Tetanus Toxoid Vaccine Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022-2027)

The Tetanus Toxoid Vaccine Market is segmented by Vaccine Type (Diphtheria, Tetanus, and Pertussis (DTaP), Diphtheria and Tetanus (DT), Tetanus, Diphtheria, and Pertussis (Tdap), Other Vaccines), End User (Hospitals and Clinics, Other End Users), and Geography (North America, Europe, Asia-Pacific, Middle East & Africa, and South America). The report offers the value (in USD million) for the above segments.

Tetanus Toxoid Vaccine Market Snapshot

Tetanus Toxoid Vaccine Market Size
Study Period: 2018 - 2026
Base Year: 2021
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 4.8 %
Tetanus Toxoid Vaccine Market Key Players

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Market Overview

The tetanus toxoid vaccine market is expected to register a CAGR of 4.8% during the forecast period (2022-2027).

The tetanus toxoid vaccine market is significantly impacted by COVID-19. According to the study published in the National Institutes of Health in January 2021, "Does tetanus vaccination contribute to reduced severity of the COVID-19 infection?" tetanus vaccination may help to reduce the severity of COVID-19 infection, but more research is needed to confirm or refute the effectiveness of the tetanus toxoid vaccine against COVID-19. Additionally, according to the article published in the Frontier Journal in October 2021, by Jennifer Monereo-Sánchez, vaccination against diphtheria or tetanus is linked to less severe COVID-19 symptoms. By stimulating the immune system, these vaccinations may protect against severe COVID-19 symptoms.

Tetanus, also known as lockjaw disease, is a non-communicable serious disease caused by a bacterial toxin that affects the nervous system, leading to painful muscle contractions, particularly the jaw and neck muscles. It is caused by Clostridium tetani (C. tetani) found in human and animal feces, soil, and street dust. The bacteria enter the body through wounds. Some of the symptoms include lockjaws (paralysis of the jaw), muscle stiffness, back pain, difficulties in breathing, and spasms. Most cases of tetanus occur in people who have never been vaccinated or in adults who have not kept up with their 10-year booster shots. There are different vaccines that include protection against tetanus are DTaP vaccine, DT vaccine, Tdap vaccine, and Td vaccine.

According to the Center For Diseases and Control Prevention in 2021, between 500–600 cases (approximately 0.4 cases per 100,000 population) were reported per year in the United States. As the number of cases has increased in recent years, the market is expected to grow in the coming years.

Rising cases of tetanus and diphtheria, new products under the clinical trials, and increasing government initiatives regarding vaccination and immunization are the key driving factors of the tetanus toxoid vaccine market. For instance, according to the Clinicaltrials. gov in 2020, title"Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects" is under the phase II trials.

Thus, all aforementioned factor such as rising number of cases of tetanus and diphtheria and rising in muber of trials boost the market.

Scope of the Report

As per the scope of the report, the tetanus vaccine, also known as tetanus toxoid, is a toxoid vaccine used to prevent tetanus. During childhood, five doses are recommended, with a sixth given during adolescence. After three doses, almost everyone is initially immune, but additional doses every ten years are recommended to maintain immunity. The Tetanus Toxoid Vaccine Market is segmented by Vaccine Type (Diphtheria, Tetanus, and Pertussis (DTaP), Diphtheria and Tetanus (DT), Tetanus, Diphtheria, and Pertussis (Tdap), Other Vaccines), End User (Hospitals and Clinics, Other End Users), and Geography (North America, Europe, Asia-Pacific, Middle East & Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (in USD million) for the above segments.

By Vaccine Type
Diphtheria, Tetanus, and Pertussis (DTaP)
Diphtheria and Tetanus (DT)
Tetanus, Diphtheria, And Pertussis (Tdap)
Other Vaccines
By End User
Hospitals and Clinics
Other End Users
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle East & Africa
South Africa
Rest of Middle East & Africa
South America
Rest of South America

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Key Market Trends

Diphtheria, Tetanus, and Pertussis (DTaP) Vaccine Segment is Expected to Hold a Major Market Share in the Tetanus Toxoid Vaccine Market

Diphtheria, tetanus, and pertussis (DTaP) vaccine segment holds a significant market share in the tetanus toxoid vaccine market. It is anticipated to show a similar trend over the forecast period due to the growing government initiatives to eradicate these diseases.

DTaP is a vaccine that helps in developing immunity against three deadly diseases caused by diphtheria, tetanus, and whooping cough (pertussis) in children younger than seven years old.

According to the World Health Organization (WHO) Report in 2022, the total number of Diptheria cases reported in India in 2019 was 9,622, compared to 8,788 in 2018. Similarly, the total number of tetanus is 7,071 is compared to the 7,000 cases in 2018.

According to, the World Health Organization 2021, As of November 11, 2020, five countries in the Region of the Americas had reported a total of 56 confirmed cases of diphtheria, with 16 deaths: Brazil (2 confirmed cases), the Dominican Republic (3 confirmed cases, including 2 deaths), Haiti (42 confirmed cases, including 11 deaths), Peru (4 confirmed cases, including one death), and the Bolivarian Republic of Venezuela (4 confirmed cases, including one death) (5 confirmed cases, including 2 deaths). Thus, rising the prevalence diphtheria rise in diphtheria, tetanus, and pertussis (DTaP) vaccine thereby boost the segment.

Low costs of the vaccine, increasing cases of tetanus, and increasing availability in low resource economies like Africa are the key driving factors in the diphtheria, tetanus, and pertussis (DTaP) vaccine segment.

Tetanus Toxoid Vaccine Market Growth

North America is Expected to Hold a Significant Share in the Market during the Forecast Period

North America is expected to hold a major market share in the global tetanus toxoid vaccine market due to the increasing cases of tetanus and diphtheria and higher cost, high coverage, and adoption in this region. According to the World Health Organization report in May 2019, in the 56 probable cases reported in 2019, 6 cases and 1 death were confirmed by the laboratory. The case-fatality rate among cases confirmed by laboratory or an epidemiological link was 23% in 2015, 39% in 2016, 8% in 2017, 13% in 2018, and 17% in 2019.

Furthermore, as per the same source, the age group of 6 to 14-year-olds has the highest incidence rate among confirmed cases in 2019, followed by 1 to 5-year-olds. A 5-year-old child died as a result of the fatal case. In 2019, the communities of Acul du Nord (3.58 cases per 100,000 population) in the Nord Department and Tabarre (3.07 cases per 100,000 population) in the Ouest Department reported the highest cumulative incidence rate of probable cases.

All tetanus-related deaths occurred among patients greater than 55 years of age. Furthermore, increasing focus to control the incidence and presence of well-established healthcare infrastructure is also fueling the growth of the overall regional market to a large extent.

Thus, all aforementioned factor expected boost the tatanus toxoid vaccine market in the North America region.

Tetanus Toxoid Vaccine Market Analysis

Competitive Landscape

The tetanus toxoid vaccine market is fragmented, competitive, and consists of several major players. Some of the prominent players that are currently dominating the market are Merck & Co. Inc., GlaxoSmithKline PLC, Sanofi (Sanofi Pasteur Inc.), Pfizer Inc., Bharat Biotech, Astellas Pharma Inc., Panacea Biotec Ltd, BB - NCIPD Ltd, PT Bio Farma, and Biological E Limited.

Recent Development

In June 2021, Merck & Co. Inc. and Sanofi collaborated to launch VAXELIS (diphtheria and tetanus toxoids vaccine) in the United States. The Food and Drug Administration approved the vaccine in 2018. ​

In March 2021, Stablepharma announced a collaboration with European vaccine manufacturer BB-NCIPD (Bul Bio) to develop a thermally stable version of the tetanus diphtheria (Td) vaccine using the patented StablevaX formulation and device. ​

Table of Contents


    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Rising Cases of Tetanus and Diphtheria in Some Countries

      2. 4.2.2 Growing Research and Development Activities for New Vaccines

      3. 4.2.3 Increasing Government Initiatives Programs for Vaccination

    3. 4.3 Market Restraints

      1. 4.3.1 Side-effects Associated with Toxoid Vaccine

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION (Market Size by Value – USD million)

    1. 5.1 By Vaccine Type

      1. 5.1.1 Diphtheria, Tetanus, and Pertussis (DTaP)

      2. 5.1.2 Diphtheria and Tetanus (DT)

      3. 5.1.3 Tetanus, Diphtheria, And Pertussis (Tdap)

      4. 5.1.4 Other Vaccines

    2. 5.2 By End User

      1. 5.2.1 Hospitals and Clinics

      2. 5.2.2 Other End Users

    3. 5.3 Geography

      1. 5.3.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.3.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.3.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.3.4 Middle East & Africa

        1. GCC

        2. South Africa

        3. Rest of Middle East & Africa

      5. 5.3.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 Merck & Co. Inc

      2. 6.1.2 GlaxoSmithKline Plc

      3. 6.1.3 Sanofi (Sanofi Pasteur Inc.)

      4. 6.1.4 Pfizer Inc.

      5. 6.1.5 Bharat Biotech

      6. 6.1.6 Astellas Pharma Inc.

      7. 6.1.7 Panacea Biotec Ltd

      8. 6.1.8 BB - NCIPD Ltd

      9. 6.1.9 PT Bio Farma

      10. 6.1.10 Biological E Limited

    2. *List Not Exhaustive

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies, and Recent Developments

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Frequently Asked Questions

The Global Tetanus Toxoid Vaccine Market market is studied from 2018 - 2026.

The Global Tetanus Toxoid Vaccine Market is growing at a CAGR of 4.8% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2021.

Merck & Co. Inc, GlaxoSmithKline Plc, Sanofi (Sanofi Pasteur, Inc), Pfizer, Inc, Bharat Biotech are the major companies operating in Global Tetanus Toxoid Vaccine Market.

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