| Study Period | 2019 - 2030 |
| Market Size (2025) | USD 262.59 Million |
| Market Size (2030) | USD 365.55 Million |
| CAGR (2025 - 2030) | 6.84 % |
| Fastest Growing Market | Asia Pacific |
| Largest Market | North America |
| Market Concentration | Medium |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Microscale Thermophoresis Market Analysis
The Microscale Thermophoresis Market size is estimated at USD 262.59 million in 2025, and is expected to reach USD 365.55 million by 2030, at a CAGR of 6.84% during the forecast period (2025-2030).
Microscale Thermophoresis (MST) is a powerful analytical technique used in biophysics and biochemistry to study biomolecular interactions. Technological benefits such as high sensitivity and precision, label-free detection, low sample consumption, etc., in microscale thermophoresis for measuring biomolecular interactions compared to other methods, such as surface plasmon resonance, are one of the primary factors driving the microscale thermophoresis market during the forecast period.
For instance, a June 2022 study published in the Journal of Molecules explored the interaction between lactoferrin and the iron chelator deferiprone, utilizing a label-free system. The research determined the binding affinity of deferiprone to lactoferrin through microscale thermophoresis, yielding strong binding results. These findings suggest a predictability of deferiprone secretion in breast milk. Additionally, the microscale thermophoresis technique showcased its significance in binding studies.
Similarly, a study report published in Doe Pages by the National Renewable Energy Laboratory in August 2024 showed that microscale thermophoresis has advantages over other approaches for examining molecular interactions, such as isothermal titration calorimetry, biolayer interferometry, and surface plasmon resonance, requiring a small sample size that does not need to be immobilized and high-sensitivity fluorescence detection. In addition, since the technique involves loading samples into capillaries that can be easily sealed, it can be adapted to analyze oxygen-sensitive samples. Driven by their significant advantages, microscale thermophoresis is increasingly sought after, especially in the study of enzyme-based catalysis. This area of research is crucial for a myriad of biotechnology and environmental applications.
Furthermore, a study published by MDPI in January 2022 revealed that microscale thermophoresis can effectively analyze the acid-base/deprotonation equilibrium via pKa values. This method proves invaluable in examining the pharmacokinetics and pharmacodynamics of drugs during the drug discovery process. This validation can increase confidence among researchers and pharmaceutical companies in the accuracy and reliability of microscale thermophoresis, which in turn will increase market growth during the forecast period.
However, regulatory challenges in clinical applications and the availability of alternative technologies for microscale thermophoresis are expected to hinder the market's growth over the forecast period.
Microscale Thermophoresis Market Trends
Drug Discovery Segment is Expected to Dominate the Microscale Thermophoresis Market During the Forecast Period
The drug discovery segment plays a crucial role in driving the microscale thermophoresis (MST) market due to the unique advantages that MST offers for studying biomolecular interactions, which are essential in drug discovery. Microscale thermophoresis is highly sensitive and provides accurate measurements of biomolecular interactions, making it valuable for screening potential drug candidates and studying their binding affinities with target molecules. The precise data obtained through MST can aid in identifying lead compounds and optimizing drug candidates. Hence, effective outcomes are achieved through the microscale thermophoresis technique in drug discovery, such as its ability to analyze molecular interactions in solution with minimal sample preparation.is likely to drive the segment growth.
For instance, a study published in the Journal of Trends in Analytical Chemistry in July 2024 reveals that the microscale thermophoresis technique and spectral shift approach have become valuable tools in target-based drug discovery owned to their ability of immobilization-free detection, low sample requirements, sensitivity, and scalability. The study's findings can validate the effectiveness of MST and the spectral shift approach in drug discovery applications. This validation is crucial for encouraging more researchers and pharmaceutical companies to adopt these techniques in their drug development processes, driving segment growth.
Moreover, favorable government support for the conduct of disease and drug development studies is also likely to drive the segment's growth. For example, in January 2022, the National Institutes of Health awarded USD 190,000 to the UConn Biophysics Core Facility for the acquisition of a microscale thermophoresis to support drug discovery research. Thus, the publication of support studies showing the effectiveness of microscale thermophoresis and favorable government support to boost drug research studies are some factors that drive the segment's growth.
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North America Expected to Hold the Largest Share in the Microscale Thermophoresis Market
The region's extensive biopharmaceutical research and development activities propel the North American market for microscale thermophoresis. Microscale thermophoresis is crucial for studying biomolecular interactions, protein stability, and drug-target binding kinetics, aiding drug discovery and development processes. Continuous advancements in the life sciences sector, particularly in structural biology, proteomics, and genomics, have increased the demand for precise and sensitive techniques like MST.
Researchers and scientists utilize microscale thermophoresis to investigate molecular interactions and protein functions, driving its adoption in the region. For instance, in June 2023, researchers from the Perelman School of Medicine at the University of Pennsylvania developed a short-chain variable fragment Anti-Aβ42 scFv antibody. Utilizing microscale thermophoresis, they demonstrated that their antibody produced results in treating Alzheimer's disease that were both effective and comparable to those achieved with commercially available antibodies, including 6E10 and Aducanumab. Hence, using microscale thermophoresis for antibody demonstration will likely increase the demand for microscale thermophoresis in the region, thereby boosting the market growth over the study period.
Moreover, rising biopharmaceutical research and development activities and investment by the United States-based pharmaceutical and biotechnology companies in the North American region are also factors that drive the market growth in the area. For instance, in 2023, Merck & Co. significantly ramped up its research and development efforts, allocating over USD 30 billion. This amount is more than double the company's R&D expenditure of USD 13.5 billion in 2022. The increased R&D expenditure by players suggests a commitment to advancing drug discovery efforts and bringing new therapies to market. Microscale thermophoresis, with its ability to study protein interactions and drug-target binding, can play a crucial role in accelerating the drug discovery process, potentially leading to the development of novel treatments.
Thus, researchers' continuous efforts to develop new antibodies through microscale thermophoresis and rising investment in developing new drugs are key factors likely to drive market growth in North America during the forecast period.
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Microscale Thermophoresis Industry Overview
The microscale thermophoresis market is moderately competitive and has a few major players. Companies like NanoTemper Technologies, Profacgen, Creative Proteomics, WuXi AppTec, Reaction Biology, and Creative Biostructure, among others, hold substantial market shares in the microscale thermophoresis market. New product developments, acquisitions, collaborations, and regional expansions are some of the key strategic initiatives undertaken by major players to maintain stability in the market.
Microscale Thermophoresis Market Leaders
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NanoTemper Technologies
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Profacgen
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WuXi AppTec
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Creative Biostructure
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Reaction Biology
- *Disclaimer: Major Players sorted in no particular order
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Microscale Thermophoresis Market News
- March 2024: China’s Ministry of Science and Technology investment in R&D rose 8.1% in 2023 to more than USD 458 billion. Increased R&D funding can support advanced research initiatives in fields such as biotechnology and pharmaceuticals, where microscale thermophoresis plays a critical role. This can lead to the exploration of new applications and the development of innovative solutions using this technology.
- February 2024: Eurofins showcased the integration of microscale thermophoresis within its advanced capabilities for developing Molecular Glues and PROTACs, using biophysics methods to evaluate the binary and ternary complex formation and establish crucial interaction parameters for precise targeting of proteins in therapeutic applications such as oncology, neurodegenerative diseases.
Microscale Thermophoresis Industry Segmentation
As per the scope of the report, microscale thermophoresis serves as a potent analytical tool in biophysics and biochemistry, enabling the exploration of biomolecular interactions.
The microscale thermophoresis market is segmented by application, end user, and geography. By application, the market is segmented into protein analysis, drug discovery, antibody development, and others. By the end user, the market is segmented into pharmaceutical and biotechnology companies, academic institutes and research centers, and others. By geography, the market is segmented into North America, Europe, Asia-Pacific, and the rest of the World. The market report also covers the estimated market sizes and trends for all the regions globally. The report offers the value (in USD) for the above segments.
| By Application | Protein Analysis | ||
| Drug Discovery | |||
| Antibody Development | |||
| Others | |||
| By End User | Pharmaceutical and Biotecnology Companies | ||
| Academic Institutes and Research Centers | |||
| Others | |||
| Geography | North America | United States | |
| Canada | |||
| Mexico | |||
| Europe | Germany | ||
| United Kingdom | |||
| France | |||
| Italy | |||
| Spain | |||
| Rest of Europe | |||
| Asia-Pacific | China | ||
| Japan | |||
| India | |||
| Australia | |||
| South Korea | |||
| Rest of Asia-Pacific | |||
| Rest of the World | |||
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Microscale Thermophoresis Market Research FAQs
How big is the Microscale Thermophoresis Market?
The Microscale Thermophoresis Market size is expected to reach USD 262.59 million in 2025 and grow at a CAGR of 6.84% to reach USD 365.55 million by 2030.
What is the current Microscale Thermophoresis Market size?
In 2025, the Microscale Thermophoresis Market size is expected to reach USD 262.59 million.
Who are the key players in Microscale Thermophoresis Market?
NanoTemper Technologies, Profacgen, WuXi AppTec, Creative Biostructure and Reaction Biology are the major companies operating in the Microscale Thermophoresis Market.
Which is the fastest growing region in Microscale Thermophoresis Market?
Asia Pacific is estimated to grow at the highest CAGR over the forecast period (2025-2030).
Which region has the biggest share in Microscale Thermophoresis Market?
In 2025, the North America accounts for the largest market share in Microscale Thermophoresis Market.
What years does this Microscale Thermophoresis Market cover, and what was the market size in 2024?
In 2024, the Microscale Thermophoresis Market size was estimated at USD 244.63 million. The report covers the Microscale Thermophoresis Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Microscale Thermophoresis Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.
Microscale Thermophoresis Industry Report
Statistics for the 2025 Microscale Thermophoresis market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Microscale Thermophoresis analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.
