|Study Period:||2018 - 2026|
|Fastest Growing Market:||Asia Pacific|
|Largest Market:||North America|
Need a report that reflects how COVID-19 has impacted this market and its growth?
The Hemophilia market is expected to witness a CAGR of 5.9% during the forecast period (2021-2026).
The outbreak of COVID-19 worldwide is expected to impact the market, as individuals with chronic medical conditions, such as hemophilia, should take extra precautions to minimize the risk of contracting COVID-19, as this group of the population is more prone to infectious diseases. For instance, over the past few decades, several blood-borne viruses targeted hemophilia patients requiring treatment with clotting factors derived from human plasma. They should take measures to keep their blood pressure in check and follow general guidelines to keep their immune system strong. Moreover, it is impossible to estimate how many patients with hemophilia will become infected, and whether their factor deficiency and its treatment can influence the manifestations of the infection, its natural course, treatment, and consequences. In December 2020, the World Federation of Hemophilia (WFH), European Association for Haemophilia and Allied Disorders (EAHAD), European Haemophilia Consortium (EHC), and U.S. National Hemophilia Foundation (NHF) issued a joint COVID-19 vaccination guidance for people with bleeding disorders. It stated that people with bleeding disorders were not at greater risk of contracting COVID-19 or developing a severe form of the disease. Thus, people with these disorders were more likely to get themselves treated after they get vaccinated.
Certain factors that are driving the market growth include growing prevalence of hemophilia, favorable government initiatives, and rising R&D and new product development. Furthermore, according to the World Health Organization (WHO), owing to the sex-linkage of the disorder, there is a bigger prominence in males than females. In about one-third of new diagnoses, there is no earlier family history. Hemophilia occurs worldwide and across all racial groups. According to the World Federation of Hemophilia 2019 global survey report, in 2019, there were 31,997 people diagnosed with hemophilia B, around 5,749 people with unknown hemophilia types, and around 49,083 people were diagnosed for other bleeding disorders. Moreover, according to a study report by Allison Inserro published in the American Journal of Managed Care 2019, the prevalence of hemophilia B at birth is 5 cases for all severities of hemophilia B (per 100,000 males) and 1.5 cases for severe hemophilia B (per 100,000 males). For those born with hemophilia, the chances of living a life of normal duration and quality is reduced by 64% in the upper-middle-income countries, 77% in middle income, and up to 93% in low-income countries. This indicates reduction in quality of life due to hemophilia B, increasing the need for effective hemophilia treatment, which is expected to drive the market in the coming years.
Scope of the Report
Hemophilia is a genetic bleeding disorder that prevents the blood from clotting normally. The primary symptom is uncontrolled, often spontaneous bleeding in different areas of the body. The amount of bleeding depends on the severity of hemophilia.
The hemophilia market is segmented by Disease Type (Hemophilia A, Hemophilia B, and Others), Therapy (Replacement Therapy, Gene Therapy, and Others), Product Type (Recombinant Coagulation Factor Concentrates, Plasma-derived Coagulation Factor Concentrates, and Others), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (in USD million) for the above segments.
|By Disease Type|
|Others (Immune Tolerance Induction Therapy etc.)|
|By Product Type|
|Recombinant Coagulation Factor Concentrates|
|Plasma-derived Coagulation Factor Concentrates|
|Others (Desmopressin etc.)|
Key Market Trends
Hemophilia A is Expected to Hold Significant Market Share in the Disease Type Segment
Hemophilia A is the most common severe bleeding disorder. Replacement therapy, providing the missing coagulation factor, has been the mainstay of treatment both prophylactically and to treat bleeding. According to the data published by the World Federation of Hemophilia in 2019, hemophilia is more recorded among males, and approximately 24.6 in 100.000 neonates suffer from hemophilia A. This is a rare genetic bleeding disorder projected that affected around 157,517 people worldwide in 2019. The key medication to treat hemophilia A is concentrated FVIII product, also known as clotting factor. The recombinant factor products that are developed in a laboratory using DNA technology impede the use of human-derived pools of donor-sourced plasma. Due to the advances in recombinant protein engineering and the introduction of gene therapy and novel strategies to target the coagulation cascade. In 2018, Roche announced the approval of “Hemlibra” for expanded use in the routine prophylaxis of bleeding episodes in patients with hemophilia A without factor VIII (FVIII) inhibitors. The Takeda Pharmaceutical Company Limited offers "ADVATE“, which is used to replace clotting factor (factor VIII or antihemophilic factor) is missing among people with hemophilia A (also called “classic” hemophilia). Furthermore, according to the National Clinical Registry (NCT), as of August 11, 2020, worldwide, there were about 139 ongoing clinical trials across different phases of development for hemophilia A (HA). Moreover, the increasing demand for advanced products for the diagnosis and treatment of hemophilia is projected to trigger the growth of this segment in the forecast period.
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North America Dominates the Market and Expected to do Same in the Forecast Period
The North America region dominates the global market. The major factors driving the growth of the hemophilia market in the region include the therapeutic advances in hemophilia, which led to a wave of new FDA-approved agents and increasing awareness about technologically advanced products, increasing prevalence hemophilia, and the presence of a huge patient pool. The United States is the largest market in the region. According to the World Federation of Hemophilia 2018 report, in 2018, there were about 17,757 people diagnosed with hemophilia in the United States. Furthermore, in 2019, the number of people with hemophilia in the United States increased to about 20,000 individuals, as per NHF (National Health Federation). In the United States, agencies, like hemophilia Association of America, generally offers continuous treatment for patients by introducing different co-pay initiatives. This is further expected to balance the expenditures for patients and assist them in providing access to new products. In the United States, the BioMarin company is conducting Phase III clinical trial with valoctocogene roxaparvovec (BMN 270) to assess the efficacy of BMN 270 in the treatment of hemophilia A. Therefore, advancements in the gene therapy and novel strategies to target the coagulation factors is expected to drive the market in the near future. In the United States, Genzyme Corporation offers "ALPROLIX" (Coagulation Factor IX (Recombinant), Fc Fusion Protein), an injectable medicine used to help control and prevent bleeding in people with hemophilia B. Thus, the increasing research and development in the development of new effective therapies, along with the rising prevalence of hemophilia in the United States, is expected to drive the market over the forecast period.
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The Hemophilia market is highly competitive and consists of a few major players. Companies like Bayer AG, BioMarin Pharmaceutical, Inc., CSL Behring, Kedrion, Novo Nordisk, Pfizer, Inc., Roche (Chugai Pharmaceutical Co.), Sanofi (Genzyme Corporation), Takeda Pharmaceutical (Shire Plc.)., among others, hold substantial market share in the Hemophilia market. Additionally, the key players have been involved in various startegic alliances such as acquisitions, collaborations along with the launch of advanced products and research studies to secure the position in the global market.
In February 2021, Spark Therapeutics, announced positive preliminary results from part one of its ongoing Phase 1/2 open-label, non-randomized, dose-finding study of the investigational SPK-8016 used for the treatment of hemophilia A.
In April 2020, the United States Food and Drug Administration approved Sevenfact [coagulation factor VIIa (recombinant)] manufactured by Laboratoire Francais du Fractionnement et des Biotechnologies S.A. (LFB S.A) for the treatment and control of bleeding episodes occurring in adults and adolescents 12 years of age and older with hemophilia A or B with inhibitors.
Table of Contents
1.1 Study Assumptions and Market Definition
1.2 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Growing Prevalence of Hemophilia
4.2.2 Favorable Government Initiatives
4.2.3 Rising R&D and New Product Development
4.3 Market Restraints
4.3.1 High Cost of Treatment
4.3.2 Lack of Awareness Regarding Advanced Technologies
4.4 Porter's Five Force Analysis
4.4.1 Threat of New Entrants
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Bargaining Power of Suppliers
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION
5.1 By Disease Type
5.1.1 Hemophilia A
5.1.2 Hemophilia B
5.2 By Therapy
5.2.1 Replacement Therapy
5.2.2 Gene Therapy
5.2.3 Others (Immune Tolerance Induction Therapy etc.)
5.3 By Product Type
5.3.1 Recombinant Coagulation Factor Concentrates
5.3.2 Plasma-derived Coagulation Factor Concentrates
5.3.3 Others (Desmopressin etc.)
5.4.1 North America
184.108.40.206 United States
220.127.116.11 United Kingdom
18.104.22.168 Rest of Europe
22.214.171.124 South Korea
126.96.36.199 Rest of Asia-Pacific
5.4.4 Middle East and Africa
188.8.131.52 South Africa
184.108.40.206 Rest of Middle East and Africa
5.4.5 South America
220.127.116.11 Rest of South America
6. COMPETITIVE LANDSCAPE
*List Not Exhaustive
6.1 Company Profiles
6.1.1 Bayer AG
6.1.2 BioMarin Pharmaceutical, Inc.
6.1.3 CSL Behring
6.1.4 Kedrion S.p.A
6.1.5 Novo Nordisk
6.1.6 Pfizer, Inc.
6.1.7 Roche (Chugai Pharmaceutical Co.)
6.1.8 Sanofi (Genzyme Corporation)
6.1.9 Takeda Pharmaceutical (Shire Plc.)
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
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Frequently Asked Questions
What is the study period of this market?
The Global Hemophilia Market market is studied from 2018 - 2026.
What is the growth rate of Global Hemophilia Market?
The Global Hemophilia Market is growing at a CAGR of 5.9% over the next 5 years.
Which region has highest growth rate in Global Hemophilia Market?
Asia Pacific is growing at the highest CAGR over 2021- 2026.
Which region has largest share in Global Hemophilia Market?
North America holds highest share in 2020.
Who are the key players in Global Hemophilia Market?
CSL Behring, Pfizer, Inc., Bayer AG, BioMarin Pharmaceutical Inc., Sanofi SA are the major companies operating in Global Hemophilia Market.