Anti-Fungal Drugs Market Size and Share
Anti-Fungal Drugs Market Analysis by Mordor Intelligence
The Anti-Fungal Drugs Market size is estimated at USD 17.26 billion in 2025, and is expected to reach USD 20.93 billion by 2030, at a CAGR of 3.94% during the forecast period (2025-2030).
The moderate climb reflects a maturing therapeutic space that must balance larger immunocompromised populations with drug-resistant pathogens and supply chain fragility. Rising ambient temperatures, wider agricultural azole use, and expanding oncology programs are jointly widening the clinical footprint of fungal disease, while regulators are accelerating reviews of novel mechanisms to close treatment gaps. Digitization of care, new long-acting formulations, and expanding online pharmacy networks are reshaping patient access channels. In parallel, climate-driven pathogen migration is forcing healthcare systems to revisit surveillance and stewardship strategies across temperate and tropical regions.
Key Report Takeaways
- By drug class, azoles led with a 53.47% revenue share in 2024, whereas echinocandins are set to grow the fastest at a 4.91% CAGR through 2030.
- By indication, candidiasis held 39.82% of the market in 2024, while onychomycosis is poised for the highest 4.66% CAGR to 2030.
- By dosage form, capsules accounted for 48.75% of sales in 2024; topical ointments and creams are projected to expand at a 4.42% CAGR.
- By distribution channel, hospital pharmacies held 43.81% of revenue in 2024, and online pharmacies will climb at a 6.19% CAGR.
- By geography, North America commanded 34.81% of global sales in 2024, while Asia-Pacific is forecast to post the fastest 5.17% CAGR through 2030.
Global Anti-Fungal Drugs Market Trends and Insights
Drivers Impact Analysis
Driver | (~) % Impact on CAGR Forecast | Geographic Relevance | Impact Timeline |
---|---|---|---|
Rising Incidence of Immunocompromised Patients | +0.8% | Global, concentrated in North America & Europe | Medium term (2-4 years) |
Growing OTC Availability of Topical Antifungals | +0.6% | Global, with stronger impact in APAC & emerging markets | Short term (≤ 2 years) |
Heightened Awareness & Diagnostics for Fungal Infections | +0.5% | Global, led by developed markets | Medium term (2-4 years) |
Shifting Climate Patterns Contributing to Pathogenic Fungi Emergence | +0.7% | Global, with highest impact in temperate regions expanding into new zones | Long term (≥ 4 years) |
Extensive Use of Azole Fungicides in Agriculture Accelerating Clinical Resistance | +0.4% | Global, with concentrated impact in agricultural regions | Medium term (2-4 years) |
Ongoing Innovation in Antifungal R&D Pipelines | +0.6% | Global, with leadership in North America & Europe | Long term (≥ 4 years) |
Source: Mordor Intelligence
Rising incidence of immunocompromised patients
Oncology advances and organ-transplant programs are enlarging the pool of individuals who require systemic antifungal prophylaxis or therapy. Invasive fungal infection rates surpass 25% in several high-risk cancer cohorts, while invasive aspergillosis mortality reaches 43.4% among liver failure patients compared with 15.75% for non-infected counterparts.[1]Jiri Mraz et al., “Invasive aspergillosis in liver failure,” Journal of Fungi, mdpi.com Once-weekly echinocandin regimens such as rezafungin are aligning with outpatient care models, reducing infusion frequency and freeing hospital capacity. As transplant centers expand in emerging economies, longer prophylaxis windows inflate per-patient drug volumes, directly supporting the anti-fungal drugs market.
Growing OTC availability of topical antifungals
Retail access is broadening product reach beyond prescription channels. Medicare Part D recorded 6.5 million topical antifungal claims, costing USD 231 million.[2]Centers for Disease Control and Prevention, “Antifungal prescription surveillance,” cdc.gov Primary care prescribers wrote 40% of these scripts, signaling mainstream clinician engagement. Yet only 31.2% of clotrimazole-betamethasone orders matched confirmed fungal diagnoses, underscoring stewardship gaps that may accelerate resistance. Nanoparticle carriers improve skin penetration and shorten treatment courses, while resistant strains such as Trichophyton indotineae spur demand for alternative topical azoles.
Heightened awareness and diagnostics for fungal infections
PCR panels, beta-D-glucan assays, and AI-enhanced imaging are shortening the diagnostic window, enabling earlier therapy starts that improve outcomes. The WHO 2024 fungal priority pathogen list has upgraded hospital investment in mycology labs and stewardship programs.[3]World Health Organization, “Fungal priority pathogen list 2024,” who.int Point-of-care platforms such as T2MR reduce time-to-result for bloodstream infections and support tailored regimens. Accelerated identification of Aspergillus nodules in CT scans is guiding prophylaxis decisions in hematology wards.
Shifting climate patterns driving pathogenic fungi emergence
Temperature increases allow formerly environmental fungi to thrive at 37 °C. European modelling projects a 77.5% surge in Aspergillus fumigatus exposure, potentially affecting 9 million additional residents. In the United States, coccidioidomycosis-endemic counties may more than double by 2090, exposing 45.4 million extra individuals and lifting annual economic costs from USD 3.9 billion to USD 18.5 billion. Shared molecular targets between agricultural and medical azoles are fostering cross-resistance that complicates frontline therapy. Extreme weather events also elevate traumatic inoculation risks and strain healthcare logistics, reinforcing the anti-fungal drugs market’s critical role.
Restraints Impact Analysis
Restraint | (~) % Impact on CAGR Forecast | Geographic Relevance | Impact Timeline |
---|---|---|---|
Escalating Drug Resistance Across Major Antifungal Classes | -0.9% | Global, with highest impact in regions with intensive antifungal use | Medium term (2-4 years) |
Adverse-Event Profile & Product Recalls of Systemic Agents | -0.4% | Global, with regulatory focus in North America & Europe | Short term (≤ 2 years) |
Cold-Chain Limitations for Parenteral Echinocandins in LMICs | -0.3% | Low- and middle-income countries, particularly in tropical regions | Medium term (2-4 years) |
Lengthy Regulatory Processes and High Development Costs | -0.5% | Global, with most stringent impact in North America & Europe | Long term (≥ 4 years) |
Source: Mordor Intelligence
Escalating drug resistance across major antifungal classes
Multidrug-resistant Candida auris now spans more than 40 countries and shows reduced susceptibility to azoles, echinocandins, and polyenes. Meta-analyses reveal rising resistance in Hypocreales and Microascales orders, reflecting environmental azole exposure. Only seven FDA-approved systemic classes exist, and breakthrough mold infections during prophylaxis are becoming more common, heightening the urgency for novel targets.
Adverse-event profile and product recalls of systemic agents
Hepatotoxicity monitoring requirements for azoles elevate care costs, while infusion reactions limit parenteral echinocandin use outside the hospital setting. A 2024 Brexafemme recall postponed a planned launch and cut milestone payments to SCYNEXIS, demonstrating how quality lapses can disrupt revenue projections. Complex pharmacokinetics demand therapeutic drug monitoring, placing additional burdens on already stretched stewardship teams.
Segment Analysis
By Drug Class: Echinocandins challenge azole dominance
Azoles retained 53.47% revenue in 2024, grounding the anti-fungal drugs market in well-established, broad-spectrum protocols. Their fungistatic action across Candida and Aspergillus species still underpins first-line therapy for many indications. The once-weekly echinocandin rezafungin, however, introduces a convenience advantage that is expected to propel the class at a 4.91% CAGR to 2030. Hospitals are integrating long-acting echinocandins into outpatient parenteral antifungal programs to curtail inpatient stays. Polyenes such as liposomal amphotericin B continue to anchor salvage regimens when resistance or renal impairment narrows options. Allylamines confront terbinafine-resistant dermatophytes, forcing clinicians to switch to systemic azoles earlier in treatment courses. Antimetabolite use remains confined to combination therapy for cryptococcosis and severe candidiasis but offers synergy that may preserve azole efficacy. Combination regimens overall are gaining prominence as resistance pressures grow.
A pull toward stewardship is also reshaping purchasing dynamics. Cost-optimized azole generics dominate formularies, whereas premium-priced echinocandins rely on pharmaco-economic justification linked to shorter hospital stays. As a result, the anti-fungal drugs market maintains a two-tier competitive field: scale-driven azole producers and innovation-led echinocandin developers.
Note: Segment shares of all individual segments available upon report purchase
By Indication: Onychomycosis drives growth despite candidiasis leadership
Candidiasis accounted for 39.82% of 2024 revenue, reflecting its frequency among immunosuppressed patients and its association with invasive care settings. High mortality linked to drug-resistant Candida auris keeps systemic treatment protocols under constant review and sustains investment in hospital antifungal budgets. Onychomycosis, conversely, will expand the fastest at a 4.66% CAGR, supported by aging populations and the global rise of diabetes. Japanese prescription audits underline the monetary burden of newer therapies and hint at wider traction as patient willingness to pay for shorter regimens grows. Dermatophytosis retains solid volume demand in tropical regions, though climate change is expected to broaden its prevalence in temperate zones.
Patient-centric innovations are reshaping consumer expectations. Oral terbinafine courses are giving way to brunch-dose itraconazole pulse regimens that lessen hepatic strain. Proactive screening in transplant centers is increasing early candidemia detection, while rapid antigen tests in outpatient foot clinics are raising treatment rates for nail infections. Each of these dynamics feeds incremental volumes into the anti-fungal drugs market.
By Dosage Form: Topical innovations accelerate growth
Capsules delivered 48.75% of worldwide sales in 2024 thanks to their suitability for chronic systemic courses. Nanoparticle-enhanced creams and ointments are forecast to climb at a 4.42% CAGR, as their deeper stratum-corneum penetration curtails application windows and improves adherence. Topical pipeline momentum spans microneedle patches for persistent tinea pedis to nanomicelle eye drops for fungal keratitis, creating niche revenue streams. Long-acting parenteral injections, typified by rezafungin, are opening the door to home-based intravenous antifungal care and reducing hospital pharmacy volumes.
Powders, sprays, and combination topical corticosteroid-antifungal products cover sports-related infections and inflammatory dermatomycoses in humid climates. The anti-fungal drugs market size for parenteral formulations is expected to remain stable because critical care demand offsets outpatient shifts. Packaging upgrades that extend shelf life and permit ambient storage are also easing cold-chain barriers in low-income settings.

Note: Segment shares of all individual segments available upon report purchase
By Distribution Channel: Online pharmacies lead digital transformation
Hospital pharmacies retained 43.81% of revenue in 2024, reflecting the acuity of invasive mycoses and the need for parenteral drug handling under stewardship oversight. Online pharmacies are projected to outpace all other channels with a 6.19% CAGR as consumers embrace teleconsultations and doorstep delivery. In the United States, USD 621 billion in prescription revenues flowed through all pharmacy outlets in 2023, yet specialty share dipped as biosimilars eroded biologic margins, freeing purchasing budgets to absorb novel azoles.
Retail chains remain pivotal for OTC dermatology products, particularly in Southeast Asia where pharmacy counters double as frontline care points. Pharmacy benefit managers influence formulary placement of newer systemic azoles, often demanding real-world outcome data before tier upgrades. For hospital formulations, group purchasing organizations leverage volume discounts that intensify price competition among echinocandin suppliers, shaping revenue distribution within the anti-fungal drugs market.
Geography Analysis
North America generated the largest regional revenue slice at 34.81% in 2024. High oncology and transplant caseloads sustain systemic antifungal demand, and swift FDA review cycles grant first-in-class therapies rapid market entry. Medicare data showing annual topical antifungal spending of USD 231 million illustrates robust outpatient activity. As valley fever spreads northward, the region is ramping surveillance budgets to track soil-borne pathogens and adjust local treatment guidelines. Strong reimbursement frameworks support premium pricing for next-generation agents, though stewardship mandates are tightening formulary thresholds.
Asia-Pacific is the fastest-growing geography with a 5.17% CAGR forecast to 2030. Rising discretionary incomes and public insurance expansion are lifting diagnosis and treatment rates. India’s generic manufacturers anchor global supply, and firms such as Glenmark hold 26.4% domestic share in topical segments. PIC/S alignment is simplifying cross-border trade and inviting multinational investment in regional production hubs. Digital pharmacies and tele-dermatology platforms further expand access, particularly in secondary cities where brick-and-mortar pharmacy density remains low. Growing elderly and diabetic cohorts translate into sustained onychomycosis demand, reinforcing the anti-fungal drugs market trajectory.
Europe faces climate-related exposure shifts, with Aspergillus habitat models forecasting a 77.5% rise in population at risk. Agricultural azole regulation aims to curb cross-resistance, but implementation varies across member states, complicating stewardship consistency. Brexit has triggered parallel supply chains as companies establish EU-based production to secure uninterrupted distribution. The region’s focus on antimicrobial stewardship is fuelling investments in rapid diagnostics and targeted prophylaxis protocols. Cold-chain optimization projects are underway in Mediterranean countries where summertime temperatures exceed historical norms, ensuring stable echinocandin delivery.

Competitive Landscape
Competition is moderately fragmented. Global majors leverage regulatory experience and manufacturing scale, while targeted biotech firms pursue unexploited mechanisms. Patent expiries on fluconazole, itraconazole, and voriconazole have opened the door to low-cost generics that dominate formulary slots in many hospitals. In contrast, recently approved oteseconazole keeps exclusivity until 2027 and addresses recurrent vulvovaginal candidiasis, a niche yet persistent burden.
R&D strategies revolve around either long-acting reformulations or new molecular targets. Melinta Therapeutics and Cidara Therapeutics focus on extended-release echinocandins to enable weekly dosing. SCYNEXIS deploys ibrexafungerp, a first-in-class triterpenoid, through a co-promotion deal with GSK that blends biotech agility with big-pharma marketing reach. Digital tools are also entering the fray: AI-enabled screening accelerates lead generation, while adherence-tracking apps aim to reduce premature therapy discontinuation in chronic dermatomycoses.
Manufacturing concentration in India and China poses risk, but multinational firms are diversifying active pharmaceutical ingredient sourcing to Vietnam and Eastern Europe to hedge geopolitical uncertainties. Portfolio breadth is becoming a differentiator; companies that pair systemic and topical franchises can cross-detail to diverse clinician segments, extracting greater brand equity across the anti-fungal drugs market.
Anti-Fungal Drugs Industry Leaders
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Abbott Laboratories
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Bayer AG
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Merck & Co., Inc.
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Glenmark Pharmaceuticals Limited
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GSK plc
- *Disclaimer: Major Players sorted in no particular order

Recent Industry Developments
- June 2024: Elion Therapeutics, a biotech company headquartered in New York, secured USD 81 million in funding through its Series B round. The funding is specifically earmarked for advancing its early-stage polyene anti-fungal therapy, SF001.
- January 2024: Fresenius Kabi introduced Posaconazole Injection, a generic substitute for Noxafil, for use in treating or preventing serious fungal infections in adults and children who have an increased chance of getting these infections due to a weakened immune system.
Global Anti-Fungal Drugs Market Report Scope
As per the scope of this report, anti-fungal drugs are used/prescribed for the treatment of diseases caused by fungi. The anti-fungal drugs market is segmented by drug type, indication, dosage form, and geography. By drug type, the market is segmented as echinocandins, azoles, polyenes, allylamines, and other drug types. By indication, the market is segmented as aspergillosis, dermatophytosis, candidiasis, and other indications. By dosage form, the market is segmented as powder, ointments, tablets, and other dosage forms. By geography, the market is segmented as North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The report offers the value (USD) for the above segments.
By Drug Class | Azoles | ||
Echinocandins | |||
Polyenes | |||
Allylamines | |||
Antimetabolites | |||
By Indication | Candidiasis | ||
Dermatophytosis | |||
Aspergillosis | |||
Onychomycosis | |||
Other Systemic & Opportunistic Mycoses | |||
By Dosage Form | Capsules | ||
Topical Ointments/Creams | |||
Parenteral Injectables | |||
Powders & Sprays | |||
By Distribution Channel | Hospital Pharmacies | ||
Retail Pharmacies | |||
Online Pharmacies | |||
By Geography | North America | United States | |
Canada | |||
Mexico | |||
Europe | Germany | ||
United Kingdom | |||
France | |||
Italy | |||
Spain | |||
Rest of Europe | |||
Asia-Pacific | China | ||
Japan | |||
India | |||
Australia | |||
South Korea | |||
Rest of Asia-Pacific | |||
Middle East & Africa | GCC | ||
South Africa | |||
Rest of Middle East & Africa | |||
South America | Brazil | ||
Argentina | |||
Rest of South America |
Azoles |
Echinocandins |
Polyenes |
Allylamines |
Antimetabolites |
Candidiasis |
Dermatophytosis |
Aspergillosis |
Onychomycosis |
Other Systemic & Opportunistic Mycoses |
Capsules |
Topical Ointments/Creams |
Parenteral Injectables |
Powders & Sprays |
Hospital Pharmacies |
Retail Pharmacies |
Online Pharmacies |
North America | United States |
Canada | |
Mexico | |
Europe | Germany |
United Kingdom | |
France | |
Italy | |
Spain | |
Rest of Europe | |
Asia-Pacific | China |
Japan | |
India | |
Australia | |
South Korea | |
Rest of Asia-Pacific | |
Middle East & Africa | GCC |
South Africa | |
Rest of Middle East & Africa | |
South America | Brazil |
Argentina | |
Rest of South America |
Key Questions Answered in the Report
What is the current size of the anti-fungal drugs market?
The market generated USD 17.26 million in 2025 and is projected to reach USD 20.93 million by 2030.
Which region will grow the fastest through 2030?
Asia-Pacific is expected to post the highest 5.17% CAGR, driven by expanding healthcare access and rising awareness of fungal diseases.
Which drug class is gaining share most rapidly?
Echinocandins are forecast to grow at a 4.91% CAGR, supported by the approval of once-weekly rezafungin and lower resistance rates.
Why is onychomycosis an attractive growth segment?
Aging populations, increasing diabetes prevalence, and patient preference for shorter topical courses are pushing onychomycosis volumes at a 4.66% CAGR.
How is climate change influencing antifungal demand?
Warming temperatures and altered rainfall patterns are expanding the geographic range of pathogens like Aspergillus and Coccidioides, escalating infection risk and driving therapeutic demand in new regions.
What are the main challenges limiting market growth?
Rising antifungal resistance and the safety profile of systemic agents remain the key restraints, each shaving half to nearly one percentage point off forecast CAGR.