Aptamers Market - Growth, Trends , COVID-19 Impact , and Forecasts (2021 - 2026)

Market Overview

The Aptamers Market is expected to register a CAGR of 18.5% over the forecast period.

Globally, COVID-19 is an intractable health challenge resulting in an aberrant rate of morbidity and mortality. The mode of entry for SARS-CoV-2 into host cells occurs through clathrin-mediated endocytosis. As part of the efforts to mitigate COVID-19 infections, rapid and accurate detection methods, as well as vaccine and drug designs with SARS-CoV-2 targeting capabilities are critically needed. According to a research study by Caleb Acquah et al., published in Cellular and Molecular Bioengineering Journal, January 2021, globally, there is an urgent need to develop safe innovative biomedical technologies to mitigate the direct impact of COVID-19 on public health. Moreover, research advances into aptameric systems bode well with the fact that they can be engineered for the development of effective and affordable diagnostics, therapeutics, and prophylactic vaccines for SARS-CoV-2 and other infectious pathogens. Furthermore, according to a research study by Vamkudoth Koteswara Rao et al., published in Frontiers in Nanotechnology Journal, February 2021, the study results found that aptamer-based detection is the most specific, inexpensive, and rapid detection of COVID-19 without laboratory tools. In addition, more than 900 SARS-nCoV-2 test kits are in pipeline and a few test kits are developed using Aptamer technology.

Some of the factors that are driving the market growth include high advantage of aptamers compared to antibodies, advancements in the field of aptamer development technologies and growing investment in the companies and research institutes.

Numerous advantages offered by these small molecules, in comparison to established antibodies, have also led to higher demand for these molecules across a diverse range of medical applications. They are chemically synthesized, which eliminates batch-to-batch variation and demands less time for development. Along with this, continuous advancement in technologies is expected to stimulate market growth. According to a research study by Geanina Ștefan et al., published in Electrochimica Acta Journal April 2021, the study results found that aptamers have come into the spotlight as bio-mimetic molecular recognition elements in the field of biomedicine due to various applications in diagnostics, drug delivery, therapeutics, and pharmaceutical analysis. Aptamers are composed of nucleic acid strands (DNA or RNA) that can specifically interact in a three-dimensional tailored design with the target molecule.

The market players are adopting various strategies such as product launches, developments. collaborations, partnerships, and expansions to increase market share. For instance, in August 2020, Aptamer Sciences Inc., in co-operation with POSTECH, discovered a number of aptamers that specifically bind to the COVID-19 spike protein using ViroSELEX technology, a unique aptamer discovery technology, and applied for a material patent. However, many aptamers have failed to meet the requisite safety and efficacy standards in clinical studies. Thus, companies had to terminate their clinical investigation during late-stage clinical studies. This factor is likely to affect the growth of this market negatively. In addition, other factors, such as unfavorable pharmacokinetic properties of aptamers and low awareness level and incomplete regulatory policies, may hamper the overall market growth.

Scope of the Report

As per the scope of the report, aptamers are short, single-stranded DNA or RNA (ssDNA or ssRNA) molecules, which can selectively bind to a specific target, including peptides, proteins, small molecules, carbohydrates, toxins, and even live cells. Aptamers assume various shapes, owing to their tendency to form helices or single-stranded loops. These molecules are extremely versatile and are used to bind targets with high specificity and selectivity. The aptamers market is segmented by Type (Nucleic Acid and Peptide), Application (Diagnostics, Therapeutics, Research and Development, and Other Applications), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions globally. The report offers the value (in USD million) for the above segments.

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Key Market Trends

Diagnostics Segment is Expected to Witness a Healthy Growth Rate Over the Forecast Period

Appropriate diagnosis is the most crucial factor for the treatment of diseases, especially viral diseases. Over the past few years, aptamer technology has observed a significant rise in its demand and usage all across the world. It has been used in a wide range of diagnostic as well as therapeutic applications, and several strategies are currently being explored, in a definitive or conclusive way, using aptamers against virus proteins.

The outbreak of COVID-19 and lack of specific treatment and gold-standard diagnostic system for diagnosis has made the situation more complicated. Efforts have led to the production of several diagnostic kits that are associated with limitations such as accuracy and inadequate sensitivity. Aptamers are considered as multipotent biological probes that could be promising candidates to design sensitive and specific biosensors. Moreover, few studies have introduced specific aptamer types of coronavirus, that may help to select the best approach to obtain specific aptamers for the SARS-CoV-2 virus. For instance, according to a research study by Raheleh Torabi et al., published in Molecular and Cellular Probes Journal, October 2020, the study results found that helicase enzyme has an important role in viral replication and proliferation. Therefore, it could be considered as a potent target to develop the coronavirus therapeutic aptamers. N protein could be also a potent target to detect and inhibit COVID-19 due to its crucial role in the synthesis of viral RNA and SARS detection. By applying aptamers as sensitive diagnostic elements, it will be able to fabricate rapid, sensitive, low-cost, and user-friendly diagnostic tools of small volume clinical samples.

In addition, according to a research study by Sapna Devi et al., published in Saudi Journal of Biological Sciences May 2021, Aptamer (oligonucleotide or short peptides) that can specifically bind to target molecules have increasingly become popular in developing biosensors for sensitive detection of analytes, pathogens (bacteria, virus, fungus, prions), drug residues, toxins, and cancerous cells. Thus, aptamers were found to be successful in in-vivo application in disease diagnosis. From a diagnostic point of view, aptamers are presently being designed as a bio-recognition element in a variety of diagnostic systems to detect viral proteins, either in the blood (serum or plasma) or the infected cells.

The market players are adopting various strategies such as product launches, developments. collaborations, partnerships, and expansions to increase market share. For instance, in September 2020, Aptamer Group and Cytiva entered into a new collaboration agreement to produce a rapid test for the COVID-19 infection. In addition, in June 2020, in South Korea, Aptamer Sciences Inc., launched a non-small cell lung cancer risk test which is the world's first diagnostic kit to apply aptamer technology, and it is expected to help increase the rate of an early lung cancer diagnosis with convenience and high accuracy. Hence, the above-mentioned factors are expected to drive the segment growth over the forecast period.

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