Gastric Cancer Treatment Market Size & Share Analysis - Growth Trends And Forecast (2025 - 2030)

Global Gastric Cancer Treatment Market Trends and Insights

Aging Population & H. pylori Prevalence Upswing

Demographic aging combines with lingering H. pylori infection to keep baseline incidence on an upward slope, particularly across Japan, South Korea, China, and southern Europe where historic exposure persists despite eradication programs. Hospital discharge databases in Tokyo show that people ≥65 years account for more than 70% of new gastric cancer diagnoses, confirming the demand wave entering oncology clinics. Because remission often requires lengthy multimodal therapy and frequent follow-up, older patients typically consume higher cumulative drug volumes, a dynamic that inflates lifetime spend per case inside the gastric cancer treatment market. In addition, real-world analyses indicate that geriatric toxicity management protocols have improved markedly over the past two years, enabling clinicians to sustain systemic regimens longer without dose reductions, thereby raising average selling volumes for checkpoint inhibitors and targeted agents. Payors nonetheless struggle with the budget impact of treating larger elderly cohorts, prompting a shift toward value-based reimbursement schemes that tether payment to outcomes over multiyear horizons. Although preventive measures continue to expand, their epidemiologic benefit will materialize only gradually, securing a long runway of sustained therapy demand within the gastric cancer treatment market.  

Uptake of PD-1/PD-L1 Checkpoint Inhibitors

First-line adoption of pembrolizumab plus trastuzumab and chemotherapy, approved in March 2025, raised median progression-free survival from 7.3 to 10.9 months, altering front-of-card treatment algorithms in North America and Europe. Health-technology-assessment dossiers submitted in France and Italy indicate an incremental cost per quality-adjusted life-year that falls below national willingness-to-pay thresholds when the drug is used in biomarker-positive patients, propelling formulary inclusion and anchoring revenue growth across the gastric cancer treatment market. Similarly, the perioperative use of durvalumab combinations slashed recurrence risk by 29% in randomized trials presented at ASCO 2025, prompting guideline committees to recommend immune modulation earlier in the disease course. Importantly, response durability for patients with low PD-L1 scores has improved when checkpoint blockade is paired with trastuzumab or cytotoxic agents, expanding the treatable cohort by as much as one-third according to pooled Phase 3 data.

Earlier HER2-Positive Testing Protocols

The European Union’s approval of the VENTANA CLDN18 RxDx assay in July 2024 initiated a shift toward panel-based tumor profiling that assesses HER2, CLDN18.2, FGFR2, and PD-L1 from a single biopsy slide, cutting time-to-result to fewer than five days in leading cancer centers. Adoption studies in Germany found that broad panels doubled the proportion of patients flagged for targeted therapy versus sequential single-marker testing, expanding addressable volume for trastuzumab deruxtecan, zolbetuximab, and upcoming FGFR2 inhibitors. Hospitals in metropolitan Seoul report that same-day reflex testing embeds molecular pathology into initial diagnostic workflows, allowing oncologists to start biomarker-guided regimens one treatment cycle sooner, which can improve overall survival by two to three months in curative-intent cases. Early identification also reduces futile exposure to ineffective chemotherapy, truncating toxicity-related expenditures and reinforcing payer support for systematic testing expansion. As emerging markets retrofit pathology labs with automated immunohistochemistry platforms, the gastric cancer treatment market gains a new lever for case-volume expansion driven by diagnostic penetration rather than raw incidence alone.  

China’s Volume-Based Procurement Price Drops

Under the National Reimbursement Drug List negotiations concluded in December 2024, average ex-factory prices for key gastric oncology brands fell by 60-80%, widening access for an estimated 150,000 patients annually. Manufacturers responded by adopting a tiered-pricing strategy: lower margins in China are counter-balanced by guaranteed high volumes, while pricing elsewhere now references Chinese procurement in value-based contracts. Real-world prescription audits confirm that hospital use of nivolumab and trastuzumab deruxtecan grew more than threefold in provincial centers during the first two quarters of 2025, compensating for the unit-price erosion and driving absolute revenue gains regionally. Neighboring countries such as Vietnam and Malaysia have begun exploring comparable procurement models, signaling a potential spread of the volume-at-scale paradigm that could reshape margins but also enlarge patient reach in the gastric cancer treatment market.  

High Post-Surgical Complication Costs

Major gastrectomy complications occur in 15-25% of cases and cost USD 15,000–25,000 per readmission, burdening payers and delaying adjuvant therapy, which can worsen survival outcomes by 10-15% for affected patients. Data from public hospitals in Brazil, South Africa, and Indonesia show that complication care absorbs up to 30% of total in-patient oncology budgets, crowding out funds for modern systemic agents. Enhanced recovery after surgery and laparoscopic approaches are trimming complication rates to near 10% in high-volume centers, yet capital expenditure for robotics remains prohibitive for many middle-income countries. Until broader surgical standardization is achieved, payers may cap spending on premium adjuvant drugs for high-risk candidates, dampening uptake potential across parts of the gastric cancer treatment market. Consortiums involving device makers, surgical training bodies, and multilateral lenders are exploring outcome-based financing to lower entry barriers for minimally invasive platforms, but tangible impact will take several budget cycles to manifest.  

Limited Biomarker Reimbursement Outside Tier-1 Cities

In China and India, comprehensive next-generation-sequencing panels often exceed USD 400—an amount surpassing the monthly income of large rural populations—forcing physicians to rely on chemotherapy alone for many biomarker-positive tumors. Provincial insurers in China usually reimburse only immunohistochemistry for HER2 in tertiary hospitals, leaving tests for CLDN18.2 or FGFR2 uncovered, which restricts eligibility verification for zolbetuximab or FGFR2 inhibitors. A similar disparity arises in India’s older National Health Mission facilities, where cash-pay diagnostic costs deter testing. The consequence is therapeutic inequity: published registries show that biomarker-guided therapy penetration falls below 15% outside Tier-1 urban hubs, limiting the real-world footprint of precision drugs. Telepathology and cartridge-based PCR assays promise to lower costs by up to 60%, yet scaling them requires regulatory harmonization and cloud-security frameworks that remain under development. Until such access gaps close, some growth headroom for the gastric cancer treatment market will stay unrealized.  

Segment Analysis

By Therapy Type: Immunotherapy Drives Innovation

Immunotherapy generated roughly USD 1.2 billion in revenue within the gastric cancer treatment market in 2025, representing the segment with the fastest 13.45% CAGR and confirming its foundational role in modern care algorithms. Chemotherapy nonetheless kept a formidable 42.19% share during 2024 because it remains the backbone of first-line regimens, particularly in metastatic settings, and retains price advantages that make it the default in budget-constrained hospitals. Surgical resection volumes are climbing on the back of enhanced perioperative protocols, but systemic therapy cycles per patient continue to rise as immunologic agents extend survival, thereby sustaining repeat dosing. Radiation therapy holds a modest niche, largely confined to locally advanced tumors where organ preservation strategies augment resection margins.  

The rapid pivot toward multidrug protocols blurs historical categorizations: checkpoint inhibitors now launch concurrently with cytotoxic backbones, and trastuzumab deruxtecan plus nivolumab combinations have progressed into Phase 3 testing for adjuvant settings, indicating that “combination therapy” will soon eclipse single-agent categories. Targeted therapy uptake accelerates whenever HER2 or FGFR2 testing is reimbursed, while palliative and supportive care regimens start earlier as improved survival prolongs symptom-management needs. Owing to these interlocking lines of therapy, specialist oncologists increasingly view drug selection through an integrated platform lens rather than discrete classes, a perspective that favors companies able to bundle immunotherapy, ADCs, and supportive agents into coordinated offerings across the gastric cancer treatment market.  

Note: Segment shares of all individual segments available upon report purchase

By Drug Class: FGFR2 Inhibitors Lead Growth

PD-1/PD-L1 inhibitors registered the single-largest 20.23% share of 2024 drug-class revenue, reflecting their entrenchment as standard of care across multiple lines. Yet their annual growth is moderating as penetration in high-income markets nears saturation. In contrast, FGFR2 inhibitors are projected to log the most rapid 12.55% CAGR, driven by striking response rates near 42% in FGFR2-amplified tumors and expected approvals in Japan and South Korea by 2026. On the horizon, bispecific antibodies that fuse PD-1 blockade with FGFR2 targeting are entering early clinical evaluations, setting the stage for step-change efficacy that could boost class share further.  

Cytotoxic agents retain relevance by anchoring novel regimens and maintaining reimbursement advantages, especially in markets where biosimilar doxorubicin or oxaliplatin cost pennies on the dollar compared with branded biologics. HER2 antagonists strengthened footholds after the FDA’s tumor-agnostic approval for trastuzumab deruxtecan in April 2024, which prompted universal HER2 screening for all metastatic presentations. VEGF/VEGFR inhibitors and ADCs supply important adjunct activity: vascular normalization improves immune infiltration, while ADCs deliver lethal payloads to marker-rich cells, amplifying synergy with immune checkpoint blockade. Collectively, the mosaic of drug classes underscores that sustained differentiation arises from precise patient targeting and modular combination potential, reinforcing multiplatform strategies across the gastric cancer treatment market.  

By Disease Stage: Early-Stage Gains Momentum

Early-stage 0-IA disease generated roughly USD 580 million in revenue in 2025 and leads all stages at a 13.71% CAGR as AI-assisted screening shifts diagnosis to less-advanced forms. Recurrent cases still ranked first in value, capturing 22.91% of 2024 segment dollars on account of high relapse incidence and prolonged systemic therapy. Resectable IB-III cases benefit from neoadjuvant chemotherapy coupled with immunotherapy, which raised R0 resection rates by 14% in recent multicenter trials and improved median disease-free survival by six months relative to surgery alone.  

Management of unresectable locally advanced tumors remains complex; however, nivolumab plus paclitaxel regimens achieved 38.5% response in severe peritoneal metastasis, suggesting improvement for a historically refractory subgroup. Sustained adoption of perioperative immunotherapy compresses the time gap between surgery and systemic therapy initiation, potentially curtailing micro-metastatic progression. Advanced/metastatic disease continues to generate the highest drug-volume per patient because of successive treatment lines, yet better first-line control could gradually reduce reliance on late-line cytotoxics. As stage migration favors earlier detection, future value expansion in the gastric cancer treatment market will hinge more on adjuvant innovation than on salvage therapies.  

Note: Segment shares of all individual segments available upon report purchase

By Route of Administration: Oral Formulations Expand

Intravenous infusions realized roughly USD 4.1 billion in 2025, equal to 68.82% of total spend thanks to entrenched hospital protocols and the predominance of biologics. Oral drugs, led by capecitabine and apatinib, increased at a 12.93% CAGR, underscoring strong patient preference for home-based dosing and payer interest in lowering infusion center overhead.  

Research focus is now steering toward oral checkpoint inhibitors and oral ADCs built on protease-cleavable linkers that survive gastric pH and release payload once systemically absorbed, technology initially commercialized in hematology but now targeting gastric solid tumors. Health systems in Australia documented 15% cost savings after switching suitable maintenance patients to oral therapy, reinforcing economic incentives. Telehealth-enabled adherence monitoring has further raised confidence in at-home regimens, shrinking concerns about missed doses. Provided pharmacokinetic parity is maintained, many intravenous agents could convert to oral, eroding infusion share and infusing fresh growth into the gastric cancer treatment market.  

Geography Analysis

North America generated 42.23% of global revenue in 2024 on the strength of broad insurance coverage, high drug pricing power, and expedited FDA review routes such as breakthrough therapy and real-time oncology review that speed access by six to eight months versus standard pathways. Yet growth deceleration is visible as payers layer value-based formularies: Canada’s May 2025 time-limited reimbursement for trastuzumab deruxtecan links payment continuation to interim real-world outcomes, foreshadowing broader outcome-based contracts.  

Asia-Pacific leads growth with a 15.56% CAGR, fueled by China’s volume-based procurement, India’s expanding oncology infrastructure, and Japan’s near-automatic reimbursement for approved agents within 90 days. Chinese hospital claims show nivolumab usage tripled in lower-tier cities after inclusion in the 2024 procurement round, highlighting volume elasticity. India’s government cancer hospital network added eight new tertiary centers in 2025, each equipped with molecular diagnostics labs that fast-track biomarker screening. Japanese regulators approved a new AI-guided endoscopy system in April 2025, positioning the country to sustain leadership in early detection that feeds case volumes into systemic therapy pipelines.  

Europe remains a mature yet cautious adopter, with health-technology-assessment rigor pushing companies to amass real-world evidence fast to secure national reimbursements. Germany’s statutory insurers widely reimburse perioperative immunotherapy after positive IQWiG appraisal, whereas Italy requires price-volume agreements that cap public spending. South America and the Middle East/Africa together account for just under 7% of the gastric cancer treatment market but hold latent upside as multinationals pilot patient-assistance schemes that subsidize biomarker testing and co-pay support. Broadly, geographic diversification reduces overexposure to any single reimbursement environment and adds resilience to the global gastric cancer treatment market.