Chromatography Instrumentation Market Size, Trends Report 2025

Name: Chromatography Instrumentation Market Size, Trends Report 2025 – 2030
Creator: Mordor Intelligence
License: https://www.mordorintelligence.com/privacy-policy

Global Chromatography Instrumentation Market Size and Share

Market Overview

Study Period	2019 - 2030
Market Size (2025)	USD 10.13 Billion
Market Size (2030)	USD 13.08 Billion
Growth Rate (2025 - 2030)	5.23% CAGR
Fastest Growing Market	Asia Pacific
Largest Market	North America
Market Concentration	Medium
Major Players *Disclaimer: Major Players sorted in no particular order Image © Mordor Intelligence. Reuse requires attribution under CC BY 4.0.

Chromatography Instrumentations Market Summary — Image © Mordor Intelligence. Reuse requires attribution under CC BY 4.0.

Global Chromatography Instrumentation Market Analysis by Mordor Intelligence

The chromatography instrumentation market is valued at USD 10.13 billion in 2025 and is forecast to reach USD 13.08 billion by 2030, advancing at a 5.23% CAGR. Rising regulatory scrutiny, expanding biologics pipelines, and rapid automation are reinforcing demand, while artificial-intelligence-enabled platforms are cutting laboratory cycle times by as much as 40%. Pharmaceutical and biopharmaceutical companies account for the most significant revenue contribution, driven by the US FDA’s more rigorous analytical validation guidelines that favor ultra-high-performance systems.^{[1]US Food & Drug Administration, “Q2(R2) Validation of Analytical Procedures and Q14 Analytical Procedure Development,” fda.gov} Parallel expansion of PFAS monitoring and food-safety testing is adding new application breadth, especially for ion and liquid chromatography platforms. Vendors are responding with greener solvent systems, smaller footprints, and cloud-connected software that supports predictive maintenance. Supply-chain localization for critical columns and resins further supports stable long-term growth as manufacturers mitigate geopolitical risk.

Key Report Takeaways

By device, liquid chromatography systems led with 56.8% of chromatography instrumentation market share in 2024; supercritical fluid chromatography is projected to expand at an 8.9% CAGR through 2030.
By application, pharmaceutical and biopharmaceutical laboratories held a 42.1% share of the chromatography instrumentation market size in 2024, whereas environmental testing is set to grow at a 9.4% CAGR to 2030.
By geography, North America commanded 38.7% revenue in 2024, while Asia-Pacific is poised for the fastest 7.8% CAGR through 2030.

Global Chromatography Instrumentation Market Trends and Insights

Drivers Impact Analysis

Driver	(~) % Impact on CAGR Forecast	Geographic Relevance	Impact Timeline
Chromatography integral to accelerating biologics & small-molecule drug approvals	+1.20%	Global – strongest in North America & EU	Medium term (2-4 years)
Rapid technology advances: miniaturized & UHPLC/UPGC platforms	+0.90%	Global – led by developed markets	Short term (≤ 2 years)
Stringent global food-safety and PFAS regulations upping testing volumes	+0.80%	North America & EU primary, expanding to APAC	Long term (≥ 4 years)
Expanding bioprocessing & continuous manufacturing in biopharma	+0.70%	Global – APAC fastest	Medium term (2-4 years)
Helium shortage spurring alternative-carrier-gas GC upgrades	+0.40%	Global – most acute in legacy labs	Short term (≤ 2 years)
AI-powered workflow automation slashing analytical turnaround time	+0.60%	Developed markets first, then global	Medium term (2-4 years)

Source: Mordor Intelligence

Chromatography Integral to Accelerating Biologics & Small-Molecule Drug Approvals

Updated Q2(R2) and Q14 guidance from the US FDA now requires stronger evidence of method robustness, prompting widespread upgrades to ultra-high-performance LC-MS platforms. Waters’ Empower software already supports roughly 80% of new drug dossiers worldwide, reflecting the technique’s central role in quality-by-design programs. Demand is especially strong for biocompatible columns that eliminate metal contamination of antibody therapeutics. Continuous manufacturing lines rely on in-line chromatographic monitoring to keep critical process parameters within specification, reinforcing instrumentation sales to contract development and manufacturing organizations.

Rapid Technology Advances: Miniaturized & UHPLC/UPGC Platforms

Latest-generation systems deliver pressures beyond 1,300 bar while embedding self-diagnostic sensors that trigger automated maintenance routines. AI engines now tune gradient profiles in real time, improving peak capacity without operator intervention and reducing solvent use by up to 65%. Microfluidic sample preparation modules minimize reagent consumption and accelerate throughput, allowing smaller labs to handle complex matrices. Instrument footprints continue to shrink, enabling multiplexed installations even in space-constrained facilities. These gains directly address the global shortage of trained chromatographers by reducing manual workload.

Stringent Global Food-Safety and PFAS Regulations Upping Testing Volumes

The US EPA’s Method 1633 establishes sub-ng/mL limits for dozens of PFAS compounds, expanding LC-MS/MS demand in environmental and food laboratories.^{[2]US Environmental Protection Agency, “Draft Method 1633: Analysis of PFAS in Aqueous, Solid, Biosolids, and Tissue Samples,” epa.gov} Europe’s REACH program adds similar obligations, and several APAC nations are drafting aligned rules. Vendors have introduced delay columns and dedicated stationary phases that suppress analyte degradation, increasing method sensitivity threefold. The estimated USD 220 billion cost to remediate US contamination alone underscores enduring testing volume, firmly linking regulatory action to sustained revenue for the chromatography instrumentation market.

Expanding Bioprocessing & Continuous Manufacturing in Biopharma

Asia Pacific biomanufacturers are shifting from batch to continuous downstream purification, depending on multi-column chromatography skids that deliver higher yields at lower buffer consumption. Cytiva and Pall plan USD 600 million in new resin capacity, ensuring supply of agarose beads essential for intensified processes. Inline protein-A monitoring shortens release cycles, encouraging broader installation of PAT-ready systems. Integrated software feeds analytics directly to manufacturing execution systems, tightening control loops and reducing deviation rates.

Restraints Impact Analysis

Restraint	(~) % Impact on CAGR Forecast	Geographic Relevance	Impact Timeline
High upfront and maintenance cost of advanced LC & MS-coupled systems	-0.80%	Global – most limiting in emerging markets	Long term (≥ 4 years)
Shortage of skilled chromatographers & data analysts	-0.60%	Developed markets first, now global	Medium term (2-4 years)
Volatility in supply of high-purity resins, columns & semiconductor chips	-0.50%	Worldwide	Short term (≤ 2 years)
Emerging green-solvent mandates raising compliance and redesign costs	-0.30%	EU & North America lead	Long term (≥ 4 years)

Source: Mordor Intelligence

High Upfront and Maintenance Cost of Advanced LC & MS-Coupled Systems

Next-generation LC-MS instruments often exceed USD 500,000, with service contracts adding another 12% annually, straining budgets in academia and diagnostic labs. Semiconductor tariffs risk pushing component costs higher, potentially delaying upgrades. Certified pre-owned programs from OEMs and resellers offer entry points as low as USD 14,000, yet limited warranty scope can raise lifecycle risk. Total analytical cost per complex bioanalytical sample frequently surpasses USD 100, forcing some facilities to outsource testing rather than invest internally.

Shortage of Skilled Chromatographers & Data Analysts

Retirement of experienced analysts and competition from adjacent industries have left many laboratories understaffed. Multifunctional instruments now integrate guided workflows and remote diagnostics to support novice users. While these tools ease routine tasks, advanced method development still demands expertise. Training programs lag behind market growth, prolonging vacancies and limiting throughput capacity.

Segment Analysis

By Devices: High-Performance Liquid Systems Sustain Leadership

Liquid chromatography systems captured 56.8% of 2024 revenue, reflecting broad applicability in pharma, environmental, and clinical arenas. The chromatography instrumentation market size for liquid platforms reached USD 5.75 billion in 2024 and is projected to advance at a 5.1% CAGR, buoyed by biocompatible hardware that minimizes metal adsorption of sensitive biomolecules. Supercritical fluid instruments, though smaller in absolute terms, will record the fastest 8.9% CAGR, riding pharmaceutical demand for greener chiral separations. Gas chromatography manufacturers are redesigning systems for hydrogen carriers to mitigate helium reliance, and ion chromatography gains relevance in drinking-water compliance. Consumables, especially columns engineered for PFAS and antibody analysis, drive recurring revenue and buffer suppliers from capital-spending cycles. Localization of agarose resin production in the US and Europe shields users from trans-Pacific logistics risk, improving lead times and pricing stability.

Technological differentiation now centers on embedded analytics. Instruments log every parameter change, creating traceable digital twins that feed laboratory information systems. Vendors integrate column health dashboards that predict failure, thereby protecting data integrity and reducing reruns. Compact autosamplers and solvent-saving gradient pumps align with green-chemistry mandates while preserving chromatographic resolution. These trends ensure sustained leadership for liquid systems, underpinning the overall trajectory of the chromatography instrumentation market.

Chromatography Instruments — Image © Mordor Intelligence. Reuse requires attribution under CC BY 4.0.

By Application: Environmental Testing Outpaces Traditional Domains

Pharmaceutical laboratories retained the largest 42.1% revenue slice in 2024, yet mounting PFAS and food-safety rules position environmental testing as the fastest-expanding application at 9.4% CAGR. Routine drug-release testing now requires sub-ppm impurity quantitation, driving multi-detector LC-MS configurations in pharma quality control suites. Clinical diagnostics adopt liquid chromatography-tandem mass spectrometry for vitamin-D, steroid, and toxicology panels, widening the method’s footprint beyond esoteric labs.^{[3]US Environmental Protection Agency, “Draft Method 1633: Analysis of PFAS in Aqueous, Solid, Biosolids, and Tissue Samples,” epa.gov}

Agri-food chains deploy high-throughput GC-MS screens for pesticide residues, while petrochemical operators monitor refinery streams with process GC units capable of real-time composition feedback. Across every segment, machine-learning post-processing reduces manual peak review, allowing labs to redeploy limited staff toward investigation tasks. These cross-industry drivers collectively keep the chromatography instrumentation market on a resilient growth path, even as spending priorities vary by sector.

Chromatography Instruments Market — Image © Mordor Intelligence. Reuse requires attribution under CC BY 4.0.

Geography Analysis

North America maintained 38.7% of global revenue in 2024, anchored by intensive pharmaceutical R&D pipelines and strict FDA oversight that mandate high-end analytical validation. Domestic expansion projects such as Thermo Fisher’s USD 2 billion capacity program improve access to instruments and consumables, supporting replacement cycles and new installations. Federal incentives for semiconductor onshoring also protect instrument component supply, enhancing ecosystem resilience.

Europe follows with a well-established base but faces tighter solvent and waste regulations that drive early adoption of greener technologies. Laboratories pivot toward low-flow UHPLC and hydrogen carrier gas solutions to comply with environmental directives. EU Horizon research funds continue to seed next-generation detection methods, sustaining regional innovation pipelines.

Asia-Pacific represents the principal growth engine, expanding at a 7.8% CAGR to 2030. China and India jointly account for over half of regional demand as contract research organizations, vaccine producers, and generics manufacturers scale operations. Government initiatives to upgrade food-safety testing and curb industrial pollution further stimulate orders. Japanese and South Korean firms remain at the forefront of platform engineering, exporting high-precision components worldwide and reinforcing the global standing of the chromatography instrumentation market.

Competitive Landscape

Four multinationals such as Waters, Agilent, Thermo Fisher Scientific, and Shimadzu—collectively hold significant global revenue, underscoring moderate consolidation within the chromatography instrumentation market. Each leverages unique technology stacks: Waters pioneered UPLC; Agilent emphasizes modular LC platforms; Thermo Fisher integrates chromatography with Orbitrap MS; and Shimadzu champions AI-assisted workflows. Competitive tension now centers on software ecosystems that enhance regulatory compliance and remote service.

Mergers and acquisitions accelerate capability expansion. Thermo Fisher’s USD 4.1 billion purchase of Solventum’s purification and filtration unit broadens bioprocess coverage and underpins chromatography resin supply. Smaller niche acquisitions, such as PEAK Scientific’s purchase of Noblegen gas-generation technology, illustrate how specialized capabilities can earn premium market positioning. Patent filings concentrate on porous particle chemistry and chemometrics algorithms, with top inventors often exceeding 100 active US patents.

Pricing pressure persists despite vendor concentration, driven by leaner manufacturing in Asia-Pacific and the rise of certified-pre-owned equipment programs. Suppliers respond by bundling instruments with cloud subscriptions, securing annuity revenue through analytics dashboards and e-commerce consumable ordering. This balanced strategy maintains profitability while keeping barriers to entry high for new challengers, sustaining leadership positions within the chromatography instrumentation market.

Global Chromatography Instrumentation Industry Leaders

Agilent Technologies
Thermo Fisher Scientific
Merck KGaA
Sartorius AG
Bio-Rad Laboratories
*Disclaimer: Major Players sorted in no particular order

Chromatography Instrumentations Market Concentration — Image © Mordor Intelligence. Reuse requires attribution under CC BY 4.0.

Need More Details on Market Players and Competitors?

Download PDF

Recent Industry Developments

June 2025: Waters Corporation released BioResolve Protein A columns with MaxPeak Premier coating, delivering up to 7× sensitivity gains.
June 2025: Bruker introduced the timsMetabo platform for high-throughput PFAS detection.
March 2025: Cytiva and Pall announced a USD 1.5 billion investment across 13 sites, adding a new US chromatography plant.
February 2025: Thermo Fisher Scientific acquired Solventum’s Purification & Filtration business for USD 4.1 billion, targeting USD 125 million in year-five synergy gains.
October 2025: Agilent Technologies launched the Infinity III LC Series, featuring InfinityLab Assist Technology for enhanced automation and sustainability.

Table of Contents for Global Chromatography Instrumentation Industry Report

1. Introduction

1.1 Study Assumptions & Market Definition
1.2 Scope of the Study

2. Research Methodology

3. Executive Summary

4. Market Landscape

4.1 Market Overview
4.2 Market Drivers
- 4.2.1 Chromatography Integral To Accelerating Biologics & Small-Molecule Drug Approvals
- 4.2.2 Rapid Technology Advances: Miniaturized & UHPLC/UPGC Platforms
- 4.2.3 Stringent Global Food-Safety And PFAS Regulations Upping Testing Volumes
- 4.2.4 Expanding Bioprocessing & Continuous Manufacturing In Biopharma
- 4.2.5 Helium Shortage Spurring Alternative-Carrier-Gas GC System Upgrades
- 4.2.6 AI-Powered Workflow Automation Slashing Analytical Turnaround Time
4.3 Market Restraints
- 4.3.1 High Upfront And Maintenance Cost Of Advanced LC & MS-Coupled Systems
- 4.3.2 Shortage Of Skilled Chromatographers & Data Analysts
- 4.3.3 Volatility In Supply Of High-Purity Resins, Columns & Semiconductor Chips
- 4.3.4 Emerging Green-Solvent Mandates Raising Compliance And Redesign Costs
4.4 Supply Chain Analysis
4.5 Regulatory Landscape
4.6 Technological Outlook
4.7 Porter's Five Forces Analysis
- 4.7.1 Threat of New Entrants
- 4.7.2 Bargaining Power of Buyers
- 4.7.3 Bargaining Power of Suppliers
- 4.7.4 Threat of Substitutes
- 4.7.5 Intensity of Competitive Rivalry

5. Market Size & Growth Forecasts (Value)

5.1 By Devices
- 5.1.1 Chromatography Systems
- 5.1.1.1 Gas Chromatography Systems
- 5.1.1.2 Liquid Chromatography Systems
- 5.1.1.3 Supercritical Fluid Chromatography Systems
- 5.1.1.4 Ion Chromatography Systems
- 5.1.1.5 Thin-Layer Chromatography Systems
- 5.1.2 Consumables
- 5.1.2.1 Columns
- 5.1.2.2 Solvents / Reagents / Adsorbents
- 5.1.2.3 Syringes / Needles
- 5.1.2.4 Membrane Filters
- 5.1.2.5 Others
- 5.1.3 Accessories
- 5.1.3.1 Column Accessories
- 5.1.3.2 Auto-Sampler Accessories
- 5.1.3.3 Pumps
- 5.1.3.4 Detectors
- 5.1.3.5 Other Accessories
5.2 By Application
- 5.2.1 Agriculture & Food Testing
- 5.2.2 Pharmaceutical & Biopharmaceutical Companies
- 5.2.3 Clinical & Diagnostic Laboratories
- 5.2.4 Environmental Testing
- 5.2.5 Chemical & Petrochemical
- 5.2.6 Forensic & Toxicology
5.3 Geography
- 5.3.1 North America
- 5.3.1.1 United States
- 5.3.1.2 Canada
- 5.3.1.3 Mexico
- 5.3.2 Europe
- 5.3.2.1 Germany
- 5.3.2.2 United Kingdom
- 5.3.2.3 France
- 5.3.2.4 Italy
- 5.3.2.5 Spain
- 5.3.2.6 Rest of Europe
- 5.3.3 Asia Pacific
- 5.3.3.1 China
- 5.3.3.2 Japan
- 5.3.3.3 India
- 5.3.3.4 South Korea
- 5.3.3.5 Australia
- 5.3.3.6 Rest of Asia Pacific
- 5.3.4 Middle East and Africa
- 5.3.4.1 GCC
- 5.3.4.2 South Africa
- 5.3.4.3 Rest of Middle East and Africa
- 5.3.5 South America
- 5.3.5.1 Brazil
- 5.3.5.2 Argentina
- 5.3.5.3 Rest of South America

6. Competitive Landscape

6.1 Market Concentration
6.2 Market Share Analysis
6.3 Company Profiles (includes Global level Overview, Market level overview, Core Segments, Financials as available, Strategic Information, Market Rank/Share for key companies, Products & Services, and Recent Developments)
- 6.3.1 Agilent Technologies
- 6.3.2 Waters Corporation
- 6.3.3 Shimadzu Corporation
- 6.3.4 Thermo Fisher Scientific
- 6.3.5 PerkinElmer Inc.
- 6.3.6 Merck KGaA
- 6.3.7 Sartorius AG
- 6.3.8 Bio-Rad Laboratories
- 6.3.9 Restek Corporation
- 6.3.10 Gilson Inc.
- 6.3.11 Phenomenex Inc.
- 6.3.12 Cytiva
- 6.3.13 Bruker Corporation
- 6.3.14 Hitachi High-Tech Corporation
- 6.3.15 LECO Corporation
- 6.3.16 Danaher (SCIEX)
- 6.3.17 GE Healthcare Life Sciences
- 6.3.18 Pall Corporation
- 6.3.19 Knauer Wissenschaftliche Geräte
- 6.3.20 Tosoh Bioscience
- 6.3.21 Trajan Scientific & Medical
- 6.3.22 YMC Co. Ltd.

7. Market Opportunities & Future Outlook

7.1 White-space & Unmet-Need Assessment

**Competitive Landscape covers- Business Overview, Financials, Products and Strategies and Recent Developments

You Can Purchase Parts Of This Report. Check Out Prices For Specific Sections

Get Price Break-up Now

Global Chromatography Instrumentation Market Report Scope

The chromatography instrumentations market is segmented by devices (chromatography systems (gas chromatography systems, liquid chromatography systems, fluid chromatography systems, and thin layer chromatography systems), consumables (columns, solvents/reagents/adsorbents, syringes/needles, and others) and accessories (column accessories, auto-sampler accessories, pumps, and other accessories)), application (agriculture pharmaceutical firms, clinical research organizations, environmental testing), geography (North America, Europe, Asia-Pacific, Middle East & Africa, and South America). The market report also covers the estimated market sizes and trends for 17 countries across major global regions. The report offers the value (in USD million) for the above segments.

By Devices	Chromatography Systems	Gas Chromatography Systems
		Liquid Chromatography Systems
		Supercritical Fluid Chromatography Systems
		Ion Chromatography Systems
		Thin-Layer Chromatography Systems

	Consumables	Columns
		Solvents / Reagents / Adsorbents
		Syringes / Needles
		Membrane Filters
		Others

	Accessories	Column Accessories
		Auto-Sampler Accessories
		Pumps
		Detectors
		Other Accessories
By Application	Agriculture & Food Testing
	Pharmaceutical & Biopharmaceutical Companies
	Clinical & Diagnostic Laboratories
	Environmental Testing
	Chemical & Petrochemical
	Forensic & Toxicology

Geography	North America	United States
		Canada
		Mexico

	Europe	Germany
		United Kingdom
		France
		Italy
		Spain
		Rest of Europe

	Asia Pacific	China
		Japan
		India
		South Korea
		Australia
		Rest of Asia Pacific

	Middle East and Africa	GCC
		South Africa
		Rest of Middle East and Africa

	South America	Brazil
		Argentina
		Rest of South America

By Devices

Chromatography Systems	Gas Chromatography Systems
	Liquid Chromatography Systems
	Supercritical Fluid Chromatography Systems
	Ion Chromatography Systems
	Thin-Layer Chromatography Systems
Consumables	Columns
	Solvents / Reagents / Adsorbents
	Syringes / Needles
	Membrane Filters
	Others
Accessories	Column Accessories
	Auto-Sampler Accessories
	Pumps
	Detectors
	Other Accessories

By Application

Agriculture & Food Testing

Pharmaceutical & Biopharmaceutical Companies

Clinical & Diagnostic Laboratories

Environmental Testing

Chemical & Petrochemical

Forensic & Toxicology

Geography

North America	United States
	Canada
	Mexico
Europe	Germany
	United Kingdom
	France
	Italy
	Spain
	Rest of Europe
Asia Pacific	China
	Japan
	India
	South Korea
	Australia
	Rest of Asia Pacific
Middle East and Africa	GCC
	South Africa
	Rest of Middle East and Africa
South America	Brazil
	Argentina
	Rest of South America

Need A Different Region or Segment?

Customize Now

Key Questions Answered in the Report

What is the current size of the chromatography instrumentation market?

The chromatography instrumentation market stands at USD 10.13 billion in 2025 and is set to reach USD 13.08 billion by 2030.

Which device type captures the highest market share?

Liquid chromatography platforms lead with 56.8% of global revenue thanks to their versatility across pharmaceutical, environmental, and clinical workflows.

Which application area will grow the fastest through 2030?

Environmental testing is projected to expand at a 9.4% CAGR through 2030 due to stringent PFAS and food-safety regulations.

Who are the top players in this market?

Waters, Agilent, Thermo Fisher Scientific, and Shimadzu together control more than 80% of worldwide revenues.

Why is AI important in modern chromatography?

AI-enabled workflows can cut analytical turnaround by up to 40%, enhance data reliability, and ease skilled-labour shortages through predictive maintenance and automated method optimisation.

What regions offer the strongest growth outlook?

Asia-Pacific is forecast to grow at 7.8% CAGR, driven by expanding biomanufacturing capacity, rising healthcare investment, and tighter regulatory compliance standards.

Page last updated on: June 20, 2025