Gene Synthesis Market Size & Share Analysis - Growth Trends & Forecasts (2023 - 2028)

The Gene Synthesis Market is Segmented by Method (Oligonucleotide Synthesis and Gene Assembly), End User (Academic and Research Institute, Biopharmaceutical Companies, and Contract Research Organizations), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (in USD million) for the above segments.

Gene Synthesis Market Size

Gene Synthesis Market Summary
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Study Period 2018 - 2028
Base Year For Estimation 2022
Forecast Data Period 2023 - 2028
CAGR 8.00 %
Fastest Growing Market Asia Pacific
Largest Market North America

Major Players

Gene Synthesis Market Major Players

*Disclaimer: Major Players sorted in no particular order


Need a report that reflects how COVID-19 has impacted this market and its growth?

Gene Synthesis Market Analysis

The Gene Synthesis market is expected to register a CAGR of nearly 8% during the forecast period (2022-2027).

The COVID-19 pandemic has impacted the gene synthesis market in both ways, negatively and positively. At the start of the COVID-19 pandemic, most of the businesses and research activities around the world ceased due to the increasing rate of infection from the SARS-CoV-2 virus which not only reduced the use of gene synthesizers in laboratories but also the demand for it in the market. But in the quest for developing vaccines against the virus infection, which was rising in every corner of the world, the gene synthesizers played a very crucial role in the research and development of the vaccine as some of the vaccines are mRNA based and due to its efficiency too. For example, in January 2022, the Food and Drug Administration provided second approval to the mRNA-based COVID-19 vaccine from Moderna called Spikevax. Therefore, gene synthesis played a crucial role during the COVID-19 pandemic, and the market is expected to grow further.

The factors that are responsible for the growth of the Gene Synthesis market include increasing research and development in the field of genomics and next-generation sequencing, increased government funding for genomics, and increasing demand for personalized medicine and therapeutics for different chronic diseases. As personalized medicine aims to provide tailor-made therapies to individual patients, depending on the molecular basis of the disease, it has become popular over recent years. Healthcare technology, genomics, connected devices, big data analytics, and artificial intelligence are generating vast amounts of health-related data and insights which is enabling healthcare providers to offer better and faster diagnostics and treatment services by making more informed treatment decisions. In addition, gene synthesis is also finding its applications in the molecular diagnosis of infectious and genetic diseases. Genetic tests, which can detect genetic variations and predict how a person is likely to respond to certain drugs, are becoming commercially available. Therefore, increasing focus on personalized medicine and other factors, such as a patient-centered approach, are driving the growth of the gene synthesis market.

Factors, such as the aging global population and the rising prevalence of chronic diseases, are putting unrelenting pressure on the capacity and financial viability of the healthcare systems across the world and will also play a role in the driving growth of the gene synthesis market. Personalized medicine holds the promise of providing better patient care and a high safety margin while lowering total healthcare costs. As per the data published in December 2021 by International Diabetes Federation (IDF), there were about 537 million adults (20-79 years) who were living with diabetes in 2021 all over the globe and the federation projected that this number would rise to 783 million by 2045. The lack of skilled professional is the major restraining factor for the growth of the gene synthesis market as the devices are overly complex and needs special attention while handling and it's very difficult to find an expert professional for handling. Another factor that will also have a role in the inhibition of the market growth is the excessive cost and complexity of the devices.

Gene Synthesis Market Trends

This section covers the major market trends shaping the Gene Synthesis Market according to our research experts:

PCR-mediated Assembly is Expected to Occupy a Major Share in the Studied Market Over Forecast Period

PCR-mediated recombination is a general method applied to construct chimeric infectious molecular clones of plasma-derived HIV-1 RNA. In the gene synthesis process, chemical synthesis is typically used to create oligonucleotides of up to 120-150 nucleotides (nt) in length. Therefore, generally, gene assembly techniques are utilized to connect small oligonucleotides, to synthesize the gene of the required length. Over the past three decades, several methods have been developed to assemble relatively short synthetic oligonucleotides into longer gene sequences. And the polymerase chain reaction (PCR) - mediated assembly represents one of the most prominent approaches to the mediating assembly of the desired DNA sequence.

About the broad applications of polymerase chain reaction (PCR) systems, such as in molecular diagnostics, forensics, and epidemiology studies, the demand and acceptance of polymerase chain reaction technologies are high, which, in turn, acts as a favorable factor for the development and adoption of PCR-mediated assembly methodologies, by academia and research institutes alike. The polymerase chain reaction (PCR) technique played a very important role in concluding the Human Genome Project in 2003. Also, the key market players are working towards improving the polymerase chain reaction technique to expand its nucleic acid synthesis capacity. For example, in April 2020, Biolytic Lab announced the launch of its advanced oligo synthesizer, for high-throughput nucleic acid synthesis, called Dr. Oligo 768XLc DNA RNA Synthesizer. Therefore, owing to the above-mentioned factors, the segment is expected to witness significant growth in the future.

Human Genome Project Funding by National Institute of Health (in USD million), by Year, 2019-2021

North America Region is Expected to Hold a Significant Share in the Gene Synthesis Market

North America is comprised of the United States, Canada, and Mexico. Currently, North America dominates the market for gene synthesis and is expected to continue its stronghold in the coming future.

In the North American region, the United States holds the largest market share as compared to Canada and Mexico. The increasing prevalence of genetic and chronic disorders, such as cancer, the aging population, increasing demand for targeted and personalized medicine, and favorable government initiatives are the primary factors responsible for the large market. Another factor responsible for the dominance of the United States is the presence of key market players in the region and the high volume of ongoing scientific research activities. In the fiscal year of 2021, the National Cancer Institute of the United States was allocated a budget of USD 6.56 billion solely for cancer research.

Hence, owing to the increased funding for certain diseases and the well-established healthcare, the United States is believed to dominate the market studied.

Gene Synthesis Market - Growth Rate by Region

Gene Synthesis Industry Overview

The gene synthesis market is moderately competitive and consists of several major players. In terms of the market share, few of the major players currently dominate the market. Owing to the increasing number of diseases and rising drug discovery processes, few other smaller players are expected to enter the market. Some of the major players of the market are Merck KGaA, Genscript, Genewiz Inc., Eurofins Genomics, and Bio Basic Inc., among others.

Gene Synthesis Market Leaders

  1. Merck KGaA

  2. Genewiz Inc.

  3. Eurofins Genomics

  4. Thermo Fisher Scientific

  5. GenScript

*Disclaimer: Major Players sorted in no particular order

Gene Synthesis Market Concentration

Gene Synthesis Market News

  • In July 2022, OraSure Technologies launched its OmniGene Gut DNA and RNA product (OMR-205) for gut microbiome researchers.
  • In April 2022, DNA Script launched an early access program for their SYNTAX system customers under which organizations receive early access to the latest advancements of their enzymatic DNA synthesis technology.

Gene Synthesis Market Report - Table of Contents


    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increasing R&D in the Field of Genomics and Next Generation Sequencing

      2. 4.2.2 Increased Government Funding Toward Genomics

      3. 4.2.3 Increasing Demand for Personalized Medicine

    3. 4.3 Market Restraints

      1. 4.3.1 Lack of Skilled Professionals

      2. 4.3.2 High Cost and Complexity of Techniques

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION (Market Size by Value - USD million)

    1. 5.1 By Method

      1. 5.1.1 Oligonucleotide Synthesis

        1. Solid Phase Phosphoramidite Synthesis

        2. Microchip-based Oligonucleotide Synthesis

      2. 5.1.2 Gene Assembly

        1. Ligation-mediated Assembly

        2. PCR-mediated Assembly

    2. 5.2 By End User

      1. 5.2.1 Academic and Research Institutes

      2. 5.2.2 Biopharmaceutical Companies

      3. 5.2.3 Contract Research Organizations

    3. 5.3 Geography

      1. 5.3.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.3.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.3.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.3.4 Middle East and Africa

        1. GCC

        2. South Africa

        3. Rest of Middle East and Africa

      5. 5.3.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 ATUM (DNA2.0 Inc.)

      2. 6.1.2 Bio Basic Inc.

      3. 6.1.3 Beijing SBS Genetech Co. Ltd

      4. 6.1.4 Eurofins Genomics

      5. 6.1.5 Azenta (Genewiz Inc.)

      6. 6.1.6 Genscript

      7. 6.1.7 Merck KGaA

      8. 6.1.8 OriGene Technologies Inc.

      9. 6.1.9 Thermo Fisher Scientific Inc. (GeneArt)

    2. *List Not Exhaustive

**Subject to Availability
**Competitive Landscape Covers - Business Overview, Financials, Products and Strategies, and Recent Developments

Gene Synthesis Industry Segmentation

As per the scope of the report, gene synthesis refers to the in vitro, base-by-base synthesis of double-stranded DNA molecules. Unlike DNA replication, which occurs in-vivo or by polymerase chain reaction (PCR), gene synthesis does not require a template strand for its initiation. The Gene Synthesis Market is Segmented by Method (Oligonucleotide Synthesis and Gene Assembly), End User (Academic and Research Institute, Biopharmaceutical Companies, And Contract Research Organizations), And Geography (North America, Europe, Asia-Pacific, Middle East and Africa, And South America). The Report Offers the Value (in USD Million) For the Above Segments.

By Method
Oligonucleotide Synthesis
Solid Phase Phosphoramidite Synthesis
Microchip-based Oligonucleotide Synthesis
Gene Assembly
Ligation-mediated Assembly
PCR-mediated Assembly
By End User
Academic and Research Institutes
Biopharmaceutical Companies
Contract Research Organizations
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle East and Africa
South Africa
Rest of Middle East and Africa
South America
Rest of South America

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Gene Synthesis Market Research FAQs

The Global Gene Synthesis Market is projected to register a CAGR of 8% during the forecast period (2023-2028).

Merck KGaA, Genewiz Inc., Eurofins Genomics, Thermo Fisher Scientific and GenScript are the major companies operating in the Global Gene Synthesis Market.

Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2023-2028).

In 2023, the North America accounts for the largest market share in the Global Gene Synthesis Market.

Global Gene Synthesis Industry Report

Statistics for the 2023 Global Gene Synthesis market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Global Gene Synthesis analysis includes a market forecast outlook to 2028 and historical overview. Get a sample of this industry analysis as a free report PDF download.

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