Optical Genome Mapping Market- Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Optical Genome Mapping Market is segmented by Product Type (Instruments (Optical Genome Mapping Instrument), Consumables), End Users (Biotechnology & Pharmaceutical Companies, Research & Academic Institutions, Others), Geography (North America, Europe, Asia-Pacific, Rest of World). The report offers the value (in USD million) for the above segments.

Market Snapshot

Optical Genome Mapping Market
Study Period: 2019-2021
Base Year: 2021
Fastest Growing Market: Asia-Pacific
Largest Market: North America
CAGR: 18.5 %

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Market Overview

The optical genome mapping market is expected to register a CAGR of 18.5% over the forecast period 2022-2027.

Initially, the COVID-19 pandemic had a considerable impact on the optical genome mapping market due to the unpredicted spread. According to the article “Host genome analysis of structural variations by Optical Genome Mapping provides clinically valuable insights into genes implicated in critical immune, viral infection, and viral replication pathways in patients with severe COVID-19” published by the medRxiv in 2021 says that to understand the inter-individual variability associated with SARS-CoV-2 infections and COVID19 mortality, optical genome mapping can be a powerful tool to recognize large Structural variations (SV) affecting clinical outcome with split survival and add valuable genomic information to the current sequencing-based technology databases.

Further, the increase in Government initiatives to research more in the genome mapping area is driving the market to grow. For example, according to the information published in Press Information Bureau, the Government of India, Ministry of Science & Technology in March 2020 sanctioned the project named “GenomeIndia: Cataloguing the Genetic Variation in Indians”. The project is based on Whole Genome Sequencing (WGS) which is expected to be completed for 10,000 people in three years, representing the country's diverse population. The foundation for whole-genome sequencing was laid through optical genome mapping. To help with a genome assembly, sequenced DNA fragments can be aligned to the genome map. The information obtained from whole-genome sequencing can help the country's future human genetics research be more precise, as well as design a genome-wide association array for the Indian population, allowing for the development of precision healthcare and diagnostics for major diseases at a lower cost.

Furthermore, industry players are pursuing marketing strategies such as mergers and acquisitions, as well as product releases. for instance, in June 2022, Hamilton and Bionano Genomics, Inc. announced that they have collaborated on the development of the Long String VANTAGE for the isolation of Ultra High Molecular Weight (UHMW) DNA for optical genome mapping (OGM). An important prerequisite and initial stage in Bionano's sample preparation workflow is the extraction of high-quality and quantity UHMW DNA. UHMW DNA extraction is usually done by hand by highly skilled and experienced laboratory employees, limiting the amount of DNA extracted and its use in regular sample preparation. The businesses plan to engage with a few clinical research labs to test and further develop applications for the Long String VANTAGE and Bionano Prep SP kits, with some of these workflows expected to be commercialized by the end of 2022.

The investigated market is expected to grow throughout the analysis period for the reasons stated. However, the lack of skilled technicians to perform complex procedures restrain the market growth.

Scope of the Report

As per the scope of the report, Optical genome mapping (OGM) is a high-resolution genome-wide examination that highlights copy number and structural anomalies, including balanced translocations, using ultra-high molecular weight DNA molecules. The optical genome mapping market is segmented by Product Type (Instruments (Optical Genome Mapping Instrument), Consumables), End Users (Biotechnology & Pharmaceutical Companies, Research & Academic Institutions, Others) Geography (North America, Europe, Asia-Pacific, South America, Middle East, and Africa). The report offers the value (in USD million) for the above segments. The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (in USD million) for the above segments.

By Product Type
Instruments(Optical Genome Mapping Instrument)
By End-User
Biotechnology & Pharmaceutical Companies
Research & Academic Institutions
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Rest of World

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Key Market Trends

Optical Genome Mapping Instruments are Expected to Witness a Positive Growth Over the Forecast Period

Optical Genome Mapping Instruments are instruments used in high-resolution genome-wide studies revealing copy number and structural anomalies, including balanced translocations, using ultra-high molecular weight DNA molecules.

The study published in the MDPI journal in 2021, “Optical Genome Mapping in Routine Human Genetic Diagnostics—Its Advantages and Limitations”, explains that Optical genome mapping (OGM) has emerged as a viable technique for discovering large-scale structural variations in human genomes. It can detect structural variants that are difficult to detect using current approaches. They also explained the advantages of Optical Genome Mapping with the Bionano Saphyr system which has proven to be a valuable tool to confirm the Structural Variants initially detected by other diagnostic means. This advantage is based on the ability to obtain high-resolution breakpoints for the Structural Variants found, which may often be used to determine whether genes or regulatory elements are affected, as well as whether complex rearrangements are present.

The article published in 2021 in Gene’s journal, “Optical Genome Mapping as a Next-Generation Cytogenomic Tool for Detection of Structural and Copy Number Variations for Prenatal Genomic Analyses” elucidate that Optical Genome Mapping based assays are cost-effective, have quick turn-around times (from sample to report in 4 days), do not require custom complex bioinformatic pipelines, are high-resolution when compared to traditional methods, and can detect all  Structural Variants classes relevant for prenatal diagnostic testing in an automated manner.

As a result of the aforementioned factors, the Optical Genome Mapping Instruments segment is predicted to develop significantly throughout the forecast period.

Improvement in Paediatric Leukemia Diagnosis by Optical Genome Mapping, 2021

North America is Expected to Lead the Optical Genome Mapping Market

In 2021, North America held most of the market share for the optical genome mapping market. Increased development in the field of genetic research caused this region to emerge as the leading one. According to the Tedtallk Podcast by United States, Food and Drug Administration aired on 2021 under the topic Whole Genome Sequencing in the New Era of Smarter Food Safety, talked about the rising use of whole-genome sequencing in the public and private sectors means for food safety. Whole-genome sequencing (WGS) is a cutting-edge technology that the United States Food and Drug Administration (FDA) has put into a novel and health-promoting application. Whole-genome sequencing reveals an organism's entire DNA makeup, allowing the United States Food and Drug Administration to better comprehend variances within and between species. With the help of optical genome mapping, genome sequencing is way easier and enables the United States Food and Drug Administration to distinguish between species with a level of precision that is not possible with current technologies.

The presence of manufacturers in the country, as well as key product releases, have all contributed to the growth of the optical genome mapping market. There is an ongoing clinical trial (2022) titled” Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort” sponsored by Bionano Genomics, a California-based company. The objective of the trial is Optical Genome Mapping (OGM) using the Bionano Genomics Saphyr system to detect the genomic structural variants (SVs) in human DNA.

The analyzed market is predicted to grow in the North American region as a result of the preceding factors.

Global Optical Genome Mapping Market - Growth Rate by Region

Competitive Landscape

The optical genome mapping market competition is expected to intensify as several major competitors focus on expanding their product portfolios through acquisitions and collaborations. The competitive landscape includes an analysis of a few international as well as local companies which hold the market shares and are well known. Include Bionano Genomics, OpGen, Nabsys, Nucleome Informatics Private Limited, and PerkinElmer Inc. among others.

Recent Development

In February 2022, Arima Genomics launched two new product offerings named Arima-HiC+ FFPE kit in which scientists will be able to find and discover structural variants in their 3D genomic data with this tool. By combining structural variant detection with 3D genome orientation data, researchers will gain a better understanding of how variants affect gene and cellular function. Finally, these findings will benefit scientists in the discovery of novel disease mechanisms and therapeutic targets.

In October 2021 Bionano Genomics announced the acquisition of BioDiscovery, leading software company with high-class solutions for the analysis, interpretation, and reporting of genomics data. The Bionano and BioDiscovery teams will collaborate to create a version of NxClinical that includes optical genome mapping data alongside existing next-generation sequencing and microarray data types. Future goals include RNA expression profiling, epigenetics including methylation, and maybe proteomics in the future.

Table of Contents


    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Rapidly Increasing Bio-Pharmaceutical Advances in Drug Development Coupled with Government Funding

      2. 4.2.2 Cost-effectiveness and Accuracy

    3. 4.3 Market Restraints

      1. 4.3.1 Lack of Skilled Technicians & Complex Procedures

    4. 4.4 Porter's Five Force Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION (Market Size by Value - USD million)

    1. 5.1 By Product Type

      1. 5.1.1 Instruments(Optical Genome Mapping Instrument)

      2. 5.1.2 Consumables

    2. 5.2 By End-User

      1. 5.2.1 Biotechnology & Pharmaceutical Companies

      2. 5.2.2 Research & Academic Institutions

      3. 5.2.3 Others

    3. 5.3 Geography

      1. 5.3.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.3.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.3.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.3.4 Rest of World


    1. 6.1 Company Profiles

      1. 6.1.1 Bionano Genomics

      2. 6.1.2 OpGen

      3. 6.1.3 Nabsys

      4. 6.1.4 Nucleome Informatics Private Limited

      5. 6.1.5 PerkinElmer, Inc.

    2. *List Not Exhaustive

**Subject to Availability
**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments

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Frequently Asked Questions

The Global Optical Genome Mapping Market market is studied from 2019 - 2021.

The Global Optical Genome Mapping Market is growing at a CAGR of 18.5% over the next 5 years.

Asia-Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2021.

Bionano Genomics, OpGen, Nabsys , Nucleome Informatics Private Limited, PerkinElmer, Inc. are the major companies operating in Global Optical Genome Mapping Market.

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