Gene Therapy Market - Growth, Trends, COVID-19 Impact, and Forecasts (2021 - 2026)

The Gene Therapy market is segmented by Indication (Cancer, Metabolic Disorders, Eye Disorders, Cardiovascular Diseases, and Others), Technology (Adeno Virus Vector, Adeno-associated Virus Vector, Lentiviral Vector, Retroviral Vector, Herpes Virus Vector and Others), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (in USD million) for the above segments.

Market Snapshot

Gene Therapy Market Overview
Study Period: 2018 - 2026
Base Year: 2020
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 28.32 %
Gene Therapy Market Key Players

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Market Overview

The Gene Therapy Market was estimated to be USD 6,659.93 million in 2020 and is poised to grow at a CAGR of 28.32% by 2026 to reach USD 11,739.75 million.

The COVID-19 pandemic is expected to have a positive effect on the gene therapy market. Gene and cell therapy technology is expected to be used extensively in the development of vaccines used to treat COVID-19. For example, in January 2021, vaccine candidates developed by Mass General Brigham and made by utilizing gene-therapy technology elicited strong immune responses in animal models for the treatment of COVID-19. The vaccine candidate was named AAVCOVID and the researchers received a USD 2.1 million grant to further develop the technology from the Bill & Melinda Gates Foundation. The vaccine which is being developed is likely to be far more convenient than the ones being sold in the market currently, as it has single-dose and can be stored at room temperature. Different approaches are being used by other researchers, like those from the University of Pennsylvania. In collaboration with Regeneron, the researchers are using adeno-associated viral vectors to transport lab-made antibodies into the body. These developments are expected to affect market growth in a positive manner.

The factors that drive market growth include technological advancements, rising investments in R&D, and the growing prevalence of target diseases.

Gene therapies are developed for the treatment of diseases by modifying genetic information, which includes inactivating genes that function improperly or replacing a gene, which causes disease with a healthy copy of the gene. Gene therapy is being used to treat several diseases and has shown promising results. Diseases such as Cystic Fibrosis, Cancer, Heart diseases, Diabetes, AIDS, Hemophilia can be cured by this method of treatment. Gene therapy is usually used to correct the defective gene to cure a specific disease or helps the body better fight against the diseases. There has been an increasing prevalence of many target diseases, such as cancer, rheumatoid arthritis, diabetes, Parkinson's disease, Alzheimer’s disease, etc. that have been cured by several gene therapies present already in the market. There has also been an increase in several genetic and numerous life-threatening disorders, especially heart diseases, AIDS, cystic fibrosis, and age-related disorders. Although gene therapy was initially targeted for inherited diseases, it is now used in the treatment of a variety of acquired problems including cancer and HIV. Initially delivered through viruses, now there are safer direct or biochemical vectors, while in the future nano-particles might deliver the drug of choice directly to the nucleus of affected cells. For instance, according to the World Health Organization, an estimated 17.9 million people die due to cardiovascular diseases worldwide, each year. This represents 35% of global deaths. As gene therapy provides a complete cure to patients affected with genetic and other life-threatening disorders, rather than ease symptoms that happen with other treatments, it is becoming more popular.

Investment in research and development activities is also expected to have a significant effect on the market. Companies such as Pfizer Inc., are aiming to build a gene therapy platform with a strategy focused on establishing a transformational portfolio through in-house capabilities and enhancing those capabilities through strategic collaborations, expansion of R&D activities, as well as potential licensing and M&A activities. For instance, Pfizer announced in August 2019 that it was investing USD 500 million to expand a manufacturing facility in North Carolina which plays a central role in its efforts to become a major player in the gene therapy industry.

Scope of the Report

Gene therapy is an advanced medical treatment that involves the transfer of a normal or healthy gene to replace a defective gene in a cell. It can be used to cure various chronic and genetic disorders in human beings.

Gene therapy is a way of fixing genetic disorders by introducing a normal and healthy gene in place of defective genes in a cell, in order to prevent or cure different types of genetic and chronic disorders for which no final cure has been developed.

The Gene Therapy market is segmented by Indication into Cancer, Metabolic Disorders, Eye Disorders, Cardiovascular Diseases, and Others. By Technology, it has been segmented into Adeno Virus Vector, Adeno-associated Virus Vector, Lentiviral Vector, Retroviral Vector, Herpes Virus Vector and Others. By Geography, the market has been segmented into North America, Europe, Asia-Pacific, Middle East and Africa, and South America. The report offers the value (in USD million) for the above segments.

By Indication
Cancer
Metabolic Disorders
Eye Disorders
Spinal Muscular Atrophy
Other Indications
By Technology
Adeno Virus Vector
Adeno-associated Virus Vector
Lentiviral Vector
Retroviral Vector
Herpes Virus Vector
Others
Geography
North America
United States (By Indication, and By Technology)
Canada (By Indication, and By Technology)
Mexico (By Indication, and By Technology)
Europe
Germany (By Indication, and By Technology)
United Kingdom (By Indication, and By Technology)
France (By Indication, and By Technology)
Italy (By Indication, and By Technology)
Spain (By Indication, and By Technology)
Rest of Europe (By Indication, and By Technology)
Asia-Pacific
China (By Indication, and By Technology)
Japan (By Indication, and By Technology)
India (By Indication, and By Technology)
Australia (By Indication, and By Technology)
South Korea (By Indication, and By Technology)
Rest of Asia-Pacific (By Indication, and By Technology)
Middle East and Africa
GCC (By Indication, and By Technology)
South Africa (By Indication, and By Technology)
Rest of Middle East and Africa (By Indication, and By Technology)
South America
Brazil (By Indication, and By Technology)
Argentina (By Indication, and By Technology)
Rest of South America (By Indication, and By Technology)

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Key Market Trends

Cancer is Expected to Hold Significant Market Share in the Indication Segment

The ever-rising prevalence of cancer all across the globe is a major factor driving the growth of this segment. According to Globocan 2020, an estimated 19,292,789 new cancer cases and 9,958,133 deaths due to cancers were reported in 2020 worldwide. In the treatment of cancer, various gene therapy strategies are currently employed. These include anti-angiogenic gene therapy, pro-drug activating suicide gene therapy, gene therapy-based immune modulation, oncolytic virotherapy, correction/compensation of gene defects, antisense, genetic manipulation of apoptotic and tumor invasion pathways and RNAi strategies. The cancer types, such as brain, lung, breast, pancreatic, liver, colorectal, prostate, bladder, head and neck, skin, ovarian, and renal cancer have been the target for these therapies.

Transferring genes into cancer cells have been one of the most difficult aspects of present-day gene therapy. Researchers are studying ways to alleviate the problems in this technique. Genes are taken into cancer cells with the help of a carrier known as a vector. The most common types of carriers that are used in gene therapy are viruses as they can enter cells and then deliver genetic material. Viruses are then changed in such a way so that they cannot result in any serious disorders.

Many key players in the market are focused on adopting strategies, such as mergers and acquisitions, to enhance their product portfolio, which in turn, is expected to propel the market growth over the forecast period. For instance, in December 2018, Kineta Inc. entered into a strategic research collaboration with Pfizer Inc. to develop RIG-I agonist immunotherapies for the treatment of cancer. In 2019, Amgen finalized a strategic collaboration with the Chinese company BeiGene, investing around USD 2.8 billion to gain a presence in China. The investment provided Amgen with an R&D pact and ownership of about one-fifth of BeiGene. Thus, developments such as these have led to the growth of the overall market.

Gene Therapy Market Key Trends

North America Dominates the Market and Expected to do Same in the Forecasted Period

For gene therapy, in the United States, the DHHS (Department of Health and Human Services) has been appointed to oversee clinical trials. Two other separate organizations within DHHS, the U.S. FDA (Food and Drug Administration) and the OHRP (Office for Human Research Protections) have authority that is described in the CFR (Code of Federal Regulations). Gene therap technologies are being given increasing approval by the afore-mentioned organizations, which is expected to drive market growth. For example, in May 2019, AveXis, a Novartis company, had announced that it had received US FDA approval for Zolgensma (onasemnogene abeparvovec-xioi) to treat pediatric patients younger than 2 years of age having spinal muscular atrophy (SMA) with bi-allelic mutations in the survival motor neuron 1 (SMN1) gene.

Companies are also engaging in collaborations to increase their market share.In February 2020, Biogen partnered with Sangamo Therapeutics in a USD 2.7 billion deal. The partnership is expected to focus initially on two preclinical Sangamo gene therapy candidates – ST-501 for Alzheimer’s and ST-502 for Parkinson’s disease, plus an undisclosed neuromuscular target. The partnership also includes exclusive rights for up to nine other undisclosed neurological targets. Such developments are expected to have a positive effect on market development.

Gene Therapy Market Growth by Region

Competitive Landscape

The global Gene Therapy market is highly competitive and consists of a few major players. Companies like Amgen Inc., Bluebird Bio, Gilead Sciences, Inc., Novartis AG, Orchard Therapeutics, Sibiono GeneTech Co. Ltd., Spark Therapeutics (Roche AG), and UniQure N.V., among others, hold the substantial market share in the Gene Therapy market.

There have various strategic alliances such as collaborations, acquisitions along with launch of advanced products to secure the position in the global market. In December 2019, Roche Group announced that it had acquired Spark Therapeutics in a deal valued at USD 4.8 billion. This is expected to strengthen the position of Roche in the gene therapy market.

Recent Developments

In January 2021, Biogen announced that it will partner with Germany's ViGeneron to develop gene therapies for inherited eye diseases.

In January 2020, Bluebird Bio Inc. launched the first gene therapy product for treating beta-thalassemia in the European Union. The product was named Zynteglo.

Table of Contents

  1. 1. INTRODUCTION

    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study

  2. 2. RESEARCH METHODOLOGY

  3. 3. EXECUTIVE SUMMARY

  4. 4. MARKET DYNAMICS

    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Rising Investments in the R&D

      2. 4.2.2 Technological Advancements

      3. 4.2.3 Growing Prevalence of Target Diseases like Cancer

    3. 4.3 Market Restraints

      1. 4.3.1 Lack of Standard Regulations

      2. 4.3.2 High Price of Products

    4. 4.4 Porter's Five Force Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION

    1. 5.1 By Indication

      1. 5.1.1 Cancer

      2. 5.1.2 Metabolic Disorders

      3. 5.1.3 Eye Disorders

      4. 5.1.4 Spinal Muscular Atrophy

      5. 5.1.5 Other Indications

    2. 5.2 By Technology

      1. 5.2.1 Adeno Virus Vector

      2. 5.2.2 Adeno-associated Virus Vector

      3. 5.2.3 Lentiviral Vector

      4. 5.2.4 Retroviral Vector

      5. 5.2.5 Herpes Virus Vector

      6. 5.2.6 Others

    3. 5.3 Geography

      1. 5.3.1 North America

        1. 5.3.1.1 United States (By Indication, and By Technology)

        2. 5.3.1.2 Canada (By Indication, and By Technology)

        3. 5.3.1.3 Mexico (By Indication, and By Technology)

      2. 5.3.2 Europe

        1. 5.3.2.1 Germany (By Indication, and By Technology)

        2. 5.3.2.2 United Kingdom (By Indication, and By Technology)

        3. 5.3.2.3 France (By Indication, and By Technology)

        4. 5.3.2.4 Italy (By Indication, and By Technology)

        5. 5.3.2.5 Spain (By Indication, and By Technology)

        6. 5.3.2.6 Rest of Europe (By Indication, and By Technology)

      3. 5.3.3 Asia-Pacific

        1. 5.3.3.1 China (By Indication, and By Technology)

        2. 5.3.3.2 Japan (By Indication, and By Technology)

        3. 5.3.3.3 India (By Indication, and By Technology)

        4. 5.3.3.4 Australia (By Indication, and By Technology)

        5. 5.3.3.5 South Korea (By Indication, and By Technology)

        6. 5.3.3.6 Rest of Asia-Pacific (By Indication, and By Technology)

      4. 5.3.4 Middle East and Africa

        1. 5.3.4.1 GCC (By Indication, and By Technology)

        2. 5.3.4.2 South Africa (By Indication, and By Technology)

        3. 5.3.4.3 Rest of Middle East and Africa (By Indication, and By Technology)

      5. 5.3.5 South America

        1. 5.3.5.1 Brazil (By Indication, and By Technology)

        2. 5.3.5.2 Argentina (By Indication, and By Technology)

        3. 5.3.5.3 Rest of South America (By Indication, and By Technology)

  6. 6. COMPETITIVE LANDSCAPE

    1. 6.1 Company Profiles

      1. 6.1.1 Amgen Inc.

      2. 6.1.2 Biogen Inc.

      3. 6.1.3 Bluebird Bio Inc.

      4. 6.1.4 Gilead Sciences, Inc. (Kite Pharma)

      5. 6.1.5 Novartis AG

      6. 6.1.6 Orchard Therapeutics

      7. 6.1.7 Sibiono GeneTech Co. Ltd.

      8. 6.1.8 Spark Therapeutics (Roche)

      9. 6.1.9 UniQure N.V.

      10. 6.1.10 Abeona Therapeutics

      11. 6.1.11 Generation Bio

      12. 6.1.12 Poseida Therapeutics

      13. 6.1.13 Astellas Pharma

      14. 6.1.14 Voyager Therapeutics

      15. 6.1.15 Elevate Bio

      16. 6.1.16 Editas Medicine

    2. *List Not Exhaustive
  7. 7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Subject to Availability
**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments

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Frequently Asked Questions

The Global Gene Therapy Market market is studied from 2018 - 2026.

The Global Gene Therapy Market is growing at a CAGR of 28.32% over the next 5 years.

The Global Gene Therapy Market is valued at 6659 Million USD in 2018.

The Global Gene Therapy Market is valued at 11739 Million USD in 2026.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2020.

Gilead Sciences, Inc., Novartis, Amgen Inc., Bluebird Bio, Biogen Inc are the major companies operating in Global Gene Therapy Market.

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