| Study Period | 2019 - 2030 |
| Base Year For Estimation | 2024 |
| Forecast Data Period | 2025 - 2030 |
| Historical Data Period | 2019 - 2023 |
| Market Size (2025) | USD 1.84 Billion |
| Market Size (2030) | USD 2.10 Billion |
| CAGR (2025 - 2030) | 2.73% |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Europe Dipeptide Peptidase 4 (DPP-4) Inhibitors Market Analysis by Mordor Intelligence
The Europe Dipeptide Peptidase 4 Inhibitors Market size is estimated at USD 1.84 billion in 2025, and is expected to reach USD 2.10 billion by 2030, at a CAGR of 2.73% during the forecast period (2025-2030).
Diabetes poses a significant health challenge on a global scale, and Europe is no different. As the number of diabetes cases continues to rise, the need for efficient treatments is more pressing than ever. Within the wide range of medications offered, Dipeptidyl Peptidase 4 (DPP-4) inhibitors have become a favored option for diabetes management, especially in Europe.
DPP-4 inhibitors are a class of oral medications used in the management of type 2 diabetes. They work by inhibiting the enzyme dipeptidyl peptidase 4, which increases the concentration of incretin hormones such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide). These hormones help regulate blood sugar levels by stimulating insulin secretion and inhibiting glucagon release from the pancreas, thereby reducing blood glucose levels.
DPP-4 inhibitors are favored by healthcare professionals and patients due to their efficacy in lowering blood glucose levels without causing significant hypoglycemia (low blood sugar). They are also generally well-tolerated and have a low risk of weight gain, making them suitable for a wide range of patients, including those with comorbidities.
As Europe grapples with the challenges posed by the diabetes epidemic, DPP-4 inhibitors have emerged as valuable tools in the management of this chronic condition. Their efficacy, safety, oral administration, and potential cardiovascular benefits make them a preferred choice for healthcare providers and patients alike. Moving forward, addressing the underlying causes of diabetes and promoting preventive measures will be crucial in mitigating the burden of this disease on individuals and healthcare systems across Europe.
Europe Dipeptide Peptidase 4 (DPP-4) Inhibitors Market Trends and Insights
Increasing diabetes prevalence
The European region witnessed an alarming increase in the prevalence of diabetes in recent years. Patients with diabetes require many corrections throughout the day to maintain nominal blood glucose levels, such as oral anti-diabetic medication or ingestion of additional carbohydrates by monitoring their blood glucose levels. The rate of newly diagnosed Type 1 and Type 2 diabetes cases is seen to increase, mainly due to obesity, unhealthy diet, and physical inactivity. The rapidly increasing incidence and prevalence of diabetic patients and healthcare expenditure are indications of the increasing usage of diabetic drugs.
Dipeptidyl peptidase 4 (DPP-4) inhibitors are effective in treating type 2 diabetes, as they maintain blood glucose levels through the degradation of incretin peptides, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic polypeptide. Oral Anti-Diabetic Drugs are available internationally and are recommended for use when treatment escalation for type 2 diabetes is required along with lifestyle management.
They are typically the first medications used in treating type 2 diabetes due to their wide range of efficacy, safety, and mechanisms of action. They help diabetes patients control their condition and lower the risk of diabetes complications. These agents present the advantages of easier management and lower cost, so they became an attractive alternative to insulin with better acceptance, which enhances adherence to the treatment.
The government and the companies are working towards better diabetes management. For instance, in the United Kingdom, the National Service Framework (NSF) program is improving services by setting national standards to improve service quality and tackle variations in care. The Association of British HealthTech Industries (ABHI) launched a diabetes section, enabling diabetes technology companies to work together in the first forum of its kind.
Owing to the rising rate of obesity, growing genetic factors for type-2 diabetes, the increasing prevalence, and the factors above, the market will likely continue to grow.
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Germany held the highest market share in the European Dipeptide Peptidase 4 (DPP-4) Inhibitors Market in the current year
Diabetes is a significant health problem and one of the tremendous challenges for healthcare systems all over Germany. The prevalence of known type 1 & 2 diabetes in the German adult population is very high, along with many patients not yet diagnosed with the disease. Due to an aging population and unhealthy lifestyle, the prevalence of type 2 diabetes is expected to increase steadily over the next few years. High-quality care, including adequate monitoring, control of risk factors, and active self-management, are the key factors for preventing complications in German patients with type 2 diabetes.
The disease's growing incidence, prevalence, and progressive nature encouraged the development of new drugs to provide additional treatment options for diabetic patients. Non-insulin treatments, used as first-line therapies for patients with type 2 diabetes, currently capture more than half the sales in the anti-diabetic market. Over the past decade, two important classes entered this market: dipeptidyl peptidase-4 inhibitors (DPP-4) and sodium-glucose cotransporter-2 inhibitors (SGLT-2).
These agents work in various ways to reduce blood sugar levels in people with type 2 diabetes. Some stimulate insulin secretion by the pancreas, and others improve the responsiveness of cells to insulin or prevent glucose production by the liver. Others slow the absorption of glucose after meals. Also, the use of oral anti-diabetes drugs is rising because new-generation oral drugs, such as DPP-4 and SGLT-2, reduce the rate of CV risk in diabetes patients.
According to the German Diabetes Centre (DDZ), about 8.5 million people in Germany are affected by diabetes. The number of people with type 2 diabetes in Germany will continue to increase over the next twenty years. German law requires public plans to cap out-of-pocket health care costs and to cover all medically necessary treatment, including insulin.
Germany is one of the developed countries with advanced healthcare facilities. Moreover, reimbursement and pricing policies are highly regulated, which drives the market. The roll-out of many new products, increasing international research collaborations in technology advancement, and increasing awareness about diabetes among the people are some market opportunities for the players in the German market.
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Competitive Landscape
The European Dipeptide Peptidase 4 (DPP-4) Inhibitors Market is consolidated, with a few major manufacturers like Eli Lilly, AstraZeneca, Merck, Boehringer Ingelheim, Novartis, etc., gaining presence in major countries. At the same time, the remaining market comprises other local or region-specific manufacturers.
Europe Dipeptide Peptidase 4 (DPP-4) Inhibitors Industry Leaders
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AstraZeneca
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Takeda
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Novartis
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Merck & Co., Inc.
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Eli Lilly and Company
- *Disclaimer: Major Players sorted in no particular order
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Recent Industry Developments
- March 2024: Daiichi Sankyo made marketing alliance agreement with Mitsubishi Tanabe Pharma Corp for its DPP-4 inhibitor tablets, under the brand name Tenelia, will expire in September. The marketing deal for its SGLT2 inhibitor or Canaglu tablets will also expire that month.
- July 2022: European Commission released the Commission Implementing Decision granting marketing authorization under Regulation (EC) No 726/2004 of the European Parliament and the Council for "Sitagliptin/Metformin hydrochloride Accord - sitagliptin/metformin hydrochloride."
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Europe Dipeptide Peptidase 4 (DPP-4) Inhibitors Market Report Scope
Dipeptidyl peptidase 4 (DPP-4) inhibitors are a pharmacological drug class for treating Type 2 diabetes. They help to control glycemia by increasing the levels of active incretins. The European Dipeptide Peptidase 4 (DPP-4) Inhibitors Market is segmented into drugs (Sitagliptin (Januvia), Saxagliptin (Onglyza), Linagliptin (Tradjenta), Alogliptin (Vipidia), Vildagliptin (Galvus), and others), and geography. The report offers the value (in USD) and volume (in units) for the above segments.
Drugs
| Januvia (Sitagliptin) |
| Onglyza (Saxagliptin) |
| Tradjenta (Linagliptin) |
| Vipidia (Alogliptin) |
| Galvus (Vildagliptin) |
| Others |
Geography
| France |
| Germany |
| Italy |
| Spain |
| United Kingdom |
| Russia |
| Rest of Europe |
| Drugs | Januvia (Sitagliptin) |
| Onglyza (Saxagliptin) | |
| Tradjenta (Linagliptin) | |
| Vipidia (Alogliptin) | |
| Galvus (Vildagliptin) | |
| Others | |
| Geography | France |
| Germany | |
| Italy | |
| Spain | |
| United Kingdom | |
| Russia | |
| Rest of Europe |
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Key Questions Answered in the Report
How big is the Europe Dipeptide Peptidase 4 Inhibitors Market?
The Europe Dipeptide Peptidase 4 Inhibitors Market size is expected to reach USD 1.84 billion in 2025 and grow at a CAGR of 2.73% to reach USD 2.10 billion by 2030.
What is the current Europe Dipeptide Peptidase 4 Inhibitors Market size?
In 2025, the Europe Dipeptide Peptidase 4 Inhibitors Market size is expected to reach USD 1.84 billion.
Who are the key players in Europe Dipeptide Peptidase 4 Inhibitors Market?
AstraZeneca, Takeda, Novartis, Merck & Co., Inc. and Eli Lilly and Company are the major companies operating in the Europe Dipeptide Peptidase 4 Inhibitors Market.
What years does this Europe Dipeptide Peptidase 4 Inhibitors Market cover, and what was the market size in 2024?
In 2024, the Europe Dipeptide Peptidase 4 Inhibitors Market size was estimated at USD 1.79 billion. The report covers the Europe Dipeptide Peptidase 4 Inhibitors Market historical market size for years: 2019, 2020, 2021, 2022, 2023 and 2024. The report also forecasts the Europe Dipeptide Peptidase 4 Inhibitors Market size for years: 2025, 2026, 2027, 2028, 2029 and 2030.
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Europe Dipeptide Peptidase 4 (DPP-4) Inhibitors Market Report
Statistics for the 2025 Europe Dipeptide Peptidase 4 (DPP-4) Inhibitors market share, size and revenue growth rate, created by Mordor Intelligence™ Industry Reports. Europe Dipeptide Peptidase 4 (DPP-4) Inhibitors analysis includes a market forecast outlook for 2025 to 2030 and historical overview. Get a sample of this industry analysis as a free report PDF download.
