Squalene Market Size & Share Analysis - Growth Trends And Forecast (2025 - 2030)

Global Squalene Market Trends and Insights

Surging Demand for Plant-derived Squalene in Premium Skincare

Plant-derived squalene meets consumer requests for clean, multifunctional actives that protect against ultraviolet A (UVA)-induced oxidative stress and stimulate collagen formation ^{[1]Martins et al., “Skin Photoprotection by Squalane,” MDPI.COM}. Asian beauty brands highlight the ingredient’s non-comedogenic profile, dovetailing with a regional move toward skin-barrier health. European firms scale olive-oil and amaranth supply streams, converting agricultural by-products into high-purity inputs. Positioning strategies are reinforced by labels that trace origin and carbon savings, building trust among Generation Z (Gen Z) buyers who scrutinize ingredient sourcing. Product formulators now incorporate squalene concentrations as low as 0.005% to improve texture without compromising stability, anchoring the squalene market in premium price tiers.

Rapid Adoption in Vaccine Adjuvants & Lipid-nanoparticle Drugs

Clinical data show that squalene-based emulsions outperform mineral oil comparators in antibody titers, prompting national stockpiles to specify GMP-grade supply. The modality proved vital during COVID-19, when scalable lipid carriers were needed for messenger Ribonucleic Acid (mRNA) vaccines. Croda’s multi-year contract with Amyris secures biotechnology-derived material that satisfies stringent pharmacopeial limits while eliminating marine sourcing risk. Oncology pipelines that hinge on lipid nanoparticles for targeted delivery further enlarge high-margin demand, explaining why GMP-grade volumes grow faster than cosmetic grades in the squalene market.

Shift Toward Fermentation & Synthetic-biology Production

Precision fermentation introduces a controlled bioprocess that decouples squalene output from harvest cycles and climatic vagaries. Amyris and partner refineries have demonstrated tonne-scale runs that deliver repeatable purity at less than 0.5 parts per million (ppm) residual solvents. The approach aligns with the United States' executive ambition for 30% of domestic chemical demand to shift to biomanufacturing by 2040. Recent metabolic-pathway edits in Saccharomyces cerevisiae delivered 2.3-fold productivity gains, compressing cost curves and widening biotech participation. Multinational cosmetics groups have started to embed forward-purchase clauses for fermentation-derived squalene, locking in supply and further energizing the squalene market.

Expansion of Sustainable-beauty Standards Across Asia-Pacific (APAC)

Japan’s Ministry of Health, Labour and Welfare updated its Positive List for cosmetic raw materials, explicitly encouraging plant-based squalene to curb shark exploitation. Regulatory reforms coincide with e-commerce growth, where ingredient transparency is a filter in 35% of skin-care searches. Surveys by BLOOM Association revealed that 53% of sampled Asian creams still contained shark-origin material, signaling a replacement window that favors certified vegetable or biosynthetic alternatives. Korean and Chinese multinationals now publish supplier audits and life-cycle analyses, amplifying competitive pressure to source sustainable grades. These developments keep Asia-Pacific in the fast lane of the squalene market.

Ethical & Regulatory Bans on Shark-derived Sourcing

The BLOOM Association estimates that 3 million deep-sea sharks are slaughtered annually for squalene extraction, sparking import restrictions and labelling mandates in the European Union ^{[2]BLOOM Association, “Shark Trade Report,” BLOOMASSOCIATION.ORG}. North America applies similar scrutiny via Lacey-Act enforcement, forcing brand owners to certify non-animal origins. The immediate effect is a squeeze on legacy supply chains that had relied on low-cost marine oil. Transition costs weigh on smaller formulators, although the policy accelerates market share gains for vegetable and biosynthetic streams in the squalene market.

Climate-driven Volatility in Olive-oil Based Feedstock Prices

Mediterranean droughts cut olive yields by double-digit percentages in 2024, lifting crude-oil prices and reducing the availability of high-squalene cultivars such as Nocellara de Belice. Variability complicates planning for European refiners that previously depended on olive pomace. Manufacturers diversify toward amaranth and sugarcane, yet these alternatives entail processing adjustments and new supplier audits. Cost swings feed into cosmetic-grade pricing and can blunt margin gains in the squalene market until weather patterns normalise or fermentation scale widens.

Segment Analysis

By Source: Plant-based Alternatives Drive Market Transformation

Vegetable derivatives led with 38.18% of the Squalene market size in 2024 and are forecast to expand at 6.95% CAGR through 2030. The leadership stems from upgrades in olive oil pomace extraction, amaranth seed processing, and sugarcane farnesene hydrogenation that displace shark liver oil altogether. Amaranth-based PhytoSquene satisfies European Pharmacopoeia purity while remaining free of animal-origin contaminants, giving formulators an immediate compliance route. Though still modest, biosynthetic volumes rise quickest as precision fermentation eliminates crop-yield swings and shortens lead times.

Animal-source barrels continue to contract as consumer sentiment and customs codes turn unfavourable. Other minor feedstocks, such as wheat germ and rice bran oils, address specific regional supply gaps but lack the scalability of olive or cane pathways. Overall, plant and biosynthetic inputs reshape the competitive map, lowering entry barriers and broadening the geographic footprint of the squalene market.

Note: Segment shares of all individual segments available upon report purchase

By Purity Grade: Pharmaceutical Applications Command Premium Positioning

Cosmetic grade dominated with 68.81% share of the Squalene market share in 2024, owing to global skin-care adoption. Brands leverage the ingredient for sebum-like emolliency that enhances spreadability at low inclusion rates, reinforcing a premium aura in anti-aging and barrier-repair lines. GMP grade, demanded by vaccine and oncology stakeholders, records a faster 6.60% CAGR as biopharma pipelines progress. Controlled microbial processes and deeper analytical validation push per-kilogram prices several multiples above cosmetic norms. 

Food grade applications emerge in functional beverages and nutritional capsules where squalene’s antioxidant and anti-inflammatory traits support metabolic health claims. Each grade commands distinct audit and documentation protocols, requiring producers to segment production lines or partner with toll manufacturers. The tiered approach protects margins and enhances resilience in the squalene market.

By End-User Industry: Cosmetics Dominance Reflects Consumer Premiumization

Cosmetics generated 70.06% of global demand in 2024 and remain on a 6.60% CAGR trajectory through 2030, anchored in Asia-Pacific e-commerce expansion and continual product launches that feature clean-label actives. Formulators employ squalene to boost moisturization without a greasy after-feel, aligning with sensorial expectations across age groups. Though smaller in volume, pharmaceutical uptake underpins value growth as squalene’s immune-enhancing profile secures a foothold in next-generation adjuvants and nano-delivery formats.

Food and nutraceutical segments test micro-encapsulated squalene in omega-3 blends to support cholesterol modulation and anti-oxidative performance in diabetic cohorts. Industrial lubricants leverage high thermal stability for specialty applications but stay niche. The cross-industry dispersion strengthens sales diversity, mitigating single-segment risk in the squalene market.

Note: Segment shares of all individual segments available upon report purchase

Geography Analysis

Europe’s 42.04% share of the Squalene market size in 2024 reflects a combination of stringent sustainability directives and advanced personal-care manufacturing ecosystems. Regulatory bodies restrict shark inputs while encouraging traceable plant or biosynthetic origins, pushing formulators toward certifications that enhance brand equity. Olive oil by-products remain key, but climate variability prompts investment in amaranth and cane pathways. Biopharma clusters in Germany and France raise GMP-grade demand, and collaborative funding, such as L’Oréal’s EUR 35 million injection into a regional fermentation hub, cements supply security.

Asia-Pacific is the fastest-growing region at a projected 6.77% CAGR to 2030. Rising disposable incomes in China, Japan, and South Korea stimulate premium skin-care consumption that integrates squalene for barrier-repair and anti-aging benefits. Ministry of Health, Labor and Welfare (MHLW)’s ingredient-positive list encourages local brands to phase out marine-derived material, and social-commerce platforms amplify consumer scrutiny of clean sourcing. Replacement of shark squalene, documented at 53% prevalence in 2024, presents immediate upside for plant and biosynthetic variants. Regional contract manufacturers already retrofit lines to handle vegetable inputs, further entrenching the growth outlook of the squalene market.

North America combines biotechnology innovation with policy support that favours domestic biomanufacturing. Precision-fermentation ventures concentrate around the San Francisco Bay Area and Boston, supplying both cosmetic and vaccine-ready grades. United States Environmental Protection Agency (EPA)’s low-priority listing of squalene under Toxic Substances Control Act (TSCA) lowers regulatory friction, while the White House bioeconomy agenda channels grants toward scale-up infrastructure. South America and the Middle East & Africa contribute modest but rising volumes as knowledge of sustainable beauty penetrates local markets and as sugarcane resources in Brazil create potential feedstock synergies. Collectively, regional demand convergence reinforces the global expansion path of the squalene market.