3D Cell Culture Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The 3D Cell Culture Market is segmented by Product (Scaffold-Based 3D Cell Cultures, Scaffold-Free 3D Cell Cultures, Microchips and 3D Bioreactors), Application (Drug Discovery, Tissue Engineering, Clinical Applications, and Other Applications), End User (Research Laboratories and Institutes, Biotechnology and Pharmaceutical Companies and Other End Users), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (in USD million) for the above segments.

Market Snapshot

3D Cell Culture Market Overview
Study Period: 2018 - 2026
Base Year: 2021
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 12.5 %
3D Cell Culture Market Major Players

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Market Overview

The 3D cell culture market is expected to register a CAGR of 12.5% during the forecast period of 2021-2026. 

The COVID-19 pandemic is expected to have a significant impact on the market. Researchers working on COVID-19 with relevant matrices for 3D cell culture and suitable for air-liquid interface culture, need to investigate in vitro the mechanisms of the systemic consequences of cell cultures and to test potential therapies in a physiological microenvironment. This is the primary reason why 3D cell cultures are used in COVID-19 research. According to an article appearing in Frontiers Online in March 2021 titled, '3D Tissue Models as an Effective Tool for Studying Viruses and Vaccine Development', there are benefits of using 3D tissue culture techniques over 2D tissue culture when studying viral infections and the implications with regards to studying COVID-19. The study also found that techniques like organoids and spheroid cultures have been shown to replicate systems of viral infection more accurately than 2D cultures and to produce morphology and biochemical behaviors required to allow for viral infection in cases where 2D cultures do not.

The 3D cell culture market is witnessing stable growth due to the factors, like the use of 3D cell culture models as alternative tools for in vivo testing, development of automated large-scale cell culture systems, and rising need for organ transplantation. The 3D cell culture and co-culture models have huge benefits, since they not only enable drug safety and efficacy assessment in a more in vivo–like context than traditional 2D cell cultures, but they can eliminate the species differences that pose limitations in the interpretation of the preclinical outcomes, by allowing drug testing directly in human systems. Additionally, with the increase in demand for organ transplantation, there is likely to be a demand for 3D cell cultures as there is a need to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro. According to the organdonor.gov websites of the United States Health Resources and Services Administration, 107,103 number of patients were on the national organ transplant waiting list in the year 2020. Data from the website also states that each year, 39,000 organ transplants are conducted in the United States. Thus, the increase in organ transplants is increasing demand for research models, where 3D cell cultures are used. This is expected to boost market growth.

Scope of the Report

3-dimensional (3D) cell culture is an artificially created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions. This report analyzes and discusses the 3D cell culture market. 

The 3D Cell Culture Market is segmented by Product (Scaffold-Based 3D Cell Cultures, Scaffold-Free 3D Cell Cultures, Microchips and 3D Bioreactors), Application (Drug Discovery, Tissue Engineering, Clinical Applications, and Other Applications), End User (Research Laboratories and Institutes, Biotechnology and Pharmaceutical Companies and Other End Users), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (in USD million) for the above segments.

By Product
Scaffold-Based 3D Cell Cultures
Micropatterned Surface Microplates
Other Products
Scaffold-Free 3D Cell Cultures
Hanging drop microplates
Microfluidic 3D cell culture
Other Products
3D Bioreactors
By Application
Drug Discovery
Tissue Engineering
Clinical Applications
Other Applications
By End User
Research Laboratories and Institutes
Biotechnology and Pharmaceutical Companies
Other End Users
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle East and Africa
South Africa
Rest of Middle East and Africa
South America
Rest of South America

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Key Market Trends

The Microchips Segment under Product is Expected to see Significant Growth Rate Over the Forecast Period

Microchips are also called organ-on-a-chip or microsystems. Microchips can integrate microfluidic technologies with cells that are cultured within the micro fabricated 3D devices, using various techniques from the microchip industry. 2-dimensional (2D) culture models and animal models have been used for mechanism research and drug development. However, 2D models and animal models cannot mimic the physiology of human tissue, in terms of number of cell types and properties. Thus, conventional models cannot precisely reflect human and have not been able to accurately predict in vivo responses related to drug treatment. In this regard, many industries have been looking for, and developing a new platform, to replace animal models or flask cell-culture models, and recently, organs-on-a-chip (OoCs) emerged as an alternative candidate for cell experiments and drug screening. The main advantage of these chips is that they can be manufactured at low cost. Furthermore, they allow to test a wide range of concentrations in the dosage of medicine. This advantage is expected to drive the demand for microchips, primarily to considerably accelerate scientific research. In recent years, there has been innovative uses of the organ on a chip technology for drug discovery process. For example, in March 2019, the private space exploration company SpaceX announced that it plans to soon launch a Dragon cargo capsule that will contain four microchips embedded with living human cells designed to model various aspects of human physiology. This is expected to speed up analysis and glean insights on human physiology that can be used later for drug development. As a result, due to the aforementioned advantages and research in microchip 3D cell culture technologies are expected to drive the market’s growth.

3D Cell Culture Market Key Players

North America Captured the Largest Market Share and is Expected to Retain its Dominance

North America dominates the overall 3D cell culture market with the United States being the major contributor to the market. The United States is focusing on R&D and has been making significant investments in research on 3D cell culture, for the past few years. This has resulted in technological advancements in the country. Many American applicants feature among the main patent applicants for the 3D cell culture domain. American applicants tend to develop their technologies in the United States, as well as in Asia. There have also been huge investments in the bioengineering sector in the United States over the past few years. Bio engineering involves 3D cell culture research too. According to the National Institute of Health, in 2020, the total investment in various bio engineering technologies amounted to USD 5,646, an increase from USD 5,091 in 2019. These factors have augmented the US 3D cell culture market.

3D Cell Culture Market Growth

Competitive Landscape

The 3D cell culture market is highly competitive and consists of several major players. In terms of market share, few of the major players currently dominate the market. The presence of major market players, such as Corning Incorporated, Lonza AG, Merck KGaA, and Thermo Fisher Scientific, is increasing the overall competitive rivalry in the market.

Recent Developments

In January 2021, Jellagen Limited, a biotechnology company that manufactures high-value Collagen Type 0 derived from jellyfish, announced the launch of its JellaGel Hydrogel, a 3D hydrogel. JellaGel provides customers with a non-mammalian, natural, biochemically simple, consistent, and easy to use hydrogel that can transform their research

In December 2020, eNuvio Inc., announced the launch of its reusable 3D cell culture microplate called the EB-Plate. This new plate allows researchers to generate embryoid bodies, the necessary first step to growing larger self-assembled 3D cultures known as spheroids or organoids from stem cells.

Table of Contents


    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Use of 3D Cell Culture Models as Alternative Tools for In Vivo Testing

      2. 4.2.2 Development of Automated Large-scale Cell Culture Systems

      3. 4.2.3 Rising Need for Organ Transplantation

    3. 4.3 Market Restraints

      1. 4.3.1 Lack of Experienced and Skilled Professionals

      2. 4.3.2 Budget Restriction for Small- and Medium-sized Laboratories

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry


    1. 5.1 By Product

      1. 5.1.1 Scaffold-Based 3D Cell Cultures

        1. Micropatterned Surface Microplates

        2. Hydrogels

        3. Other Products

      2. 5.1.2 Scaffold-Free 3D Cell Cultures

        1. Hanging drop microplates

        2. Microfluidic 3D cell culture

        3. Other Products

      3. 5.1.3 Microchips

      4. 5.1.4 3D Bioreactors

    2. 5.2 By Application

      1. 5.2.1 Drug Discovery

      2. 5.2.2 Tissue Engineering

      3. 5.2.3 Clinical Applications

      4. 5.2.4 Other Applications

    3. 5.3 By End User

      1. 5.3.1 Research Laboratories and Institutes

      2. 5.3.2 Biotechnology and Pharmaceutical Companies

      3. 5.3.3 Other End Users

    4. 5.4 Geography

      1. 5.4.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.4.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.4.4 Middle East and Africa

        1. GCC

        2. South Africa

        3. Rest of Middle East and Africa

      5. 5.4.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 BiomimX SRL

      2. 6.1.2 CN Bio Innovations

      3. 6.1.3 Corning Incorporated

      4. 6.1.4 Hurel Corporation

      5. 6.1.5 InSphero AG

      6. 6.1.6 Lonza AG

      7. 6.1.7 Merck KGaA

      8. 6.1.8 MIMETAS BV

      9. 6.1.9 Nortis Inc.

      10. 6.1.10 Thermo Fisher Scientific

      11. 6.1.11 Sartorius AG

      12. 6.1.12 Promocell GmbH

    2. *List Not Exhaustive

**Competitive Landscape Covers - Business Overview, Financials, Products and Strategies, and Recent Developments

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Frequently Asked Questions

The Global 3D Cell Culture Market market is studied from 2018 - 2026.

The Global 3D Cell Culture Market is growing at a CAGR of 12.5% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2020.

Corning Incorporated, Lonza AG, Thermo Fisher Scientific, Merck KGaA, MIMETAS BV are the major companies operating in Global 3D Cell Culture Market.

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