Protein Sequencing Market Size & Share Analysis - Growth Trends & Forecasts (2025 - 2030)

The Protein Sequencing Market Report Segments the Industry Into by Products and Services (Instruments, Reagents and Consumables, Softwares and Services), Application (Biomarker Discovery, Protein Engineering Studies, and More), End User (Pharmaceutical Companies, and More), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, South America). The Market Forecasts are Provided in Terms of Value (USD).

Protein Sequencing Market Size and Share

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Compare market size and growth of Protein Sequencing Market with other markets in Healthcare Industry

Protein Sequencing Market Analysis by Mordor Intelligence

The Protein Sequencing Market size is estimated at USD 1.67 billion in 2025, and is expected to reach USD 2.08 billion by 2030, at a CAGR of 4.51% during the forecast period (2025-2030).

Demand growth reflects an ecosystem shift from classical mass-spectrometry workflows toward single-molecule approaches that reveal protein variants and post-translational modifications in real time. Pharmaceutical companies deepen adoption to accelerate target validation, while Contract Research Organizations (CROs) capture incremental outsourcing budgets. Platform developers bundle instruments with consumables and analytics software, turning reagent sales into recurring revenue streams that cushion price pressure on hardware. North America retains spending leadership through entrenched R&D infrastructure, yet Asia-Pacific outpaces all regions in growth as local biopharma investment rises and regulatory pathways align with global norms.

Key Report Takeaways

  • By products & services, software & services held 38.83% revenue share in 2024; reagents & consumables is expanding at a 7.63% CAGR through 2030.
  • By application, biotherapeutics quality control & discovery captured 36.61% of protein sequencing market share in 2024, while synthetic biology & cell-free systems is projected to climb at a 12.32% CAGR to 2030.
  • By end user, pharmaceutical companies commanded 53.78% share of the protein sequencing market size in 2024, whereas CROs record the fastest 8.59% CAGR during the forecast period.
  • By geography, North America led with a 43.63% share in 2024; Asia-Pacific is set to advance at an 8.83% CAGR to 2030.

Segment Analysis

By Products & Services: Software Integration Drives Platform Adoption

The segment generated the largest contribution to the protein sequencing market in 2024, with Software & Services accounting for 38.83% of revenue. Instruments remain essential, but value increasingly migrates to cloud analytics subscriptions that translate complex spectra into actionable readouts. Growth accelerates in Reagents & Consumables, which expand at a 7.63% CAGR as single-molecule workflows rely on branded chips and chemistry kits. Integrated ecosystems create vendor lock-in that stabilises recurring turnover and underpins predictable cash flows for suppliers.

Customers now prioritise end-to-end solutions that bundle assay kits, AI algorithms, and workflow automation. Developers embed real-time quality metrics and adaptive chemistries, shortening run times and reducing failed experiments. Over the forecast window, instrument margins may compress as competition rises, while software-as-a-service models and reagent volumes sustain profitability. As a result, the protein sequencing market is expected to experience a broader shift toward service-centred revenue without diluting ongoing hardware innovation.

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Note: Segment shares of all individual segments available upon report purchase

By Application: Synthetic Biology Emerges as Growth Engine

Synthetic Biology & Cell-free Systems is the fastest-expanding use case, growing at 12.32% CAGR and steadily enlarging its share within the protein sequencing market. Demand is driven by rapid prototyping of therapeutic enzymes and vaccine antigens, which benefit from cell-free platforms that bypass cloning cycles and expedite functional testing. Biotherapeutics Quality Control & Discovery preserved the leading 36.61% share due to regulatory mandates for sequence confirmation and impurity profiling across monoclonal antibodies, fusion proteins, and bispecific formats.

Breakthroughs in enzyme engineering demonstrate why single-molecule accuracy matters: computational redesign achieved 100-fold catalytic gains relative to earlier AI-guided efforts, validating proteome sequencing as a critical feedback tool. Growing sensitivity further enables biomarker discovery in oncology and neurodegeneration, extending the technology’s impact into clinical diagnostics. Overall, the protein sequencing market size for application segments exhibits a characteristic barbell pattern, pairing steady demand in quality control with outsized growth from synthetic biology.

By End User: CROs Capitalize on Outsourcing Trends

Pharmaceutical companies retained a dominant 53.78% share of the protein sequencing market in 2024, underpinned by pipeline breadth and budget size. Yet CROs register the quickest 8.59% CAGR as they absorb tasks that require specialised personnel and high-capex instruments. This shift reflects internal cost-containment priorities and the desire for variable rather than fixed R&D expenditure.

Academic institutes extend capabilities through shared core facilities but frequently partner with CROs for large-scale studies, mirroring biopharma’s outsourcing behaviour. Biotechnology startups leverage CRO-led services to access proteomics early without spending scarce venture capital on equipment. Over time, the market may bifurcate between integrated R&D giants with in-house platforms and a services layer that blankets smaller innovators. Both cohorts, however, will continue to drive reagent consumption and software utilisation, sustaining expansion of the overall protein sequencing market.

Market Share by End User
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Note: Segment shares of all individual segments available upon report purchase

Geography Analysis

North America generated 43.63% of revenue in 2024, benefiting from deep venture capital pools, corporate R&D clustering, and established regulatory pathways. Leading suppliers such as Thermo Fisher Scientific and Quantum-Si operate extensive manufacturing and support networks that reinforce regional dominance. Nevertheless, high labour and operational costs temper incremental growth, resulting in a mid-single-digit CAGR across the outlook period.

Asia-Pacific is the fastest mover with an 8.83% CAGR, propelled by government initiatives that underwrite local biomanufacturing capacity and streamline ethics review for multi-centre studies. China finances large-scale biotechnology parks, while Japan, South Korea, and India expand academic-industry collaborations. The influx of multinational clinical trials stimulates demand for high-throughput proteomics, enlarging the regional protein sequencing market.

Europe exhibits steady progress, anchored by long-standing proteomics centres and pan-EU funding mechanisms such as Horizon Europe. Harmonised documentation standards facilitate cross-border sample exchange, which enables consortium-driven discovery efforts. Markets in South America, the Middle East, and Africa remain emergent but show promise as diagnostics programmes expand and public health agencies recognise the value of protein-level surveillance. Collectively, geographic diversification cushions suppliers against cyclical spending patterns and broadens the global protein sequencing market footprint.

Growth Rate by Region
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Competitive Landscape

The competitive field features a mix of diversified instrument vendors and venture-backed specialists. Thermo Fisher’s USD 3.1 billion purchase of Olink in 2024 extended its reach into proximity-based protein assays and signalled rising consolidation among incumbents. Agilent, Waters, and Bruker defend share through incremental mass-spectrometry upgrades and bundled informatics. Emerging entrants including Quantum-Si, Encodia, and Erisyon focus on semiconductor chips, fluorescent barcodes, or time-of-flight nanopore readouts that promise single-molecule precision.

Strategic alliances proliferate: Quantum-Si signed distribution pacts with Avantor to widen laboratory access across North America. Meanwhile, AI platform providers court hardware makers to embed predictive algorithms directly within run control software, sharpening competitive differentiation. Price competition intensifies in mid-throughput instruments where multiple players now offer comparable specifications. Yet high-end single-molecule systems remain differentiated by chemistry fidelity, throughput, and ecosystem maturity, giving first movers a defensible moat.

Going forward, success will hinge on integrated value propositions that knit instruments, reagents, and cloud analytics into cohesive user experiences. Suppliers able to flatten learning curves and lower total cost of ownership are poised to capture incremental share. Venture funding momentum and technological breakthroughs suggest additional mergers or strategic partnerships as companies seek scale and complementary capabilities within the protein sequencing market.

Protein Sequencing Industry Leaders

  1. Agilent Technologies, Inc.

  2. SGS SA

  3. Shimadzu Corporation

  4. Thermo Fisher Scientific Inc.

  5. Selvita SA

  6. *Disclaimer: Major Players sorted in no particular order
Protein Sequencing Market Concentration
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Recent Industry Developments

  • June 2025: Formation Bio announced the launch of its AI tool Muse in partnership with OpenAI and Sanofi to accelerate drug development, particularly for multiple sclerosis treatments, leveraging generative AI for protein mapping and creation. The partnership represents a significant advancement in AI-driven protein design capabilities.
  • May 2025: Quantum-Si reported 84% revenue increase in Q1 2025 compared to Q1 2024, demonstrating strong market traction for its Next-Generation Protein Sequencing platform. The company expanded its international channel partner network to 23 partners and remains on track for successful protein sequencing on a prototype system by end of 2025.
  • January 2025: Quantum-Si launched the Platinum Pro, an advanced benchtop sequencer for enhanced protein analysis in proteomics research, featuring an enlarged touchscreen interface and Pro Mode for custom application development. The system shipped in Q1 2025 with distribution partnership through Avantor for the U.S. and Canada markets.
  • January 2025: UK Biobank launched the world's largest proteomics study, analyzing up to 5,400 proteins across 600,000 samples with funding from 14 biopharmaceutical companies. The study will combine proteomic data with genetic and imaging information to facilitate AI model development for disease prediction.

Table of Contents for Protein Sequencing Industry Report

1. Introduction

  • 1.1 Study Assumptions & Market Definition
  • 1.2 Scope of the Study

2. Research Methodology

3. Executive Summary

4. Market Landscape

  • 4.1 Market Overview
  • 4.2 Market Drivers
    • 4.2.1 Rising Prevalence of Chronic Diseases
    • 4.2.2 Advancements in Sequencing Technologies
    • 4.2.3 Growing Focus on Target-Based Drug Development
    • 4.2.4 Increased R&D Funding in Proteomics
    • 4.2.5 Expanding Applications in Biotherapeutics and Biomarker Discovery
    • 4.2.6 Decreasing Cost of Sequencing Services
  • 4.3 Market Restraints
    • 4.3.1 High Cost of Instruments and Services
    • 4.3.2 Complexity of Data Interpretation
    • 4.3.3 Regulatory Hurdles
    • 4.3.4 Limited Standardization Across Platforms
  • 4.4 Porter’s Five Forces Analysis
    • 4.4.1 Threat of New Entrants
    • 4.4.2 Bargaining Power of Buyers
    • 4.4.3 Bargaining Power of Suppliers
    • 4.4.4 Threat of Substitutes
    • 4.4.5 Competitive Rivalry

5. Market Size & Growth Forecasts (Value in USD)

  • 5.1 By Products & Services
    • 5.1.1 Instruments
    • 5.1.1.1 Mass Spectrometry
    • 5.1.1.2 Edman Degradation Systems
    • 5.1.1.3 Single-Molecule Sequencers
    • 5.1.2 Reagents & Consumables
    • 5.1.3 Software & Services
  • 5.2 By Application
    • 5.2.1 Biomarker Discovery
    • 5.2.2 Protein Engineering Studies
    • 5.2.3 Biotherapeutics QC & Discovery
    • 5.2.4 Synthetic Biology & Cell-free Systems
    • 5.2.5 Others
  • 5.3 By End User
    • 5.3.1 Pharmaceutical Companies
    • 5.3.2 Biotechnology Firms
    • 5.3.3 Contract Research Organizations
    • 5.3.4 Academic & Research Institutes
    • 5.3.5 Others
  • 5.4 By Geography
    • 5.4.1 North America
    • 5.4.1.1 United States
    • 5.4.1.2 Canada
    • 5.4.1.3 Mexico
    • 5.4.2 Europe
    • 5.4.2.1 Germany
    • 5.4.2.2 United Kingdom
    • 5.4.2.3 France
    • 5.4.2.4 Italy
    • 5.4.2.5 Spain
    • 5.4.2.6 Rest of Europe
    • 5.4.3 Asia-Pacific
    • 5.4.3.1 China
    • 5.4.3.2 Japan
    • 5.4.3.3 India
    • 5.4.3.4 Australia
    • 5.4.3.5 South Korea
    • 5.4.3.6 Rest of Asia-Pacific
    • 5.4.4 Middle East & Africa
    • 5.4.4.1 GCC
    • 5.4.4.2 South Africa
    • 5.4.4.3 Rest of Middle East & Africa
    • 5.4.5 South America
    • 5.4.5.1 Brazil
    • 5.4.5.2 Argentina
    • 5.4.5.3 Rest of South America

6. Competitive Landscape

  • 6.1 Market Concentration
  • 6.2 Market Share Analysis
  • 6.3 Company Profiles (includes Global level Overview, Market level overview, Core Segments, Financials as available, Strategic Information, Market Rank/Share for key companies, Products & Services, and Recent Developments)
    • 6.3.1 Thermo Fisher Scientific
    • 6.3.2 Agilent Technologies
    • 6.3.3 Waters Corporation
    • 6.3.4 Bruker Corporation
    • 6.3.5 Shimadzu Corporation
    • 6.3.6 Rapid Novor
    • 6.3.7 Quantum-Si
    • 6.3.8 Encodia
    • 6.3.9 Erisyon
    • 6.3.10 Charles River Laboratories
    • 6.3.11 SGS SA
    • 6.3.12 Selvita SA
    • 6.3.13 Alphalyse
    • 6.3.14 Creative Proteomics
    • 6.3.15 Proteome Factory
    • 6.3.16 Bioinformatics Solutions
    • 6.3.17 MS Bioworks
    • 6.3.18 Allumiqs
    • 6.3.19 PPD Laboratories
    • 6.3.20 Danaher Corporation
    • 6.3.21 Protein Metrics

7. Market Opportunities & Future Outlook

  • 7.1 White-space & Unmet-Need Assessment
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Global Protein Sequencing Market Report Scope

As per the scope of this report, protein sequencing is the process of determining the amino acid sequence of all or part of a protein or peptide. These techniques are helpful in the identification of proteins and characterize their post-translational modifications. The Protein Sequencing Market is Segmented by Products and Services (Instruments (Mass Spectrometry, Edman Degradation), Reagents and Consumables Software and Services), Applications (Biomarker Discovery, Protein Engineering Studies, Biotherapeutics, and Others), End-User (Pharmaceutical & Biotechnology Companies, Research Centers, Others), Geography (North America, Europe, Asia-Pacific, Middle East and Africa, South America). The market report also covers the estimated market sizes and trends for 17 countries across major regions globally. The report offers the value (in USD million) for the above segments.

By Products & Services Instruments Mass Spectrometry
Edman Degradation Systems
Single-Molecule Sequencers
Reagents & Consumables
Software & Services
By Application Biomarker Discovery
Protein Engineering Studies
Biotherapeutics QC & Discovery
Synthetic Biology & Cell-free Systems
Others
By End User Pharmaceutical Companies
Biotechnology Firms
Contract Research Organizations
Academic & Research Institutes
Others
By Geography North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East & Africa GCC
South Africa
Rest of Middle East & Africa
South America Brazil
Argentina
Rest of South America
By Products & Services
Instruments Mass Spectrometry
Edman Degradation Systems
Single-Molecule Sequencers
Reagents & Consumables
Software & Services
By Application
Biomarker Discovery
Protein Engineering Studies
Biotherapeutics QC & Discovery
Synthetic Biology & Cell-free Systems
Others
By End User
Pharmaceutical Companies
Biotechnology Firms
Contract Research Organizations
Academic & Research Institutes
Others
By Geography
North America United States
Canada
Mexico
Europe Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle East & Africa GCC
South Africa
Rest of Middle East & Africa
South America Brazil
Argentina
Rest of South America
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Key Questions Answered in the Report

What is the current value of the protein sequencing market?

The protein sequencing market size is USD 1.67 billion in 2025 and is projected to reach USD 2.08 billion by 2030.

Which segment is expanding fastest within the market?

Synthetic Biology & Cell-free Systems leads growth with a 12.32% CAGR through 2030.

Why are Contract Research Organizations gaining ground?

CROs grow at 8.59% CAGR because they offer specialised expertise and eliminate the need for drug developers to invest in high-cost instruments.

Which region holds the largest market share?

North America accounts for 43.63% of 2024 revenue owing to entrenched R&D infrastructure and a dense supplier base.

What technology trends are reshaping the competitive landscape?

Single-molecule sequencing, AI-powered data interpretation, and integrated instrument-software ecosystems drive differentiation and vendor consolidation.

How are high instrument costs being addressed?

Vendors introduce subscription financing, reagent rental models, and cloud-based analytics bundles to lower upfront capital and operational barriers.

Page last updated on: June 19, 2025

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