Cell Surface Markers Detection Market - Growth, Trends, COVID-19 Impact, and Forecasts (2021 - 2026)

The Cell Surface Markers Detection Market is segmented by Products (Flow Cytometry, Hematology Analyzers, Cell Imaging Systems, Reagents and Kits, and Other Products), Applications (Disease Diagnosis and Identification, Research and Drug Discovery and Other Applications), and Geography (North America, Europe, Asia-Pacific, Middle-East and Africa, and South America).

Market Snapshot

Cell Surface Markers Detection Picture 1
Study Period: 2018- 2026
Base Year: 2020
Fastest Growing Market: Asia-Pacific
Largest Market: North America
CAGR: 8.2 %

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Market Overview

The cell surface markers detection market was estimated to register a CAGR of 8.2% during the forecast period.

The COVID-19 pandemic is expected to have a significant impact on the market. Cell surface markers refer to carbohydrates and proteins that are attached to the cell membrane, thus, allowing cell surface markers to play a crucial role in intercellular signaling. Many research projects are being carried out that involve the interaction of COVID-19 antibodies with cell surface markers. For example, in February 2021, a research article titled 'COVID-19 Impairs Immune Response to Candida Albicans' was published in Frontiers in Immunology. The research paper studied and compared the cell surface marker expression on the monocytes of COVID-19 patients with healthy controls. The study found an increased rate of fungal coinfections during COVID-19 in patients. The rate of secondary fungal infections increases in many COVID-19 patients due to their decrease in immunity. Thus, the use of cell surface markers to study fungal infection is expected to boost growth. Such initiatives help to drive a better understanding of the disease leading to innovative ways to find a cure. More such research projects are being conducted across the globe, where cell surface markers are used to study the effect of COVID-19. Thus, developments such as these are expected to boost market growth.

The major factors that are driving the market growth include the increasing demand for precision medicine, increased use of diagnostics, and technological advances related to increased throughput and automation. For example, over 200 cell-surface markers have been identified as being overexpressed in lung cancers. These include markers like Cytokeratin fragment 21-1 and EGFR gene mutation. Diagnostic procedures are used to detect the presence of tumor cells in the blood through these markers. An increase in the number of cancer cases worldwide is expected to positively impact the demand for biomarkers, thus boosting the growth of the cell surface markers detection market. For instance, according to the Globocan 2020 report, the total number of breast cancer in 2020 was 2,261,419, followed by lung cancer at 2,206,771 cases and prostate cancer at 1,414,259 cases. Since cell surface markers serve as monograms to help identify and classify cells, the proteins expressed on the surface of cancerous cells serve as markers of specific tumor types. This molecule identification helps in disease diagnoses, to find direct treatment for the disease, drug discovery, and has many other uses. This is expected to boost the market growth. There are many companies that are involved in marker preparation which is likely to boost the market growth. For instance, Becton, Dickinson, and Company manufacture the BD Lyoplate Human Cell Surface Marker Screening Panel for use in research laboratories. The BD Lyoplate Human Cell Surface Marker Screening panel can be used for screening primary cells or tissues and cell lines, and it is compatible for use with flow cytometry and bioimaging technology platforms. Such innovative products with a wide variety of applications are expected to boost the market growth.

Scope of the Report

Cell surface markers detection refers to the separation of fluorescent cells by various processes such as flow cytometry. As per the scope of this report, cell surface markers detection refers to the separation and identification of target cells by using analytical methods. The cell surface markers detection market is segmented by products (flow cytometry, hematology analyzers, cell imaging systems, reagents and kits, and other products), applications (disease diagnosis and identification, research and drug discovery and other applications), and geography (North America, Europe, Asia-Pacific, Middle-East and Africa, and South America). The report offers the value (in USD million) for the above segments.

Flow Cytometry
Hematology Analyzers
Cell Imaging Systems
Reagents and Kits
Other Products
Disease Diagnosis and Identification
Research and Drug Discovery
Other Applications
North America
United States
United Kingdom
Rest of Europe
South Korea
Rest of Asia-Pacific
Middle-East and Africa
South Africa
Rest of Middle-East and Africa
South America
Rest of South America

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Key Market Trends

Flow Cytometry Segment is Expected to Grow at the Fastest Rate

The flow cytometry technique is used to detect the presence of cell types within a population. It is conducted by passing single cells through a highly focused laser. Antibodies that are specific to cell surface markers of interest are added to a sample and are then allowed to bind with the cells. These antibodies are coupled with fluorochromes which have a characteristic of emitting light at various wavelengths. The cell population is then passed through a laser, and the process excites the fluorochromes and captures the light that is emitted. The cells can then be subsequently sorted into subpopulations based on the markers present through a series of histograms, and dot plots called a gating strategy. Cell surface markers expressed on the cell surface can be used to define cell subtypes and function when they are labeled with fluorescent-labeled antibodies and analyzed by flow cytometry. Clinical flow cytometry has the capacity to identify and quantify intracellular proteins associated with immune function. Cell surface-based flow cytometry is able to detect rare events. Thus it is used extensively for detecting stem cells or cancerous cells. For example, cell surface-based flow cytometry can be used to detect CD341 hematopoietic stem cells in peripheral blood under resting conditions. It can also be used to evaluate minimal residual disease in patients with hematologic malignancy, such as hairy cell leukemia.

The role of flow cytometry has broadened to include the study of immune system disorders, including primary immunodeficiency disorders, by using cell surface markers. For instance, cell-surface staining by using flow cytometry is often used for investigating lymphocyte clonality. T-cell clonality studies are particularly useful in the evaluation of primary immunodeficiency disorders associated with a restricted T-cell. According to a study titled, 'Flow cytometry: Surface markers and beyond' published in JACI Online in 2019, the application of flow cytometry as a clinical laboratory method has evolved from the identification of cell-surface markers to characterizing intracellular proteins and providing multiple different approaches to assess immune function and characterizing and diagnosing immunologic disorders. Flow cytometry is used extensively in diagnosing cancer. Since the countries with a high Human Development Index (HDI) invest more in healthcare, there is a greater number of cancer diagnostic tests that are conducted, and more cancer cases are detected in these countries (International Agency for Research on Cancer, 2020). This is likely to boost the market growth.

Trend 1

North America Dominates the Market and is Expected to Retain its Market Share During the Forecast Period

The North American region is the largest market for cell surface markers. Rapidly growing applications in disease diagnostics, the presence of well-established research institutions, and the biotech industry are primary reasons behind the large market size. The United States currently dominates the market for cell surface marker detection in North America and is expected to continue its stronghold for a few more years. High healthcare expenditure, a high technological adaptation rate, and an increasing focus on precise and timely diagnostics are driving the market growth in the United States. The United States has many companies operating in this sector, due to which demand from the country is expected to be robust during the forecast period. Some of the United States-specific companies include Nexcelom Bioscience LLC, Cofactor Genomics Inc., Abbott Laboratories, Beckman Coulter Inc., and many others. The increased product launches by these players are expected to boost the market growth. For example, in November 2020, Bio-Rad Laboratories, Inc., a United States-based research and clinical diagnostic company, launched three StarBright Dyes specifically developed for flow cytometry. The dyes include StarBright Blue 700, StarBright Violet 440, and StarBright Violet 610, and they are fluorescent nanoparticles that are conjugated to Bio-Rad’s flow antibodies, providing maximal brightness and improved resolution. They can be used for detecting surface proteins in market detection. Initiatives like these by major players are likely to boost growth.

Cell Surface Markers Detection Market - Growth Rate by Region

Competitive Landscape

The cell surface markers detection market is comprised of many global players, especially on the instrument front. These companies include Becton, Dickinson and Company, Nihon Kohden Corporation, Luminex Corporation, Sysmex Corporation, and Thermo Fisher Scientific Inc., among others. Several biotech startups, however, are active in the reagent, consumables, and other niche fields. There is an ongoing trend of further consolidation, with the acquisition of new technology being a major focus. There are also some instances of acquisition of product lines and brands between key market participants.

Recent Developments

In October 2020, Becton, Dickinson and Company, announced that it had received 510(k) clearance from the United States Food and Drug Administration (FDA) for the BD FACSLyric Flow Cytometer with the integrated BD FACSDuet Sample Preparation System.

In June 2020, Sysmex America Inc. announced the launch of its XF-1600 flow cytometer that provides laboratories with improved flexibility and efficiency for a wide range of applications.

Table of Contents


    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study




    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Increased Use in Diagnostics

      2. 4.2.2 Technological Advances Related to Increased Throughput and Automation

      3. 4.2.3 Increasing Demand for Precision Medicine

    3. 4.3 Market Restraints

      1. 4.3.1 High Cost of Instruments

      2. 4.3.2 Complexity of Techniques

    4. 4.4 Porter's Five Forces Analysis

      1. 4.4.1 Threat of New Entrants

      2. 4.4.2 Bargaining Power of Buyers/Consumers

      3. 4.4.3 Bargaining Power of Suppliers

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry


    1. 5.1 Product

      1. 5.1.1 Flow Cytometry

      2. 5.1.2 Hematology Analyzers

      3. 5.1.3 Cell Imaging Systems

      4. 5.1.4 Reagents and Kits

      5. 5.1.5 Other Products

    2. 5.2 Application

      1. 5.2.1 Disease Diagnosis and Identification

      2. 5.2.2 Research and Drug Discovery

      3. 5.2.3 Other Applications

    3. 5.3 Geography

      1. 5.3.1 North America

        1. United States

        2. Canada

        3. Mexico

      2. 5.3.2 Europe

        1. Germany

        2. United Kingdom

        3. France

        4. Italy

        5. Spain

        6. Rest of Europe

      3. 5.3.3 Asia-Pacific

        1. China

        2. Japan

        3. India

        4. Australia

        5. South Korea

        6. Rest of Asia-Pacific

      4. 5.3.4 Middle-East and Africa

        1. GCC

        2. South Africa

        3. Rest of Middle-East and Africa

      5. 5.3.5 South America

        1. Brazil

        2. Argentina

        3. Rest of South America


    1. 6.1 Company Profiles

      1. 6.1.1 Abbott Laboratories

      2. 6.1.2 Danaher Corporation (Beckman Coulter, Inc)

      3. 6.1.3 Becton, Dickinson and Company

      4. 6.1.4 Bio Rad Laboratories Inc.

      5. 6.1.5 F. Hoffmann-La Roche Ltd

      6. 6.1.6 Luminex Corporation

      7. 6.1.7 Nihon Kohden Corporation

      8. 6.1.8 Qiagen NV

      9. 6.1.9 Siemens Healthineers

      10. 6.1.10 Thermo Fisher Scientific Inc.

      11. 6.1.11 Grifols SA

      12. 6.1.12 Johnson & Johnson (Janssen Diagnostics BVBA)

      13. 6.1.13 Immucor Inc.

      14. 6.1.14 F. Hoffmann-La Roche Ltd

      15. 6.1.15 Sysmex Corporation

    2. *List Not Exhaustive

**Subject to Availability
**Competitive Landscape Covers - Business Overview, Financials, Products and Strategies, and Recent Developments

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Frequently Asked Questions

The Cell Surface Markers Detection Market market is studied from 2018 - 2026.

The Cell Surface Markers Detection Market is growing at a CAGR of 8.2% over the next 5 years.

Asia-Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2020.

Becton, Dickinson and Company, Luminex Corporation, Thermo Fisher Scientific, Inc., Nihon Kohden Corporation, Sysmex Corporation are the major companies operating in Cell Surface Markers Detection Market.

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