Cell-free Protein Expression Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Cell-free Protein Expression Market is segmented by Product Type (Accessories and Consumables and Lysate Systems), Application, and Geography.

Market Snapshot

Cell-free Protein Expression Market 1
Study Period: 2018 - 2026
Base Year: 2021
Fastest Growing Market: Europe
Largest Market: North America
CAGR: 5.74 %

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Market Overview

The cell-free protein expression market is expected to register a CAGR of nearly 6.1%, during the forecast period, 2019-2024.

  • The major factors for the growth of the cell-free protein expression market include the increasing R&D in the fields of proteomics and genomics, high prevalence of cancer and infectious diseases, and shorter-expression time and structural modification.
  • Cell-free protein expression employs cell lysates to produce the desired recombinant proteins. The primary advantage of this technique is the aversion of workflow hurdles of maintaining cell culture or living cells. Cell lysates are produced by the breakdown and use of cellular components of eukaryotic or bacterial cells. Currently, several cell-free protein expression systems are commercially available, based on E. coli, rabbit reticulocytes, wheat germs, human cell lines, and insect cells.
  • An in vitro protein expression system has significant advantages over living cell-based protein expression, including a shorter duration of the process, isotopic labeling of proteins, incorporation of non-natural amino acids, and optimization of protein complexes.
  • The ability to enable high throughput production, pertaining to the recent trend of more research in personalized medicine and growing needs for biological therapies for the management of cancer, is a major driver for the adoption of cell-free protein expression techniques, by pharmaceutical and biotechnology firms.

Scope of the Report

As per the scope of this report, cell-free protein expression or in vitro protein synthesis is a process that involves the production of the recombinant proteins in cell lysate solution, without using cell culture or living cells. Cell-free protein expression can be carried out using different cell lysates, such as those of E. coli, rabbit reticulocytes, wheat germs, human cells, and insect cells. 

By Products
Accessories and Consumables
Lysate Systems
E. Coli Lysate
Wheat Germ Extract Lysate
Rabbit Reticulocyte Lysate
Insect Cell Lysate
Human Cell Lysate
Other Lysate Systems
By Application
Enzyme Engineering
High Throughput Production
Protein Labeling
Protein-Protein Interaction
Other Applications
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle-East and Africa
South Africa
Rest of Middle-East and Africa
South America
Rest of South America

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Key Market Trends

The E. Coli Lysate Segment of the Lysate Systems is Expected to be the Fastest Growing Segment Over the Forecast Period

E. coli lysates are the most commonly used systems among all available commercial lysate systems. E. coli lysates are devoid of endogenous genetic messages and have advantages, such as very high protein yield and tolerability to most additives. Furthermore, E. coli-based systems are being used in recombinant techniques for the manufacture of various biological therapeutics and insulin. Continuous use has enabled research on interactions and tolerability of the byproducts of E. coli-based systems, and significant present scientific literature enables its rapid adoption by industries and academics.

In E. coli-based systems, codons used are different, with some being eukaryotic specific. Additionally, post-translational modifications are not possible, which in turn, limit the system’s usage in the synthesis of specific human therapeutics. Significant advancements have been, however, made in order to address these problems. Therefore, the E. coli lysate sub-segment is expected to register a steady growth rate during the forecast period, owing to high adoption rates and recent developments.

Cell-free Protein Expression Market 2

North America is Expected to Dominate the Market

North America is found to hold a major share in the cell-free protein expression market, and it is expected to show a similar trend over the forecast period, without significant fluctuations. The primary factors behind the large market size include the increasing prevalence of chronic diseases, such as cancer, aging population, growing demand for targeted and personalized medicine, the presence of major R&D facilities, and favorable government initiatives in the United States. There is a growing trend of cell-based research in the US academia and biotechnology industries. In recent years, several government initiatives have been supplementing the growth of the cell-free protein expression market in the United States.

For instance, 2015 saw the introduction of the Precision Medicine Initiative in the United States, which was intended to revolutionize the treatment of many chronic diseases, including cancer. Initiatives like these are presenting a favorable environment for pharmaceutical and biotechnology firms to develop and market protein-based therapeutics, thus, fueling the growth of the cell-free protein expression market.

Cell-free Protein Expression Market 3

Competitive Landscape

The market studied is a moderately consolidated market, owing to the presence of small and large market players. Some of the market players are biotechrabbit GmbH, CellFree Sciences Co. Ltd, Cube Biotech GmbH, GeneCopoeia Inc., Jena Bioscience GmbH, Promega Corporation, Qiagen NV, Sigma-Aldrich Corporation (Merck KGaA), Takara Bio Inc., and Thermo Fisher Scientific Inc.

Table of Contents


    1. 1.1 Study Deliverables

    2. 1.2 Study Assumptions

    3. 1.3 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increasing R&D in the Fields of Proteomics and Genomics

      2. 4.2.2 Growing Burden of Cancer and Infectious Diseases

      3. 4.2.3 Shorter Expression Time and Structural Modification

    3. 4.3 Market Restraints

      1. 4.3.1 High Cost of Protein Expression Systems

      2. 4.3.2 Lack of Effective Systems for Post-translational Modifications

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry


    1. 5.1 By Products

      1. 5.1.1 Accessories and Consumables

      2. 5.1.2 Lysate Systems

        1. E. Coli Lysate

        2. Wheat Germ Extract Lysate

        3. Rabbit Reticulocyte Lysate

        4. Insect Cell Lysate

        5. Human Cell Lysate

        6. Other Lysate Systems

    2. 5.2 By Application

      1. 5.2.1 Enzyme Engineering

      2. 5.2.2 High Throughput Production

      3. 5.2.3 Protein Labeling

      4. 5.2.4 Protein-Protein Interaction

      5. 5.2.5 Other Applications

    3. 5.3 Geography

      1. 5.3.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.3.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.3.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.3.4 Middle-East and Africa

        1. GCC

        2. South Africa

        3. Rest of Middle-East and Africa

      5. 5.3.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 Biotechrabbit GmbH

      2. 6.1.2 CellFree Sciences Co. Ltd

      3. 6.1.3 Cube Biotech GmbH

      4. 6.1.4 GeneCopoeia Inc.

      5. 6.1.5 Jena Bioscience GmbH

      6. 6.1.6 Promega Corporation

      7. 6.1.7 Creative Biolabs

      8. 6.1.8 Merck KGaA

      9. 6.1.9 Takara Bio Inc.

      10. 6.1.10 Thermo Fisher Scientific Inc.

    2. *List Not Exhaustive

**Subject to Availability
**Competitive Landscape Covers - Business Overview, Financials, Products and Strategies, and Recent Developments

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Frequently Asked Questions

The Cell-free Protein Expression Market market is studied from 2018 - 2026.

The Cell-free Protein Expression Market is growing at a CAGR of 5.74% over the next 5 years.

Europe is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2020.

CellFree Sciences Co. Ltd, Cube Biotech GmbH, Thermo Fisher Scientific Inc., Takara Bio Inc., Merck KGaA are the major companies operating in Cell-free Protein Expression Market.

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