Downstream Processing Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Downstream Processing Market is segmented by Technique (Purification Techniques, Solid-Liquid Separation and Clarification/Concentration), Product, Application and Geography

Market Snapshot

Downstream Processing Market Overview
Study Period: 2018 - 2026
Base Year: 2021
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 13.8 %
Downstream Processing Market Key Players

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Market Overview

The downstream processing market will show a rapid growth due to the growth of biotechnology sector globally, rising R&D expenditure in biopharmaceutical companies and increase in the prominence of contract manufacturing organizations.

There has been extraordinary development that has been seen recently in the biotechnology industry and that has pushed the growth of global downstream processing market. The downstream processing helps to find extensive use in the biotechnology sector to isolate and purify the biological products. Therefore the isolation of biological products has thus helped the overall pharmaceutical industry to make strides.

There is also a considerable increase in the sales of biotechnology products that helps in the growth of the market. Consequently, continual innovations in the biotechnology sector are possible to deliver plenty of development opportunities to the regional market over the forecast period. For instance, in September 2019, National Aluminium Company Limited (NALCO) has launched Aluminium Alloy 1200 (AA 1200), adding one more downstream product to its existing product range. This alloy is similar to alloy AA 1100 and has a wide application in the manufacture of LED lamp cap In addition, the growing prevalence of chronic diseases such as cancer, cardiovascular and diabetes has increased the demand for the biopharmaceuticals and further increased the demand for the sensors and further fuel the market growth. According to Cancer Research UK, new cancer cases may increase to 28 million yearly by 2040 compared to 17 million in 2018.

However, the lack of skilled professionals and the high cost of the devices are expected to impede the market growth

Scope of the Report

As per the scope of the report, downstream processing is a part of a bioprocess that include the recovery and purification of biosynthetic products. The downstream process is found to be an essential part in the manufacturing of vaccines, antibodies, antibiotics and hormones, such as insulin and humans growth hormone. The downstream processing thus includes five stages; solid-liquid separation, intracellular products are released, concentration, chromatography method is used for purification and formulation.

By Technique
Purification Techniques
Solid-Liquid Separation
By Product
Chromatography Columns and Resins
Other Products
By Application
Antibodies Production
Vaccines Production
Insulin Production
Other Applications
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle-East and Africa
South Africa
Rest of Middle-East and Africa
South America
Rest of South America

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Key Market Trends

Antibodies Production is Expected to Dominate the Downstream Processing Market During the Forecast Period

Antibodies are found to be one of the most predominant modalities offered by the biopharmaceutical industry today. There is an evolution of certain new methods in bioprocessing of antibodies that has further augmented the growth of the market. These new methods include continuous biomanufacturing, alternative expression systems, and non‐chromatographic separation formats. For instance, in June 2018, Novasep has launched a downstream processing tool that combines batch and continuous chromatography for monoclonal antibodies, recombinant proteins and blood factors.

Moreover, as antibiotic resistance is on the rise, there is an increase in demand for the development of antibodies that act against resistant strains. Hence, in turn, there is an is increasing demand for downstream processing for antibody production at industrial scale. The downstream process is thus an essential part in the manufacturing of vaccines, antibodies, antibiotics and hormones, such as insulin and humans growth hormones also, that helps in the growth of the market.

Downstream Processing Market Key Trends

Asia Pacific is Found to be the Fastest Growing Region

Asia Pacific is anticipated to be the fastest-growing market due to the factors such as increasing R&D infrastructure, considerable investments made by the market players and increasing government support are fuelling the growth of the market in the Asia Pacific region.

Owing to the recent advancements, there is a substantial rise in sales of biotechnology products in the region. There is also the establishment of vendors and supply chains for bioprocessing consumables and equipment across major developing countries, that is projected to contribute to the growth of the region.

Downstream Processing Market Growth Rate

Competitive Landscape

There has been a presence of a considerable number of companies that are significantly contributing to the market growth. The market players are found investing massive wealth to transform the product line as the rivalry in the market is increasing with rapid pace. Likewise, with varying technology the need for better technology infrastructures are rising, so cater the need of the customers, market participants are continuously inventing new products.

Table of Contents


    1. 1.1 Study Deliverables

    2. 1.2 Study Assumptions

    3. 1.3 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Growth of Biotechnology Sector Globally

      2. 4.2.2 Rising R&D Expenditure in Biopharmaceutical Companies

      3. 4.2.3 Increase in the Prominence of Contract Manufacturing Organizations

    3. 4.3 Market Restraints

      1. 4.3.1 High Cost of Instruments

      2. 4.3.2 Purification Bottleneck

    4. 4.4 Porter's Five Force Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry


    1. 5.1 By Technique

      1. 5.1.1 Purification Techniques

      2. 5.1.2 Solid-Liquid Separation

      3. 5.1.3 Clarification/Concentration

    2. 5.2 By Product

      1. 5.2.1 Chromatography Columns and Resins

      2. 5.2.2 Filters

      3. 5.2.3 Evaporators

      4. 5.2.4 Centrifuges

      5. 5.2.5 Other Products

    3. 5.3 By Application

      1. 5.3.1 Antibodies Production

      2. 5.3.2 Vaccines Production

      3. 5.3.3 Insulin Production

      4. 5.3.4 Other Applications

    4. 5.4 Geography

      1. 5.4.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.4.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.4.4 Middle-East and Africa

        1. GCC

        2. South Africa

        3. Rest of Middle-East and Africa

      5. 5.4.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 Thermo Fisher Scientific Inc.

      2. 6.1.2 GE Healthcare

      3. 6.1.3 Sartorius Stedim Biotech S.A.

      4. 6.1.4 Merck KGaA (Merck Millipore)

      5. 6.1.5 Danaher Corporation

      6. 6.1.6 3M Company

      7. 6.1.7 Lonza Group AG

      8. 6.1.8 Eppendorf AG

      9. 6.1.9 Repligen Corporation

    2. *List Not Exhaustive

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments

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Frequently Asked Questions

The Downstream Processing Market market is studied from 2018 - 2026.

The Downstream Processing Market is growing at a CAGR of 13.8% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2020.

Thermo Fisher Scientific Inc., GE Healthcare, Sartorius Stedim Biotech S.A., Merck KGaA (Merck Millipore), Lonza Group are the major companies operating in Downstream Processing Market.

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