Liver Cancer Therapeutics Market - Growth, Trends, COVID-19 Impact, and Forecast (2021 - 2026)

The Global Liver Cancer Therapeutics Market is Segmented by Type (Hepatocellular Carcinoma, Cholangiocarcinoma, Hepatoblastoma, and Other Types), Therapy (Targeted Therapy, Radiation Therapy, Immunotherapy, and Chemotherapy), and Geography (North America, Europe, Asia-Pacific, Middle-East and Africa, and South America). The Report Offers the Value (in USD million) for the Above-mentioned Segments.

Market Snapshot

Liver Cancer Therapeutics Market Overview
Study Period: 2018 - 2026
Base Year: 2020
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 11.2 %

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Market Overview

The Global Liver Cancer Therapeutics Market is expected to register a CAGR of 11.2% over the forecast period.

Globally, the COVID-19 pandemic has diverted resources from healthcare services for patients with diseases such as cancer. COVID-19 also causes organ dysfunction, complicating cancer treatment. With an outbreak of COVID-19 in most countries across the world, modifications of cancer management have been adopted to accommodate the crisis and minimize the exposure of cancer patients to the infection.

According to a research article by Chan S.L. et al., published in Liver Cancer Journal 2020, in patients with hepatocellular carcinoma (HCC), the COVID-19 exacerbates existing chronic liver disease and complicates the management of cancer. Cancer patients have a higher risk of infection and worse outcomes, especially those who recently underwent cancer treatment.

Furthermore, the study found that the COVID-19 pandemic became a major public health challenge to the integrity of healthcare systems in many countries across the world, and its negative impact on medical care for cancer patients is a concern. During the COVID-19 pandemic, adjustment of clinical management is necessary to minimize the patient's risk of the infection and divert resources to handle the outbreak.

The major factors driving the market growth include the rising burden of liver cancer, increasing research and development investments for the development of novel therapies, and government initiatives to increase cancer awareness. The change in the current lifestyle led to the exposure of a large population to certain risk factors that contribute to liver cancer. The risk factors include type 2 diabetes, hepatitis, metabolic disorders, excess body weight, alcohol consumption, and smoking.

According to the GLOBOCAN data, globally, in 2020, there were around 905,677 (4.7%) new liver cancer cases and 830,180 (8.3%) deaths due to liver cancer. Moreover, the high demand for therapeutic drugs for liver cancer will create wide opportunities for the market players to produce more drugs. Thus, the market is expected to witness significant growth over the forecast period.

There are increasing research and development activities in the development of new therapeutics for liver cancer. For instance, according to National Clinical Trial (NCT) Registry 2020, Hoffmann-La Roche Ltd started a phase Ib/II study to assess the efficacy and safety of multiple immunotherapy-based treatment combinations in patients with advanced liver cancers (Morpheus-Liver). The trial started in November 2020, and it is expected to be completed in July 2024.

However, factors, such as side effects associated with certain medications and the high cost of cancer therapies and stringent regulatory scenario, are expected to impede market growth over the forecast period.

Scope of the Report

As per the scope of the report, liver cancer is cancer that begins in the liver cells. It is a chronic, life-threatening, and progressive disorder that begins in the cells of the liver. Liver cancer can be of different types, such as cancer that begins in hepatocyte cells known as primary hepatic cancer and cancer that spreads to the liver from other parts of the body known as metastatic cancer. The global liver cancer therapeutics market is segmented by type (hepatocellular carcinoma, cholangiocarcinoma, hepatoblastoma, and other types), therapy (targeted therapy, radiation therapy, immunotherapy, and chemotherapy), and geography (North America, Europe, Asia-Pacific, Middle-East and Africa, and South America). The report offers the value (in USD million) for the above-mentioned segments.

By Type
Hepatocellular Carcinoma
Cholangio Carcinoma
Hepatoblastoma
Other Types
By Therapy
Targeted Therapy
Radiation Therapy
Immunotherapy
Chemotherapy
Geography
North America
United States
Canada
Mexico
Europe
Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific
China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle-East and Africa
GCC
South Africa
Rest of Middle-East and Africa
South America
Brazil
Argentina
Rest of South America

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Key Market Trends

Hepatocellular Carcinoma is Expected to be the Fastest Growing Segment in the Market

Hepatocellular carcinoma (HCC) is a common form of liver cancer, which occurs in people suffering from chronic liver diseases like cirrhosis. Globally, it is one of the major causes leading to cancer-related deaths.

Pharmaceutical companies adopted various strategies to maintain the balance between the supply and demand of liver cancer therapeutics. Health organizations have issued necessary guidelines and recommendations for managing hepatocellular carcinoma patients during the COVID-19 pandemic. For instance, the European Society of Medical Oncology (ESMO), American Society of Clinical Oncology (ASCO), National Institute of Health and Care Excellence (NICE) have proposed guidelines. The guidelines include that during the COVID-19 pandemic 2020, patients with chronic liver disease, such as hepatocellular carcinoma (HCC), and COVID-19 were recommended to admit for inpatient care as per the European Society for Medical Oncology, which shows the positive impact on the market.

Furthermore, several research studies confirmed that patients with hepatocellular carcinoma are at a higher risk of contracting the infection. According to a research study by Giuliana Amaddeo et al., published in JHEP Reports Journal 2021, the study was conducted in 6 referral centers in the metropolitan area of Paris, France, to assess the impact of the COVID-19 pandemic on the management of patients with hepatocellular carcinoma (HCC). The study results found that in a metropolitan area of Paris, hepatocellular carcinoma (HCC) patients were highly impacted by the COVID-19 pandemic, and there was a significantly longer treatment delay in 2020 compared to 2019. This indicates that during the COVID-19 pandemic 2020, the treatment for hepatocellular carcinoma (HCC) patients was delayed as healthcare resources were occupied to provide services to COVID-19 patients, which showed a short-term negative impact on segment growth.

According to a research article by Eunsun Kim et al., published in Experimental & Molecular Medicine Journal 2020, stated that globally, hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer, which is the fourth most common cause of cancer-related deaths. The incidence rate associated with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is increasing, and the global burden of mortality from hepatocellular carcinoma (HCC) is predicted to reach 1 million deaths annually by 2030. It is asymptomatic in its early stage, which significantly delays its timely diagnosis.

It is observed that the Asian and African countries have higher incidence rates of hepatocellular carcinoma than the developed world due to the disparity in the major risk factors causing hepatocellular carcinoma such as hepatitis B (HBV) and hepatitis C virus (HCV) infection in those regions.

The increasing burden of hepatocellular carcinoma is expected to increase a huge demand for liver cancer therapeutics. In August 2018, Eisai Inc. received the US Food and Drug Administration (FDA) approval for lenvatinib (Lenvima) for patients with unresectable hepatocellular carcinoma (HCC). Hence, the rising incidence of cancer and high unmet medical needs are the major factors that drive the segment growth over the forecast period.

Liver Cancer Therapeutics Market Share

North America is Expected to Hold Significant Market Share Over the Forecast Period

The major factors driving the market growth in North America include the rising incidence of liver cancer in the country, the presence of key market players, and the launch of novel products, which will influence growth in the region.

As per the Centers for Disease Control and Prevention (CDC), the geriatric population that includes patients with serious underlying medical conditions, including people with liver disease, might be at higher risk for severe illness from COVID-19. Patients with hepatocellular carcinoma (HCC), which occurs most often in people with chronic liver diseases, such as hepatitis B or hepatitis C, are at higher risk for severe COVID-19 than those without hepatocellular carcinoma.

According to a research article by Hidenori Toyoda et al., published in Hepatology Communications Journal 2020, during the COVID‐19 pandemic 2020, strict measures were implemented by the government to prevent the spread of COVID-19, which adversely affected the routine monitoring of chronic liver disease such as hepatocellular carcinoma (HCC).

According to the estimates of the American Society of Clinical Oncology, there were around 42,220 adults who were diagnosed with liver cancer in the United States in 2018 (of which there are 30,610 men and 11,610 women). In 2020, there were around 42,810 new liver cancer cases in the United States. The increasing cases of liver cancer in the United States are expected to increase the demand for liver cancer therapeutics in the management of the disease.

In the United States, the increasing research and development activities in the development of novel therapeutics for the liver are also expected to drive market growth. For instance, in May 2020, the Food and Drug Administration (FDA) approved atezolizumab (Tecentriq) and bevacizumab (Avastin) as an initial treatment for people with liver cancer that spread or that can’t be treated with surgery.

Therefore, the increased incidence of liver cancer in the United States with the rising demand for liver cancer treatment, which is driving the market over the forecast period.

Liver Cancer Therapeutics Market Growth Rate By Region

Competitive Landscape

The liver cancer therapeutics market studied is a consolidated competitive, owing to the presence of a few major market players. The key market players are focusing on R&D to bring innovative treatments for the treatment of liver cancer. Some of the market players are Bristol‑Myers Squibb Company, Eisai Co. Ltd, Exelixis Inc., Merck & Co. Inc., and Bayer AG.

Recent Developments

  • In November 2020, Exelixis Inc. received the United States Food and Drug Administration (FDA) approval for CABOMETYX in Japan for the treatment of unresectable hepatocellular carcinoma.
  • In November 2020, Zymeworks Inc. received the US Food and Drug Administration (FDA) breakthrough therapy designation for zanidatamab in patients with previously-treated HER2 gene-amplified biliary tract cancer (BTC).

Table of Contents

  1. 1. INTRODUCTION

    1. 1.1 Study Assumptions

    2. 1.2 Scope of the Study

  2. 2. RESEARCH METHODOLOGY

  3. 3. EXECUTIVE SUMMARY

  4. 4. MARKET DYNAMICS

    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Rising Burden of Liver Cancer

      2. 4.2.2 Increasing R&D Investments for the Development of Novel Therapies

      3. 4.2.3 Government Initiatives to Increase the Cancer Awareness

    3. 4.3 Market Restraints

      1. 4.3.1 Side Effects Associated with Certain Medications Coupled with High Cost of Cancer Therapies

      2. 4.3.2 Stringent Regulatory Scenario

    4. 4.4 Porter's Five Force Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION

    1. 5.1 By Type

      1. 5.1.1 Hepatocellular Carcinoma

      2. 5.1.2 Cholangio Carcinoma

      3. 5.1.3 Hepatoblastoma

      4. 5.1.4 Other Types

    2. 5.2 By Therapy

      1. 5.2.1 Targeted Therapy

      2. 5.2.2 Radiation Therapy

      3. 5.2.3 Immunotherapy

      4. 5.2.4 Chemotherapy

    3. 5.3 Geography

      1. 5.3.1 North America

        1. 5.3.1.1 United States

        2. 5.3.1.2 Canada

        3. 5.3.1.3 Mexico

      2. 5.3.2 Europe

        1. 5.3.2.1 Germany

        2. 5.3.2.2 United Kingdom

        3. 5.3.2.3 France

        4. 5.3.2.4 Italy

        5. 5.3.2.5 Spain

        6. 5.3.2.6 Rest of Europe

      3. 5.3.3 Asia-Pacific

        1. 5.3.3.1 China

        2. 5.3.3.2 Japan

        3. 5.3.3.3 India

        4. 5.3.3.4 Australia

        5. 5.3.3.5 South Korea

        6. 5.3.3.6 Rest of Asia-Pacific

      4. 5.3.4 Middle-East and Africa

        1. 5.3.4.1 GCC

        2. 5.3.4.2 South Africa

        3. 5.3.4.3 Rest of Middle-East and Africa

      5. 5.3.5 South America

        1. 5.3.5.1 Brazil

        2. 5.3.5.2 Argentina

        3. 5.3.5.3 Rest of South America

  6. 6. COMPETITIVE LANDSCAPE

    1. 6.1 Company Profiles

      1. 6.1.1 F. Hoffmann-La Roche Ltd

      2. 6.1.2 Bayer AG

      3. 6.1.3 Bristol-Myers Squibb Company

      4. 6.1.4 Celsion Corporation

      5. 6.1.5 Eisai Co. Ltd

      6. 6.1.6 Exelixis Inc.

      7. 6.1.7 Eli Lilly and Company

      8. 6.1.8 Merck & Co. Inc.

      9. 6.1.9 Pfizer Inc

      10. 6.1.10 AbbVie Inc

      11. 6.1.11 Amgen Inc

      12. 6.1.12 AstraZeneca Plc

      13. 6.1.13 Johnson & Johnson

      14. 6.1.14 Novartis AG

      15. 6.1.15 Sanofi SA

    2. *List Not Exhaustive
  7. 7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies, and Recent Developments

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Frequently Asked Questions

The Global Liver Cancer Therapeutics Market market is studied from 2018 - 2026.

The Global Liver Cancer Therapeutics Market is growing at a CAGR of 11.2% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2020.

Bristol‑Myers Squibb Company, Eisai Co., Ltd., Exelixis Inc, Merck & Co. Inc., Bayer AG are the major companies operating in Global Liver Cancer Therapeutics Market.

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