Single Photon Emission Computed Tomography (SPECT) Market Size & Share Analysis - Growth Trends and Forecast (2026 - 2031)

Global Single Photon Emission Computed Tomography (SPECT) Market Trends and Insights

Growing Burden of Oncology and Cardiovascular Diseases

Global cancer incidence hit 20 million new cases in 2022 and is projected to surge 77% by 2050 as populations age^{[1]World Health Organization, “Cancer Tomorrow,” who.int}. Parallel to this trend, cardiovascular disease caused 19.2 million deaths in 2023, keeping nuclear cardiology in high demand. SPECT remains the first-line gatekeeper: bone scans stage metastatic disease and myocardial-perfusion imaging triages revascularization candidates. The American Heart Association’s 2024 guideline reaffirmed SPECT for assessing myocardial viability, solidifying procedure volumes. Hospitals increasingly install hybrid SPECT/CT units to capture oncologic attenuation correction and coronary calcium scoring in a single visit, reinforcing system-replacement momentum.

Accelerating Adoption of Hybrid SPECT/CT Systems

Hybrid configurations accounted for 62.45% revenue in 2025 and will outpace standalone gamma cameras with a 5.45% CAGR to 2031. January 2025 joint guidelines from SNMMI, ASNC, and SCCT defined hybrid SPECT/CT as standard cardiac practice, mandating attenuation correction to curb false positives. GE HealthCare’s Aurora, cleared by the FDA in May 2025, uses a 75 cm bore and 40 mm crystal to trim scan time 30%, while Siemens’ Symbia Pro.specta ROI calculator shows payback in under three years for high-volume sites. Hospitals view hybrid adoption as future-proof, enabling theranostics dosimetry and quantitative SPECT imaging that standalone cameras cannot handle. Capital budgets pivot accordingly despite higher acquisition costs.

Advancements in Digital CZT and AI-Enabled Reconstruction

Digital CZT detectors held 36.44% share in 2025 yet are scheduled to grow fastest at 5.67% CAGR through 2031. GE HealthCare’s StarGuide GX, CE-marked in November 2025, marries dual-sided CZT arrays with NVIDIA acceleration, raising sensitivity 2.67-fold and enabling 1 mSv cardiac studies. Energy resolution improves from 10% in NaI systems to 5%-6% with CZT, sharpening lesion delineation and reducing equivocal reads. AI denoising engines such as Clarify DL compress acquisition time further, helping outpatient centers double daily throughput. Supply constraints at crystal manufacturers Kromek and Redlen, however, keep NaI cameras relevant for cost-sensitive buyers.

Strengthening Tc-99m Generator and Radiopharmacy Networks

Technetium-99m drives 45.65% of radioisotope revenue, and vendor vertical integration now safeguards supply. GE HealthCare’s December 2024 acquisition of Nihon Medi-Physics brought 13 radiopharmacies under its umbrella, guaranteeing tracer availability. The U.S. Department of Energy’s September 2025 USD 32 million grant to SHINE Technologies aids a domestic Mo-99 plant, while CMS proposes a USD 10 dose add-on for U.S.-made Mo-99 starting 2026. These measures lessen dependence on six aging research reactors that still produce 95% of global Mo-99, reducing supply-chain risk and supporting procedure stability.

Vulnerability of Mo-99/Tc-99m Global Supply Chain

Six reactors generate 95% of the world’s Mo-99, making outages disruptive. When Curium’s European reactors paused in October 2024, United Kingdom clinics rationed doses, extending cardiac waitlists by weeks. Hospitals reverted to higher-dose thallium-201 protocols, highlighting a critical safety and efficiency setback. Reactor operators must also transition from highly enriched uranium targets to low-enriched fuel, temporarily lowering yields by about 20%, compounding supply tension. NorthStar’s RadioGenix provides a cyclotron-based alternative, yet current output covers only a fraction of demand. Until redundancy improves, the Single-Photon Emission Computed Tomography market remains exposed to isotope shocks.

Capital Intensity and Budget Constraints for SPECT/CT Upgrades

Hybrid SPECT/CT units cost USD 400,000–600,000, straining public-hospital budgets where competing modalities vie for funds. United Kingdom NHS replacement guidelines continue to prioritize CT and MRI, pushing nuclear-medicine upgrades down the queue^{[2]NHS England, “Capital Equipment Planning 2024,” england.nhs.uk}. In India and Southeast Asia, 15-year-old Anger cameras still pass regulatory linearity checks, further delaying refresh cycles. PET/CT, though pricier, can siphon oncology budgets, undermining SPECT capital plans. Financing innovations, vendor leasing, and proven ROI calculators help, but capex constraints shave half a percentage point off forecast growth.

Segment Analysis

By System Type: Hybrid Upgrades Prevail in Replacement Cycles

Hybrid SPECT/CT platforms captured 62.45% of 2025 revenue and are predicted to grow at a 5.45% CAGR through 2031. This dominance stems from integrated attenuation correction, anatomical registration, and theranostics capabilities that justify a 40% premium over standalone units. GE HealthCare’s Aurora, FDA-cleared in May 2025, trims acquisition time 30%, lifting daily myocardial-perfusion throughput to 20 patients. Siemens’ Symbia Pro.specta supports isotopes up to 588 keV, enabling Lu-177 post-therapy scans. Standalone gamma cameras survive in mobile fleets and rural settings where CT adds limited benefit. Digirad’s portable Ergo unit, priced under USD 250,000, fills this niche but lacks hybrid features essential for ACR oncology accreditation.

Hospitals view hybrid systems as strategic assets that future-proof nuclear-medicine departments. ROI calculators demonstrate breakeven in under three years when repeat studies drop 18% and same-day reporting accelerates billing cycles. Single-Photon Emission Computed Tomography market size for hybrid platforms is forecast to reach USD 1.9 billion by 2031, accounting for nearly 70% of total equipment revenue. As accreditation bodies tighten standards, the share gap between hybrid and standalone units will widen, reinforcing the former’s leadership within the Single-Photon Emission Computed Tomography market.

Note: Segment shares of all individual segments available upon report purchase

By Detector Technology: CZT Momentum Builds Despite NaI Incumbency

Sodium-iodide (NaI) cameras held 63.56% of 2025 revenue, yet CZT systems are advancing at the fastest clip. Full-ring CZT scanners provide 4-to-10-fold sensitivity and 5% energy resolution, enabling 1 mSv cardiac studies that rival PET dose levels^{[3]European Association of Nuclear Medicine, “CZT Adoption Survey,” eanm.org}. Spectrum Dynamics’ Veriton-CT, a 360° CZT ring, halves scan times with organ-specific geometries but carries a USD 1 million-plus list price. Kais er Permanente adopted CZT-based cardiac amyloidosis screening in April 2025, validating clinical differentiation in a large integrated network.

Cost and supply advantages keep NaI relevant, particularly in emerging markets. Still, Single-Photon Emission Computed Tomography market share migration favors CZT, projected to rise above 45% by 2031. AI denoising workflows amplify performance gains, making CZT the detector of choice for outpatient centers chasing productivity. Vendors hedge by dual-detector portfolios, but future R&D resources tilt toward semiconductor-based designs.

By Application: Cardiology Surges on Guideline Endorsements

Oncology contributed 42.45% of 2025 revenue, yet cardiology will expand fastest at a 6.01% CAGR through 2031. The 2024 American Heart Association update cemented SPECT’s role in ischemia assessment, and two-minute CZT protocols now enable same-day stress-rest exams. CMS pass-through codes for novel PET tracers paradoxically grow nuclear procedure volumes by broadening referral pipelines. Single-Photon Emission Computed Tomography market size for cardiology is projected to reach USD 1.3 billion by 2031, lifting its revenue share toward 45%. Oncology growth moderates as PET substitutes in tumor staging, but thyroid, neuroendocrine, and bone metastasis use cases preserve a sizeable floor.

Neurology, endocrine, and renal studies jointly form a stable mid-single-digit growth cohort, buoyed by aging demographics and evolving movement-disorder work-ups. As theranostic therapies proliferate, quantitative SPECT expands from academic centers into community hospitals, adding high-value post-therapy scans that raise average revenue per patient.

By End User: Imaging Centers Accelerate on Throughput Economics

Hospitals held 47.32% revenue in 2025, yet diagnostic imaging centers will grow at 6.54% CAGR as site-of-service migration gains momentum. Two-minute CZT studies allow centers to schedule 20 cardiac patients daily, versus 12 under NaI protocols, boosting scanner utilization 60%. Lower overhead lets centers undercut hospital outpatient departments by 15%-20% on commercial contracts. Specialty and academic sites advance steadily on theranostics research, but the fastest share growth accrues to independent networks aggregating payers and self-pay volumes. By 2031, imaging centers could account for nearly one-third of Single-Photon Emission Computed Tomography market revenue.

Note: Segment shares of all individual segments available upon report purchase

By Radioisotope: I-123 Climbs on Thyroid and Movement-Disorder Work-ups

Technetium-99m generators remain the backbone at 45.65% of 2025 revenue. Iodine-123 volumes are set for a 6.43% CAGR through 2031, fueled by thyroid-nodule evaluation and Parkinson’s disease diagnosis with DaTscan. Though I-123 costs 2-3 times more per dose, superior 159 keV photon energy yields clearer images and lower radiation. Alpha-emitters like Ra-223 introduce low-volume, high-value imaging for theranostic dosimetry, and hybrid SPECT/CT scanners now feature protocols aligned with these therapies. Single-Photon Emission Computed Tomography market share for I-123 is expected to reach 18% by 2031, reflecting broader adoption in endocrine and neuro applications.

Geography Analysis

North America generated 42.23% of 2025 revenue, buoyed by 15-20 million annual myocardial-perfusion studies and policy incentives supporting domestic Mo-99 supply. DOE’s USD 32 million grant to SHINE Technologies and CMS’s proposed USD 10 Mo-99 add-on de-risk isotope logistics, stabilizing procedure volumes. High installed bases temper growth, so the region advances at a moderate 3.5% CAGR through 2031 as hospitals stretch upgrade cycles to ten years. Nonetheless, hybrid SPECT/CT installations concentrate in bariatric-capable and theranostics-ready platforms such as GE’s Aurora.

Asia-Pacific will post the fastest 4.54% CAGR, propelled by China’s 1,200-plus PET/CT fleet that spurs downstream demand for lower-cost SPECT in tier-two cities and India’s mandated detector-linearity upgrades. United Imaging’s aggressively priced hybrid systems win provincial tenders, while Japanese centers maintain per-capita utilization near U.S. levels. Regulatory fragmentation slows cross-border equipment flows, yet International Atomic Energy Agency technical-cooperation projects in Southeast Asia expand nuclear-medicine access, seeding long-term growth.

Europe advances at 3.2% CAGR. Germany and France refresh fleets on seven-year cycles, but reactor maintenance at Belgium’s BR2 and the Netherlands’ Pallas periodically restricts isotope supply, causing utilization dips. Middle East-Africa and South America together deliver mid-single-digit growth as Gulf Cooperation Council hospital expansions and Brazil’s public procurement cycles lift installed bases. Site-of-service migration and private imaging centers gain traction in Gulf states offering bundled cardiac check-up packages.