Knock out Mouse Model Market - Growth, Trends, COVID-19 Impact, and Forecasts (2022 - 2027)

The Knock out Mouse Model market is segmented by Type (Constitutive Knockout Mouse, Conditional Knockout Mouse, Protein Function Knockout Mouse), Application, End-User and Geography

Market Snapshot

Knock Out Mouse Model Market Size
Study Period: 2018 - 2026
Base Year: 2021
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 5.2 %
Knock Out Mouse Model Market Key Players

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Market Overview

The Knock Out Mouse Model Market Size is projected to register a CAGR of 5.2% during the forecast period.

Factors that are driving the Knockout Mouse market growth include increasing development of novel and innovative drugs and medical devices, rising demand for personalized medicine, and rise in the advancements of gene editing tools.

Additionally, Knockout Mouse market is expanding, with the increase in R&D activities in pharmaceutical industries. These mice models are being used in many applications, such as oncology studies, immunology and inflammation studies, central nervous system studies (anxiety and other disorders), cardiovascular studies, and diabetes studies..

According to World Health Organization, in 2017 and 2018, the number of approved New Molecular Entity Drugs (NMEs) & New Biologics (New BLAs).increased to 46 and 59, respectively, compared to 45 in 2015. In 2018, 19 of the 59 novel approved drugs were considered first-in-class, 34 received orphan designation for treating rare diseases, and 24 received fast-track designation, as they are intended for serious conditions with unmet medical needs.

However, alternatives to animal testing and regulations for the ethical use of animals are the major factors that are restraining the growth of the Knock out Mouse Model market.

Scope of the Report

As per the Scope, a knockout mouse is a laboratory mouse in which one or more genes have been turned off or knocked out in order to develop a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. Knockout mice are used to study alterations and functions in an organism when a particular gene is absent. Studying knockout mice can provide information about how the knocked-out gene normally functions, including the gene's biochemical, developmental, physical, and behavioral roles. Knockout mouse are often used to discover the functions of human genes and to study human diseases.

By Type
Constitutive Knockout Mouse
Conditional Knockout Mouse
Protein Function Knockout Mouse
By Application
Other Applications
By End-User
Clinical Research Organizations
Pharma & Biotechnology Companies
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle East and Africa
South Africa
Rest of Middle East and Africa
South America
Rest of South America

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Key Market Trends

Constitutive Knockout Mouse segment Holds Significant Share in Knock out Mouse Model Market

A constitutive Knockout mouse is also called as conventional or whole-body Knockout mouse. A constitutive Knockout mouse is a mouse model in which the target gene is permanently inactivated in the whole animal, in every cell of the organism. This gene inactivation is achieved at all stages of development, from the one-cell embryo stage through adulthood.

A constitutive Knockout mouse is used to determine main functions of the gene or protein, to study human pathologies caused by gene inactivation or deficiency, induce a phenotype to create a disease model or in vivo research tool.

Some of the disadvantages of this model are that it causes embryonic lethality in about 15% of all cases and may modify the animal physiology, adaptation and compensation mechanisms, resulting in false results.

Additionally, strategic initiatives adopting by the market players such as product launches, partnerships and collaborations are likely to drive the segments growth.

In November 2019, Envigo RMS LLC signed an agreement to acquire the assets of the research models business unit of Horizon Discovery Group plc.

rising pharmaceutical investment and expenditure is augmenting the demand for the knock out mouse models which is contributing to the market growth.

Knock Out Mouse Model Market Trends

North America dominate the Global Knock out Mouse Model Market

North America is expected to dominate the market share with its well-established healthcare infrastructure, better regulatory framework, and government support and presence of many large biotechnological and bio pharmaceutical firms in the developed countries like United States and Canada.

These companies are highly focused on new drug and biologics development, with continuous support from the government in the form of funding from several government bodies and investors, which fuels the growth of this market.

According to the UNESCO Science Report, ‘the USA carries out 46% of global research and development (R&D) in life sciences, making it as the global leader. As R&D activities are increasing, an increased usage of animal models, such as mice, for research is expected.

In 2016, The Jackson Laboratory a company based in United States received USD 28.3 million funding for over 5 years from the NIH to the second phase of its Knockout Mouse Production and Phenotyping Project (KOMP2).

Knock Out Mouse Model Market Growth

Competitive Landscape

Global Knock out Mouse Model market is made up of a network of players involved in research and product development, component manufacturing, distribution and sales, and post-sale services. Key developments in the market include in April 2017, Envigo launched the “R2G2” a RG double knockout model, was created by backcrossing the common gamma chain gene mutation (IL2RG) on to a unique C57BL/6 and 129 mixed background mouse with a mutation in the recombination activating gene 2 (Rag2).

Table of Contents


    1. 1.1 Study Deliverables

    2. 1.2 Study Assumptions

    3. 1.3 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Rise in the Advancements of Gene Editing Tools

      2. 4.2.2 Growing Research and Development activities by Pharmaceutical and Biopharmaceutical Companies

      3. 4.2.3 Rising Demand for Personalized Medicine

    3. 4.3 Market Restraints

      1. 4.3.1 Alternatives to Animal Testing

      2. 4.3.2 Regulations for the Ethical Use of Animals

    4. 4.4 Porter's Five Force Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry


    1. 5.1 By Type

      1. 5.1.1 Constitutive Knockout Mouse

      2. 5.1.2 Conditional Knockout Mouse

      3. 5.1.3 Protein Function Knockout Mouse

    2. 5.2 By Application

      1. 5.2.1 Oncology

      2. 5.2.2 Neurology

      3. 5.2.3 Cardiovascular

      4. 5.2.4 Other Applications

    3. 5.3 By End-User

      1. 5.3.1 Clinical Research Organizations

      2. 5.3.2 Pharma & Biotechnology Companies

      3. 5.3.3 Others

    4. 5.4 Geography

      1. 5.4.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.4.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.4.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.4.4 Middle East and Africa

        1. GCC

        2. South Africa

        3. Rest of Middle East and Africa

      5. 5.4.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 Charles River Laboratories International Inc.

      2. 6.1.2 Cyagen Biosciences.

      3. 6.1.3 Envigo

      4. 6.1.4 genOway

      5. 6.1.5 Ozgene Pty Ltd.

      6. 6.1.6 Taconic Biosciences, Inc.


      8. 6.1.8 TRANS GENIC INC.

    2. *List Not Exhaustive

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies, and Recent Developments

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Frequently Asked Questions

The Knock out Mouse Model Market market is studied from 2018 - 2026.

The Knock out Mouse Model Market is growing at a CAGR of 5.2% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2021.

Envigo, genOway, Cyagen Biosciences, Charles River Laboratories International Inc., TRANS GENIC INC. are the major companies operating in Knock out Mouse Model Market.

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