DNA Synthesis Market Size
DNA Synthesis Market Analysis
The DNA Synthesis Market size is estimated at USD 3.74 billion in 2025, and is expected to reach USD 7.74 billion by 2030, at a CAGR of 15.69% during the forecast period (2025-2030).
DNA Synthesis Market Overview
The DNA synthesis industry is experiencing significant transformation amid broader shifts in healthcare spending and research priorities. Government initiatives worldwide are demonstrating strong commitment to advancing precision medicine and biotechnology research capabilities. For instance, the United Kingdom's Department for Business and Trade announced plans to allocate 2.4% of GDP to R&D initiatives by 2027. This surge in healthcare investment reflects growing recognition of synthetic biology's potential to address complex medical challenges and drive innovation in therapeutic development.
The technological landscape is rapidly evolving, marked by substantial private investment in novel synthesis approaches and platforms. In August 2023, Atantares secured USD 13.9 million in funding to develop molecular chips aimed at improving enzyme efficiency. The molecular chips used complementary metal-oxide-semiconductor (CMOS) chip technology, which is battery-powered, and stores the hard drive’s configuration and other information. The company aimed to use the technology in high-throughput DNA synthesis. This follows the broader industry trend of strategic funding, exemplified by Ansa Biotechnologies raising USD 68 million in April 2022 to advance DNA synthesis processes and launch customizable services. These investments are accelerating the development of more efficient, sustainable, and precise synthesis technologies.
The regulatory environment continues to mature, with significant developments in therapy approvals demonstrating increasing acceptance of DNA-based treatments. A landmark development occurred in December 2023 when the FDA approved Casgevy and Lyfgenia as the first cell-based gene therapies for sickle cell disease in patients aged 12 and older. These approvals represent a crucial shift in regulatory perspective toward advanced therapeutic applications of synthetic DNA, establishing important precedents for future innovations in the field.
The expanding application scope of DNA synthesis technologies is being driven by growing disease burden and diagnostic needs. According to the World Health Organization's February 2024 report, approximately 20 million new cancer cases were reported globally in 2022, highlighting the critical need for advanced diagnostic and therapeutic solutions. This trend is particularly evident in the United States, where the American Cancer Society projects around 2.04 million new cancer cases in 2025, underscoring the increasing demand for precise molecular diagnostic tools and personalized treatment approaches utilizing synthetic DNA technologies.
DNA Synthesis Market Trends
Advancements in Synthetic Biology and Next-Generation Synthesis Technologies
The DNA synthesis market is experiencing significant growth driven by revolutionary advances in synthetic biology and next-generation synthesis technologies. Companies are developing innovative approaches like enzymatic DNA synthesis, microfluidic-based synthesis platforms, and DNA laser printing technologies that offer unprecedented precision and control over DNA sequence assembly. These technological breakthroughs have enabled researchers to synthesize longer DNA sequences with higher accuracy while significantly reducing synthesis time and costs.
The integration of artificial intelligence and machine learning algorithms with DNA synthesis platforms has further accelerated the development of novel synthesis methods. These advanced computational tools help optimize synthesis protocols, predict potential synthesis challenges, and improve the overall success rate of DNA construction. Additionally, the emergence of semiconductor-based synthesis platforms and thermal control systems has enabled more precise control over reaction conditions. This was exemplified when Evonetix installed their innovative DNA synthesis platform featuring semiconductor chips and thermal controllers at Imperial College London in October 2023, showcasing how next-generation technologies are transforming traditional synthesis approaches and enabling more efficient production of synthetic DNA sequences.
Growing R&D Investments and Expansion in Drug & Gene Therapy Development
The substantial increase in research and development investments, particularly in drug discovery and gene therapy development, is propelling the DNA synthesis market forward. Government initiatives and private sector funding are creating a robust environment for advancement in synthetic biology research. For instance, the research funding provided for gene therapy by the National Institute of Health in United States is expected to increase from USD 562 million in 2023 to USD 618 million in 2025. This increased funding has enabled research institutions and biotechnology companies to expand their capabilities in developing novel gene therapies and precision medicine applications using synthetic DNA.
The recent breakthroughs in gene therapy development have further accelerated the demand for high-quality synthetic DNA. The approval of groundbreaking gene therapies like BEQVEZ (fidanacogene elaparvovec-dzkt) by the FDA in April 2024 for treating hemophilia B demonstrated the practical applications of synthetic DNA in developing life-changing treatments.
Rising Demand for Customized DNA Sequences and Automation in High-Throughput Platforms
The increasing demand for customized DNA sequences and automated high-throughput synthesis platforms is fundamentally transforming the DNA synthesis landscape. Research institutions and biotechnology companies are increasingly seeking tailored DNA constructs for various applications, from gene editing to synthetic biology projects. This trend is evidenced by the growing number of service providers offering customized DNA synthesis solutions with rapid turnaround times.
The automation of DNA synthesis processes through high-throughput platforms has become crucial in meeting the escalating demand for synthetic DNA while maintaining quality and efficiency. Companies are investing heavily in developing automated systems that can handle multiple synthesis reactions simultaneously while ensuring high accuracy and reproducibility. This is particularly important given the projected increase in demand for molecular diagnostics and personalized medicine applications. The integration of robotics and advanced chemistry in automated platforms has significantly reduced turnaround times and costs while enhancing the reproducibility and quality control in DNA synthesis workflows.
DNA Synthesis Market Product and Service Segment Analysis
Reagents and Consumables Segment in DNA Synthesis Market
The reagents and consumables segment maintains its dominant position in the DNA synthesis market, commanding signficant market share in 2024. This segment's leadership is primarily attributed to the recurring nature of consumable purchases and the essential role these materials play in DNA synthesis workflows. The segment's strength is further reinforced by increasing R&D activities in pharmaceutical and biotechnology companies, driving consistent demand for high-quality reagents. Advanced synthesis technologies and automation platforms have also contributed to higher consumption rates of specialized reagents and consumables. Quality control requirements and standardization needs across DNA synthesis operations have led to increased adoption of validated reagent systems. The segment's robust performance is additionally supported by the expanding application scope in diagnostics, therapeutics, and research applications, necessitating a steady supply of reliable reagents and consumables.
DNA Synthesis Services Segment in DNA Synthesis Market
The DNA synthesis services segment emerges as the fastest-growing category, projected to achieve a remarkable CAGR of 16.5% from 2025 to 2030. This accelerated growth trajectory is driven by increasing outsourcing trends among pharmaceutical and biotechnology companies seeking specialized expertise and cost-effective solutions. The segment's expansion is further fueled by advancements in automation and high-throughput synthesis platforms, enabling service providers to offer faster turnaround times and more competitive pricing. Rising demand for customized DNA sequences, particularly in therapeutic development and synthetic biology applications, continues to boost service adoption. Contract research organizations (CROs) and CDMOs are expanding their service capabilities to meet the growing demand for complex DNA synthesis requirements. The integration of advanced technologies and quality control measures by service providers has enhanced reliability and accuracy, making outsourcing an attractive option for both large and small-scale organizations.
DNA Synthesis Market Type Segment Analysis
Oligonucleotide Synthesis Segment in DNA Synthesis Market
The oligonucleotide synthesis segment maintains its dominant position in the DNA synthesis market, commanding approximately 65% of the market share in 2024. This substantial market presence is primarily driven by the widespread application of oligonucleotides in diagnostic testing, PCR applications, and molecular biology research. The segment's strength is further reinforced by the increasing demand for synthetic DNA primers in COVID-19 testing protocols and other molecular diagnostic applications. Advanced automation technologies and improved synthesis efficiency have made oligonucleotide production more accessible and cost-effective for research institutions and pharmaceutical companies. The segment's robust performance is also supported by the growing adoption of next-generation sequencing technologies, which require high-quality synthetic oligonucleotides. Additionally, the emergence of personalized medicine and the expansion of molecular diagnostic capabilities have created sustained demand for custom oligonucleotide sequences.
Gene Synthesis Segment in DNA Synthesis Market
The gene synthesis segment is experiencing remarkable growth, projected to expand at an impressive CAGR of 17% from 2025 to 2030. This accelerated growth trajectory is fueled by increasing applications in synthetic biology, protein engineering, and therapeutic development. The segment's expansion is particularly notable in advanced therapeutic applications, including cell and gene therapy development, where longer DNA constructs are essential. Technological advancements in synthesis methods, including improved enzyme technologies and assembly techniques, are enabling the production of longer and more complex gene sequences with higher accuracy. The rising demand for CRISPR-based gene editing applications and the development of novel biologics are creating substantial opportunities for this segment. Furthermore, the integration of artificial intelligence and machine learning in gene design and optimization is enhancing the efficiency and reliability of gene synthesis processes, contributing to the segment's rapid growth.
DNA Synthesis Market Application Segment Analysis
Research and Development Segment in DNA Synthesis Market
The research & development (R&D) segment dominates the DNA synthesis market, commanding signicant market share in 2024. This substantial market position is primarily driven by the extensive application of DNA synthesis in cloning, gene editing, and drug discovery processes. The segment's prominence is further reinforced by increasing investments in genomics research and the adoption of CRISPR and other gene-editing technologies. Academic and research institutes, along with pharmaceutical companies, contribute significantly to this segment's dominance through their continuous demand for custom DNA sequences. The integration of automation and high-throughput platforms has particularly benefited R&D applications, enabling faster and more efficient research processes. Additionally, the segment's growth is supported by expanding applications in synthetic biology and the development of novel research methodologies requiring customized DNA sequences.
Therapeutics Segment in DNA Synthesis Market
The therapeutics segment emerges as the fastest-growing segment in the DNA synthesis market, projected to expand at an impressive CAGR of approximately 18% from 2025 to 2030. This remarkable growth trajectory is primarily fueled by the increasing adoption of gene therapy applications and preventive medicine developments. The segment's rapid expansion is supported by technological advancements in synthesis methods and growing investments in personalized medicine initiatives. Rising demand for targeted therapeutic solutions and the development of novel gene-based treatments continue to drive innovation in this segment. The integration of DNA synthesis in therapeutic applications has been particularly accelerated by improvements in delivery mechanisms and increased success rates in clinical trials. Furthermore, the segment benefits from growing collaborations between biotechnology companies and research institutions, fostering the development of innovative therapeutic solutions.
DNA Synthesis Market Application Segment Analysis
Pharmaceutical and Biotechnology Companies Segment in DNA Synthesis Market
The pharmaceutical and biotechnology companies segment holds a signficant position in the market. This leadership position is primarily driven by these companies' substantial R&D investments in genomics research, drug development, and gene therapy applications. The segment's dominance is further strengthened by the increasing adoption of synthetic biology approaches in drug discovery and development processes. Major pharmaceutical companies are expanding their internal DNA synthesis capabilities to support their growing pipeline of genetic medicine products. The integration of advanced synthesis technologies and automation platforms within their research facilities has enhanced their operational efficiency. Additionally, the rising demand for personalized medicine and targeted therapeutics has prompted these companies to increase their DNA synthesis capabilities, further solidifying their market position.
CROs and CDMOs Segment in DNA Synthesis Market
Contract Research Organizations (CROs) and Contract Development and Manufacturing Organizations (CDMOs) represent the fastest-growing segment in the DNA synthesis market, with a projected CAGR of 16% from 2024 to 2029. This remarkable growth is attributed to the increasing trend of outsourcing DNA synthesis services by pharmaceutical companies and research institutions seeking cost-effective solutions. The segment's expansion is further fueled by these organizations' investments in state-of-the-art synthesis technologies and high-throughput platforms. CROs and CDMOs are increasingly offering specialized services such as custom oligonucleotide synthesis, gene synthesis, and related analytical services. Their ability to provide scalable solutions, maintain high quality standards, and offer competitive pricing has made them attractive partners for both large pharmaceutical companies and emerging biotech firms. The segment's growth is also supported by the rising demand for rapid turnaround times and specialized expertise in complex DNA synthesis projects.
DNA Synthesis Market Geography Segment Analysis
DNA Synthesis Market in North America
North America represents the dominant region in the global DNA synthesis market, driven by robust biotechnology and pharmaceutical sectors, extensive research activities, and advanced healthcare infrastructure. The region benefits from the presence of major market players, leading research institutions, and significant investments in genomics research. The United States and Canada form the key markets, with both countries demonstrating strong capabilities in synthetic biology research and development. The region's leadership position is reinforced by favorable regulatory frameworks, increased adoption of precision medicine approaches, and growing applications in drug discovery and development.

DNA Synthesis Market in United States
The United States maintains its position as the largest market for DNA synthesis in North America, accounting for approximately 83% of the regional market share in 2024. The country's dominance is attributed to its extensive network of biotechnology companies, research institutions, and academic centers actively engaged in genomics research. The presence of major pharmaceutical companies, coupled with substantial government funding for genomics research and synthetic biology initiatives, continues to drive market growth. The U.S. market benefits from advanced research infrastructure, high healthcare spending, and increasing demand for personalized medicine applications. The country also leads in technological innovations and new product developments in the DNA synthesis space.
DNA Synthesis Market in Canada
Canada emerges as the fastest-growing market in North America, projected to grow at approximately 15% CAGR from 2025-2030. The country's rapid growth is fueled by increasing investments in biotechnology research, growing adoption of synthetic biology applications, and expanding pharmaceutical research activities. Canadian research institutions and biotech companies are increasingly focusing on developing innovative DNA synthesis technologies and applications. The country's supportive regulatory environment, combined with government initiatives to promote biotechnology research and development, creates favorable conditions for market expansion. Canada's growing expertise in genomics research and increasing collaborations between academic institutions and industry players further accelerate market growth.
DNA Synthesis Market in Europe
Europe represents the second-largest regional market for DNA synthesis globally, characterized by strong presence of established biotechnology companies and research organizations. The region's market is driven by advanced healthcare infrastructure, significant investments in genomics research, and growing adoption of personalized medicine approaches. Key countries including Germany, France, United Kingdom, Italy, and Spain contribute significantly to the regional market growth. The European market benefits from strong regulatory frameworks, increased focus on precision medicine, and growing applications in pharmaceutical research and development.
DNA Synthesis Market in Germany
Germany stands as the largest DNA synthesis market in Europe, holding approximately 27% of the regional market share in 2024. The country's leadership position is supported by its robust pharmaceutical and biotechnology sectors, advanced research infrastructure, and strong focus on innovative healthcare solutions. German research institutions and companies are at the forefront of developing novel DNA synthesis technologies and applications. The country's significant investments in life sciences research, coupled with strong industry-academia collaborations, continue to drive market growth.
DNA Synthesis Market in United Kingdom
The United Kingdom emerges as the fastest-growing market in Europe, with an expected growth rate of approximately 16% from 2025-2030. The country's rapid market expansion is driven by increasing investments in genomics research, growing adoption of synthetic biology applications, and strong government support for biotechnology initiatives. British research institutions and companies are actively involved in developing innovative DNA synthesis technologies and applications. The UK's leadership in genomics research, combined with its strong focus on precision medicine and therapeutic applications, positions it for sustained growth.
DNA Synthesis Market in Asia-Pacific
The Asia-Pacific region represents a rapidly expanding market for DNA synthesis, characterized by growing healthcare infrastructure, increasing research and development activities, and rising investments in biotechnology. Countries including China, Japan, India, Australia, and South Korea are making significant contributions to regional market growth. The region demonstrates strong potential for market expansion, driven by increasing adoption of molecular diagnostics, growing focus on personalized medicine, and rising healthcare expenditure.
DNA Synthesis Market in China
China emerges as the largest market for DNA synthesis in the Asia-Pacific region, supported by its extensive biotechnology sector, significant research investments, and growing focus on precision medicine. The country's market leadership is driven by the presence of major domestic players, increasing government support for biotechnology research, and expanding applications in pharmaceutical development. Chinese institutions and companies are actively advancing their capabilities in DNA synthesis technologies and applications.
DNA Synthesis Market in India
India represents the fastest-growing market in the Asia-Pacific region, driven by rapid expansion of its biotechnology sector, increasing research activities, and growing adoption of molecular diagnostic technologies. The country's market growth is supported by rising healthcare expenditure, growing focus on personalized medicine, and increasing investments in research infrastructure. Indian companies and research institutions are increasingly participating in the development of innovative DNA synthesis applications and technologies.
DNA Synthesis Market in Middle East and Africa
The Middle East & Africa region represents an emerging market for DNA synthesis, with growing opportunities in research and diagnostic applications. The region's market is characterized by increasing investments in healthcare infrastructure, rising adoption of advanced diagnostic technologies, and growing focus on biotechnology research. While currently at a nascent stage compared to developed markets, the region shows potential for growth driven by increasing healthcare spending and government initiatives to promote biotechnology development. GCC represent the largest market share in the region, while South Africa demonstrates the fastest growth potential.
DNA Synthesis Market in South America
The South American DNA synthesis market demonstrates growing potential, characterized by increasing investments in healthcare infrastructure and rising adoption of molecular diagnostic technologies. The region's market growth is driven by expanding research activities, growing awareness of personalized medicine, and increasing healthcare expenditure. While the market currently represents a smaller share globally, it shows promising growth prospects due to rising government initiatives to promote biotechnology research and development. Brazil emerges as both the largest and fastest growing market in the region.
DNA Synthesis Industry Overview
Top Companies in DNA Synthesis Market
The DNA synthesis market is led by prominent players including Bioneer Corporation, Danaher Corporation (Integrated DNA Technologies, Inc.), Eton Bioscience, Inc, Eurofins Scientific, GenScript Biotech Corporation, LGC Biosearch Technologies, Thermo Fisher Scientific Inc., and Twist Bioscience. These companies demonstrate consistent focus on product innovation through development of advanced synthesis technologies, automated platforms, and high-throughput systems. The industry witnesses regular launches of novel services offering faster turnaround times, improved accuracy, and cost-effective solutions. Market leaders are expanding their geographical presence through strategic partnerships, distribution agreements, and establishment of new facilities across key regions. Companies are also investing significantly in research and development to enhance their technological capabilities and service offerings while maintaining strong quality standards and regulatory compliance.
Consolidated Market with Strong Regional Players
The DNA synthesis market exhibits a semi-consolidated structure with a mix of global conglomerates and specialized regional players. The top tier comprises large multinational corporations with integrated operations across the life sciences value chain, offering comprehensive product portfolios and services. These established players leverage their strong distribution networks, technical expertise, and financial resources to maintain market leadership. The middle segment consists of specialized regional players focusing on specific geographic markets or application areas, while maintaining competitive advantages through customized solutions and local market understanding.
The industry has witnessed significant merger and acquisition activity as larger companies seek to expand their technological capabilities and geographic reach. Strategic acquisitions focus on companies with complementary technologies, established customer relationships, or strong regional presence. Partnerships and collaborations between companies are common, particularly for developing new synthesis technologies or expanding service offerings. Market participants are increasingly forming alliances with academic institutions and research organizations to advance their technological capabilities and strengthen their market position.
Innovation and Service Excellence Drive Success
Success in the DNA synthesis market increasingly depends on technological innovation, service quality, and operational efficiency. Incumbent players must continuously invest in advanced synthesis technologies, automation capabilities, and digital platforms to maintain their competitive edge. Companies need to focus on reducing synthesis costs while improving accuracy and turnaround times. Building strong relationships with key customer segments, particularly pharmaceutical companies and research institutions, remains crucial. Additionally, developing specialized expertise in emerging applications like gene therapy and synthetic biology can provide significant competitive advantages.
Market contenders can gain ground by focusing on niche applications, offering specialized services, or serving underserved geographic markets. Success factors include developing proprietary synthesis technologies, establishing efficient production processes, and maintaining high quality standards. Companies must navigate evolving regulatory requirements, particularly regarding biosecurity and quality control. The ability to provide comprehensive technical support, customize solutions, and maintain competitive pricing will become increasingly important. Future growth opportunities lie in expanding service offerings, developing innovative synthesis methods, and establishing strategic partnerships with key stakeholders in the biotechnology and pharmaceutical sectors.
DNA Synthesis Market Leaders
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Bioneer Corporation
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Danaher Corporation (Integrated DNA Technologies, Inc.)
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Eurofins Scientific
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Thermo Fisher Scientific Inc.
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Twist Bioscience
- *Disclaimer: Major Players sorted in no particular order

DNA Synthesis Market News
- January 2025: Elegen announced the launch of ENFINIA Plasmid DNA, a faster, cost-effective solution for clonal synthesis of long and complex genes. ENFINIA Plasmid DNA provides access to high-complexity clonal genes up to 15 kb, NGS-verified and shipped globally from Elegen’s United States facilities in just 10 business days. Pricing was promised to not exceed USD 0.20 per bp for standard complexity sequences above 3 kb in length.
- November 2024: Ansa Biotechnologies, Inc., the trusted partner for complex DNA synthesis, today announced that it can now deliver its Ansa Clonal DNA product in lengths up to 5 kb. The longer constructs are made possible due to a new proprietary, sequence-agnostic assembly technology that was recently validated and released into production.
- May 2024: Integrated DNA Technologies (IDT) unveiled the 25,000 square-foot facility in Coralville, Iowa, United States. This expansion marked a significant augmentation of its synthetic biology operations, doubling its footprint in this critical field.
- May 2024: Molecular Assemblies, Inc. launched its partnering program for licensing Molecular Assemblies' Fully Enzymatic Synthesis (FES) technology for onsite synthesis. FES technology accelerates the production of long, pure, and accurate DNA to power a new rapidly emerging generation of therapeutics and diagnostics.
DNA Synthesis Industry Segmentation
As per the scope of the report, DNA synthesis refers to the artificial process of creating deoxyribonucleic acid (DNA) molecules. It occurs in laboratory settings for genetic engineering and research applications.
The DNA synthesis market is segmented as product and service, type, application, end-user, and geography. By product and service, the market is segmented by instruments, reagents and consumables, and DNA synthesis services. By type, the market is segmented by oligonucleotide synthesis and gene synthesis. By application, the market is segmented by diagnostics, therapeutics, and research and development. By end-user, the market is segmented by pharmaceutical and biotechnology companies, CROs and CDMOs, academic and research institutes, and others. By geography, the market is segmented into North America, Europe, Asia-Pacific, the Middle East and Africa, and South America. The market report also covers the estimated market sizes and trends for 17 countries across major regions, globally. The report offers the value (in USD) for the above-mentioned segments.
By Product and Service | Instruments | ||
Reagents and Consumables | |||
DNA Synthesis Services | |||
By Type | Oligonucleotide Synthesis | ||
Gene Synthesis | |||
By Application | Diagnostics | ||
Therapeutics | |||
Research and Development | |||
By End User | Pharmaceutical and Biotechnology Companies | ||
CROs and CDMOs | |||
Academic and Research Institutes | |||
Others | |||
Geography | North America | United States | |
Canada | |||
Mexico | |||
Europe | Germany | ||
United Kingdom | |||
France | |||
Italy | |||
Spain | |||
Rest of Europe | |||
Asia-Pacific | China | ||
Japan | |||
India | |||
Australia | |||
South Korea | |||
Rest of Asia-Pacific | |||
Middle East and Africa | GCC | ||
South Africa | |||
Rest of Middle East and Africa | |||
South America | Brazil | ||
Argentina | |||
Rest of South America |
Instruments |
Reagents and Consumables |
DNA Synthesis Services |
Oligonucleotide Synthesis |
Gene Synthesis |
Diagnostics |
Therapeutics |
Research and Development |
Pharmaceutical and Biotechnology Companies |
CROs and CDMOs |
Academic and Research Institutes |
Others |
North America | United States |
Canada | |
Mexico | |
Europe | Germany |
United Kingdom | |
France | |
Italy | |
Spain | |
Rest of Europe | |
Asia-Pacific | China |
Japan | |
India | |
Australia | |
South Korea | |
Rest of Asia-Pacific | |
Middle East and Africa | GCC |
South Africa | |
Rest of Middle East and Africa | |
South America | Brazil |
Argentina | |
Rest of South America |
DNA Synthesis Market Research Faqs
How big is the DNA Synthesis Market?
The DNA Synthesis Market size is expected to reach USD 3.74 billion in 2025 and grow at a CAGR of 15.69% to reach USD 7.74 billion by 2030.
What is the current DNA Synthesis Market size?
In 2025, the DNA Synthesis Market size is expected to reach USD 3.74 billion.
Which is the fastest growing region in DNA Synthesis Market?
Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).
Which region has the biggest share in DNA Synthesis Market?
In 2025, the North America accounts for the largest market share in DNA Synthesis Market.
What years does this DNA Synthesis Market cover, and what was the market size in 2024?
In 2024, the DNA Synthesis Market size was estimated at USD 3.15 billion. The report covers the DNA Synthesis Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the DNA Synthesis Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.