PD-1 and PD-L1 Inhibitors Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Market is Segmented by Type (PD-1 Inhibitors and PD-L1 Inhibitors), Application, and Geography.

Market Snapshot

CAGR
Study Period: 2018 - 2026
Base Year: 2021
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: >18.5 %

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Market Overview

The PD-1 and PD-L1 inhibitors market studied was anticipated to witness a CAGR of nearly 18.5% during the forecast period. The major factor attributing to the growth of the market is a steep rise in the global prevalence of various cancers along with increasing elderly population across the geographical locations, mainly in developed and emerging economies. For instance, according to the World Health Organization Report, cancer is a leading cause of death worldwide, accounting for an estimated 9.6 million deaths, and lung cancer was identified as the most common cause of death, with 1.76 million deaths in 2018. Thus, the rise in the volume of the patient pool results in a higher demand for the market fueling the global market growth over the forecast period.

Scope of the Report

Programmed cell death protein 1 (PD-1) inhibitors and programmed cell death ligand 1 (PD-L1) inhibitors are a group of new checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PDL1 immune checkpoint proteins present on the surface of cells. These immune checkpoint inhibitors are also active in pregnancy following tissue allografts and emerging as a front-line treatment in immunotherapy for several types of cancer. An indication of specific staining interpretation defines tumor PD-L1 status.

Type of Inhibitors
PD-1 Inhibitors
PD-L1 Inhibitors
Application
Hodgkin Lymphoma
Kidney Cancer
Melanoma
Non-small Cell Lung Cancer
Other Applications
End User
Hospital Pharmacies
Retail Pharmacies
Online Pharmacies
Geography
North America
United states
Canada
Mexico
Europe
Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific
China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle-East and Africa
GCC
South Africa
Rest of Middle-East and Africa
South America
Brazil
Argentina
Rest of South America

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Key Market Trends

The PD-1 Inhibitors Segment is Expected to Hold the Largest Market Share in the PD-1 and PD-L1 Inhibitors Market

The PD-1 inhibitors segment is expected to account for the largest revenue over the forecast period the dominance of the segment can be attributed to the increased volume of research activities, approvals, and rise in prescriptions of these drugs such as nivolumab and pembrolizumab. Furthermore, increased adoption of pembrolizumab (KEYTRUDA), the first PD-1 inhibitor since its approval in 2014 due to its proven efficiency to treat multiple FDA-Approved indications like melanoma, non–small cell lung cancer (NSCLC), head and neck squamous cell cancer (HNSCC), and others which are highly prevalent globally driving the growth of the segment market. On the other hand, the PD-L1 inhibitor segment is expected to witness the fastest CAGR during the forecast period owing to a steep rise in the adoption of durvalumab (IMFINZI), avelumab (BAVENCIO) and others in the segment. Huge investments by the key players in the development of these products are further fuel the segment propelling the global market revenue over the forecast period.

cancer-image

The PD-1 Inhibitors Segment is Expected to Hold the Largest Market Share in the PD-1 and PD-L1 Inhibitors Market

North America is expected to dominate the overall PD-1 and PD-L1 inhibitors market throughout the forecast period. The dominance is due to the growing prevalence of various chronic diseases like diabetes, skin cancer, urothelial carcinomas, lung cancers, and the presence of a huge population of baby boomers during the forecast period in the United States necessitated the efficient treatment. For instance, according to the American Cancer Society Inc. estimates for 2020, lung cancer is the second most common cancer leading to 135,720 deaths in both men and women. The statistics also report that about 13% of all lung cancers are small cell lung cancer (SCLC) and 84% non-small cell lung cancer (NSCLC) in the United States which is expected to continue in the future resulting in higher demand for these products fueling the market in the region. Moreover, the significant share of market revenue in the region can be attributed to the presence of major key players and huge investment in the R&D activities to develop new products and generic drugs along with incentives by the government to encourage the innovations to decrease the growing disease burden which is likely to provide more opportunities to the growth of PD-1 and PD-L1 inhibitors market during the forecast period.

PD-1 and PD-L1 Inhibitors Market

Competitive Landscape

The PD-1 and PD-L1 inhibitors market is moderately competitive and consists of several major players. Some of the companies are expanding their market position by adopting various strategies such as acquisitions and mergers, research collaboration, while others are investing in clinical trials to extend the treatment of other indications with the existing drugs to address the unmet challenges of the disease burden driving the market share. For instance, in June 2019, Merck received accelerated approval from the USFDA for its pembrolizumab (KEYTRUDA) for the treatment of patients with metastatic SCLC with disease progression on or after platinum-based chemotherapy and at least one other prior line of therapy, which is likely to boost the market share during the forecast period. Few of the major players currently dominating the industry in terms of revenue are F. Hoffmann-La Roche AG, Merck & Co. Inc., Regeneron Pharmaceuticals Inc., AstraZeneca PLC, and Bristol‑MyersSquibbCompany.

Table of Contents

  1. 1. INTRODUCTION

    1. 1.1 Study Deliverables

    2. 1.2 Study Assumptions

    3. 1.3 Scope of the Study

  2. 2. RESEARCH METHODOLOGY

  3. 3. EXECUTIVE SUMMARY

  4. 4. MARKET DYNAMICS

    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Rising Investments in R&D and Clinical Trials by Bio-pharmaceutical Industries

      2. 4.2.2 Increased Encouragement Initiatives by the Regulatory Authorities with Favorable Approvals and Special Designations

      3. 4.2.3 Growing Burden of Different Cancers

    3. 4.3 Market Restraints

      1. 4.3.1 Risk of Complications Associated with the Highly Expensive Oncology Treatment

      2. 4.3.2 Challenges in Development with Uncertainty in Regulatory Process and High Costs of Tedious Clinical Trials

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION

    1. 5.1 Type of Inhibitors

      1. 5.1.1 PD-1 Inhibitors

      2. 5.1.2 PD-L1 Inhibitors

    2. 5.2 Application

      1. 5.2.1 Hodgkin Lymphoma

      2. 5.2.2 Kidney Cancer

      3. 5.2.3 Melanoma

      4. 5.2.4 Non-small Cell Lung Cancer

      5. 5.2.5 Other Applications

    3. 5.3 End User

      1. 5.3.1 Hospital Pharmacies

      2. 5.3.2 Retail Pharmacies

      3. 5.3.3 Online Pharmacies

    4. 5.4 Geography

      1. 5.4.1 North America

        1. 5.4.1.1 United states

        2. 5.4.1.2 Canada

        3. 5.4.1.3 Mexico

      2. 5.4.2 Europe

        1. 5.4.2.1 Germany

        2. 5.4.2.2 United Kingdom

        3. 5.4.2.3 France

        4. 5.4.2.4 Italy

        5. 5.4.2.5 Spain

        6. 5.4.2.6 Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. 5.4.3.1 China

        2. 5.4.3.2 Japan

        3. 5.4.3.3 India

        4. 5.4.3.4 Australia

        5. 5.4.3.5 South Korea

        6. 5.4.3.6 Rest of Asia-Pacific

      4. 5.4.4 Middle-East and Africa

        1. 5.4.4.1 GCC

        2. 5.4.4.2 South Africa

        3. 5.4.4.3 Rest of Middle-East and Africa

      5. 5.4.5 South America

        1. 5.4.5.1 Brazil

        2. 5.4.5.2 Argentina

        3. 5.4.5.3 Rest of South America

  6. 6. COMPETITIVE LANDSCAPE

    1. 6.1 Company Profiles

      1. 6.1.1 Bristol-Myers Squibb Company

      2. 6.1.2 Merck & Co.

      3. 6.1.3 F. Hoffmann-La Roche AG

      4. 6.1.4 Sanofi AG

      5. 6.1.5 Amgen Inc.

      6. 6.1.6 Gilead Sciences Inc.

      7. 6.1.7 AstraZeneca PLC

      8. 6.1.8 Novartis AG

      9. 6.1.9 Pfizer Inc.

      10. 6.1.10 Regeneron Pharmaceuticals Inc.

    2. *List Not Exhaustive
  7. 7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies, and Recent Developments

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Frequently Asked Questions

The PD-1 and PD-L1 Inhibitors Market market is studied from 2018 - 2026.

The PD-1 and PD-L1 Inhibitors Market is growing at a CAGR of >18.5% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2021.

Bristol‑Myers Squibb Company, Regeneron Pharmaceuticals Inc, AstraZeneca plc, F. Hoffmann-La Roche AG, Merck & Co Inc are the major companies operating in PD-1 and PD-L1 Inhibitors Market.

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