Global Label-Free Detection (LFD) Market - Growth, Trends, COVID-19 Impact, and Forecasts (2021 - 2026)

The Global Label-Free Detection (LFD) Market is segmented By Product, Technology (Surface Plasmon Resonance, Bio-Layer Interferometry, Isothermal Titration Calorimetry, Differential Scanning Calorimetry, and Other LFD Technologies), By Application, By End-user and Geography.

Market Snapshot

label free detection lfd market
Study Period: 2018 - 2026
Base Year: 2020
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 8.5 %

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Market Overview

The Global Label-Free Detection (LFD) Market is expected to register a CAGR of 8.5% during the forecast period. The main advantage in LFD techniques is that more direct information can be acquired as the method uses only native proteins and ligands. Innovations in LFD techniques include modification of mass spectrometry to develop surface-enhanced laser desorption/ionization (SELDI) time of flight (TOF)- mass spectrometry (MS) which is an innovative approach that offers on-chip purification of the proteins of interest and subsequent ionization of the retained molecules to be detected. Other innovations in LFD techniques include the modification of surface plasmon resonance (SPR) to develop Localized Surface Plasmon Resonance (LSPR) which provides advantages like lower fabrication costs and higher sensitivity. As per Pfizer Inc, annual report 2019, Pfizer’s expenditures on research and development (R&D) in 2019 was around USD 8.65 billion. This was an increase compared to 2018 which was about USD 8.1 billion. Furthermore, with the introduction of new innovations in the label-free detection technologies the market is expected to experience significant growth.

Scope of the Report

As per the scope of the report, Label-Free Detection (LFD)s is a method for detecting biomolecules and their interactions. The LFD method has made tremendous advancements due to the combination of knowledge in material sciences, computational design, and nanofabrication. The global label-free detection (LFD) market is segmented by product, technology, application, end-user and geography.

By Product
Biosensor Chips
By Technology
Mass Spectrometry
Surface Plasmon Resonance (SPR)
Bio-Layer Interferometry
Isothermal Titration Calorimetry
Differential Scanning Calorimetry
Other Lfd Technologies
By Application
Binding Kinetics
Binding Thermodynamics
Endogenous Receptor Detection
Hit Confirmation
Lead Generation
Other Applications
By End-User
Pharmaceutical & Biotechnology Companies
Academic & Research Institutes
Other End-Users
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle-East and Africa
South Africa
Rest of Middle-East and Africa
South America
Rest of South America

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Key Market Trends

Surface Plasmon Resonance (SPR) Segment is Expected to Hold Largest Share of Global Label-Free Detection (LFD) Market

  • Based on technology used, surface plasmon resonance (SPR) technology segment is expected to hold significant market share in the global label-free detection market due to its wide application range and compatibility with a wide range of biomolecules. However, the bio-layer interferometry segment is expected to grow at the fastest rate over the forecast period. 
  • According to the National Institutes for Health (NIH), total clinical research funding by the National Institutes for Health (NIH) in 2017, 2018 and 2019 was USD 12,695 million, USD 13,870 million, and USD 15,023 million. As clinical research funding increasing which will boost the market in the near future. Furthermore, interferometry provides advantages like less fluctuation in the refractive index of the samples being tested and microfluidic-free nature of bio-layer interferometry label-free detection systems. Hence, owing to above all factors the segment is expected to show growth over the forecast period.
LFD key trend 1.png

North America Region Holds the Largest Market Share of Label-Free Detection (LFD) Market

North America dominates the global label-free detection market due to technological advancement and high government funding in the region. Also, increasing prevalence of disease and the growth in drug discovery programs in the region. According to the National Clinical Trials Registry (NCT), in 2019, the number of registered clinical studies alone in the United States was around 108,790. Furthermore, partnerships between pharmaceutical companies and academic institutes and the presence of several pharmaceutical and biotechnological companies will also augment the growth of the market.

Global Label-Free Detection (LFD) Market2

Competitive Landscape

The Label-Free Detection (LFD) Market is fragmented competitive and consists of several major players. The companies are implementing certain strategic initiatives such as merger, new product launch, acquisition and partnerships that help them in strengthening their market position. Further, these leaders have products for all the end users, a strong grographical presence and also focusing on product innovations.

Table of Contents


    1. 1.1 Study Deliverables

    2. 1.2 Study Assumptions

    3. 1.3 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increasing R&D Activities Through Research Partnerships Between Pharmaceutical Companies and Academic Institutes

      2. 4.2.2 Innovations in Label-free Detection Technologies

    3. 4.3 Market Restraints

      1. 4.3.1 High Cost of Instruments

      2. 4.3.2 Issues in Sensitivty and Throughput

    4. 4.4 Porter's Five Force Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry


    1. 5.1 By Product

      1. 5.1.1 Consumables

        1. Biosensor Chips

        2. Microplates

      2. 5.1.2 Instruments

    2. 5.2 By Technology

      1. 5.2.1 Mass Spectrometry

      2. 5.2.2 Surface Plasmon Resonance (SPR)

      3. 5.2.3 Bio-Layer Interferometry

      4. 5.2.4 Isothermal Titration Calorimetry

      5. 5.2.5 Differential Scanning Calorimetry

      6. 5.2.6 Other Lfd Technologies

    3. 5.3 By Application

      1. 5.3.1 Binding Kinetics

      2. 5.3.2 Binding Thermodynamics

      3. 5.3.3 Endogenous Receptor Detection

      4. 5.3.4 Hit Confirmation

      5. 5.3.5 Lead Generation

      6. 5.3.6 Other Applications

    4. 5.4 By End-User

      1. 5.4.1 Pharmaceutical & Biotechnology Companies

      2. 5.4.2 Academic & Research Institutes

      3. 5.4.3 Other End-Users

    5. 5.5 Geography

      1. 5.5.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.5.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.5.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.5.4 Middle-East and Africa

        1. GCC

        2. South Africa

        3. Rest of Middle-East and Africa

      5. 5.5.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 Ametek Inc.

      2. 6.1.2 Corning Incorporated

      3. 6.1.3 Cytiva (GE Healthcare)

      4. 6.1.4 Horiba Ltd.

      5. 6.1.5 Malvern Panalytical

      6. 6.1.6 PerkinElmer Inc.

      7. 6.1.7 Shimadzu Corporation

      8. 6.1.8 Thermo Fisher Scientific

      9. 6.1.9 Fluidic Analytics

    2. *List Not Exhaustive

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments

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Frequently Asked Questions

The Global Label-Free Detection (LFD) Market market is studied from 2018 - 2026.

The Global Label-Free Detection (LFD) Market is growing at a CAGR of 8.5% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2020.

Thermo Fisher Scientific, PerkinElmer Inc, Corning Incorporated, Ametek Inc, Cytiva (GE Healthcare) are the major companies operating in Global Label-Free Detection (LFD) Market.

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