bio Inc. New product launches, collaborations, mergers, and acquisitions are the key initiatives undertaken by the leading players in this vertical to sustain the competition. For instance, in February 2019, ArcticZymes launched its first ligase enzyme, T4 DNA ligase, which is a widely used enzyme in the ligase family with an aim of growing a synergistic portfolio beyond novel enzyme products.

Table of Contents


    1. 1.1 Study Assumptions

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increase in Prevalence of Birth Genetic Disorders and Infectious Diseases

      2. 4.2.2 Advent in Ligases as Therapeutic Interventions of Cancer

      3. 4.2.3 Rising Research Activities for Sequencing Applications

    3. 4.3 Market Restraints

      1. 4.3.1 Risk of High Sensitivity of the Enzyme

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry


    1. 5.1 By Source

      1. 5.1.1 Microorganisms

        1. Bacteria

        2. Virus

        3. Other Microorganisms

      2. 5.1.2 Animal

      3. 5.1.3 Plant

    2. 5.2 By Application

      1. 5.2.1 Polymerase Chain Reaction

      2. 5.2.2 Cloning

      3. 5.2.3 Mutation Detection

      4. 5.2.4 Next-generation Sequencing

      5. 5.2.5 Drug Target

    3. 5.3 By End User

      1. 5.3.1 Diagnostic Centers and Hospitals

      2. 5.3.2 Research Institutes

    4. 5.4 Geography

      1. 5.4.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.4.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.4.4 Middle East & Africa

        1. GCC

        2. South Africa

        3. Rest of Middle East & Africa

      5. 5.4.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 Agilent Technologies Inc.

      2. 6.1.2 ArcticZymes

      3. 6.1.3 Becton, Dickinson and Company

      4. 6.1.4 Merck KGaA

      5. 6.1.5 New England Biolabs

      6. 6.1.6 Promega Corporation

      7. 6.1.7 QIAGEN

      8. 6.1.8 Takara Bio Inc.

      9. 6.1.9 Thermo Fisher Scientific

    2. *List Not Exhaustive

**Subject to Availability
**Competitive Landscape Covers- Business Overview, Financials, Products and Strategies and Recent Developments

You can also purchase parts of this report. Do you want to check out a section wise price list?

Frequently Asked Questions

The Ligases Enzyme Market market is studied from 2018 - 2026.

The Ligases Enzyme Market is growing at a CAGR of 5.5% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2021.

ArcticZymes, Becton, Dickinson and Company , Agilent Technologies , Merck KGaA , Thermo Fisher Scientific are the major companies operating in Ligases Enzyme Market.

80% of our clients seek made-to-order reports. How do you want us to tailor yours?

Please enter a valid email id!

Please enter a valid message!