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The vaccine adjuvants market is valued at approximately USD 665.86 million in 2020 and is expected to witness a revenue of USD 1478.32 million in 2026, with a CAGR of 13.37% over the forecast period.
During the COVID-19 pandemic, as the import and export activities have been restricted due to the lockdown, it is expected to impact the market studied for a short period of time due to shortage and irregular supply of products. However, this might allow local manufacturers to increase their presence in the market. Supply disruption and product shortages have been observed in several countries due to the temporary lockdowns of manufacturing sites. According to a research article in Nature Reviews Immunology 2020, aluminum-based vaccine adjuvants offers a glide path to induce high levels of neutralizing antibody, which is increasingly recognized as a cornerstone of the protection afforded by COVID-19 vaccines. Additionally, in May 2020, GSK intended to produce 1 billion doses of its pandemic vaccine adjuvant system, in 2021, to support the development of multiple adjuvanted COVID-19 vaccine candidates. Thus, the COVID-19 pandemic is expected to significantly impact the studied market growth positively.
The propelling factors for the growth of the vaccine adjuvants market include the unmet needs for vaccines against certain diseases, expanding government recommendations for immunizations, technological innovations, and increasing use of recombinant subunit and synthetic vaccines.
Across the world, various governmental organizations are promoting and raising awareness regarding immunization against various diseases, like anthrax, BCG, hepatitis, HPV, influenza, varicella, smallpox, and other conditions. In 2019, the US government allocated USD 290 million in foreign aid for the Global Alliance for Vaccines and Immunization (GAVI, now called GAVI, the Vaccine Alliance) and USD 226 million for the Department of Health and Human Services (HHS) to support child vaccine campaigns abroad. Such initiation from the government regarding immunization in the country increases the use of vaccine adjuvants and shows a positive impact on the market.
The adjuvant market is gaining a boost from the increasing use of recombinant subunit vaccines. As usage is increasing, the demand for various adjuvants is expanding. Over the coming years, more developments are expected to take place, increasing the need for adjuvants. The market is also expected to grow at a moderate rate, primarily fuelled by the increasing adoption of biologics and biosimilars and rising R&D in vaccines across the world.
Toxicity is the single-most crucial impediment while introducing most of the adjuvants for human use. Toxicity may also increase the financial burden on market players during the development and manufacturing phases. Thus, the negative impacts of the toxicity of adjuvants on vaccine manufacturing cost and safety profiles of vaccines are hindering the growth of the market.
Scope of the Report
As per the scope of the report, an adjuvant is a pharmacological or immunological agent that helps in synergizing and directing the adaptive immune response to a vaccine agent. Adjuvants are basically compounds that improve the body’s immunogenic reaction against antigens. Therefore, adjuvants are majorly added to vaccines to augment their capability to persuade long-term protection and safety against any kind of infection. The Vaccine Adjuvants Market is Segmented by Type, Route of Administration, Disease Type, Application, and Geography. By Type, the market is segmented into Mineral Salt-based Adjuvant, Tensoactive Adjuvants, Adjuvant Emulsions, Liposome Adjuvants, Carbohydrate Adjuvants, Bacteria-derived Adjuvants, Virus-like Particles (VLP), and Other Types. By Usage, the market is segmented into Active Immunostimulants, Carriers, and Vehicle Adjuvants. By Disease Type, the market is segmented into Infectious Disease and Cancer. By Application, the market is segmented into Research Applications and Commercial Applications. By Geography, the market is segmented into North America, Europe, Asia-Pacific, the Middle East and Africa, and South America. The report offers the value (in USD million) for the above segments.
|Mineral Salt-based Adjuvant|
|Virus-like Particles (VLP)|
|By Disease Type|
Key Market Trends
The Mineral Salt-Based Adjuvants Segment is Expected to Witness Highest CAGR During the Forecast Period
The Mineral Salt-Based Adjuvants segment is expected to witness significant growth over the forecast period. Alum-based vaccine adjuvants are the most commonly and most widely used adjuvants for human vaccines. Aluminium salts include aluminium hydroxide, aluminium phosphate, and aluminium hydroxyphosphate. Aluminium-based salts are also being used for research purposes to increases the efficacy of the vaccines. Apart from alum, salts of calcium, iron, and zirconium have also been used regularly as alternatives to alum salt. Calcium phosphate has been used regularly for diphtheria-tetanus-pertussis (DTP), polio, yellow fever, and BCG vaccines. It adsorbs soluble antigens and presents them in a particulate form to the immune system. According to the research article published in 2020, the developments in mineral salt-based adjuvants are in progress to enhance the adjuvant activity of aluminium adjuvants, which include the use of Nano-aluminum adjuvants for improved absorption of antigen.
Additionally, in Jun 2020, Clover Biopharmaceuticals AUS Pty Ltd has initiated a Phase 1 clinical trial for COVID-19 with SCB-2019 vaccine plus Alum adjuvant to assess safety, reactogenicity, and immunogenicity of SCB-2019 at multiple dose levels, administered as two injections Intramuscularly in healthy subjects. Thus, the ongoing research activities and extensive advantages of mineral salt-based adjuvants in the vaccine, especially for the development of vaccines against COVID-19, is expected to drive the market growth over the forecast period.
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North America is Holds a Significant Share in the Market During the Forecasted Period
North America is expected to observe tremendous growth in the studied market over the forecast period. The major factors driving the vaccine adjuvants market’s growth in the North American region are the presence of key market players, availability of advanced technologies, and the increasing expenditure on R&D for vaccines.
According to the Centers for Disease Control and Prevention (CDC) estimates, around 16 diseases are now preventable as a result of childhood vaccines, and the routine immunization of American children born between 1994-2018 has prevented more than 419 million illnesses, 26.8 million hospitalizations, and 936,000 early deaths.
According to the Centers for Disease Control and Prevention (CDC), adjuvants such as aluminium hydroxyphosphate sulfate, monophosphoryl lipid A (MPL) + aluminium salt, oil-in-water emulsions composed of squalene, MPL, and QS-21 (a natural compound from Chilean soapbark tree combined in a liposomal formulation), and cytosine phosphoguanine (CpG) are currently used in the vaccines such as DtaP (Daptacel, Infanrix), Hep A (Havrix, Vaqta), Hep B (Engerix-B, Recombivax), HPV (Gardasil 9), Pneumococcal (Prevnar 13), Cervarix, Fluad, Shingrix, and Heplisav-B in the United States. Furthermore, there has been a growing interest in the adjuvant technology for the development of vaccines against COVID-19 and this scenario is expected to drive the studied market growth in the region during the pandemic.
Additionally, according to the National Clinical Trials (NCT) Registry, as of 21 September 2020, in the United States, there are approximately 500 vaccine clinical trials under development, which is expected to show a positive impact on the market studied because these adjuvants are effective in enhancing or activating the immune system. Thus, given the ongoing clinical trials related to vaccine development and the high research activities in the United States is expected to drive the studied market growth in North America over the forecast period.
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The Vaccine Adjuvants market is moderately consolidated and consists of many major players. The companies such as Adjuvatis, GlaxoSmithKline plc, Croda International plc, Merck KGaA, and Novavax Inc are key players among others. The major companies have conducted product launches, approvals, acquisitions, and collaborations for the development of novel vaccine adjuvants, thereby, building a competitive landscape in the market. For instance, in April 2020, GlaxoSmithKline plc collaborated with Sanofi to develop an adjuvanted vaccine for COVID-19. Also, in the coming years, few other players are expected to enter the market owing to the high scope of expansion in the product portfolio globally.
In Aug 2020, Croda International plc acquired Avanti Polar Lipids Inc., one of the leaders in drug delivery systems for next-generation pharmaceuticals.
In Feb 2020, Clover Biopharmaceuticals AUS Pty Ltd and GlaxoSmithKline plc entered into a research collaboration to evaluate the coronavirus (COVID-19) vaccine with the pandemic adjuvant system.
Table of Contents
1.1 Study Assumption and Market Definition
1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Expanding Government Recommendations for Immunizations
4.2.2 Unmet Vaccine Market Needs for Certain Diseases
4.2.3 Increasing Use of Recombinant Subunit and Synthetic Vaccines
4.3 Market Restraints
4.3.1 Side Effects and High Toxicity of Adjuvants
4.3.2 High R&D Cost of Developing a New Adjuvant
4.4 Porter's Five Forces Analysis
4.4.1 Threat of New Entrants
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Bargaining Power of Suppliers
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION
5.1 By Type
5.1.1 Mineral Salt-based Adjuvant
5.1.2 Tensoactive Adjuvants
5.1.3 Adjuvant Emulsions
5.1.4 Liposome Adjuvants
5.1.5 Carbohydrate Adjuvants
5.1.6 Bacteria-derived Adjuvants
5.1.7 Virus-like Particles (VLP)
5.1.8 Other Types
5.2 By Usage
5.2.1 Active Immunostimulants
5.2.3 Vehicle Adjuvants
5.3 By Disease Type
5.3.1 Infectious Disease
5.4 By Application
5.4.1 Research Applications
5.4.2 Commercial Applications
5.5.1 North America
188.8.131.52 United States (By Type, By Route of Administration, By Disease Type, and By Application)
184.108.40.206 Canada (By Type, By Route of Administration, By Disease Type, and By Application)
220.127.116.11 Mexico (By Type, By Route of Administration, By Disease Type, and By Application)
18.104.22.168 Germany (By Type, By Route of Administration, By Disease Type, and By Application)
22.214.171.124 United Kingdom (By Type, By Route of Administration, By Disease Type, and By Application)
126.96.36.199 France (By Type, By Route of Administration, By Disease Type, and By Application)
188.8.131.52 Italy (By Type, By Route of Administration, By Disease Type, and By Application)
184.108.40.206 Spain (By Type, By Route of Administration, By Disease Type, and By Application)
220.127.116.11 Rest of Europe (By Type, By Route of Administration, By Disease Type, and By Application)
18.104.22.168 China (By Type, By Route of Administration, By Disease Type, and By Application)
22.214.171.124 Japan (By Type, By Route of Administration, By Disease Type, and By Application)
126.96.36.199 India (By Type, By Route of Administration, By Disease Type, and By Application)
188.8.131.52 Australia (By Type, By Route of Administration, By Disease Type, and By Application)
184.108.40.206 South Korea (By Type, By Route of Administration, By Disease Type, and By Application)
220.127.116.11 Rest of Asia-Pacific (By Type, By Route of Administration, By Disease Type, and By Application)
5.5.4 Middle East and Africa
18.104.22.168 GCC (By Type, By Route of Administration, By Disease Type, and By Application)
22.214.171.124 South Africa (By Type, By Route of Administration, By Disease Type, and By Application)
126.96.36.199 Rest of Middle East and Africa (By Type, By Route of Administration, By Disease Type, and By Application)
5.5.5 South America
188.8.131.52 Brazil (By Type, By Route of Administration, By Disease Type, and By Application)
184.108.40.206 Argentina (By Type, By Route of Administration, By Disease Type, and By Application)
220.127.116.11 Rest of South America (By Type, By Route of Administration, By Disease Type, and By Application)
6. COMPETITIVE LANDSCAPE
*List Not Exhaustive
6.1 Company Profiles
6.1.1 Adjuvance Tecchnologies, Inc.
6.1.3 Agenus, Inc.
6.1.4 Aphios Corporation
6.1.5 Chemtrade Logistics INC.
6.1.6 Croda International Plc (Brenntag Biosector AS)
6.1.7 CSL Limited
6.1.8 Dynavax Technologies Corporation
6.1.9 GlaxoSmithKline Plc
6.1.11 Merck KGaA
6.1.12 Novavax Inc
6.1.13 OZ Biosciences
6.1.14 Pacific GeneTech Limited
6.1.15 Seppic (Air Liquide)
6.1.16 Thermo Fisher Scientific Inc.
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
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Frequently Asked Questions
What is the study period of this market?
The Global Vaccine Adjuvants Market market is studied from 2018 - 2026.
What is the growth rate of Global Vaccine Adjuvants Market?
The Global Vaccine Adjuvants Market is growing at a CAGR of 13.37% over the next 5 years.
What is Global Vaccine Adjuvants Market size in 2018?
The Global Vaccine Adjuvants Market is valued at 665 Million USD in 2018.
What is Global Vaccine Adjuvants Market size in 2026?
The Global Vaccine Adjuvants Market is valued at 1478 Million USD in 2026.
Which region has highest growth rate in Global Vaccine Adjuvants Market?
Asia Pacific is growing at the highest CAGR over 2021- 2026.
Which region has largest share in Global Vaccine Adjuvants Market?
North America holds highest share in 2020.
Who are the key players in Global Vaccine Adjuvants Market?
- Merck KGaA
- GlaxoSmithKline plc
- Novavax Inc.
- Croda International plc
Are the major companies operating in Global Vaccine Adjuvants Market.