Large Molecules Drug Substance CDMO Market Size & Share Analysis - Growth, Trends & Forecasts (2025 - 2030)

The Large Molecules Drug Substance CDMO Market Report is Segmented by Service (Contract Manufacturing (Clinical and Commercial), Contract Development (Cell Line Development and Process Development), Source (Mammalian, Microbial, and Other Sources), and End Users (Biotech Companies, Research Institutes, and Other End Users). The Report Offers the Value (in USD) for the Above Segments.

Large Molecules Drug Substance CDMO Market Size & Share Analysis - Growth, Trends & Forecasts (2025 - 2030)

Large Molecules Drug Substance CDMO Market Size

Large Molecules Drug Substance CDMO Market Summary
Study Period 2019 - 2030
Market Size (2025) USD 12.10 Million
Market Size (2030) USD 18.28 Million
CAGR (2025 - 2030) 8.60 %
Fastest Growing Market Asia Pacific
Largest Market North America
Market Concentration Medium

Major Players

Large Molecules Drug Substance CDMO Market Major Players

*Disclaimer: Major Players sorted in no particular order

Compare market size and growth of Large Molecules Drug Substance CDMO Market with other markets in Healthcare Industry

Biotechnology

Pharmaceuticals

Healthcare IT

Medical Devices

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Device Drug Combination

Large Molecules Drug Substance CDMO Market Analysis

The Large Molecules Drug Substance CDMO Market size is estimated at USD 12.10 million in 2025, and is expected to reach USD 18.28 million by 2030, at a CAGR of 8.6% during the forecast period (2025-2030).

The market is driven by the increasing approval of molecules for drugs, the rising incidence of chronic and infectious diseases, the growing demand for biologics and biosimilars, and the increasing R&D investment by pharmaceutical companies for large molecules.

The increasing investment for the facility expansion that provides the large molecules of drug substance CDMO services is expected to boost the market during the forecast period. For instance, in January 2022, Alcami, a CDMO, reported a USD 10 million investment to expand its laboratory operation in Durham, North Carolina. The investment sought to expand the laboratory by over 6700 ft², incorporating state-of-the-art equipment. It aimed to bolster extensive molecule characterization capabilities for biologics at various development stages. The facility would support both parenteral manufacturing projects and independent analytical clients.

Moreover, strategic activities by the market players, such as mergers and acquisitions and partnership and services expansion, are expected to contribute to the market during the forecast period. For instance, in May 2023, Aurigene Pharmaceutical Services Limited, a subsidiary of Dr. Reddy's Laboratories, reported the construction of a new and advanced facility that will be used to develop and manufacture therapeutic proteins, antibodies, and viral vectors. This facility will be complemented by exclusive access to a large-scale GMP manufacturing facility with a drug substance capacity of 15,000 liters and fill-finish capabilities, allowing for seamless production of commercial quantities.

In September 2022, FUJIFILM Diosynth embarked on an expansion of its sizable microbial manufacturing facility in Billingham, the United Kingdom. The project, spanning an area of 1858 square meters (20,000 sq. ft), will cater to the increasing need for microbial development and production.

Hence, all the above factors mentioned, such as increasing investment for the production of large molecules of drug substances and strategic initiatives taken by the market players, are anticipated to grow the market during the forecast period. However, compliance issues while outsourcing and changing scenarios within developing countries are expected to restrain the market's growth during the forecast period.

Large Molecules Drug Substance CDMO Industry Overview

The large molecule drugs substance market is moderately competitive due to the presence of several companies operating globally as well as regionally. The companies are focused on expanding the facilities for large molecules drug substance. Some major market players are Thermo Fisher Scientific Inc., Eurofins Scientific, Wuxi Biologics, Samsung Biologics, and Catalent Inc.

Large Molecules Drug Substance CDMO Market Leaders

  1. Thermo Fisher Scientific Inc.

  2. Eurofins Scientific

  3. Wuxi Biologics

  4. Samsung Biologics

  5. Catalent, Inc.

  6. *Disclaimer: Major Players sorted in no particular order
Large Molecules Drug Substance CDMO Market Concentration
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Large Molecules Drug Substance CDMO Market News

  • February 2024: Eurofins CDMO Alphora established a state-of-the-art pilot-scale biologics development facility. Eurofins CDMO Alphora Inc. successfully combined its expertise in API and HPAPI with comprehensive biologics capabilities through the completion of its biologics pilot scale facility.
  • September 2023: Samsung Biologics reported a new agreement with Bristol Myers Squibb for large-scale manufacturing of a Bristol Myers Squibb commercial antibody cancer drug substance.

Large Molecules Drug Substance CDMO Market Report - Table of Contents

1. INTRODUCTION

  • 1.1 Study Assumptions and Market Definitions
  • 1.2 Scope of the Study

2. RESEARCH METHODOLOGY

3. EXECUTIVE SUMMARY

4. MARKET DYNAMICS

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Increasing Large Molecule Drug Approvals
    • 4.2.2 Rising Incidence Of Infectious Diseases and Increasing Demand for Biologics and Biosimilars
    • 4.2.3 Rising R&D Investment by The Pharmaceutical for Large Molecules
  • 4.3 Market Restraints
    • 4.3.1 Stringent Government Regulations
    • 4.3.2 Compliance Issues with Outsourcing
  • 4.4 Porter's Five Forces Analysis
    • 4.4.1 Bargaining Power of Suppliers
    • 4.4.2 Bargaining Power of Buyers/Consumers
    • 4.4.3 Threat of New Entrants
    • 4.4.4 Threat of Substitute Products
    • 4.4.5 Intensity of Competitive Rivalry

5. MARKET SEGMENTATION (Market Size by Value – USD)

  • 5.1 By Service
    • 5.1.1 Contract Manufacturing
    • 5.1.1.1 Clinical
    • 5.1.1.2 Commercial
    • 5.1.2 Contract Development
    • 5.1.2.1 Cell Line Development
    • 5.1.2.2 Process Development
  • 5.2 By Sources
    • 5.2.1 Mammalian
    • 5.2.2 Microbial
    • 5.2.3 Others
  • 5.3 By End User
    • 5.3.1 Biotech Companies
    • 5.3.2 Research Institutes
    • 5.3.3 Others
  • 5.4 Geography
    • 5.4.1 North America
    • 5.4.1.1 United States
    • 5.4.1.2 Canada
    • 5.4.1.3 Mexico
    • 5.4.2 Europe
    • 5.4.2.1 United Kingdom
    • 5.4.2.2 Germany
    • 5.4.2.3 France
    • 5.4.2.4 Spain
    • 5.4.2.5 Italy
    • 5.4.2.6 Rest of Europe
    • 5.4.3 Asia Pacific
    • 5.4.3.1 India
    • 5.4.3.2 Japan
    • 5.4.3.3 China
    • 5.4.3.4 Australia
    • 5.4.3.5 South Korea
    • 5.4.3.6 Rest of Asia Pacific
    • 5.4.4 Middle East and Africa
    • 5.4.4.1 GCC
    • 5.4.4.2 South Africa
    • 5.4.4.3 Rest of the Middle East and Africa
    • 5.4.5 South America
    • 5.4.5.1 Brazil
    • 5.4.5.2 Argentina
    • 5.4.5.3 Rest of South America

6. COMPETITIVE LANDSCAPE

  • 6.1 Company Profiles
    • 6.1.1 Thermo Fisher Scientific Inc.
    • 6.1.2 Eurofins Scientific
    • 6.1.3 Wuxi Biologics
    • 6.1.4 Samsung Biologics
    • 6.1.5 Catalent, Inc.
    • 6.1.6 Rentschler Biopharma Se
    • 6.1.7 Agc Biologics
    • 6.1.8 Recipharm Ab (Publ)
    • 6.1.9 Siegfried Holding AG
    • 6.1.10 Boehringer Ingelheim
    • 6.1.11 Fujifilm Diosynth Biotechnologies
  • *List Not Exhaustive

7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Subject to Availability
**Competitive Landscape Covers - Business Overview, Financials, Products and Strategies, and Recent Developments
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Large Molecules Drug Substance CDMO Industry Segmentation

As per the scope of the report, the large molecules drug substance contract development and manufacturing organization (CDMO) market refers to the pharmaceutical and biotechnology industry sector that provides outsourcing services for developing and manufacturing large molecule drugs. Large molecules typically include proteins, peptides, monoclonal antibodies, and other biologically derived substances. The CDMO market for large molecules of drug substances is segmented by service, contract development, source, and geography. By services, the market is segmented into contract manufacturing and contract development. The market is segmented by source, such as mammalian, microbial, and others. By end user, the market is segmented as biotech companies, research institutes, and other end users. The market is segmented by geography as North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report also covers the estimated market sizes and trends for 17 countries across major regions globally. The report offers the value (in USD) for the above segments.

By Service Contract Manufacturing Clinical
Commercial
Contract Development Cell Line Development
Process Development
By Sources Mammalian
Microbial
Others
By End User Biotech Companies
Research Institutes
Others
Geography North America United States
Canada
Mexico
Europe United Kingdom
Germany
France
Spain
Italy
Rest of Europe
Asia Pacific India
Japan
China
Australia
South Korea
Rest of Asia Pacific
Middle East and Africa GCC
South Africa
Rest of the Middle East and Africa
South America Brazil
Argentina
Rest of South America
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Large Molecules Drug Substance CDMO Market Research FAQs

How big is the Large Molecules Drug Substance CDMO Market?

The Large Molecules Drug Substance CDMO Market size is expected to reach USD 12.10 million in 2025 and grow at a CAGR of 8.60% to reach USD 18.28 million by 2030.

What is the current Large Molecules Drug Substance CDMO Market size?

In 2025, the Large Molecules Drug Substance CDMO Market size is expected to reach USD 12.10 million.

Who are the key players in Large Molecules Drug Substance CDMO Market?

Thermo Fisher Scientific Inc., Eurofins Scientific, Wuxi Biologics, Samsung Biologics and Catalent, Inc. are the major companies operating in the Large Molecules Drug Substance CDMO Market.

Which is the fastest growing region in Large Molecules Drug Substance CDMO Market?

Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).

Which region has the biggest share in Large Molecules Drug Substance CDMO Market?

In 2025, the North America accounts for the largest market share in Large Molecules Drug Substance CDMO Market.

What years does this Large Molecules Drug Substance CDMO Market cover, and what was the market size in 2024?

In 2024, the Large Molecules Drug Substance CDMO Market size was estimated at USD 11.06 million. The report covers the Large Molecules Drug Substance CDMO Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Large Molecules Drug Substance CDMO Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.

Large Molecules Drug Substance CDMO Industry Report

Statistics for the 2025 Large Molecules Drug Substance CDMO market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Large Molecules Drug Substance CDMO analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.