Continuous Bioprocessing Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Continuous Bioprocessing market is Segmented by Product (Filtration Systems and Consumables, Chromatography Systems and Consumables, Bioreactors, Sterilizers, Centrifuges, and Others (Incubators and Shakers, Cell Culture Media, Buffers and Reagents, and Consumables)), by Application (Commercial and Research and Development), by End User (Pharmaceutical and Biotechnology Companies, CDMOs and CROs, Academic and Research Institutes), and Geography (North America, Europe, Asia-Pacific, Middle-East and Africa, and South America). The report offers the value (in USD million) for the above segments.

Market Snapshot

Continuous Bioprocessing Market Size
Study Period: 2019-2027
Base Year: 2021
Fastest Growing Market: Asia-Pacific
Largest Market: North America
CAGR: 23 %

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Market Overview

The continuous bioprocessing market is expected to witness a CAGR of 23% during the study period, 2022-2027.

In recent times, countries have faced a huge threat of COVID-19. As per the World Health Organization (WHO), coronavirus disease is an infectious disease, and most people infected with the COVID-19 virus will experience mild to moderate respiratory illness.

Most pharmaceutical and biotechnological companies have reallocated their resources in research and development (R&D) departments toward identifying new molecules or leads for the treatment of COVID-19.​ This has impacted the research and development activities of biopharmaceuticals for other chronic diseases.

In the early phase of the pandemic, due to the lockdown measures, trade restrictions, and high infection rate, many pharmaceutical and biotechnology companies were hit, and their work was impacted, especially R&D activities, as the clinical and other types of trials were delayed by more than six months.

According to the study “Impact of COVID19 on Operational Activities of Manufacturing Organizations—A Case Study and Industry 4.0-Based Survive-Stabilise-Sustainability (3S) Framework,” published in March 2021, restrictions imposed by local authorities have had the highest impact on operational activities, followed by unavailability of transport and unavailability of workers; scarcity of raw materials increased workload and decrease in working days have had a significant impact on the biopharmaceutical organizations. increase in machine failures, overproduction, and insufficient production to fulfill demand, also had an impact on operational activities, thus leaving a significant impact on the market.

The factors propelling the studied market growth are the growing adoption of continuous processing, increasing technological advancements in the continuous processing space, and increasing demand for biopharmaceuticals. Along with it, increasing investments and government initiatives boosting biomanufacturing will also contribute positively to market growth.

Continuous bioprocessing is being readily adopted as one of the future forms of biomanufacturing production because it operates on the same scale in both clinical production and commercialization, using flexible infrastructure that can respond quickly to changing market pressures. The use of flexible infrastructures such as single-use flow paths and small surgical vessels with the same bioreactor size will reduce significant investment while making technology transfer operations easier and maintaining quality profiles.

Additionally, the rising burden of chronic diseases such as cancer, neurological disorders, cardiovascular diseases, rare diseases, and others will propel the demand for biopharmaceuticals, thereby driving the continuous bioprocessing market. For instance, as per the 2020 statistics by GLOBOCAN 2020, an estimated number of 19,292,789 people were diagnosed with cancer in 2020. As per the same source mentioned above, the number of people suffering from cancer is estimated to reach 30.2 million by 2040. Thus, the growing burden of cancer globally will significantly increase the demand for biosimilars, thus driving the market.

Moreover, rising investments in the studied market will also lead to lucrative growth of the market. For instance, in September 2021, Gamma Biosciences made a strategic investment in Nirrin Technologies, a provider of next-generation sensors and analytics for real-time, in-process monitoring and analysis in upstream and downstream bioprocessing applications and continuous processing for the biopharma and life science industries.

  • However, strict regulations for continuous bioprocessing and high equipment costs are expected to hinder market growth.

Scope of the Report

As per the scope of the report, the manufacturing of a production unit is considered continuous if it is able to process continuous flow inputs for a long period of time. The output may be continuous or split into smaller packets generated in a circular manner. The Continuous Bioprocessing market is Segmented by Product (Filtration Systems and Consumables, Chromatography Systems and Consumables, Bioreactors, Sterilizers, Centrifuges, and Others (Incubators and Shakers, Cell Culture Media, Buffers and Reagents, and Consumables)), by Application (Commercial and Research and Development), by End User (Pharmaceutical and Biotechnology Companies, CDMOs and CROs, Academic and Research Institutes), and Geography (North America, Europe, Asia-Pacific, Middle East & Africa, and South America). The report offers the value (in USD million) for the above segments. The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (in USD million) for the above segments.

By Product
Filtration Systems and Consumables
Chromatography Systems and Consumables
Others (Incubators and Shakers, Cell Culture Media, Buffers and Reagents and Consumables)
By Application
Research and Development
By End User
Pharmaceutical and Biotechnology Companies
CDMOs and CROs
Academic and Research Institutes
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle-East and Africa
South Africa
Rest of Middle-East and Africa
South America
Rest of South America

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Key Market Trends

Research and Development Segment is Expected to Account for the Largest Market Share During the Forecast Period

The research and development segment is expected to grow significantly during the study period due to the increasing research and development expenditure, rising demand for biopharmaceuticals, the establishment of new facilities, and technological advancements in the segment.

For instance, in March 2021, Transcenta announced a major breakthrough in its continuous perfusion cell culture platform by achieving volumetric productivity of > 6 g/L per day while maintaining process and product quality attributes in a state of control for a 4-week culture. This productivity improvement represents a 15-fold increase in drug substance output per year as compared to the same cell line in the conventional fed-batch process. This can increase the productivity of single-use bioreactors by approximately 130 kg or 1.3 metric tons of total drug substance per year. Thus, such advancements and increasing productivity through continuous bioprocessing will lead to lucrative growth of the market.

Furthermore, in March 2021, The United States Pharmacopeia (USP) and Phlow Corp. collaborated to build a new laboratory that will develop test methods and standards for continuous manufacturing. This establishment is focused on product development, tech transfer, and drug application filings using continuous manufacturing to foster wider adoption of continuous manufacturing by generic drugs and other pharmaceutical manufacturers.

Moreover, the establishment of continuous biomanufacturing facilities which are focused on research and development activities will also contribute to the market growth. For instance, in July 2019, GlaxoSmithKline opened a continuous manufacturing facility in Singapore with an investment of USD 95 million. Such inflow of investments will drive market growth.

  • Thus, due to the above-mentioned factors, the studied segment is expected to contribute to the significant growth of the market.
Biotechnology Funding

North America is Expected to Hold a Significant Share in the Market and Expected to do Same in the Forecast Period

The primary driving factors for the growth of the North American continuous processing markets are the increasing burden of chronic diseases, product launches, key strategic initiatives by market players, the establishment of continuous bioprocessing facilities, and technological advancement in the studied market.

The United States within North America is expected to hold a significant share of the studied market during the study period. For instance, according to the estimates of the 2022 American Cancer Society, Inc., about 236,740 new cases of lung cancer will be diagnosed in the country in 2022. The same source also states that 79,000 new cases of kidney cancer and 13,920 deaths will be reported in 2022 from Kidney cancer. The high burden of cancer is expected to boost the demand for biosimilar and other biopharmaceuticals, thus driving the continuous bioprocessing market.

In March 2022, Phlow Corp., a U.S.-based essential medicines public benefit company, entered into strategic alliances with both Virginia Commonwealth University’s (VCU) Medicines for All Institute and AMPAC Fine Chemicals to provide contract continuous manufacturing research and development (R&D) services for small molecule pharmaceutical products. Such partnerships will ramp up the operation of continuous manufacturing facilities, thus, driving the market.

The study “A Comparative Investment Analysis of Batch Versus Continuous Pharmaceutical Manufacturing Technologies,” published in January 2022, suggested that continuous manufacturing has the potential to make manufacturing of oral solid dosage pharmaceuticals more economically attractive in the country than foreign manufacturing of those products. Thus, studies indicating the economic benefits in the US will boost the continuous manufacturing process in the country, which will significantly contribute to the market growth.

  • Therefore, due to the above-mentioned factors, the studied market is expected to lead to lucrative growth in the market.
Continuous Bioprocessing Market Report

Competitive Landscape

The Continuous Bioprocessing market is fairly competitive and consists of several major players. In terms of market share, a few of the major players are currently dominating the market. Some of the companies which are currently dominating the market are 3M, Thermo Fisher Scientific, Merck KGaA, Sartorius AG, Eppendorf SE, and others.

Recent Development

  • In February 2022, CellulaREvolution raised GBP 1.75 million from a group of notable investors in a round led by Happiness Capital which will be used to accelerate research & development and strengthen their commercial team as they prepare to launch continuous cell culture technology.
  • In January 2022, WuXi Biologics invested EUR 325 million to establish a biomanufacturing facility that is designed to run continuous bioprocessing.

Table of Contents


    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Growing Adoption of Continuous Bioprocessing

      2. 4.2.2 Increasing Demand for Biopharmaceuticals

      3. 4.2.3 Technological Advancements in Continous Bioprocessing Space

    3. 4.3 Market Restraints

      1. 4.3.1 Strict Regulations for Continuous Bioprocessing Coupled with High Equipment Cost

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION (Market Size by Value - USD Million)

    1. 5.1 By Product

      1. 5.1.1 Filtration Systems and Consumables

      2. 5.1.2 Chromatography Systems and Consumables

      3. 5.1.3 Bioreactors

      4. 5.1.4 Sterilizers

      5. 5.1.5 Centrifuges

      6. 5.1.6 Others (Incubators and Shakers, Cell Culture Media, Buffers and Reagents and Consumables)

    2. 5.2 By Application

      1. 5.2.1 Commercial

      2. 5.2.2 Research and Development

    3. 5.3 By End User

      1. 5.3.1 Pharmaceutical and Biotechnology Companies

      2. 5.3.2 CDMOs and CROs

      3. 5.3.3 Academic and Research Institutes

    4. 5.4 Geography

      1. 5.4.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.4.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.4.4 Middle-East and Africa

        1. GCC

        2. South Africa

        3. Rest of Middle-East and Africa

      5. 5.4.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 3M

      2. 6.1.2 Thermo Fisher Scientific

      3. 6.1.3 Merck KGaA

      4. 6.1.4 Sartorius AG

      5. 6.1.5 Eppendorf SE

      6. 6.1.6 Danaher (Pall Corporation)

      7. 6.1.7 Bio-Rad Laboratories, Inc.

      8. 6.1.8 Repligen Corporation

      9. 6.1.9 Bionet


      11. 6.1.11 FUJIFILM

      12. 6.1.12 WuXi Biologics

    2. *List Not Exhaustive

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments

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Frequently Asked Questions

The Global Continuous Bioprocessing Market market is studied from 2019 - 2027.

The Global Continuous Bioprocessing Market is growing at a CAGR of 23% over the next 5 years.

Asia-Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2021.

3M, Thermo Fisher Scientific, Merck KGaA, Sartorius AG, Eppendorf SE are the major companies operating in Global Continuous Bioprocessing Market.

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