Pruritus Therapeutics Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

The Pruritus Therapeutics Market Report Segments the Industry by Product Type (Corticosteroids, Antihistamines, Local Anesthetics, Counterirritants, Immunosuppressants, Calcineurin Inhibitors, and More), Disease Type (Atopic Dermatitis, Allergic Contact Dermatitis, and More), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, South America). The Market Forecasts are Provided in Terms of Value (USD).

Pruritus Therapeutics Market Size and Share

Pruritus Therapeutics Market (2025 - 2030)
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Pruritus Therapeutics Market Analysis by Mordor Intelligence

The Pruritus Therapeutics Market size is estimated at USD 9.97 billion in 2025, and is expected to reach USD 12.26 billion by 2030, at a CAGR of 4.22% during the forecast period (2025-2030).

Advancements in mechanism-specific biologics and small-molecule inhibitors are shifting treatment away from broad immunosuppression toward precision medicine, especially after the first-in-class IL-31 receptor antagonist approval in late 2024. Regulatory harmonization and digital health uptake further widen patient reach, while rising disease awareness repositions chronic itch from a symptom to its own therapeutic category. White-space indications such as cholestatic and oncologic pruritus are beginning to attract investment as legacy segments mature. Nevertheless, payer scrutiny and evolving JAK inhibitor safety profiles temper near-term revenue acceleration.

Key Report Takeaways

  • By product type, corticosteroids led with 35.63% of pruritus therapeutic market share in 2024, whereas JAK inhibitors are on track for the fastest 5.68% CAGR through 2030. 
  • By disease type, atopic dermatitis held a 29.87% share of the pruritus therapeutic market size in 2024, while neuropathic pruritus is projected to expand at a 6.25% CAGR to 2030. 
  • By geography, North America dominated with 37.65% revenue share in 2024, while Asia-Pacific is expected to post an 8.29% CAGR through 2030.

Segment Analysis

By Product Type: JAK Inhibitors Challenge Corticosteroid Dominance

Corticosteroids retained a 35.63% revenue share in 2024, yet cumulative safety concerns and tachyphylaxis curb repeat prescriptions. JAK inhibitors contributed a modest share in 2024 but are projected to grow fastest at 5.68% CAGR, buoyed by 19.9% complete clearance rates shown by upadacitinib against dupilumab in head-to-head data. The pruritus therapeutic market size for JAK inhibitors could reach USD 2.4 billion by 2030 if label expansions continue. Antihistamines remain first-line for acute flare control, whereas calcineurin inhibitors occupy pediatric niches thanks to favorable safety in thin skin.

Nanofiber transdermal films enhance the delivery of counter-irritants and local anesthetics, raising adherence in mild cases. PDE-4 inhibitors are moving from psoriasis into atopic dermatitis, diversifying topical portfolios. Opioid receptor antagonists now feature in late-stage trials for cholestatic itch, while TRPM8 agonists explore cold-receptor modulation. Combination therapy and precision dosing are emerging norms, further fragmenting the pruritus therapeutic market.

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Note: Segment shares of all individual segments available upon report purchase

By Disease Type: Neuropathic Pruritus Emerges as Growth Driver

Atopic dermatitis commanded 29.87% of the pruritus therapeutic market share in 2024 on the back of robust biologic pipelines. Neuropathic pruritus, traditionally relegated to gabapentinoids, is forecast to deliver a 6.25% CAGR through 2030 as mechanistic understanding progresses. Urticaria awaits FDA action on dupilumab, potentially redirecting patient flows toward biologics. Cholestatic pruritus awaits the first dedicated therapy following positive Phase III results for linerixibat GSK.

Hematologic and oncologic pruritus segments expand as survivorship climbs, spurring demand for supportive care. Cross-indication use of IL-31 antagonists could blur disease boundaries, accelerating product uptake across the pruritus therapeutic market. Improved patch-test panels aid allergic contact dermatitis management, lifting diagnosis rates. Together, these shifts diversify revenue streams while reducing dependence on atopic dermatitis.

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Note: Segment shares of all individual segments available upon report purchase

Geography Analysis

North America held 37.65% of 2024 revenue owing to early biologic access; yet, biosimilar competition and tighter PBM formularies are slowing incremental growth. Medicare fee cuts of 46% (inflation-adjusted) on dermatology procedures between 2007 and 2024 are nudging providers toward cost-optimized regimens. Large PBMs have already removed certain high-price biologics to favor low-cost adalimumab biosimilars. Even so, clinical-trial density and swift FDA review times retain the region’s influence on global launch sequencing within the pruritus therapeutic market.

Asia-Pacific is on track for an 8.29% CAGR, benefiting from synchronized adoption of ICH guidelines and middle-class insurance expansion. China approved 228 new drugs in 2024, with accelerated pathways covering 71 molecules. Japan continues to deliver world-first dermatology approvals, including chronic spontaneous urticaria coverage for dupilumab, and facilitates topical roflumilast commercialization through co-development alliances. India’s clearance of abrocitinib underscores regulatory convergence trends, while nationwide telehealth platforms extend specialty care to tier-2 cities.

Europe exhibits steady but moderated growth as biosimilar price competition intensifies. EMA cardiovascular warnings on JAK inhibitors influence physician choice, especially for older adults. Brexit-driven regulatory divergence adds filing complexity, although ICH efforts maintain broad alignment. Long-term opportunities lie in the Middle East, Africa, and South America, where improving infrastructure and NGO-backed access programs broaden the addressable base for the pruritus therapeutic market.

Growth Rate by Region
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Competitive Landscape

The pruritus therapeutics market is moderately concentrated. AbbVie’s combined Skyrizi and Rinvoq sales exceeded USD 6 billion in 2025, rising 70.5% year-on-year. Strategic M&A is reshaping portfolios—Incyte paid USD 750 million upfront for Escient’s MRGPR antagonist platform, while Johnson & Johnson acquired NM26 bispecific technology for USD 1.25 billion. Digital therapeutics tie-ups are becoming differentiators; Galderma partners with device companies to integrate scratch-monitoring into treatment algorithms.

Patent expiries are accelerating biosimilar waves: 14 adalimumab copies already compete in the United States, and ustekinumab generics debut in 2025. Portfolio diversification now extends into microbiome-based sprays and TRPM8 modulators, enabling smaller entrants to carve niches. Real-world evidence and patient-access programs increasingly underpin competitive advantage, especially where payers demand proof of value across the pruritus therapeutic market.

Legacy immunosuppressants still deliver volume sales in emerging regions but face share erosion in developed markets. Biologic developers are countering with discounted vial programs and outcome-based contracts. Companies that combine broad indication footprints with advanced manufacturing appear best positioned to sustain margin resilience.

Pruritus Therapeutics Industry Leaders

  1. Cara Therapeutics

  2. AbbVie Inc.

  3. EPI Health LLC

  4. Sanofi

  5. Galderma S.A.

  6. *Disclaimer: Major Players sorted in no particular order
Pruritus Therapeutics Market Concentration
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Recent Industry Developments

  • June 2025: Galderma announced two-year data from long-term nemolizumab studies demonstrating sustained efficacy and favorable safety profile, with over 85% of patients achieving significant reductions in eczema severity and itch, reinforcing the drug's strategic importance in the expanding pruritus therapeutic market.
  • April 2025: AbbVie reported first-quarter 2025 results with immunology portfolio growth of 16.6%, driven by Skyrizi revenue increase of 70.5% and Rinvoq growth of 57.2%, while receiving European Commission marketing authorization for Rinvoq in giant cell arteritis.
  • March 2025: Novartis licensed Kyorin's preclinical chronic hives candidate for USD 55 million upfront in an USD 830 million deal, demonstrating continued strategic investment in the pruritus therapeutic space.
  • December 2024: FDA approved nemolizumab (Nemluvio) for moderate-to-severe atopic dermatitis in patients aged 12 and older, marking the first IL-31 receptor alpha-targeting monoclonal antibody approval and expanding treatment options for previously difficult-to-treat patients.
  • September 2024: Organon completed acquisition of Dermavant including VTAMA (tapinarof) cream, expanding its dermatology portfolio and market presence in the growing topical treatment segment for psoriasis and atopic dermatitis.

Table of Contents for Pruritus Therapeutics Industry Report

1. Introduction

  • 1.1 Study Assumptions & Market Definition
  • 1.2 Scope of the Study

2. Research Methodology

3. Executive Summary

4. Market Landscape

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Increasing Prevalence of Dermatological Disorders
    • 4.2.2 Presence of High Unmet Medical Needs
    • 4.2.3 Aging Population with Chronic Inflammatory Skin Diseases
    • 4.2.4 Commercial Launch of Biologics & JAK Inhibitors
    • 4.2.5 Rapid Uptake of Tele-Dermatology & E-Prescription Platforms
    • 4.2.6 Innovative R&D Advancements in Neurogenic Itch Mechanisms
  • 4.3 Market Restraints
    • 4.3.1 Limited Understanding of Pruritus Pathophysiology
    • 4.3.2 Safety Concerns Over Long-Term Immunosuppressant Usage
    • 4.3.3 Availability of Symptomatic Non-Prescription Alternatives
    • 4.3.4 Fragmented Reimbursement for Novel Biologics
  • 4.4 Regulatory Landscape
  • 4.5 Porter’s Five Forces Analysis
    • 4.5.1 Threat of New Entrants
    • 4.5.2 Bargaining Power of Buyers
    • 4.5.3 Bargaining Power of Suppliers
    • 4.5.4 Threat of Substitute Products
    • 4.5.5 Intensity of Competitive Rivalry

5. Market Size & Growth Forecasts (Value in USD)

  • 5.1 By Product Type
    • 5.1.1 Corticosteroids
    • 5.1.2 Antihistamines
    • 5.1.3 Local Anesthetics
    • 5.1.4 Counterirritants
    • 5.1.5 Immunosuppressants
    • 5.1.6 Calcineurin Inhibitors
    • 5.1.7 Opioid Receptor Antagonists
    • 5.1.8 Antidepressants
    • 5.1.9 PDE-4 Inhibitors
    • 5.1.10 JAK Inhibitors
  • 5.2 By Disease Type
    • 5.2.1 Atopic Dermatitis
    • 5.2.2 Allergic Contact Dermatitis
    • 5.2.3 Urticaria
    • 5.2.4 Cholestatic Pruritus
    • 5.2.5 Hematologic Pruritus
    • 5.2.6 Neuropathic Pruritus
    • 5.2.7 Oncologic Pruritus
    • 5.2.8 Other Disease Type
  • 5.3 By Geography
    • 5.3.1 North America
    • 5.3.1.1 United States
    • 5.3.1.2 Canada
    • 5.3.1.3 Mexico
    • 5.3.2 Europe
    • 5.3.2.1 Germany
    • 5.3.2.2 United Kingdom
    • 5.3.2.3 France
    • 5.3.2.4 Italy
    • 5.3.2.5 Spain
    • 5.3.2.6 Rest of Europe
    • 5.3.3 Asia-Pacific
    • 5.3.3.1 China
    • 5.3.3.2 Japan
    • 5.3.3.3 India
    • 5.3.3.4 Australia
    • 5.3.3.5 South Korea
    • 5.3.3.6 Rest of Asia-Pacific
    • 5.3.4 Middle East & Africa
    • 5.3.4.1 GCC
    • 5.3.4.2 South Africa
    • 5.3.4.3 Rest of Middle East & Africa
    • 5.3.5 South America
    • 5.3.5.1 Brazil
    • 5.3.5.2 Argentina
    • 5.3.5.3 Rest of South America

6. Competitive Landscape

  • 6.1 Market Concentration
  • 6.2 Market Share Analysis
  • 6.3 Company Profiles (includes Global level Overview, Market level overview, Core Segments, Financials as available, Strategic Information, Market Rank/Share for key companies, Products & Services, and Recent Developments)
    • 6.3.1 AbbVie Inc.
    • 6.3.2 Pfizer Inc.
    • 6.3.3 Sanofi
    • 6.3.4 Galderma S.A.
    • 6.3.5 Cara Therapeutics
    • 6.3.6 Actavis (Teva)
    • 6.3.7 Astellas Pharma Inc.
    • 6.3.8 Trevi Therapeutics
    • 6.3.9 EPI Health LLC
    • 6.3.10 Johnson & Johnson
    • 6.3.11 Eli Lilly & Co.
    • 6.3.12 Bayer AG
    • 6.3.13 GlaxoSmithKline plc
    • 6.3.14 Novartis AG
    • 6.3.15 Regeneron Pharmaceuticals
    • 6.3.16 Incyte Corporation
    • 6.3.17 LEO Pharma
    • 6.3.18 Maruho Co., Ltd.
    • 6.3.19 Amgen Inc.
    • 6.3.20 Ocera Therapeutics

7. Market Opportunities & Future Outlook

  • 7.1 White-space & Unmet-need Assessment
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Global Pruritus Therapeutics Market Report Scope

As per the scope of the report, pruritus is a condition of the skin accompanied by an unpleasant and irritating itching sensation over the skin that provokes scratching. Some chemical substances, like histamine, prostaglandins, proteases, substance P, and bile salts, may cause it. Sometimes accompanied by crusts, excoriations, hyperpigmentation, lichenification, pyoderma, increased skin creasing, and burnished nail. 

The pruritus therapeutics market is expected to grow at a CAGR of 3.5% over the forecast period. The pruritus therapeutics market is segmented by product type (corticosteroid, antihistamine, local anesthetic, counterirritant, immunosuppressant, calcineurin inhibitors, and other product types), disease type (atopic dermatitis/eczema, allergic contact dermatitis, urticaria, cutaneous T-cell, and other disease types) and geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (in USD million) for the above segments.

By Product Type Corticosteroids
Antihistamines
Local Anesthetics
Counterirritants
Immunosuppressants
Calcineurin Inhibitors
Opioid Receptor Antagonists
Antidepressants
PDE-4 Inhibitors
JAK Inhibitors
By Disease Type Atopic Dermatitis
Allergic Contact Dermatitis
Urticaria
Cholestatic Pruritus
Hematologic Pruritus
Neuropathic Pruritus
Oncologic Pruritus
Other Disease Type
By Geography North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East & Africa GCC
South Africa
Rest of Middle East & Africa
South America Brazil
Argentina
Rest of South America
By Product Type
Corticosteroids
Antihistamines
Local Anesthetics
Counterirritants
Immunosuppressants
Calcineurin Inhibitors
Opioid Receptor Antagonists
Antidepressants
PDE-4 Inhibitors
JAK Inhibitors
By Disease Type
Atopic Dermatitis
Allergic Contact Dermatitis
Urticaria
Cholestatic Pruritus
Hematologic Pruritus
Neuropathic Pruritus
Oncologic Pruritus
Other Disease Type
By Geography
North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East & Africa GCC
South Africa
Rest of Middle East & Africa
South America Brazil
Argentina
Rest of South America
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Key Questions Answered in the Report

What is the current value of the pruritus therapeutic market?

The pruritus therapeutic market was valued at USD 9.97 billion in 2025 and is projected to reach USD 12.26 billion by 2030.

Which product class is growing fastest in the pruritus therapeutic market?

JAK inhibitors are forecast to expand at a 5.68% CAGR through 2030, the fastest among all product categories.

Which is the fastest growing region in Pruritus Therapeutics Market?

Asia-Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).

Why is Asia-Pacific the most attractive growth region?

Regulatory harmonization with ICH guidelines, expanded insurance coverage, and first-in-world approvals in Japan are driving an 8.29% CAGR in Asia-Pacific.

What is the biggest safety concern influencing prescribing trends?

Long-term cardiovascular and malignancy risks linked to JAK inhibitors have prompted FDA and EMA warnings, shaping clinician choice, especially for elderly patients.

Which unmet indication represents a major white-space opportunity?

Cholestatic pruritus remains largely untreated; positive Phase III data for linerixibat could open the first dedicated therapy for this condition and unlock new revenue.

Page last updated on: June 23, 2025

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