Central Nervous System Therapeutics Market - Growth, Trends, COVID-19 Impact, and Forecasts (2021 - 2026)

The Central Nervous System Therapeutics Market is segmented by Disease (Neurovascular Diseases, Trauma, Mental Health, Degenerative Disease, Infectious Diseases, Cancer, and Others), Drug Class (Analgesics, Nervous System Drugs, Anesthetics, Anti-Parkinson Drugs, Anti-Epileptics, and Other Drug Classes), and Geography (North America, Europe, Asia-Pacific, Middle-East and Africa, and South America). The report offers the value (in USD million) for the above segments.

Market Snapshot

CAGR Graph
Study Period: 2018-2026
Base Year: 2020
Fastest Growing Market: Asia Pacific
Largest Market: North America
CAGR: 5.9 %

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Market Overview

The central nervous system (CNS) therapeutics market is projected to register a CAGR of nearly 5.9% over the forecast period (2021 - 2026).

With the increasing COVID-19 cases worldwide, healthcare services diverted all resources toward patients suffering from COVID-19 disease. Although COVID-19 severely affects the respiratory system, it has been reported to show effects on central and peripheral systems. These included encephalopathy, inflammation, ischaemic stroke, and peripheral neurological disorders. A research study published in JAMA Neurology involving 214 patients in China showed that patients with severe illness from COVID-19 had neurologic manifestations of acute cerebrovascular disease, impaired consciousness, and skeletal muscle injury. Additionally, clinical trials on the repurposing of anti-depressants for COVID-19 may have minimal impact on the CNS therapeutics market.

An increase in the number of patients suffering from CNS disease is likely to be the key factor contributing to the growth of the CNS therapeutics market. According to the WHO, in 2019, stroke and Alzheimer's are the second and seventh top-most causes for deaths globally. A study published in The Lancet finds that neurological diseases are the third common cause of disability and premature deaths and are estimated to increase with age in Europe. Additionally, a rise in generics is expected to drive the penetration of neurologic drugs to lower and middle-income countries, making them affordable. Along with this, increasing awareness programs may result in drugs being easily accessible. Innovation in drug delivery systems, such as nanoparticles, creates opportunities for new drugs. A recent Rutgers research in 2020 was conducted for the treatment of neurological disorders by creating a micro-environment and suppressing inflammation using nanomaterials, polymers, and neural proteins. Therefore, all the above factors are expected to contribute to the growth of the CNS therapeutics market.

R&D is a complex process and an important decision within the pharmaceutical industry. It involves a detailed study of the safety and efficacy of novel drugs, along with meeting regulatory guidelines before releasing them into the market. According to the analysis by Tufts Center for the Study of Drug Development in 2018, CNS drug development is 20% more time-consuming and takes 38% longer time to get approved than other non-CNS drugs. Moreover, expenditure in R&D may not always yield higher returns, making it a risky investment. As a result, drugs are priced higher to recover the spending. Hence, risky R&D spending for developing CNS drugs may discourage pharmaceutical companies from investing in CNS therapeutics. Furthermore, adverse reactions reported for certain CNS drugs, such as anti-epileptic drugs, may inhibit the overall market growth.

Scope of the Report

The central nervous system therapeutics market includes treatment of disease of the central nervous system, including the brain and spinal cord. The market is segmented by disease (neurovascular diseases, trauma, mental health, degenerative disease, infectious diseases, cancer, and others), drug class (analgesics, nervous system drugs, anesthetics, anti-Parkinson drugs, anti-epileptics, and other drug classes), and Geography (North America, Europe, Asia-Pacific, Middle-East and Africa, and South America). The report offers the value (in USD million) for the above segments.

By Disease
Neurovascular Diseases
Trauma
Mental Health
Anxiety Disorders
Epilepsy
Psychotic Disorders
Other Diseases
Degenerative Diseases
Alzheimer's Disease
Parkinson's Disease
Multiple Sclerosis
Amyotrophic Lateral Sclerosis
Other Degenerative Diseases
Infectious Diseases
Cancer
Other Infectious Diseases
By Drug Class
Analgesics
Nervous System Drugs
Anesthetics
Anti-Parkinson Drugs
Anti-Epileptics
Other Drug Classes
By Geography
North America
United States
Canada
Mexico
Europe
Germany
United Kingdom
France
Italy
Spain
Rest of Europe
Asia-Pacific
China
Japan
India
Australia
South Korea
Rest of Asia-Pacific
Middle-East and Africa
GCC
South Africa
Rest of Middle-East and Africa
South America
Brazil
Argentina
Rest of South America

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Key Market Trends

Degenerative Disease are Expected to Dominate the CNS Therapeutics Market over the Forecast Period

The degenerative disease segment occupies a major share of the market over the forecast period (2021 - 2026). This disease occurs when nerve cells in the brain and peripheral nervous systems lose their function and die. The major share of it is attributed to the increasing prevalence of Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.

According to the WHO, globally, 50 million people suffer from dementia, with nearly 60% living in low and middle-income countries. It estimates the number to reach 82 million by 2030. Atlas of MS shows that 2.8 million people live with multiple sclerosis worldwide and 10 million with Parkinson’s disease as per the Parkinson’s Foundation. The treatment options for these diseases are very few. Currently, five approved drugs are widely used for Alzheimer’s, and 146 clinical studies are recruiting, which are in Phases 1, 2, and 3. Recently, FDA approved Ongentys capsules for Parkinson’s disease when a patient’s medications are not working well and Zeposia capsules for relapsing forms of multiple sclerosis. According to Alzheimer's Europe, it is estimated that about 7.8 million individuals in the European Union are with dementia. Furthermore, the Harvard NeuroDiscovery Center estimates that nearly 12 million Americans may suffer from neurodegenerative diseases 30 years from now if there are no measures taken. Therefore, the rise in prevalence of these diseases, drug development pipeline, and the potential of this segment opens opportunities for clinical studies, product launches, and strategic collaborations.

Mortality

North America is Expected to Dominate the Central Nervous System Therapeutics Market

North America is expected to dominate the CNS therapeutics market over the forecast period (2021 - 2026).

According to GBD 2019, neurological disorders ranked third for the cause of deaths in Canada and fourth in the United States. The Alzheimer’s Disease Fact and Figures Report estimated that 5.8 million Americans are living with dementia, among which 5.6 million are aged 65 years and above in 2019. The same source also reports that the total costs for Alzheimer’s were USD 290 billion, which includes Medicare (51%), Medicaid (17%), Out of Pocket (22%), and other costs (11%).

Government funding and support for research activities are increasing due to the rising burden of the disease. The US congress invested about USD 10 million in multiple sclerosis research and may increase the funding by USD 20 million. CDC established a National Neurological Conditions Surveillance System (NNCSS) for tracking the disease. In 2019, Canada released its first national strategy for tackling dementia. The Canadian Institutes of Health Research spent around USD 200 million for research activities on dementia, and it is providing an additional USD 31.6 million over 5 years, which is likely to bring together individuals for advanced research opportunities. A large number of clinical studies are undergoing in North America, especially in the United States. Among the total neurological disease clinical studies being conducted, worldwide, more than half are in the United States. In March 2021, US President Biden signed the American Rescue Plan Act 2021. According to the act, a portion of spending is allotted to mental health services, further increasing the government activities toward neurological diseases. The rising burden of the disease and healthcare infrastructure and supportive government initiatives make North America a very attractive opportunity for industries.

Regional Growth Rate

Competitive Landscape

The central nervous system therapeutics market remains moderately competitive, with key players in the market. However, the need for innovation in the treatment and drug delivery system and clinical trials and strategic collaboration is likely to help companies maintain their market position. Some of the major players include Biogen Inc, Otsuka Pharmaceutical Co. Ltd, Eli Lilly and Company, Merck & Co., AstraZeneca, Takeda Pharmaceutical Company Limited, Novartis AG, Teva Pharmaceutical Industries Ltd, Johnson & Johnson Private Limited, Pfizer Inc., and GlaxoSmithKline PLC.

Recent Developments

  • In April 2021, Biogen announced the approval of TECFIDERA (dimethyl fumarate) by the National Medical Products Administration (NMPA) to treat relapsing multiple sclerosis expanding its presence in China.
  • In April 2021, Otsuka and Lundbeck announced the continuation of recruiting patients for phase III clinical trials for brexpiprazole to treat patients with Alzheimer's dementia.

Table of Contents

  1. 1. INTRODUCTION

    1. 1.1 Study Assumptions and Market Definition

    2. 1.2 Scope of the Study

  2. 2. RESEARCH METHODOLOGY

  3. 3. EXECUTIVE SUMMARY

  4. 4. MARKET DYNAMICS

    1. 4.1 Market Overview

    2. 4.2 Market Drivers

      1. 4.2.1 Rise in Burden of CNS Disorders

      2. 4.2.2 Increase in Generic Drugs

      3. 4.2.3 Development of Novel Drug Delivery Systems

    3. 4.3 Market Restraints

      1. 4.3.1 Adverse Events Associated with CNS Therapeutics

      2. 4.3.2 High R&D Costs

    4. 4.4 Industry Attractiveness - Porter's Five Forces Analysis

      1. 4.4.1 Bargaining Power of Buyers/Consumers

      2. 4.4.2 Bargaining Power of Suppliers

      3. 4.4.3 Threat of New Entrants

      4. 4.4.4 Threat of Substitute Products

      5. 4.4.5 Intensity of Competitive Rivalry

  5. 5. MARKET SEGMENTATION

    1. 5.1 By Disease

      1. 5.1.1 Neurovascular Diseases

      2. 5.1.2 Trauma

      3. 5.1.3 Mental Health

        1. 5.1.3.1 Anxiety Disorders

        2. 5.1.3.2 Epilepsy

        3. 5.1.3.3 Psychotic Disorders

        4. 5.1.3.4 Other Diseases

      4. 5.1.4 Degenerative Diseases

        1. 5.1.4.1 Alzheimer's Disease

        2. 5.1.4.2 Parkinson's Disease

        3. 5.1.4.3 Multiple Sclerosis

        4. 5.1.4.4 Amyotrophic Lateral Sclerosis

        5. 5.1.4.5 Other Degenerative Diseases

      5. 5.1.5 Infectious Diseases

      6. 5.1.6 Cancer

      7. 5.1.7 Other Infectious Diseases

    2. 5.2 By Drug Class

      1. 5.2.1 Analgesics

      2. 5.2.2 Nervous System Drugs

      3. 5.2.3 Anesthetics

      4. 5.2.4 Anti-Parkinson Drugs

      5. 5.2.5 Anti-Epileptics

      6. 5.2.6 Other Drug Classes

    3. 5.3 By Geography

      1. 5.3.1 North America

        1. 5.3.1.1 United States

        2. 5.3.1.2 Canada

        3. 5.3.1.3 Mexico

      2. 5.3.2 Europe

        1. 5.3.2.1 Germany

        2. 5.3.2.2 United Kingdom

        3. 5.3.2.3 France

        4. 5.3.2.4 Italy

        5. 5.3.2.5 Spain

        6. 5.3.2.6 Rest of Europe

      3. 5.3.3 Asia-Pacific

        1. 5.3.3.1 China

        2. 5.3.3.2 Japan

        3. 5.3.3.3 India

        4. 5.3.3.4 Australia

        5. 5.3.3.5 South Korea

        6. 5.3.3.6 Rest of Asia-Pacific

      4. 5.3.4 Middle-East and Africa

        1. 5.3.4.1 GCC

        2. 5.3.4.2 South Africa

        3. 5.3.4.3 Rest of Middle-East and Africa

      5. 5.3.5 South America

        1. 5.3.5.1 Brazil

        2. 5.3.5.2 Argentina

        3. 5.3.5.3 Rest of South America

  6. 6. COMPETITIVE LANDSCAPE

    1. 6.1 Company Profiles

      1. 6.1.1 Biogen

      2. 6.1.2 Otsuka Pharmaceutical Co. Ltd

      3. 6.1.3 Eli Lilly and Company

      4. 6.1.4 Merck KGaA

      5. 6.1.5 AstraZeneca

      6. 6.1.6 Takeda Pharmaceutical Coompany Limited

      7. 6.1.7 Novartis AG

      8. 6.1.8 Teva Pharmaceutical Industries Ltd

      9. 6.1.9 Johnson & Johnson Private Limited

      10. 6.1.10 Pfizer Inc.

      11. 6.1.11 GlaxoSmithKline PLC

    2. *List Not Exhaustive
  7. 7. MARKET OPPORTUNITIES AND FUTURE TRENDS

**Subject to Availability
**Competitive Landscape covers - Business Overview, Financials, Products and Strategies and Recent Developments

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Frequently Asked Questions

The Global Central Nervous System Therapeutics Market market is studied from 2018 - 2026.

The Global Central Nervous System Therapeutics Market is growing at a CAGR of 5.9% over the next 5 years.

Asia Pacific is growing at the highest CAGR over 2021- 2026.

North America holds highest share in 2020.

Biogen, Novartis AG, Merck KGaA, Eli Lilly and Company, Johnson & Johnson Private Limited are the major companies operating in Global Central Nervous System Therapeutics Market.

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