Proton Pump Inhibitors Market Size & Share Analysis - Growth Trends & Forecasts (2023 - 2028)

The Report Covers Proton Pump Inhibitors Market Statistics and it is Segmented by Drug Type (OTC Drugs (Omeprazole, Lansoprazole, Esomeprazole, and Other OTC Drugs) and Prescription Drugs (Rabeprazole, Dex lansoprazole, Pantoprazole, and Other Prescription Drugs) and Geography (North America, Europe, Asia-Pacific, Middle East & Africa, and South America). The Values are Provided in Terms of USD Million for above segments.

Proton Pump Inhibitors (PPIS) Market Size

Proton Pump Inhibitors Market Summary
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Study Period 2019-2027
Base Year For Estimation 2022
Forecast Data Period 2023 - 2028
CAGR 4.50 %
Fastest Growing Market Asia Pacific
Largest Market North America

Major Players

Proton Pump Inhibitors Market Major Players

*Disclaimer: Major Players sorted in no particular order


Need a report that reflects how COVID-19 has impacted this market and its growth?

Proton Pump Inhibitors (PPIS) Market Analysis

The proton pump inhibitors market is poised to grow at a CAGR of 4.5% during the forecast period of the study.

Many researchers have found that proton pump inhibitors have increased the risk of COVID-19 in patients taking these medications. An article published by PubMed Central in February 2022, reported that proton pump inhibitors (PPI) use was marginally associated with a nominal but statistically significant increase in the risk of COVID-19 infection, and PPI use also increased the risk of poor outcomes in patients with COVID-19. This factor affected the market growth as patients undergoing proton-pump inhibitor therapy was advised to consume fewer medications and avoid these medications unless it is an emergency. Thus, COVID-19 has a significant impact on the growth of the studied market. However, currently, as the pandemic subsided and fewer people are getting infected with the virus, the studied market is expected to have favorable growth during the forecast period of the study.

Proton pump inhibitors are the gold standard medication for gastroesophageal reflux disease (GERD), and the increasing prevalence of GERD and the rising acceptance of novel drug delivery systems are the two most prominent factors driving the growth of the market.

Additionally, the risk factors, such as aging, obesity, delayed stomach emptying, changing lifestyles associated with smoking, and consumption of alcohol, coffee, fatty, and fried foods are the major reasons for the occurrence of GERD. Furthermore, according to the data published by WHO in October 2022, it is estimated that by 2030 1 in 6 people in the world will be aged 60 years or over, and by 2050, the world’s population of people aged 60 years and older will double to 2.1 billion. With the increasing geriatric population, the usage of proton pump inhibitors is expected to increase as aging is a major risk factor for GERD. Hence, this factor is expected to enhance the market growth.

Furthermore, players in this market are developing novel products and coming up with new product launches to leverage market opportunities. For instance, in March 2021, Xiromed LLC, the New Jersey-based generic division of Insud Pharmaceuticals, launched Omeprazole Delayed-Release Capsules, 20mg, generic for Prilose. Such a launch of drugs is propelling the growth of the market.

Thus, the increasing prevalence of GERD, along with the growing risk factors are likely to increase the demand for proton pump inhibitors, which is expected to drive the market’s growth. Also, the increasing shift from prescription to OTC drugs is driving the growth of the proton pump inhibitor market. However, the increasing use of generic products in the market and the side effects associated with the drugs may hamper the market growth.

Proton Pump Inhibitors (PPIS) Market Trends

This section covers the major market trends shaping the Proton Pump Inhibitors Market according to our research experts:

The Esomeprazole Segment is Expected to Account for a Significant Share Over the Forecast Period

Esomeprazole is expected to have a significant share of the revenue as it is mostly indicated to treat the symptoms of GERD, heartburn, and other disorders involving excessive stomach acids. The shift from being a prescription-only drug to being sold as an over-the-counter (OTC) drug is likely to be a major driving force for the sales of the drug shortly.

In addition, major market players are focused on research and development and market expansion activities to bring new and reliable formulations to the market. For instance, in August 2021, the Subject Matter Expert Committee (SEC) functioning under CDSCO recommended Sun Pharma conduct a phase 3 clinical trial of esomeprazole dual-release gastro-resistant tablets 80mg vs esomeprazole gastro-resistant tablets 40mg bids for the proposed indication.

Additionally, the strategic initiatives taken by the market players are propelling the growth of the segment. For instance, in March 2021, Daiichi Sankyo Co., Ltd. transferred the marketing and distribution rights for the proton pump inhibitor Nexium capsules 10 mg and 20 mg and Nexium granules for suspension 10 mg and 20 mg (esomeprazole magnesium) to AstraZeneca in Japan.

Thus, owing to all the above-mentioned factors, the Esomeprazole segment is expected to achieve high growth rates.

Estimated Number of New Cases of Stomach Cancer (In Thousands), By Gender, United  States, 2022

North America is Expected to Account for A Significant Share of the Market

North America currently dominates the proton pump inhibitors market and is anticipated to show a similar trend over the forecast period without significant fluctuations. There is a rising burden of GERD in the United States, Canada, and Mexico due to people’s shift toward unhealthy lifestyles. According to an article published by the journal of annals of esophagus in March 2022, it is estimated that 40% of the United States population experience GERD symptoms, and 10–20% of people are being affected on a weekly basis.

In the United States, proton pump inhibitors are one of the most widely prescribed drugs, and increased PPI use has been observed in United States ambulatory settings for the last few years. Furthermore, many firms are spending heavily on promoting their brands. The widespread use of PPIs has also gained the attention of the American Board of Internal Medicine; as a result, the board conducted a campaign to promote the appropriate use of PPIs.

Moreover, product launches in generic categories are also expected to impact the market. For instance, in February 2021, Dr. Reddy’s Laboratories Ltd. launched lansoprazole DR, orally disintegrating tablets, a therapeutic equivalent generic version of Prevacid soluTab delayed-release orally disintegrating tablets, 15 mg and 30 mg, approved by the United States Food and Drug Administration (USFDA). Such generic drug launches are also propelling the growth of the market.

Thus, owing to the abovementioned factors, the proton pump inhibitor market in the North American region is expected to project growth over the forecast period.

Proton Pump Inhibitors Market - Growth Rate by Region

Proton Pump Inhibitors (PPIS) Industry Overview

The proton pump inhibitors market is moderately fragmented, owing to the presence of various players in the market. The market players are focusing on acquiring market shares by focusing on aggressive advertisements and awareness programs among patients. The major key players in the market include AstraZeneca, Bayer AG, Cadila Pharmaceuticals, GlaxoSmithKline PLC, and Pfizer, among others.

Proton Pump Inhibitors (PPIS) Market Leaders

  1. Bayer AG

  2. Pfizer Inc.

  3. Takeda Pharmaceuticals

  4. Cadila Pharmaceuticals

  5. AstraZeneca

*Disclaimer: Major Players sorted in no particular order


Proton Pump Inhibitors (PPIS) Market News

  • In April 2022, Daewon Pharmaceutical launched Escorten, one of the first proton-pump inhibitor drugs in Korea. It is an esomeprazole magnesium trihydrate available in 10mg.
  • In January 2022, TWI Pharmaceuticals USA launched the generic formulation of Dexilant in the United States. It is a dexlansoprazole used to treat heartburn caused by GERD (Gastroesophageal Reflux Disease) and to heal erosive esophagitis. It is available as dexlansoprazole delayed release 30mg and 60mg capsules.

Proton Pump Inhibitors (PPIS) Market Report - Table of Contents


    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increasing Burden of Gastroesophageal Reflux Disease (GERD)

      2. 4.2.2 Rising Acceptance of Novel Drug Delivery Systems

    3. 4.3 Market Restraints

      1. 4.3.1 Increasing Use of Generic Products

      2. 4.3.2 Side Effects Related to Proton Pump Inhibitors

    4. 4.4 Industry Attractiveness - Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry


    1. 5.1 By Drug Type

      1. 5.1.1 OTC (Over-the-counter) Drugs

        1. Omeprazole

        2. Lansoprazole

        3. Esomeprazole

        4. Other OTC Drugs

      2. 5.1.2 By Prescription Drugs

        1. Rabeprazole

        2. Dexlansoprazole

        3. Pantoprazole

        4. Other Prescription Drugs

    2. 5.2 By Geography

      1. 5.2.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.2.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.2.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.2.4 Middle East & Africa

        1. GCC

        2. South Africa

        3. Rest of Middle East & Africa

      5. 5.2.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 AstraZeneca

      2. 6.1.2 Bayer AG

      3. 6.1.3 Cadila Pharmaceuticals

      4. 6.1.4 Eisai Inc.

      5. 6.1.5 GlaxoSmithKline PLC

      6. 6.1.6 Pfizer Inc.

      7. 6.1.7 Takeda Pharmaceuticals

      8. 6.1.8 Sanofi SA

      9. 6.1.9 Perrigo Company PLC

      10. 6.1.10 Dr. Reddy's Laboratories

      11. 6.1.11 Redhill Pharma Limited

      12. 6.1.12 Cipla Limited

    2. *List Not Exhaustive

**Subject to Availability
**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments

Proton Pump Inhibitors (PPIS) Industry Segmentation

As per the scope of the report, proton pump inhibitors (PPIs) are a group of drugs whose main action is the long-lasting reduction of gastric acid production. They are the most potent inhibitors of acid secretion available. 

The Proton Pump Inhibitors Market is Segmented by Drug Type (OTC Drugs (Omeprazole, Lansoprazole, Esomeprazole, and Other OTC Drugs) and Prescription Drugs (Rabeprazole, Dexlansoprazole, Pantoprazole, and Other Prescription Drugs) and Geography (North America, Europe, Asia-Pacific, Middle East & Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions. The report offers the market sizes and forecasts in value (USD million) for the above segments.

By Drug Type
OTC (Over-the-counter) Drugs
Other OTC Drugs
By Prescription Drugs
Other Prescription Drugs
By Geography
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle East & Africa
South Africa
Rest of Middle East & Africa
South America
Rest of South America

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Proton Pump Inhibitors (PPIS) Market Research FAQs

The Proton Pump Inhibitors Market is projected to register a CAGR of 4.5% during the forecast period (2023-2027).

Bayer AG, Pfizer Inc., Takeda Pharmaceuticals, Cadila Pharmaceuticals and AstraZeneca are the major companies operating in the Proton Pump Inhibitors Market.

Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2023-2027).

In 2023, the North America accounts for the largest market share in the Proton Pump Inhibitors Market.

Proton Pump Inhibitors Industry Report

Statistics for the 2023 Proton Pump Inhibitors market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Proton Pump Inhibitors analysis includes a market forecast outlook to 2028 and historical overview. Get a sample of this industry analysis as a free report PDF download.

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