Tangential Flow Filtration Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

The Tangential Flow Filtration Market Report is Segmented by Product Type (Systems, Membrane Filters, and Accessories), Technology (Ultrafiltration, Microfiltration, and Reverse Osmosis/ Nanofiltration), End-User (Biopharma Manufacturers, and More), Geography (North America, Europe, Asia-Pacific, The Middle East and Africa, and South America). The Market Forecasts are Provided in Terms of Value (USD).

Tangential Flow Filtration Market Size and Share

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Tangential Flow Filtration Market Analysis by Mordor Intelligence

The tangential flow filtration market reached USD 2.69 billion in 2025 and is on course to attain USD 4.77 billion by 2030, advancing at a 12.13% CAGR. Sustained investment in process-intensified, continuous biomanufacturing lines, the rapid scale-up of gene therapy plants, and an accelerated shift toward single-use equipment all underpin this double-digit expansion. Contract development organizations in Asia are commissioning large-footprint greenfield plants, while incumbent North American and European producers are retrofitting legacy facilities to boost throughput without expanding cleanroom space. Ongoing integration of inline analytics with filtration skids shortens process-development cycles and lowers failure rates, pushing end users to favor fully integrated system packages. At the same time, supply-chain friction in GMP-grade membranes and tightening rules on plastic waste are sharpening vendor focus on material innovation and recycling programs.

Key Report Takeaways

  • By product type, systems held 46.34% of tangential flow filtration market share in 2024, whereas membrane filters are projected to expand at a 14.67% CAGR through 2030.
  • By technology, ultrafiltration led with 57.53% revenue share in 2024; microfiltration is poised for the fastest growth at a 14.83% CAGR to 2030.
  • By application, vaccines and monoclonal antibodies accounted for a 34.62% share of the tangential flow filtration market size in 2024, while cell and gene therapy vectors are forecast to grow at 15.67% CAGR through 2030.
  • By geography, North America dominated with 39.62% revenue share in 2024; Asia-Pacific is projected to post the highest 13.56% CAGR up to 2030.
  • By end user, biopharma manufacturers commanded 58.4% demand in 2024, yet CDMOs are advancing at a 15.67% CAGR to 2030.

Segment Analysis

By Product Type: Integrated Systems Anchor Procurement Strategies

Systems accounted for a 46.34% tangential flow filtration market share in 2024, reflecting user preference for turnkey assemblies that couple pumps, controllers, and real-time sensors under a single validation envelope. Demand remains resilient because multinationals routinely upgrade installed skids to align with tightening data-integrity and automation mandates. In parallel, the tangential flow filtration market size allocated to membrane filters is climbing at a 14.67% CAGR to 2030 as single-use programs require fresh cassettes for each campaign. Disposable membrane uptake is particularly sharp in gene therapy suites, where cross-contamination risk is less acceptable and changeover speed carries premium value.

Accessories such as pre-conditioners, flow-path sensors, and disposable conductivity probes are the smallest dollar segment yet record steady, mid-single-digit growth. Suppliers bundle these add-ons with service agreements, expanding revenue beyond hardware. Repligen’s recently launched SoloVPE Plus system exemplifies the push toward integrated analytics, shortening concentration tests by 70% and feeding back to automated filter-control loops. This convergence of hardware and analytics delivers higher margins to vendors while reducing batch-failure risk for users.

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Note: Segment shares of all individual segments available upon report purchase

By Technology: Microfiltration Narrows the Gap with Ultrafiltration

Ultrafiltration retained 57.53% revenue in 2024 given its entrenchment in buffer-exchange and concentration steps for classical biologics. Nevertheless, microfiltration is projected to expand at a 14.83% CAGR through 2030, propelled by high-cell-density perfusion cultures that depend on tight cell-retention cutoffs. The tangential flow filtration market size apportioned to microfiltration modules is therefore growing faster than the macroscale figure, stimulated by viral vector facilities that demand precise pore distribution for debris removal.
Breakthroughs in polymer chemistry, specifically polyethersulfone blends and regenerated-cellulose coatings, are boosting flux stability and fouling resistance during long perfusion runs. Innovations are also surfacing in gradient-pore architectures that pair high retentate selectivity with low trans-membrane pressure, features that align with the shear-sensitivity of new biologic entities. Reverse osmosis and nanofiltration remain niche, handling mainly utility water polishing, and their share is unlikely to budge materially across the forecast window.

By Application: Gene Therapy Vectors Catalyze Segment Diversification

Vaccines and monoclonal antibodies held a 34.62% share of the tangential flow filtration market in 2024 and still represent the largest revenue block. However, cell and gene therapy vectors are rising at a 15.67% CAGR over 2025-2030, riding a pipeline wave of approved adeno-associated virus and lentivirus products. This redirection of capital towards personalized and curative treatments compels filter vendors to validate cassettes that can separate full from empty capsids without undue shear.
Plasma-derived proteins remain a stable yet low-growth niche as recombinant substitutes erode addressable demand. Specialty areas such as biosimilars and bispecific antibodies add moderate diversification, but the gravitational center of innovation clearly sits with gene therapy. Asahi Kasei’s virus-removal Planova range illustrates the performance required, integrating validated logs of viral clearance without compromising product recovery.

Tangential Flow Filtration Market: Market Share by Application
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Note: Segment shares of all individual segments available upon report purchase

By End User: CDMOs Accelerate Outsourcing Momentum

Biopharma manufacturers consumed 58.4% of equipment in 2024, yet CDMOs are registering a 15.67% CAGR that will narrow the gap quickly. Smaller biotechnology sponsors find it capital-efficient to outsource complex filtration steps rather than invest in fully compliant facilities. Established pharmaceutical majors likewise divest non-core production as they reorient toward discovery. Consequently, the tangential flow filtration market increasingly hinges on service providers that negotiate long-term supply agreements and co-develop bespoke filtration trains to attract molecule owners.
Asia-based giants like Samsung Biologics and Lotte Biologics illustrate this surge. Samsung’s USD 6 billion expansion adds one of the globe’s largest single sites for hybrid single-use and stainless operations, locking in multiple Western sponsors. CDMOs differentiate by deploying cutting-edge analytics, so suppliers bundling sensors, software, and membranes into one invoice gain procurement preference.

Geography Analysis

North America generated 39.62% of 2024 revenue in the tangential flow filtration market, supported by advanced R&D clusters, a well-defined FDA validation pathway, and deep installed capacity across vaccines, antibodies, and viral vectors. Mergers such as Thermo Fisher Scientific’s USD 4.1 billion purchase of Solventum’s purification business underscore the region’s role as the gravitational center for technology consolidation. Persistent talent shortages and raw-material lead-time spikes, however, are prompting some producers to weigh dual-continental supply chains.

Asia-Pacific is on track to post a 13.56% CAGR through 2030, translating into the fastest regional expansion worldwide. Several headline projects, including Samsung Biologics’ USD 6 billion “Plant 5” build and Lotte Biologics’ USD 3.3 billion greenfield complex, are raising local demand for high-capacity filtration skids. Chinese CDMOs such as WuXi Biologics and Chime Biologics are similarly scaling viral-vector suites, further inflating order books. Favorable tax incentives, comparatively low labor costs, and short shipping lanes for polymer resins amplify the region’s competitiveness, although lingering IP and regulatory alignment challenges moderate uptake among some multinational sponsors.

Europe enjoys steady mid-single-digit growth owing to a robust pharmaceutical base and strict environmental statutes that encourage water-reuse and biodegradable filter elements. Brexit-related cross-border friction and high energy prices inflate operating costs but simultaneously bolster the case for continuous processing that squeezes more product out per kilowatt consumed. Middle East & Africa and South America are nascent yet viewable growth pockets; both benefit from government life-science funding programs but still lack the dense supplier and talent ecosystems found in mature markets.

Tangential Flow Filtration Market CAGR (%), Growth Rate by Region
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Competitive Landscape

The tangential flow filtration market is moderately concentrated, with the top five suppliers collectively controlling a sizable slice of global revenue. Danaher’s Pall unit, Merck KGaA, Sartorius AG, Thermo Fisher Scientific, and Repligen anchor the field, each promoting integrated hardware-analytics platforms. Recent consolidation accelerates this tilt. Thermo Fisher’s Solventum acquisition broadens its purification footprint and offers significant cross-selling to its installed base of bioreactors and chromatography columns. Donaldson Company’s purchase of Solaris Biotechnology enhances its single-use filtration portfolio, illustrating how mid-tier entrants are bulking up capability to chase higher-margin biopharma opportunities.

Technology competition centers on membrane material science, fouling-resistant surface coatings, and embedded sensors that enable closed-loop control. Vendors increasingly couple skids with digital twins and AI-driven predictive maintenance modules to reduce downtime and increase usable membrane life. Single-use portfolios remain pivotal, yet suppliers are working on hybrid offerings that pair disposable flow paths with reusable stainless pressure housings, balancing sustainability mandates with efficiency.
Service wrap-arounds such as process-development consulting, installation qualification, and operator training are critical loyalty levers. CDMOs signing multi-year manufacturing contracts often negotiate life-cycle pricing that bundles membranes, spares, and software licenses into monthly fees, tilting competition away from pure capital expenditure bids.

Tangential Flow Filtration Industry Leaders

  1. Danaher Corporation

  2. Merck KGaA

  3. Sartorius AG

  4. Repligen Corporation

  5. Parker Hannifin Corporation

  6. *Disclaimer: Major Players sorted in no particular order
Tangential Flow Filtration Market Concentration
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Recent Industry Developments

  • February 2025: Thermo Fisher Scientific completed its USD 4.1 billion acquisition of Solventum’s purification and filtration business.
  • January 2025: Donaldson Company acquired Solaris Biotechnology to widen its single-use filtration capabilities.
  • December 2024: Filtration Technology Corporation finalized a 55,000-square-foot plant expansion to support its Invicta cartridge line.
  • July 2024: Repligen agreed to acquire chromatography innovator Tantti, adding complementary purification technologies.
  • June 2024: Ecolab Life Sciences and Repligen launched DurA Cycle affinity resin for monoclonal antibody purification.

Table of Contents for Tangential Flow Filtration Industry Report

1. Introduction

  • 1.1 Study Assumptions & Market Definition
  • 1.2 Scope of the Study

2. Research Methodology

3. Executive Summary

4. Market Landscape

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Single-Use Systems Slash Change-Over Time
    • 4.2.2 Growing Adoption of Continuous Bioprocessing
    • 4.2.3 High-Throughput Screening Cassettes for Gene-Therapy Vectors
    • 4.2.4 Biopharma Shift to High-Cell-Density Perfusion
    • 4.2.5 CAPEX-Light CDMO Build-Outs in Emerging Asia
    • 4.2.6 ESG-Driven Water-Recycling Mandates
  • 4.3 Market Restraints
    • 4.3.1 Shear-Sensitive Modalities Limit Flux Rates
    • 4.3.2 Scarcity Of GMP-Grade Hollow-Fiber Supply
    • 4.3.3 Learning-Curve Risk in Process-Automation Adoption
    • 4.3.4 Export-Control Rules on Single-Use Plastics
  • 4.4 Regulatory Landscape
  • 4.5 Porter's Five Forces Analysis
    • 4.5.1 Threat of New Entrants
    • 4.5.2 Bargaining Power of Buyers
    • 4.5.3 Bargaining Power of Suppliers
    • 4.5.4 Threat of Substitutes
    • 4.5.5 Competitive Rivalry

5. Market Size & Growth Forecasts (Value, USD)

  • 5.1 By Product Type
    • 5.1.1 Systems
    • 5.1.1.1 Single-use Tangential Flow Filtration Systems
    • 5.1.1.2 Re-usable Tangential Flow Filtration Systems
    • 5.1.2 Membrane Filters
    • 5.1.2.1 Polyethersulfone
    • 5.1.2.2 Regenerated Cellulose
    • 5.1.2.3 Other Membranes
    • 5.1.3 Accessories
  • 5.2 By Technology
    • 5.2.1 Ultrafiltration
    • 5.2.2 Microfiltration
    • 5.2.3 Reverse Osmosis / Nanofiltration
  • 5.3 By Application
    • 5.3.1 Vaccines & mAbs
    • 5.3.2 Cell & Gene-Therapy Vectors
    • 5.3.3 Plasma-derived Proteins
    • 5.3.4 Other Applications
  • 5.4 By End-User
    • 5.4.1 Biopharma Manufacturers
    • 5.4.2 Contract Development & Manufacturing Organisations (CDMOs)
    • 5.4.3 Other End-Users
  • 5.5 Geography
    • 5.5.1 North America
    • 5.5.1.1 United States
    • 5.5.1.2 Canada
    • 5.5.1.3 Mexico
    • 5.5.2 Europe
    • 5.5.2.1 Germany
    • 5.5.2.2 United Kingdom
    • 5.5.2.3 France
    • 5.5.2.4 Italy
    • 5.5.2.5 Spain
    • 5.5.2.6 Rest of Europe
    • 5.5.3 Asia-Pacific
    • 5.5.3.1 China
    • 5.5.3.2 Japan
    • 5.5.3.3 India
    • 5.5.3.4 Australia
    • 5.5.3.5 South Korea
    • 5.5.3.6 Rest of Asia-Pacific
    • 5.5.4 Middle East & Africa
    • 5.5.4.1 GCC
    • 5.5.4.2 South Africa
    • 5.5.4.3 Rest of Middle East & Africa
    • 5.5.5 South America
    • 5.5.5.1 Brazil
    • 5.5.5.2 Argentina
    • 5.5.5.3 Rest of South America

6. Competitive Landscape

  • 6.1 Market Concentration
  • 6.2 Market Share Analysis
  • 6.3 Company Profiles (includes Global level Overview, Market level overview, Core Business Segments, Financials, Headcount, Key Information, Market Rank, Market Share, Products and Services, and analysis of Recent Developments)
    • 6.3.1 Danaher Corporation
    • 6.3.2 Merck KGaA
    • 6.3.3 Sartorius AG
    • 6.3.4 Repligen Corp.
    • 6.3.5 Parker Hannifin Corporation
    • 6.3.6 Alfa Laval
    • 6.3.7 Andritz Group
    • 6.3.8 Meissner Filtration
    • 6.3.9 Sterlitech Corp.
    • 6.3.10 Solaris Biotechnology
    • 6.3.11 Thermo Fisher Scientific
    • 6.3.12 3M Company
    • 6.3.13 Cytiva
    • 6.3.14 GE HealthCare
    • 6.3.15 Asahi Kasei
    • 6.3.16 Koch Membrane Systems
    • 6.3.17 Donaldson Company
    • 6.3.18 Miltenyi Biotec
    • 6.3.19 Graver Technologies
    • 6.3.20 Cobetter Filtration

7. Market Opportunities & Future Outlook

  • 7.1 White-space & Unmet-Need Assessment
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Global Tangential Flow Filtration Market Report Scope

As per the scope of this report, tangential flow filtration involves various products that help in the efficient and rapid purification and separation of biomolecules and can be applied to a vast range of biological fields, such as biochemistry, protein chemistry, microbiology, immunology, and microbiology. 

The tangential flow filtration treatment market is segmented by product type, technology, and geography. The product type segment is further segmented into systems, membrane filters, and accessories. The system segment is divided into single-use tangential flow filtration systems and reusable tangential flow filtration systems. The membrane filters are divided into polyethersulfone, regenerated cellulose, and other membrane filters. The technology segment is further divided into ultrafiltration, microfiltration, and reverse osmosis. The geography segment is further segmented into North America, Europe, Asia-Pacific, the Middle East and Africa, and South America. The market report also covers the estimated market sizes and trends for 17 countries across major global regions. The report offers the value (in USD) for the above segments.

By Product Type Systems Single-use Tangential Flow Filtration Systems
Re-usable Tangential Flow Filtration Systems
Membrane Filters Polyethersulfone
Regenerated Cellulose
Other Membranes
Accessories
By Technology Ultrafiltration
Microfiltration
Reverse Osmosis / Nanofiltration
By Application Vaccines & mAbs
Cell & Gene-Therapy Vectors
Plasma-derived Proteins
Other Applications
By End-User Biopharma Manufacturers
Contract Development & Manufacturing Organisations (CDMOs)
Other End-Users
Geography North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East & Africa GCC
South Africa
Rest of Middle East & Africa
South America Brazil
Argentina
Rest of South America
By Product Type
Systems Single-use Tangential Flow Filtration Systems
Re-usable Tangential Flow Filtration Systems
Membrane Filters Polyethersulfone
Regenerated Cellulose
Other Membranes
Accessories
By Technology
Ultrafiltration
Microfiltration
Reverse Osmosis / Nanofiltration
By Application
Vaccines & mAbs
Cell & Gene-Therapy Vectors
Plasma-derived Proteins
Other Applications
By End-User
Biopharma Manufacturers
Contract Development & Manufacturing Organisations (CDMOs)
Other End-Users
Geography
North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East & Africa GCC
South Africa
Rest of Middle East & Africa
South America Brazil
Argentina
Rest of South America
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Key Questions Answered in the Report

What is the current size of the tangential flow filtration market and how fast is it growing?

The market stands at USD 2.69 billion in 2025 and is projected to reach USD 4.77 billion by 2030, advancing at a 12.13% CAGR.

Which product category holds the largest share?

Integrated systems lead with a 46.34% revenue share thanks to their turnkey design and embedded analytics.

Which region is expected to post the strongest growth?

Asia-Pacific is forecast to expand at a 13.56% CAGR through 2030, driven by multi-billion-dollar CDMO capacity additions.

How are CDMOs influencing demand?

CDMOs are expanding at a 15.67% CAGR, accelerating purchases of single-use membranes and high-capacity skids to attract outsourced projects.

What technology trend is most reshaping filtration workflows?

Continuous bioprocessing is integrating tangential flow filtration into steady-state operations, trimming facility footprints by up to 70% and boosting consistency.

What is the chief supply-side restraint?

Limited global capacity for GMP-grade hollow fiber membranes is stretching lead times to 12-18 months and inflating project costs.

Tangential Flow Filtration Market Report Snapshots