Sarcoma Drugs Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

The Sarcoma Drugs Market Report is Segmented by Type of Treatment (Chemotherapy, Targeted Therapy, Immuno Therapy, and More), by Indication (Soft Tissue Sarcoma, Osteosarcoma and More), by Therapy (First Line and Second Line), by Route of Administration (Oral and Injectables) and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The Market Forecasts are Provided in Terms of Value (USD).

Sarcoma Drugs Market Size and Share

Sarcoma Drugs Market (2025 - 2030)
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Compare market size and growth of Sarcoma Drugs Market with other markets in Healthcare Industry

Sarcoma Drugs Market Analysis by Mordor Intelligence

The sarcoma therapeutics market is valued at USD 1.61 billion in 2025 and is forecast to reach USD 2.42 billion by 2030, advancing at an 8.61% CAGR. The current sarcoma therapeutics market growth stems from faster regulatory reviews, orphan-drug incentives and rising pharmaceutical investment in precision oncology. Breakthrough approvals—such as Tecelra for synovial sarcoma and Romvimza for tenosynovial giant cell tumor—validate the commercial potential of rare-tumor assets, while radioligand programs backed by large-scale isotope manufacturing move the modality toward mainstream use. Consolidation deals by Merck KGaA and ONO Pharmaceutical illustrate how multinationals are building scale in the sarcoma therapeutics market through targeted acquisitions. Regional dynamics add further momentum: North America benefits from robust reimbursement for orphan drugs, whereas Asia-Pacific gains from China’s aggressive price negotiations paired with expanding diagnostic infrastructure.

Key Report Takeaways


  • By drug class, targeted therapy led with 46.45% of sarcoma therapeutics market share in 2024; immunotherapy is projected to grow at 9.12% CAGR through 2030.
    By indication, soft tissue sarcoma accounted for 51.23% of sarcoma therapeutics market size in 2024, while osteosarcoma is set to expand at 9.48% CAGR to 2030.
    By therapy line, first-line regimens represented 62.23% of sarcoma therapeutics market size in 2024; second-line and refractory care advances at 10.26% CAGR.
    By route of administration, injectables commanded 81.23% share of sarcoma therapeutics market size in 2024, yet oral agents are rising at 9.86% CAGR.
    By geography, North America retained 40.23% sarcoma therapeutics market share in 2024, whereas Asia-Pacific is forecast to post a 10.67% CAGR through 2030.

Segment Analysis

By Drug Class: Targeted Therapy Dominance Amid Immunotherapy Surge

Targeted therapy held a 46.45% sarcoma therapeutics market share in 2024, driven by kinase inhibitors and antibody-drug conjugates keyed to distinct sarcoma mutations. Vimseltinib’s launch introduced a non-surgical option for TGCT, and precision diagnostics underpin payer acceptance. Immunotherapy surged at a 9.12% CAGR through 2030, with Tecelra validating engineered T-cell approaches and checkpoint-plus-chemotherapy regimens reducing relapse risk in soft tissue sarcoma[1]Source: Memorial Sloan Kettering Cancer Center, “Immunotherapy Clinical Trial Shows Promise for Treating Rare Sarcomas,” mskcc.org .

Pipeline innovation reinforces both classes. Bispecific antibodies such as LM-299 target PD-1 and VEGF simultaneously, while ERK and MDM2 inhibitors secured by Mosaic aim to counter resistance. Hybrid modalities that combine cytotoxic payloads with immune activation blur class boundaries yet collectively expand the sarcoma therapeutics market.

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By Indication: Soft Tissue Sarcoma Leadership with Osteosarcoma Momentum

Soft tissue sarcoma captured 51.23% of sarcoma therapeutics market size in 2024, supported by a broad drug armamentarium against NTRK, CDK4/6 and MDM2 alterations. The SU2C-SARC032 data showed a 43% relapse-risk drop when immunotherapy joined surgery and radiation, elevating immune-based combinations within treatment guidelines. Companion diagnostics focus spending on biomarker-positive patients, reinforcing payer confidence and fortifying soft tissue sarcoma’s anchor role in the sarcoma therapeutics market.

Osteosarcoma is forecast to expand at a 9.48% CAGR, driven by renewed R&D targeting pediatric and young-adult need gaps. Adoptive-cell therapies and next-generation kinase inhibitors pursue chemoresistant clones, while global registries streamline trial enrollment. Smaller indications—GIST, Ewing sarcoma and liposarcoma—add incremental volume through tumor-agnostic approvals, but osteosarcoma provides the clearest upside for incremental sarcoma therapeutics market revenue despite its lower incidence.

By Therapy Line: First-Line Stability with Refractory Innovation

First-line regimens represented 62.23% of sarcoma therapeutics market size in 2024, reflecting reliance on doxorubicin-based chemotherapy paired with guideline-endorsed targeted drugs. Uptake of biomarker-guided first-line therapy is growing for NTRK-positive and PDGFR-mutant disease, yet price-conscious payers still favor generics when mutation prevalence is low.

Second-line and refractory care advances at a 10.26% CAGR as sponsors exploit flexible trial designs and companion diagnostics to speed novel mechanisms to market. Tecelra’s single-arm approval in synovial sarcoma set a precedent that encourages further refractory-focused innovation, sustaining differentiation within the sarcoma therapeutics market

Sarcoma Drugs Market: Market Share by Therapy Line
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By Route of AdministrationBy Route of Administration: Injectable Dominance with Oral Convenience Trend: Injectable Dominance with Oral Convenience Trend

Injectables accounted for 81.23% sarcoma therapeutics market share in 2024 because monoclonal antibodies, radioligands and CAR-T products require parenteral delivery and close monitoring. Subcutaneous reformulations aim to shorten chair time, but the structural primacy of hospital-based infusion remains intact.

Oral agents are growing at 9.86% CAGR as reformulated kinase inhibitors let patients self-administer at home, improving adherence and cutting infusion costs. Bioavailability and drug-interaction management pose challenges, yet successful launches could further diversify revenue for the sarcoma therapeutics market.

Geography Analysis

North America held 40.23% sarcoma therapeutics market share in 2024, buoyed by swift FDA pathways, strong orphan-drug reimbursement and a concentration of specialty cancer centers. The United States drives volume through broad commercial coverage and rising CAR-T reimbursement ceilings, while Canada scales precision-oncology programs inside its single-payer model. Incremental uptake of radioligand therapy is anticipated as Novartis and partners commission new isotope plants, ensuring supply continuity. Growing advocacy networks also accelerate enrollment in post-approval studies that feed value-based contracts, further anchoring North America’s role in the sarcoma therapeutics market.

Europe contributes a sizable portion of global demand yet exhibits heterogeneous access timelines. Germany and France reimburse most new orphan treatments within 12 months, but Central and Eastern Europe still wrestle with multi-year delays, muting pan-regional penetration. EMA-approved products benefit from 10-year exclusivity, fostering launch sequencing strategies that prioritize the largest five EU economies. Facility investments such as Orano Med’s thorium-228 site in France will reduce isotope import dependence and may reposition Europe as a supply hub for radiopharmaceutical components, reinforcing the region’s strategic weight in the sarcoma therapeutics market.

Asia-Pacific is projected to post a 10.67% CAGR, outpacing all other regions. China’s 2024 formulary added 26 oncology drugs after average price cuts of 63%, offering larger patient pools at lower price points yet sharpening value expectations. Japan maintains mature orphan-drug incentives, and Australia leverages rapid-review pathways that attract early clinical trials. India expands molecular-testing coverage, though high out-of-pocket spending tempers uptake. Cross-border licensing deals between multinational innovators and local manufacturers facilitate distribution and technology transfer, underpinning sustained expansion of the sarcoma therapeutics market across Asia-Pacific.

Sarcoma Drugs Market CAGR (%), Growth Rate by Region
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Competitive Landscape

The sarcoma therapeutics market shows moderate consolidation. Top players strengthened positions through high-value deals, including ONO Pharmaceutical’s USD 2.4 billion purchase of Deciphera and Merck KGaA’s USD 3.9 billion bid for SpringWorks Therapeutics. These transactions bundled approved assets with late-stage pipelines, accelerating revenue synergy and deepening specialty-oncology footprints. Market leaders now hold expanded commercial infrastructures, which speeds physician education and companion-diagnostic integration.

Technology platforms define competitive edges. Novartis scales radioligand capacity via two U.S. plants while PanTera raises USD 102.5 million to close actinium-225 gaps, ensuring supply for investigational conjugates. Merck licenses LM-299 to diversify into bispecifics[2]Source: Merck & Co., “Merck Enters Into Exclusive Global License for LM-299,” merck.com , and Bristol Myers Squibb joins BioNTech on dual-checkpoint antibodies, aiming to counter heterogenous immune escape biopharmadive.com. Smaller biotechs focus on niche subtypes, exploiting orphan exclusivity to secure premium pricing despite narrow addressable populations.

Competitive intensity rises in second-line settings where clinical unmet need persists. Companies pursue adaptive trial designs to outpace rivals, while companion diagnostics gate patient access and protect pricing integrity. Patent cliffs remain distant for most newly approved therapies, safeguarding high gross margins. Overall, strategic acquisitions, manufacturing scale-ups and biomarker specialization shape the evolving structure of the sarcoma therapeutics market.

Sarcoma Drugs Industry Leaders

  1. Eisai Co., Ltd.

  2. Bayer AG

  3. Pfizer Inc.

  4. Novartis AG

  5. Johnson and Johnson Inc.

  6. *Disclaimer: Major Players sorted in no particular order
Sarcoma Drugs Market Concentration
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Recent Industry Developments

  • May 2025: Thermosome obtained FDA Orphan-Drug Designation for its soft tissue sarcoma candidate
  • January 2025: FDA granted breakthrough therapy designation to letetresgene autoleucel for unresectable or metastatic myxoid/round-cell liposarcoma

Table of Contents for Sarcoma Drugs Industry Report

1. Introduction

  • 1.1 Study Assumptions & Market Definition
  • 1.2 Scope of the Study

2. Research Methodology

3. Executive Summary

4. Market Landscape

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Rising incidence of sarcoma cases
    • 4.2.2 Accelerated approvals & orphan-drug incentives
    • 4.2.3 Uptake of precision & immuno-oncology agents
    • 4.2.4 Radioligand therapies for micro-metastatic disease
    • 4.2.5 Crowdfunded early-access programs in major economies
  • 4.3 Market Restraints
    • 4.3.1 High treatment cost & reimbursement gaps
    • 4.3.2 Limited patient pool for late-phase trials
    • 4.3.3 Radio-isotope supply bottlenecks
  • 4.4 Value / Supply-Chain Analysis
  • 4.5 Regulatory Landscape
  • 4.6 Technological Outlook
  • 4.7 Porter’s Five Forces
    • 4.7.1 Threat of New Entrants
    • 4.7.2 Bargaining Power of Suppliers
    • 4.7.3 Bargaining Power of Buyers
    • 4.7.4 Threat of Substitutes
    • 4.7.5 Competitive Rivalry

5. Market Size & Growth Forecasts (Value)

  • 5.1 By Drug Class
    • 5.1.1 Cytotoxic Chemotherapy
    • 5.1.2 Targeted Therapy
    • 5.1.3 Immunotherapy (Checkpoint, Cytokine, Cell-based)
    • 5.1.4 Radioligand & Other Novel Agents
  • 5.2 By Indication
    • 5.2.1 Soft Tissue Sarcoma
    • 5.2.2 Osteosarcoma
    • 5.2.3 Ewing Sarcoma
    • 5.2.4 Gastro-intestinal Stromal Tumor (GIST)
    • 5.2.5 Liposarcoma & Others
  • 5.3 By Therapy Line
    • 5.3.1 First-line
    • 5.3.2 Second-line & Refractory
  • 5.4 By Route of Administration
    • 5.4.1 Injectable
    • 5.4.2 Oral
  • 5.5 By Region
    • 5.5.1 North America
    • 5.5.1.1 United States
    • 5.5.1.2 Canada
    • 5.5.1.3 Mexico
    • 5.5.2 Europe
    • 5.5.2.1 Germany
    • 5.5.2.2 United Kingdom
    • 5.5.2.3 France
    • 5.5.2.4 Italy
    • 5.5.2.5 Spain
    • 5.5.2.6 Rest of Europe
    • 5.5.3 Asia-Pacific
    • 5.5.3.1 China
    • 5.5.3.2 India
    • 5.5.3.3 Japan
    • 5.5.3.4 South Korea
    • 5.5.3.5 Australia
    • 5.5.3.6 Rest of Asia-Pacific
    • 5.5.4 South America
    • 5.5.4.1 Brazil
    • 5.5.4.2 Argentina
    • 5.5.4.3 Rest of South America
    • 5.5.5 Middle East and Africa
    • 5.5.5.1 GCC
    • 5.5.5.2 South Africa
    • 5.5.5.3 Rest of Middle East and Africa

6. Competitive Landscape

  • 6.1 Market Concentration
  • 6.2 Market Share Analysis
  • 6.3 Company Profiles (includes Global level Overview, Market level overview, Core Segments, Financials as available, Strategic Information, Market Rank/Share for key companies, Products & Services, and Recent Developments)
    • 6.3.1 Novartis AG
    • 6.3.2 Pfizer Inc.
    • 6.3.3 F. Hoffmann-La Roche Ltd
    • 6.3.4 Eli Lilly and Company
    • 6.3.5 Bayer AG
    • 6.3.6 Daiichi Sankyo Company Ltd
    • 6.3.7 Eisai Co. Ltd
    • 6.3.8 Johnson & Johnson (Janssen)
    • 6.3.9 Takeda Pharmaceutical Company Ltd
    • 6.3.10 AbbVie Inc.
    • 6.3.11 Bristol Myers Squibb Co.
    • 6.3.12 Amgen Inc.
    • 6.3.13 Blueprint Medicines Corp.
    • 6.3.14 Deciphera Pharmaceuticals Inc.
    • 6.3.15 Ipsen SA
    • 6.3.16 Karyopharm Therapeutics Inc.
    • 6.3.17 Adaptimmune Therapeutics plc
    • 6.3.18 Incyte Corp.
    • 6.3.19 AstraZeneca plc
    • 6.3.20 Regeneron Pharmaceuticals Inc.

7. Market Opportunities & Future Outlook

  • 7.1 White-space & Unmet-need Assessment
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Global Sarcoma Drugs Market Report Scope

As per the scope of the report, sarcoma is a type of cancer that can occur in various parts of the body, and it is a term used for the large group of cancers that start in the bone and soft tissues.

The sarcoma drugs market is segmented by type of treatment and geography. By type of treatment, the market is segmented as chemotherapy, targeted therapy, immunotherapy, and other treatment types. By geography, the market is segmented as North America, Europe, Asia-Pacific, Middle East and Africa, and South America.

The report offers the value (USD) for the above segments.

By Drug Class Cytotoxic Chemotherapy
Targeted Therapy
Immunotherapy (Checkpoint, Cytokine, Cell-based)
Radioligand & Other Novel Agents
By Indication Soft Tissue Sarcoma
Osteosarcoma
Ewing Sarcoma
Gastro-intestinal Stromal Tumor (GIST)
Liposarcoma & Others
By Therapy Line First-line
Second-line & Refractory
By Route of Administration Injectable
Oral
By Region North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
India
Japan
South Korea
Australia
Rest of Asia-Pacific
South America Brazil
Argentina
Rest of South America
Middle East and Africa GCC
South Africa
Rest of Middle East and Africa
By Drug Class
Cytotoxic Chemotherapy
Targeted Therapy
Immunotherapy (Checkpoint, Cytokine, Cell-based)
Radioligand & Other Novel Agents
By Indication
Soft Tissue Sarcoma
Osteosarcoma
Ewing Sarcoma
Gastro-intestinal Stromal Tumor (GIST)
Liposarcoma & Others
By Therapy Line
First-line
Second-line & Refractory
By Route of Administration
Injectable
Oral
By Region
North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
India
Japan
South Korea
Australia
Rest of Asia-Pacific
South America Brazil
Argentina
Rest of South America
Middle East and Africa GCC
South Africa
Rest of Middle East and Africa
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Key Questions Answered in the Report

Q1. How large is the sarcoma therapeutics market in 2025?

A1. The sarcoma therapeutics market size stands at USD 1.61 billion in 2025 and is projected to reach USD 2.42 billion by 2030.

Q2. Which drug class leads the sarcoma therapeutics market?

A2. Targeted therapy leads with a 46.45% market share in 2024, reflecting strong adoption of kinase inhibitors and antibody-drug conjugates.

Q3. What is the fastest-growing region for sarcoma drugs?

A3. Asia-Pacific is the fastest-growing geography, forecast to expand at a 10.67% CAGR through 2030.

Q4. Which indication offers the greatest growth potential?

A4. Osteosarcoma registers the highest CAGR at 9.48%, driven by renewed R&D focus on pediatric and young-adult populations.

Q5. How are radioligand therapies affecting the sarcoma therapeutics industry?

A5. Investments in isotope production and facility construction are easing supply constraints, enabling radioligand programs to become a long-term growth driver for the sarcoma therapeutics industry.

Page last updated on: June 27, 2025

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