Peptide Antibiotics Market Size and Share
Peptide Antibiotics Market Analysis by Mordor Intelligence
The peptide antibiotics market stood at USD 5.34 billion in 2025 and is forecast to reach USD 6.83 billion by 2030, reflecting a 5.1% CAGR over the period. Rising multidrug resistance, an expanding discovery pipeline that now contains almost 900,000 AI-identified antimicrobial peptide sequences, is accelerating product innovation.[1]Sarah Dixon, “Artificial intelligence reveals 900,000 antimicrobial peptides,” nature.com Regulatory incentives such as the FDA’s Qualified Infectious Disease Product designation extend exclusivity windows and speed approvals, improving commercial viability. Meanwhile, heavy capital deployment exemplified by CordenPharma’s EUR 900 million (USD 1,043 million) manufacturing outlay and Merck’s USD 493 million oral-delivery licensing signals sustained confidence in the peptide antibiotics market. Topical hydrogel innovations and AI-guided RiPP discovery further enlarge the addressable opportunity base, even as premium pricing and production complexity temper near-term adoption.
Key Report Takeaways
- By product type, non-ribosomal lipopeptides led with 46.1% revenue share in 2024, while ribosomal RiPPs are projected to expand at a 13.5% CAGR through 2030.
- By disease, skin infections accounted for 41.5% of the peptide antibiotics market size in 2024; hospital-acquired and ventilator-associated bacterial pneumonia are forecast to grow at a 10.2% CAGR to 2030.
- By route of administration, injectable formulations held a 70.3% share in 2024, whereas topical hydrogels are advancing at a 12.6% CAGR through 2030.
- By distribution channel, hospital pharmacies controlled 57.5% of 2024 revenues, and online pharmacies are expected to post a 14.4% CAGR between 2025 and 2030.
- By geography, North America captured 38.4% of global revenue in 2024; Asia Pacific is projected to register a 9.8% CAGR over the forecast horizon.
Global Peptide Antibiotics Market Trends and Insights
Drivers Impact Analysis
Driver | (~) % Impact on CAGR Forecast | Geographic Relevance | Impact Timeline |
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Rising Prevalence Of Multidrug-Resistant Bacterial Infections | +1.80% | Global, with highest impact in Asia Pacific and North America | Medium term (2-4 years) |
Intensifying R&D Pipeline For Ribosomal & Non-Ribosomal Peptide Antibiotics | +1.20% | North America & EU, spill-over to APAC | Long term (≥ 4 years) |
Surging Demand For Last-Resort Antibiotics In Critical Care Settings | +1.00% | Global, with acute need in ICU environments worldwide | Short term (≤ 2 years) |
Favourable Regulatory Incentives (GAIN/QIDP, Orphan Status) | +0.90% | Global, primarily US and EU markets | Short term (≤ 2 years) |
AI-Driven Genome-Mining Unlocking Novel RiPP Classes | +0.70% | Global, with early gains in US, UK, Singapore | Long term (≥ 4 years) |
Peptide-Hydrogel Delivery Platforms Expanding Topical & Implant Use-Cases | +0.60% | Global, with advanced adoption in North America and Europe | Medium term (2-4 years) |
Source: Mordor Intelligence
Rising Prevalence of Multidrug-Resistant Bacterial Infections
Carbapenem-resistant Acinetobacter baumannii now shows resistance rates above 70% in several regions, making last-line options essential. Massatide A, a fifth-class lanthipeptide, inhibits linezolid- and methicillin-resistant Staphylococcus aureus at 0.25 µg/mL, surpassing many legacy drugs. The WHO 2024 priority pathogen update highlights peptide agents as uniquely capable of bypassing conventional resistance mechanisms.[2]World Health Organization, “Antimicrobial resistance fact sheet,” who.int In intensive-care units, Stenotrophomonas maltophilia isolation rose from 7% to 15% over two decades, with ceftazidime resistance reaching 72.5%. These epidemiological shifts keep the peptide antibiotics market under constant demand pressure.
Intensifying R&D Pipeline for Ribosomal & Non-Ribosomal Peptide Antibiotics
More than 1,172 biosynthetic gene clusters for aminovinyl-cysteine peptides have been catalogued, expanding the discovery funnel. Eli Lilly’s USD 100 million (USD 115 million) AMR Action Fund commitment, coupled with its OpenAI collaboration, shows large-cap pharma pivoting toward peptide solutions. Researchers recently mined 9,601 antimicrobial peptides in Lactobacillaceae genomes, demonstrating unprecedented breadth in ribosomal candidates.[3] Rubing Du, “Uncovering Encrypted Antimicrobial Peptides in Health-Associated Lactobacillaceae by Large-Scale Genomics and Machine Learning,” Microbiome, microbiomejournal.biomedcentral.com CARB-X backing for Peptilogics underlines public-private alignment on non-ribosomal innovation. The FDA’s 2024 approval of four peptide drugs validates regulator confidence.
Favourable Regulatory Incentives (GAIN/QIDP, Orphan Status)
The FDA’s QIDP pathway grants five-year exclusivity extensions and priority reviews, accelerating launches such as AbbVie’s Emblaveo, which achieved a 76.4% cure rate in trials. EMA equivalence has smoothed European entry, with Pfizer’s aztreonam-avibactam gaining a positive CHMP opinion. The recent approval of Blujepa, the first triazaacenaphthylene inhibitor, underscores regulators' openness to novel mechanisms. BARDA funding of USD 318 million further de-risks R&D spend for qualified assets. Collectively, these incentives sustain momentum in the peptide antibiotics market.
Peptide-Hydrogel Delivery Platforms Expanding Topical & Implant Use-Cases
Self-assembling hydrogels boost bactericidal activity 64-fold when combined with oxacillin against MRSA, widening topical therapy appeal. Nanogel conjugates with cell-penetrating peptides clear over 90% of uropathogens in vivo, a 36% improvement versus conventional regimens. Boronate-ester release hydrogels sustain activity for weeks, improving anti-tuberculosis outcomes. Dissolving microneedles now deliver antimicrobial peptides with greater patient compliance for skin infections.
Restraints Impact Analysis
Restraint | (~) % Impact on CAGR Forecast | Geographic Relevance | Impact Timeline |
---|---|---|---|
High Production Costs & Premium Pricing | -1.40% | Global, with highest impact in price-sensitive markets | Short term (≤ 2 years) |
Limited Reimbursement And Pricing Incentives For Novel Antibiotics | -0.90% | Global, with acute impact in cost-constrained healthcare systems | Short term (≤ 2 years) |
Cytotoxicity & Stability Challenges In Systemic Applications | -0.80% | Global, particularly affecting IV formulations | Medium term (2-4 years) |
Stringent Regulatory Requirements For Demonstrating Superiority Over Existing Therapies | -0.60% | Global, with highest burden in highly regulated markets (US, EU) | Long term (≥ 4 years) |
Source: Mordor Intelligence
High Production Costs & Premium Pricing
Peptide synthesis requires specialized equipment, pushing production costs higher than small-molecule benchmarks. Sustainability audits show elevated process-mass intensity for complex lipopeptides, with limited CGMP capacity and purification bottlenecks. Cost-minimization studies comparing daptomycin to vancomycin highlight affordability constraints in resource-limited settings. Manufacturing setbacks, such as the FDA’s rejection of a Venatorx–Melinta BARDA-funded combination over production issues, show cost pressures can derail approvals.
Cytotoxicity & Stability Challenges in Systemic Applications
Proteolytic degradation and salt sensitivity reduce systemic peptide half-life, demanding frequent dosing or chemical modifications. Bacteria counter peptides through degradation enzymes and efflux pumps, though resistance evolution remains slower than with small molecules. Achieving therapeutic plasma levels while avoiding cytotoxicity is difficult, with protease degradation and formulation costs acting as twin hurdles. Structural tweaks such as cyclization improve stability but increase manufacturing complexity. As a result, only a fraction of discovered peptides progress to clinical stages.
Segment Analysis
By Product Type: Non-Ribosomal Dominance Meets Ribosomal Innovation
Non-ribosomal lipopeptides secured 46.1% of the peptide antibiotics market share in 2024, anchored by daptomycin and polymyxins that remain indispensable against resistant Gram-positive and Gram-negative infections. Daptomycin’s ability to evade BceAB-mediated resistance in Streptococcus pneumoniae sustains its frontline status. Polymyxin B and colistin regained importance as last-resort therapies for carbapenem-resistant organisms despite emerging MCR-gene resistance. Manufacturing advances, such as CordenPharma’s plant expansions, support supply stability for this mature segment.
Ribosomal RiPPs are projected to grow at a 13.5% CAGR, the highest among product classes. Synthetic-biology tooling has uncovered 987 new RiPP gene clusters in lichen fungi, opening fresh discovery space. Machine-learning guided evolution produced LBDA-D, which shows enhanced activity against Escherichia coli and S. aureus. Heterologous expression systems now enable scalable RiPP production, reducing historical supply constraints. As a result, the peptide antibiotics market size for ribosomal candidates is set for rapid expansion over the forecast period.
Note: Segment shares of all individual segments available upon report purchase
By Disease: Skin Infections Lead While HABP/VABP Accelerates
Skin infections accounted for 41.5% of the peptide antibiotics market size in 2024, supported by topical delivery formats that suit diabetic foot ulcers and post-surgical wounds. Locilex (pexiganan) illustrates focused development while dissolving microneedles to improve compliance in outpatient care. Long-acting lipoglycopeptides such as dalbavancin have broadened their reach beyond skin indications, reporting clinical success rates up to 100% in bloodstream infections. Growing diabetes prevalence and high rates of MRSA in community settings sustain demand for skin-directed therapeutics within the peptide antibiotics market.
Hospital-acquired and ventilator-associated bacterial pneumonia hold smaller baseline revenue but are slated for a 10.2% CAGR, the fastest among disease areas. AbbVie’s newly approved Emblaveo achieved a 76.4% cure rate in late-stage trials. Intensive-care infection rates remain high, with S. maltophilia doubling in incidence over two decades. The critical nature of respiratory infections ensures premium reimbursement and steady hospital uptake, and advanced inhalable or long-acting injectable peptides under development promise to deepen future penetration.
By Route of Administration: Injectable Dominance Challenged by Topical Innovation
Injectables maintained a 70.3% revenue share in 2024, underscoring the necessity for rapid systemic exposure in severe infections. Vancomycin achieved appropriate use in 89.1% of cardiac-surgery cases following IDSA protocols. Cold-chain infrastructure and trained infusion staff favour hospital settings, keeping the peptide antibiotics market anchored in inpatient care. However, high production costs and lengthy infusion times present cost-containment challenges for payers.
Topical hydrogels, rising at a 12.6% CAGR, employ self-assembling peptide networks that achieve minimum inhibitory concentrations as low as 2 µM against MRSA. Hydrogel microspheres now pack high drug loads with controlled release, solving earlier capacity issues. Patient preference for non-invasive therapy and the reduced risk of systemic toxicity fuel adoption. The peptide antibiotics market, therefore, shows growing modality diversification beyond traditional intravenous regimens.

Note: Segment shares of all individual segments available upon report purchase
By Distribution Channel: Hospital Pharmacy Control Meets Online Growth
Hospital pharmacies controlled 57.5% of global sales in 2024 due to the acute nature of infections addressed and the sterility requirements of many formulations. Centralized compounding units and temperature-controlled storage preserve drug integrity, reinforcing hospital leadership. The prevalence of healthcare-associated infections, estimated to affect millions annually, keeps peptide antibiotic demand concentrated in inpatient care.
Online pharmacies, forecast at a 14.4% CAGR, benefit from telehealth expansion and the advancing feasibility of oral peptide delivery. Merck’s USD 493 million Cyprumed deal aims to transform peptides into tablets, a development that would expand outpatient channels. Retail pharmacies occupy a middle ground, dispensing oral agents and select topical products, but growth remains limited until more peptide antibiotics transition to community prescribing.
Geography Analysis
North America generated 38.4% of 2024 global revenue, the highest regional contribution. The FDA’s QIDP framework expedited approvals for cutting-edge agents such as Blujepa and Emblaveo, while BARDA committed USD 318 million in contracts to antimicrobial R&D. Private investments, including Eli Lilly’s USD 100 million AMR fund and CordenPharma’s plant expansion, reinforce supply and discovery capacity. Research hubs like McMaster University continue to pioneer AI-based discovery models, expanding the peptide antibiotics market footprint across North America.
Asia Pacific is the fastest-growing region with a projected 9.8% CAGR through 2030. AstraZeneca’s USD 2.5 billion Beijing R&D center enhances local peptide capabilities, while Chinese regulators approved Vibativ for serious infections, giving Cumberland Pharmaceuticals access to a vast market. Singapore’s institutes are advancing bacteriophage-peptide synergy programs, underscoring region-wide commitment to antimicrobial resistance. Government stewardship initiatives, coupled with capacity additions across India and South Korea, drive sustained uptake within the peptide antibiotics market.
Europe remains a pivotal contributor, supported by EMA streamlined pathways and manufacturing depth. Positive CHMP opinion for Pfizer’s aztreonam-avibactam highlights regulatory efficiency. Academic centres such as Chalmers University developed peptide hydrogels that boost oxacillin potency 64-fold, demonstrating innovation strength. Meanwhile, Middle East and Africa and South America show nascent adoption, aided by improving healthcare infrastructure and awareness campaigns focused on antimicrobial stewardship.. At the same time,the region's,,,the . At the same time,

Competitive Landscape
The peptide antibiotics market features moderate concentration, with leading firms leveraging scale, AI partnerships, and manufacturing depth to secure advantage. Merck’s USD 493 million Cyprumed deal aims to overcome oral-delivery barriers that have long constrained peptide uptake.
Strategic alliances increasingly center on AI-driven discovery; Eli Lilly’s partnership with OpenAI exemplifies how generative models can compress hit-to-lead timelines. At the device interface, Amferia’s EUR 1.2 million (USD 1.3 million) investment positions its hydrogel dressings for rapid U.S. entry, achieving 64-fold potency improvements over standard care. White-space opportunities in long-acting injectables encourage players such as Melinta to invest in weekly-dosed lipoglycopeptides, extending hospital discharge options.
Emerging disruptors include Peptilogics, which secured CARB-X funding for fracture-infection therapeutics, and startups leveraging synthetic biology to create bespoke RiPPs. Competitive tactics also involve aggressively pursuing QIDP status to gain five additional years of exclusivity and access to priority FDA review queues. Overall, investment scale and regulatory expertise remain decisive factors shaping positioning within the peptide antibiotics market.
Peptide Antibiotics Industry Leaders
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Merck & Co., Inc.
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ANI Pharmaceuticals, Inc.
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Melinta Therapeutics.
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AbbVie
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Cumberland Pharmaceuticals Inc.
- *Disclaimer: Major Players sorted in no particular order

Recent Industry Developments
- March 2025: GSK received FDA approval for Blujepa (gepotidacin), the first triazaacenaphthylene bacterial topoisomerase inhibitor for uncomplicated urinary tract infections.
- March 2025: AstraZeneca announced a USD 2.5 billion R&D center in Beijing with macro-cyclic peptide collaborations.
- February 2025: AbbVie obtained FDA clearance for Emblaveo (aztreonam-avibactam) to treat multidrug-resistant Gram-negative infections.
- February 2025: Cumberland Pharmaceuticals gained Chinese approval for Vibativ (telavancin) in pneumonia and severe skin infections.
Global Peptide Antibiotics Market Report Scope
As per the scope of the report, peptide antibiotic products are commonly used in the management of various infectious diseases. These antibiotics are less toxic and highly effective as compared to the other antibiotics. The peptide antibiotics market is segmented by Product Type (Ribosomal Synthesized Peptide Antibiotics and Non-Ribosomal Synthesized Peptide Antibiotics), Disease (Skin Infection, HABP/VABP, Blood Stream Infection, and Others), Route of Administration (Injectable, Topical, and Others), Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (in USD million) for the above segments.
By Product Type | Ribosomal-synthesised peptide antibiotics | ||
Non-ribosomal-synthesised peptide antibiotics | |||
By Disease | Skin infection | ||
HABP / VABP | |||
Blood-stream infection | |||
Other infections | |||
By Route of Administration | Injectable | ||
Topical | |||
Others | |||
By Distribution Channel | Hospital pharmacies | ||
Retail pharmacies | |||
Online pharmacies | |||
By Geography | North America | United States | |
Canada | |||
Mexico | |||
Europe | Germany | ||
United Kingdom | |||
France | |||
Italy | |||
Spain | |||
Rest of Europe | |||
Asia Pacific | China | ||
Japan | |||
India | |||
South Korea | |||
Australia | |||
Rest of Asia Pacific | |||
Middle East and Africa | GCC | ||
South Africa | |||
Rest of Middle East and Africa | |||
South America | Brazil | ||
Argentina | |||
Rest of South America |
Ribosomal-synthesised peptide antibiotics |
Non-ribosomal-synthesised peptide antibiotics |
Skin infection |
HABP / VABP |
Blood-stream infection |
Other infections |
Injectable |
Topical |
Others |
Hospital pharmacies |
Retail pharmacies |
Online pharmacies |
North America | United States |
Canada | |
Mexico | |
Europe | Germany |
United Kingdom | |
France | |
Italy | |
Spain | |
Rest of Europe | |
Asia Pacific | China |
Japan | |
India | |
South Korea | |
Australia | |
Rest of Asia Pacific | |
Middle East and Africa | GCC |
South Africa | |
Rest of Middle East and Africa | |
South America | Brazil |
Argentina | |
Rest of South America |
Key Questions Answered in the Report
What is the current size of the peptide antibiotics market?
The market generated USD 5.34 billion in 2025 and is on track to reach USD 6.83 billion by 2030.
Which product category holds the largest peptide antibiotics market share?
Non-ribosomal lipopeptides led with 46.1% revenue share in 2024.
Which route of administration is growing fastest for peptide antibiotics?
Topical hydrogels are projected to grow at a 12.6% CAGR through 2030 thanks to advanced peptide-hydrogel platforms.
Why is Asia Pacific considered the fastest-growing region?
Significant healthcare investment, regulatory progress and rising antimicrobial resistance awareness drive a forecast 9.8% CAGR in Asia Pacific.
How do regulatory incentives support peptide antibiotic development?
Programs such as the FDA’s QIDP grant five extra years of exclusivity and priority review, accelerating approvals and improving commercial viability.
What are the main challenges limiting broader peptide antibiotic use?
High manufacturing costs, premium pricing, and stability issues in systemic applications remain key restraints.
Page last updated on: June 24, 2025