| Study Period | 2019 - 2030 |
| Market Size (2025) | USD 11.77 Billion |
| Market Size (2030) | USD 17.72 Billion |
| CAGR (2025 - 2030) | 8.18 % |
| Fastest Growing Market | Asia Pacific |
| Largest Market | North America |
| Market Concentration | Low |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Preparative And Process Chromatography Market Analysis
The Preparative And Process Chromatography Market size is estimated at USD 11.77 billion in 2025, and is expected to reach USD 17.72 billion by 2030, at a CAGR of 8.18% during the forecast period (2025-2030).
Preparative and Process Chromatography uses chromatography techniques at a larger scale to isolate, purify, and produce biomolecules, chemicals, and active pharmaceutical ingredients (APIs). It is distinct from analytical chromatography, which focuses on identifying or quantifying compounds in smaller quantities. The preparative and process chromatography market is being driven by significant investments in research and development (R&D), the increasing establishment of biopharmaceutical facilities, and the ongoing expansion of biopharmaceutical manufacturing capabilities during the forecast period.
The growing research and development funding for novel therapies and collaboration strategies adopted by key players are expected to drive the rising demand for preparative and process chromatography.
For instance, in August 2023, the California Institute for Regenerative Medicine (CIRM) awarded USD 32.3 million to researchers at the City of Hope to support three Phase 1 clinical trials focused on innovative cell and gene therapy treatments for HIV, acute myeloid leukemia, and severe aplastic anemia. Such investments in advanced research are anticipated to drive demand for preparative and process chromatography systems, which are essential for separating impurities and contaminants during the purification and production of biologics. This growing need for precise and efficient purification technologies will propel market growth.
Additionally, the rising incidence of chronic diseases, such as diabetes, drives the demand for novel therapeutics, prompting companies to accelerate drug production. This, in turn, increases the need for bioprocessing filtration systems and related technologies in research and development centers. For instance, according to the report published by the Diabetologia Journal in February 2024, the rising type 2 diabetes incidence in Germany, coupled with the increasing prevalence and high healthcare burden of diabetes, is driving the demand for insulin as more individuals require regular treatment to manage their condition effectively.
Notably, according to the same source mentioned above, with the prevalence of diabetes expected to increase by 54-77% by 2040, the demand for production of recombinant insulin is projected to rise which relies on preparative and process chromatography systems for efficient purification. This surge in demand for insulin and other biologics is expected to fuel market growth.
In addition, the growing establishment of biopharmaceutical facilities further propels the demand for preparative and process chromatography systems. For instance, Gland Pharma announced in February 2023 an investment of INR 400 crore (USD 48.6 million) to expand its manufacturing capabilities for biologicals, biosimilars, antibodies, and recombinant insulin in Genome Valley, Hyderabad, India. This expansion highlights the increasing focus on bioprocessing technologies, such as chromatography, to ensure efficient production and purification.
Theefore, aforemention factors such as increasing research and development funding for novel therapies, rising prevalence of chronic diseases and company's strategical activities will contribute to the preparative and process chromatography market’s growth. However, the high equipment cost and lack of skilled professionals restrain market growth.
Preparative And Process Chromatography Market Trends
Bio-Pharmaceutical Industry Segment is Expected to Witness Significant Growth Over the Forecast Period
The biopharmaceutical industry's growing R&D investments and demand for innovative treatments are driving the preparative and process chromatography market. These technologies are essential for purifying biologics like monoclonal antibodies and vaccines, supported by increased funding, strategic investments, and advancements in biotech manufacturing.
The increase in research and development (R&D) expenditures within the biopharmaceutical industry, driven by the demand for innovative treatments, significantly contributes to the growth of the preparative and process chromatography market. For instance, according to a report published by the European Federation of Pharmaceutical Industries and Associations in November 2023, pharmaceutical industry research and development investments in Germany were over EUR 9,372 million (USD 10,236.69 million). This trend highlights the positive growth in biopharmaceutical R&D spending, which is expected to boost the market over the forecast period.
Additionally, in May 2023, 3M invested around USD 150 million to enhance its biotech manufacturing capabilities and accelerate the development of filtration equipment critical for bioprocessing, biological manufacturing, and small-molecule pharmaceutical production. Such substantial investments in biopharmaceutical innovation and manufacturing infrastructure are anticipated to drive the demand for preparative and process chromatography systems.
Furthermore, many government organizations are investing in advancing research in various chronic disorders treatments, including epidemiology data collection and expenditures on drug therapy development. For instance, in March 2023, the National Institute of Health (NIH) planned to invest USD 51.1 billion in FY2024 in its research projects and the Advanced Research Projects Agency for Health (ARPAH) to support critical research activities and address public health issues. Thus, these investments are expected to fuel the adoption of chromatography technologies in R&D activities, further contributing to market growth.
In addition, companies are working on expanding their investments in research and development to treat diseases. For instance, in May 2023, OncoResponse granted with USD 13 million grant from the Cancer Prevention and Research Institute of Texas (CPRIT) and raised USD 14 million from other investors to advance cancer immunotherapy OR2805, a fully human monoclonal antibody, which is in phase1 trial used for multiple cancer indications in inducing anti-tumor activity.
Thus, the purification and analysis of such biologics heavily rely on advanced chromatography systems, underscoring their relevance in supporting biopharmaceutical research and innovation, boosting the market's growth.
Hence, these developments collectively highlight the importance of preparative and process chromatography technologies in advancing biopharmaceutical R&D and manufacturing, thus driving market growth.
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North America is Expected to Witness Significant Growth in the Preparative and Process Chromatography Market
The preparative and process chromatography market in North America is poised for significant growth. This growth is driven by robust investments in biopharmaceutical R&D, government initiatives to enhance biotechnology infrastructure, and the rising demand for biologics to address chronic diseases. The expansion of drug manufacturing facilities and increasing funding for advanced research projects underscores the region's commitment to innovation in bioprocessing technologies.
Moreover, the growing research funding from federal agencies to develop biologics for managing several life-threatening conditions is expected to drive the adoption of preparative and process chromatography.
For instance, in April 2024, the United States National Science Foundation (NSF) granted USD 20.0 million to the National Synthesis Center for Emergence in the Molecular and Cellular Sciences (NCEMS) at Penn State. This funding supports research into complex biological systems, such as cellular mechanisms, which could inform the development of disease treatments and innovations like reducing the adverse effects of aging.
Similarly, in March 2024, the University of South Florida received record federal funding of USD 692 million from agencies, including the National Institutes of Health (NIH), NSF, and U.S. Department of Defense, marking a 27% increase from FY2022. This funding supports research on the impacts of chronic insomnia on brain health and the development of new drug therapies. Such significant investments in research applications are expected to enhance the demand for advanced chromatography technologies, thereby boosting market growth in the United States.
Additionally, increasing government initiatives and substantial investments in biotechnology research are expected to drive the growth of the preparative and process chromatography market in Canada. For instance, in February 2023, the Prince Edward Island (PEI) and Canadian governments announced a USD 50 million investment in the BioAccelerator, a 75,000-square-foot biomanufacturing facility in Charlottetown's BioCommons Research Park. Led by PEI BioAlliance, this facility aims to support bioscience companies in research, product development, process scaling, and biopharmaceutical manufacturing training, boosting demand for advanced chromatography systems and thereby driving the market’s growth during the forecast period.
Furthermore, the expansion of drug manufacturing facilities in Canada is fueling market growth. In March 2023, the Canadian government committed CAD 80.5 million (USD 59 million) to the Canadian Critical Drug Initiative, supporting the establishment of a 40,000-square-foot manufacturing facility in Edmonton by Applied Pharmaceutical Innovation in collaboration with the Li Ka Shing Applied Virology Institute. This funding is expected to enhance drug research, commercialization, and production, further driving the need for efficient chromatography solutions.
Therefore, the rising demand for bio-based products, automation in industrial processes, and increasing biopharmaceutical manufacturing capacity collectively contribute to expanding the preparative and process chromatography market in the region.
In addition, the high prevalence of chronic diseases such as cancer in Mexico is expected to drive the demand for advanced treatments, thereby supporting the growth of the preparative and process chromatography market. According to the HPV Information Centre Fact Sheet 2023, approximately 9,439 women were diagnosed with cervical cancer in Mexico in 2023. This significant disease burden underscores the growing need for biologics, which rely on preparative and process chromatography systems for their development and production. The increasing demand for such bioprocessing technologies is anticipated to propel market growth in the country during the forecast period.
Consequently, heightened investments in advanced research initiatives and the expansion of regional drug manufacturing facilities are set to propel the North American market for preparative and process chromatography.
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Preparative And Process Chromatography Industry Overview
The preparative and process chromatography market is fragmented due to numerous companies, ranging from large global firms to smaller regional players, each offering various solutions. The key strategies market participants adopt are acquisitions and collaboration with other organizations to expand their footprint. The major players in the market include Danaher Corporation, Thermo Fisher Scientific Inc., Merck KGaA, Bio-Rad Laboratories Inc., Agilent Technologies, Waters Corporation, Shimadzu Corporation, Sartorius AG, Novasep Holding S.A.S, PerkinElmer Inc., among others.
Preparative And Process Chromatography Market Leaders
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Thermo Fisher Scientific Inc.
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Merck KGaA
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Bio-Rad Laboratories Inc.
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Agilent Technologies
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Danaher Corporation
- *Disclaimer: Major Players sorted in no particular order
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Preparative And Process Chromatography Market News
- November 2024: Shimadzu Corporation entered into a strategic partnership with Sepragen Corporation, a United States-based manufacturer of innovative bioprocess chromatography equipment. This collaboration grants Shimadzu the exclusive rights to market and service Sepragen’s products across Japan, South Korea, and Southeast Asia. The partnership signifies Shimadzu's expansion into the biopharmaceutical market and is expected to contribute to the preparative and process chromatography market, as there is growing demand for purification technologies in manufacturing biopharmaceutical vaccines and gene therapy drugs.
- June 2024: CatSci Ltd, a pharmaceutical process development company, acquired Reach Separations, a chromatography services provider. This acquisition enhances CatSci's capabilities by enabling the company to offer its global customers access to comprehensive and integrated preparative and process chromatographic services.
Preparative And Process Chromatography Industry Segmentation
As per the scope of the report, preparative and process chromatography refers to techniques used for the large-scale separation, purification, and production of biological or chemical compounds, critical in industries such as pharmaceuticals, biotechnology, and chemical manufacturing.
The preparative and process chromatography market is segmented into product, technique, end user, and geography. By product, the market is segmented into process chromatography and preparative chromatography. By technique, the market is segmented into liquid chromatography (LC), gas chromatography (GC), ion-exchange chromatography (IEC), and others. By end user, the market is segmented into biopharmaceutical industry, food and beverage industry, chemicals industry, agriculture industry, and others. By geography, the market is segmented into North America, Europe, Asia-Pacific, South America, and Middle East and Africa. The report also offers the market size and forecasts for 17 countries across the region. For each segment, the market sizing and forecasts have been done on the basis of value (USD).
| By Product | Process Chromatography | Systems | |
| Resins | |||
| Columns | |||
| Chemicals & Reagents | |||
| Preparative Chromatography | Systems | ||
| Resins | |||
| Columns | |||
| Chemicals & Reagents | |||
| By Technique | Liquid Chromatography (LC) | ||
| Gas Chromatography (GC) | |||
| Ion-Exchange Chromatography (IEC) | |||
| Others | |||
| By End User | Bio-Pharmaceutical Industry | ||
| Food and Beverage Industry | |||
| Chemicals Industry | |||
| Agriculture Industry | |||
| Others | |||
| Geography | North America | United States | |
| Canada | |||
| Mexico | |||
| Europe | Germany | ||
| United Kingdom | |||
| France | |||
| Italy | |||
| Spain | |||
| Rest of Europe | |||
| Asia-Pacific | China | ||
| Japan | |||
| India | |||
| Australia | |||
| South Korea | |||
| Rest of Asia-Pacific | |||
| Middle East and Africa | GCC | ||
| South Africa | |||
| Rest of Middle East and Africa | |||
| South America | Brazil | ||
| Argentina | |||
| Rest of South America | |||
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Preparative And Process Chromatography Market Research FAQs
How big is the Preparative And Process Chromatography Market?
The Preparative And Process Chromatography Market size is expected to reach USD 11.77 billion in 2025 and grow at a CAGR of 8.18% to reach USD 17.72 billion by 2030.
What is the current Preparative And Process Chromatography Market size?
In 2025, the Preparative And Process Chromatography Market size is expected to reach USD 11.77 billion.
Who are the key players in Preparative And Process Chromatography Market?
Thermo Fisher Scientific Inc., Merck KGaA, Bio-Rad Laboratories Inc., Agilent Technologies and Danaher Corporation are the major companies operating in the Preparative And Process Chromatography Market.
Which is the fastest growing region in Preparative And Process Chromatography Market?
Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).
Which region has the biggest share in Preparative And Process Chromatography Market?
In 2025, the North America accounts for the largest market share in Preparative And Process Chromatography Market.
What years does this Preparative And Process Chromatography Market cover, and what was the market size in 2024?
In 2024, the Preparative And Process Chromatography Market size was estimated at USD 10.81 billion. The report covers the Preparative And Process Chromatography Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Preparative And Process Chromatography Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.
Preparative And Process Chromatography Industry Report
Statistics for the 2025 Preparative And Process Chromatography market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Preparative And Process Chromatography analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.
