Confocal Microscope Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Confocal Microscope Market is Segmented by Type (Laser Scanning Microscopes, Spinning Disk Confocal Microscopes, Programmable Array Microscopes (PAM)), End-User (Hospitals, Diagnostic Laboratories, Academics & Research Institute, Other), and Geography (North America, Europe, Asia-Pacific, Middle East, and Africa, and South America). The report offers the value (USD million) for the above segments.

Market Snapshot

Confocal Microscope Market Size
Study Period: 2019-2027
Base Year: 2021
Fastest Growing Market: North America
Largest Market: Asia-Pacific
CAGR: 3.51 %

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Market Overview

The global Confocal Microscope market is estimated to be USD 1,016.13 million in 2021. It is expected to reach USD 1,244.76 million by 2027, registering a CAGR of 3.51% from 2022 to 2027.

COVID-19 has impacted economies and industries in several countries due to lockdowns, travel bans, and business shutdowns. The COVID-19 crisis has overburdened public health systems in many countries, highlighting the critical need for long-term health system investment. However, according to the study titled "In Vivo confocal microscopy findings after COVID-19 infection," published in Ocular Immunology and infection in August 2021, the demand for confocal microscopes was raised in COVID-19 due to conjunctivitis caused by a COVID-19 infection, the patient developed multiple unilateral subepithelial stromal opacities. As a result, the market has mixed impacts on COVID-19 on it.

A key trend driving the market growth is increased demand for confocal microscopy in diagnosing ophthalmic conditions. The market is being boosted by the increasing use of confocal microscopes in life sciences, material sciences, neurophysiology, and biology. The rising incidence of microbial keratitis is boosting demand for confocal microscopes.

According to the study titled "Confocal Microscopy and Anterior Segment Optical Coherence Tomography Imaging of the Ocular Surface and Bleb Morphology in Medically and Surgically Treated Glaucoma Patients: A Review" published in the MDPI Journal in May 2021, IVCM (in vivo confocal microscopy) is a diagnostic tool that can produce high-resolution ocular tissue images in real-time in vivo. IVCM provides rapid and noninvasive microstructural information of the ocular surface and adnexa at the cellular level, with a resolution comparable to histologic methods. Thus, the confocal microscope is extensively used in diagnosing ocular diseases, raising the demand for confocal microscopy to drive market growth.

Furthermore, in biology, life science, material science, neuroanatomy, and neurophysiology, confocal microscope adoption is increasing, which is expected to drive the market for confocal microscopes over the forecast period. as per the study titled "Modeling stem cell nucleus mechanics using confocal microscopy" published in the Biomechanics and Modelling Mechanolobiology in December 2021, Confocal images are a great tool for identifying the contribution of a variety of sub-nuclear structures and predicting global nuclear stiffness of multiple nuclei based on simple nuclear isolation protocols. The effectiveness of the confocal microscope in cell structure research in life science and biotechnology drives the market's growth.

In addition, the rising incidence of microbial keratitis is boosting the demand for confocal microscopes. According to the study titled "The epidemiology of infectious keratitis," published in The Ocular Surfaces in August 2021, fungal keratitis has over 1 million fungal infections worldwide each year, with Asia and Africa having the highest caseload. The overall annual incidence rate is 23.6 cases per 100,000 people.

Thus, all factors mentioned above are anticipated to drive the market over the forecast period. However, costs associated with the microscope and lack of trained professionals may restrain the market over the forecast period.

Scope of the Report

A confocal microscope is a standard fluorescence microscope that generates high-resolution images of material stained with fluorescent probes using special optical components. Confocal microscopy differs from traditional wide-field fluorescence microscopy in that the optical path is designed to place an aperture (opening) in front of the image detector (photomultiplier tube or camera), and the image is focused in conjunction with the focal plane of the image. The Confocal Microscope Market is Segmented by Type (Laser Scanning Microscopes, Spinning Disk Confocal Microscopes, Programmable Array Microscopes (PAM)), End-User (Hospitals, Diagnostic Laboratories, Academics & Research Institute, Other), and Geography (North America, Europe, Asia-Pacific, Middle East, and Africa, and South America). The report also covers the estimated market sizes and trends for 17 countries globally. The report offers the value (USD million) for the above segments.

By Type
Laser Scanning Microscopes
Spinning Disk Confocal Microscopes
Programmable Array Microscopes (PAM)
By End User
Diagnostic Laboratories
Academics & Research Institute
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle-East and Africa
South Africa
Rest of Middle-East and Africa
South America
Rest of South America

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Key Market Trends

Laser Scanning Microscopes Segment is Expected to Dominate the Market Over the Forecast Period

As the name implies, in a laser scanning confocal microscope (LSCM), a laser beam is swept over the sample using scanning galvanometer mirrors. Typically, the laser is directed onto a pair of scanning mirrors, sweeping the beam in x and y directions of a single field of view and then moved incrementally across the entire sample to produce an image of the optical section or slice.​

Major companies manufacturing Laser Scanning Microscopes include Leica microsystems, Nikon Corporation, Olympus Corporation, Carl Zeiss AG, Thorlabs, Brucker, and Asylum. Laser Scanning Microscopes are used in biological research to obtain high-resolution, high-contrast images of the cell or tissue. Olympus Corporation has successful products, i.e., laser scanning microscopes that include FV3000 and FVMPE-RS.

In April 2022, researchers from Fraunhofer Research Institute stated that they had developed a new rapid technology in which doctors can determine if the tumor is fully removed from the body or not during cancer surgery. This technology combines a laser scanning microscope and fluorescent tumor markers in which doctors can detect any remaining cancer cells immediately after the surgery. Cancer is one of the major burdens across the globe, advantages of laser scanning microscopes in this area are expected to grow for information about the successful removal of the tumor.

Several advancements are being made in the laser scanning microscope to improve the results' accuracy. For instance, Tohoku University and Osaka University researchers have developed a technique through which a rapid 3D image is taken without moving the observation plane, which is typically necessary for conventional laser-scanning microscopes. Hence, it is evident that laser scanning microscopes are commonly used. Hence, owing to the abovementioned factors, the segment is believed to witness steady growth over the forecast period.

Confocal Microscope Market

North America Dominates the Market and Expected to do Same in the Forecast Period.

North America holds a major share in the confocal microscopes market and is expected to show a similar trend over the forecast period mainly due to the prevalence of ophthalmic diseases and the huge investment in the research and development activities in North America; the United States will hold the largest market in the microscopy device market in the region. There has been a rising prevalence of eye diseases, such as glaucoma, cataract, macular degeneration, and diabetic retinopathy, which is anticipated to propel the market over the forecast period. As per the statistics provided by the National Eye Institute in 2019, around 1.3 million Americans were blind, and 2.9 million have low vision. An estimated 2.2 million Americans may face vision loss, and 5 million are expected to have low vision by 2030. Hence, an increase in eye disorders will lead to the growing demand for confocal microscopes to diagnose diseases anticipated to boost the market.

As per the Congressional Research Service report of January 2020, the United States spent USD 580 billion on other research and development activities, of which USD 21.1 billion was spent on higher education. As a result of the key market players' increased research and development activity to bring technologically advanced products to market, demand for advanced confocal microscopes is expected to rise over the forecast period.

Additionally, a few of the key market players in the country are developing novel products and technologies to compete with the existing products, while others are acquiring and partnering with other companies trending in the market. For instance, in April 2021, Nikon Corporation (Nikon) released the AX and AX R series of next-generation confocal microscopes. This new confocal series has a redesigned scan head with 8K x 8K resolution and ultra-high speed resonant scanning.

Thus, all the abovementioned factors are expected to boost the market growth in the region over the forecast period.

Confocal Microscope Market Analysis

Competitive Landscape

The confocal microscope market is fragmented and highly competitive. The major players have established themselves in specific segments of the market. Furthermore, the companies compete in emerging regions with global and established local players. However, key strategies are adopted by key players to consolidate their positions in the market., Bruker Corporation, Nikon Corporation, ZEISS Group, Leica Microsystem, and Olympus Corporation are prominent global confocal microscope market players.

Recent Developments

· In November 2021, Nikon Instruments Inc. released the AX R MP multiphoton confocal microscope, which can acquire high-resolution, large-field-of-view images deep within living organisms at high speeds.

· In October 2021, CrestOptics SpA reported the launch of DeepSIM, a super-resolution module designed to enhance the imaging capabilities of confocal microscope systems. The DeepSIM module can be used with Crest’s X-light V3 spinning disk or alternative confocal systems to offer high-resolution images for life science researchers.

Table of Contents


    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Rising Demand for Confocal Microscopy in The Diagnosis of Ophthalmic Conditions

      2. 4.2.2 Growing Role of Confocal Microscope in Life Sciences, Material Sciences, Neurophysiology, And Biology

      3. 4.2.3 Rising Incidence of Microbial Keratitis

    3. 4.3 Market Restraints

      1. 4.3.1 High Price of Microscope and Lack of Skilled Professionals

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION (Market Size by Value – USD million)

    1. 5.1 By Type

      1. 5.1.1 Laser Scanning Microscopes

      2. 5.1.2 Spinning Disk Confocal Microscopes

      3. 5.1.3 Programmable Array Microscopes (PAM)

    2. 5.2 By End User

      1. 5.2.1 Hospitals

      2. 5.2.2 Diagnostic Laboratories

      3. 5.2.3 Academics & Research Institute

      4. 5.2.4 Others

    3. 5.3 Geography

      1. 5.3.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.3.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.3.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.3.4 Middle-East and Africa

        1. GCC

        2. South Africa

        3. Rest of Middle-East and Africa

      5. 5.3.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 Olympus Corporation

      2. 6.1.2 Danaher Corporation (Leica Microsystem)

      3. 6.1.3 ZEISS Group (Carl Zeiss Meditec AG)

      4. 6.1.4 Nikon Corporation

      5. 6.1.5 Bruker Corporation

      6. 6.1.6 Agilient Technologies

      7. 6.1.7 Oxford Instruments plc

      8. 6.1.8 Thorlabs, Inc.

      9. 6.1.9

      10. 6.1.10 ISS.Inc

      11. 6.1.11 Horiba

      12. 6.1.12 Caliber Imaging & Diagnostics

    2. *List Not Exhaustive

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies, and Recent Developments

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Frequently Asked Questions

The Global Confocal Microscope Market market is studied from 2019 - 2027.

The Global Confocal Microscope Market is growing at a CAGR of 3.51% over the next 5 years.

The Global Confocal Microscope Market is valued at 1016 Million USD in 2019.

The Global Confocal Microscope Market is valued at 1244 Million USD in 2027.

North America is growing at the highest CAGR over 2021- 2026.

Asia-Pacific holds highest share in 2021.

Danaher Corporation (Leica Microsystem) , ZEISS Group (Carl Zeiss Meditec AG), Nikon Corporation, Bruker Corporation, Olympus Corporation are the major companies operating in Global Confocal Microscope Market.

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