Post-Operative Pain Management Market Size & Share Analysis - Growth Trends & Forecasts (2024 - 2029)

The Report Covers Postoperative Pain Management Market Growth and It is Segmented by Drug Class (Opioids, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Cyclooxygenase-2-Selective Inhibitors (COX-2) Inhibitors, and Other Drug Classes), by Route of Administration (Injectable, Oral, Topical and Other Routes), by Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Other Distribution Channels) and Geography (North America, Europe, Asia-Pacific, Middle-East and Africa and South America). The Market Provides the Value (USD) for the Above Segments.

Post-Operative Pain Management Market Size

Post Operative Pain Management Market Summary
Study Period 2019 - 2029
Market Size (2024) USD 40.46 Billion
Market Size (2029) USD 53.61 Billion
CAGR (2024 - 2029) 5.79 %
Fastest Growing Market Asia-Pacific
Largest Market North America

Major Players

Post Operative Pain Management Market Major Players

*Disclaimer: Major Players sorted in no particular order

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Post-Operative Pain Management Market Analysis

The Post Operative Pain Management Market size is estimated at USD 40.46 billion in 2024, and is expected to reach USD 53.61 billion by 2029, growing at a CAGR of 5.79% during the forecast period (2024-2029).

The COVID-19 pandemic significantly impacted the postoperative pain management market. As per the April 2022 data published by PubMed, it was observed that people across the United States and Canada suffering from chronic pain witnessed a significant increase during the pandemic. Similarly, according to the study published in the Turkish Journal of Anaesthesiology and Reanimation in June 2022, most pain care centers are forced to close their doors. All outpatient and interventional procedures were reduced due to the government's strict lockdown. Thus, the pain management market was greatly impacted. However, the market is currently recovering well owing to the resumption of surgical procedures and the decline in COVID-19 cases.

Furthermore, the factors fueling the market's growth are the growing number of surgical procedures, the rising number of emergency hospital visits, the increasing demand for non-opioid-based analgesics, and the increasing focus on palliative care.

A growing number of surgical procedures drives the demand for postoperative pain management medications. For instance, according to the Canadian Institutes of Health Information published in June 2022, in 2021, 55,300 hip and 55,285 knee replacements were performed in Canada. Additionally, according to the Organisation for Economic Co-operation and Development data published in April 2023, the number of hip replacement surgeries increased in Turkey from 41,604 in 2020 to 46,368 in 2021. With such a huge increase in the number of surgeries performed across several countries, the market for postoperative pain management drugs is expected to exhibit substantial growth, as these medications play a crucial role in managing the pain caused by surgical procedures.

Likewise, a study published in PubMed Central in January 2022 stated that, according to research conducted by the United States Institute of Medicine in June 2022, postoperative pain was a common but often undertreated disease, with 80 percent of surgery patients experiencing postoperative pain and less than half of these patients reporting appropriate pain control. Furthermore, the study states that, according to a nationwide survey, 39 percent of postoperative patients feel severe to terrible pain. Such unmet needs greatly highlight the need for postoperative pain management drugs to optimize palliative care among the patient population, thereby providing lucrative opportunities to prominent players within the market.

Additionally, strategic initiatives by the market players, such as product launches and research and development activities in the field of pain management, are expected to boost the market's growth. For instance, in April 2022, Assiut University started a trial to evaluate the population pharmacokinetics and pharmacodynamics of rectal dexmedetomidine Niosomesfor postoperative analgesia in pediatric cancer patients undergoing bone marrow biopsy and aspiration in comparison with the intravenous and rectal plain formulation. Additionally, in April 2022, Acadia Pharmaceuticals Inc. announced top-line results from a Phase 2 randomized, double-blind, placebo-controlled clinical trial evaluating the efficacy and safety of ACP-044 for acute pain following bunionectomy surgery. The primary endpoint, a comparison of cumulative pain intensity scores over 24 hours between the ACP-044 1600 mg once daily, the ACP-044 400 mg four times daily, and the placebo treatment arms, was not met.

Thus, all aforementioned market, such as the rising number of surgical procedures and strategic initiatives by the market players, is expected to boost the market over the forecast. However, concerns about the overuse of opioids are a major factor restraining the market's growth.

Post-Operative Pain Management Market Trends

Non-steroidal anti-inflammatory drugs (NSAIDs) Segment is Expected to Hold a Significant Share in the Postoperative Pain Management Market

The non-steroidal anti-inflammatory drugs (NSAIDs) segment is expected to hold a significant market share by drug class. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain, reduce inflammation, and bring down high body temperatures. The major factors fueling the segment's growth are the implementation of strategic initiatives by the market players, the growing demand for NSAIDs owing to their advantages over other drugs, and the increasing number of surgical procedures. For instance, in July 2021, Hyloris Pharmaceuticals SA, a specialty biopharmaceutical company committed to addressing unmet medical needs through the reinvention of existing medications, reported that Maxigesic IV would be available in Germany and Austria. Maxigesic IV is a novel, patented, non-steroidal anti-inflammatory drug that is a unique combination of 1000 mg of paracetamol and 300 mg of ibuprofen solution for infusion. Hyloris' partner company, AFT Pharmaceuticals, works with distribution partners with a strong local presence to commercialize the product worldwide.

Moreover, a June 2021 published study titled Adult outpatients reported better pain scores and fewer adverse effects when their postoperative pain was treated with NSAIDs than codeine. Such studies indicating the efficacy of NSAIDs in postoperative pain management contribute to the segment's growth. Additionally, product launches by the market players are expected to propel the market's growth. For instance, in December 2021, Heron Therapeutics, Inc. announced that the U.S. Food and Drug Administration (FDA) has approved its supplemental New Drug Application (sNDA) for ZYNRELEF (bupivacaine and meloxicam) extended-release solution to significantly expand the indication.

Thus, the segment is expected to grow significantly over the forecast period due to the abovementioned factors.

Post Operative Pain Management Market: Estimated Funding for Chronic Pain (in Million), United States, 2021-2024

North America is Expected to Hold a Significant Share in the Market and Expected to do Same in the Forecast Period

The United States is expected to hold a significant share of the market in North America. The major factors bolstering the market's growth are the growing number of surgical procedures, the surge in awareness regarding postoperative pain management drugs, the increasing number of product approvals, and the rising focus on palliative care.

The increase in the number of surgeries in the country is expected to propel the growth of the market. For instance, the Personalised Orthopaedics of the Palm Beaches statistics published in November 2021 show that almost 800,000 knee replacements are performed each year in the United States, and the number is estimated to increase year on year. Additionally, Cedars-Sinai data updated in January 2022 shows that coronary artery bypass graft surgery (CABG), also known as coronary artery bypass or bypass surgery, is the most common type of heart surgery. More than 300,000 people have successful bypass surgery in the United States each year. Such statistics are likely to increase the demand for postoperative pain management medications within the country, thereby boosting the market's growth.

In addition, several market players are engaged in implementing strategic initiatives, thereby contributing to the market's growth. For instance, in May 2021, Allay Therapeutics, a clinical-stage biotechnology company pioneering ultra-sustained analgesic products to transform postsurgical pain management and recovery, reported the first-ever clinical data showing non-opioid pain relief lasting two weeks after a single administration.

Moreover, an increasing number of product approvals is also expected to contribute to the market's growth. For instance, in May 2021, The FDA has approved a Heron Therapeutics combination medicine designed to manage postoperative pain and assist patients avoid the use of narcotic painkillers, a regulatory decision that comes after the agency previously rejected the biotech's applications. The Heron medication, which combines bupivacaine and meloxicam, is approved to treat postsurgical pain for up to 72 hours after three procedures: bunionectomy, open surgery hernia repair, and total knee replacement.

Thus, owing to the abovementioned factors, the market is expected to witness significant growth over the forecast period.

Postoperative Pain Management Market - Growth Rate by Region

Post-Operative Pain Management Industry Overview

The postoperative pain management market is fragmented, with the presence of several global and international market players. The key players are adopting different growth strategies to enhance their market presence, such as partnerships, agreements, collaborations, new product launches, geographical expansions, mergers, and acquisitions. Some of the key players in the market are Pfizer Inc., AbbVie, GlaxoSmithKline plc, Heron Therapeutics, and AFT Pharmaceuticals.

Post-Operative Pain Management Market Leaders

  1. AbbVie (Allergan)

  2. Heron Therapeutics

  3. Pfizer Inc.

  4. AFT Pharmaceuticals

*Disclaimer: Major Players sorted in no particular order

Post Operative Pain Management Market Concentration
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Post-Operative Pain Management Market News

  • April 2023: Cali Biosciences Co., Ltd. initiated Phase III studies of its core product, CPL-01 (long-acting ropivacaine), with dosing in hernia patients already begun and dosing in bunion patients scheduled to start next month.
  • March 2022: Health Canada issued a Notice of Compliance (NOC) to commercialize Heron Therapeutics' ZYNRELEF (bupivacaine, an amide local anesthetic, and meloxicam, a nonsteroidal anti-inflammatory drug (NSAID) extended-release solution) for instillation into the surgical wound for postoperative analgesia after a bunionectomy, open inguinal herniorrhaphy, and total knee arthroplasty surgical procedures.

Post-Operative Pain Management Market Report - Table of Contents

  1. 1. INTRODUCTION

    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study

  2. 2. RESEARCH METHODOLOGY

  3. 3. EXECUTIVE SUMMARY

  4. 4. MARKET DYNAMICS

    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Growing Number of Surgical Procedures

      2. 4.2.2 Increasing Demand for Non-Opioid Based Anaelgesics

      3. 4.2.3 Increasing Focus Towards Palliative Care

    3. 4.3 Market Restraints

      1. 4.3.1 Concerns Pertaining to the Overuse of Opioids

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Bargaining Power of Buyers/Consumers

      2. 4.4.2 Bargaining Power of Suppliers

      3. 4.4.3 Threat of New Entrants

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION (Market Size by Value -USD)

    1. 5.1 By Drug Class

      1. 5.1.1 Opioids

      2. 5.1.2 Non-steroidal anti-inflammatory drugs (NSAIDS)

      3. 5.1.3 Cyclooxygenase-2-selective inhibitors (COX-2) inhibitors

      4. 5.1.4 Other Drug Classes

    2. 5.2 By Route of Administration

      1. 5.2.1 Injectable

      2. 5.2.2 Oral

      3. 5.2.3 Topical

      4. 5.2.4 Other Routes of Administration

    3. 5.3 By Distribution Channel

      1. 5.3.1 Hospital Pharmacies

      2. 5.3.2 Retail Pharmacies

      3. 5.3.3 Other Distribution Channels

    4. 5.4 Geography

      1. 5.4.1 North America

        1. 5.4.1.1 United States

        2. 5.4.1.2 Canada

        3. 5.4.1.3 Mexico

      2. 5.4.2 Europe

        1. 5.4.2.1 Germany

        2. 5.4.2.2 United Kingdom

        3. 5.4.2.3 France

        4. 5.4.2.4 Italy

        5. 5.4.2.5 Spain

        6. 5.4.2.6 Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. 5.4.3.1 China

        2. 5.4.3.2 Japan

        3. 5.4.3.3 India

        4. 5.4.3.4 Australia

        5. 5.4.3.5 South Korea

        6. 5.4.3.6 Rest of Asia-Pacific

      4. 5.4.4 Middle East and Africa

        1. 5.4.4.1 GCC

        2. 5.4.4.2 South Africa

        3. 5.4.4.3 Rest of Middle East and Africa

      5. 5.4.5 South America

        1. 5.4.5.1 Brazil

        2. 5.4.5.2 Argentina

        3. 5.4.5.3 Rest of South America

  6. 6. COMPETITIVE LANDSCAPE

    1. 6.1 Company Profiles

      1. 6.1.1 AbbVie (Allergan)

      2. 6.1.2 Heron Therapeutics

      3. 6.1.3 Cali Biosciences

      4. 6.1.4 Innocoll

      5. 6.1.5 Bayer AG

      6. 6.1.6 Haleon PLC (GSK)

      7. 6.1.7 Pacira Pharmaceuticals Inc.

      8. 6.1.8 Johnson & Johnson (Janssen Pharmaceuticals)

      9. 6.1.9 AFT Pharmaceuticals

      10. 6.1.10 Alembic Pharmaceuticals

      11. 6.1.11 Cipla Inc. (InvaGen Pharmaceuticals Inc.)

      12. 6.1.12 SiteOne Therapeutics

      13. 6.1.13 Pfizer Inc.

    2. *List Not Exhaustive
  7. 7. MARKET OPPORTUNITIES AND FUTURE TRENDS

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Post-Operative Pain Management Industry Segmentation

As per the report's scope, postoperative pain is defined as a complex response to tissue trauma post-surgical procedures. It comprises both surgery-related pain and pain linked with central nervous system hypersensitivity. The purpose of postoperative pain management medications is to minimize adverse effects while reducing or eliminating pain and discomfort. The Postoperative Pain Management Market is Segmented by Drug Class (Opioids, Non-steroidal anti-inflammatory drugs (NSAIDs), Cyclooxygenase-2-selective inhibitors (COX-2) inhibitors, and Other Drug classes), by Route of Administration (Injectable, Oral, Topical and Other Routes), by Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Other Distribution Channels) and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (in USD) for the above segments. The market report also covers the estimated market sizes and trends for 17 countries across major global regions. The report offers the value (in USD) for the above segments.

By Drug Class
Opioids
Non-steroidal anti-inflammatory drugs (NSAIDS)
Cyclooxygenase-2-selective inhibitors (COX-2) inhibitors
Other Drug Classes
By Route of Administration
Injectable
Oral
Topical
Other Routes of Administration
By Distribution Channel
Hospital Pharmacies
Retail Pharmacies
Other Distribution Channels
Geography
North America
United States
Canada
Mexico
Europe
Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific
China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East and Africa
GCC
South Africa
Rest of Middle East and Africa
South America
Brazil
Argentina
Rest of South America
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Post-Operative Pain Management Market Research FAQs

The Post Operative Pain Management Market size is expected to reach USD 40.46 billion in 2024 and grow at a CAGR of 5.79% to reach USD 53.61 billion by 2029.

In 2024, the Post Operative Pain Management Market size is expected to reach USD 40.46 billion.

AbbVie (Allergan), Heron Therapeutics, Pfizer Inc. and AFT Pharmaceuticals are the major companies operating in the Post Operative Pain Management Market.

Asia-Pacific is estimated to grow at the highest CAGR over the forecast period (2024-2029).

In 2024, the North America accounts for the largest market share in Post Operative Pain Management Market.

In 2023, the Post Operative Pain Management Market size was estimated at USD 38.12 billion. The report covers the Post Operative Pain Management Market historical market size for years: 2019, 2020, 2021, 2022 and 2023. The report also forecasts the Post Operative Pain Management Market size for years: 2024, 2025, 2026, 2027, 2028 and 2029.

Post-Operative Pain Management Industry Report

Statistics for the 2024 Post-Operative Pain Management market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Post-Operative Pain Management analysis includes a market forecast outlook to 2029 and historical overview. Get a sample of this industry analysis as a free report PDF download.

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Post-Operative Pain Management Market Size & Share Analysis - Growth Trends & Forecasts (2024 - 2029)