Active Pharmaceutical Ingredients (API) Market Snapshot
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The active pharmaceutical ingredients (API) market is expected to register a CAGR of nearly 5.84 % during the forecast period with a revenue of approximately USD 174.96 million in 2020 and is expected to reach USD 245.88 million by the year 2026.
In 2020, the outbreak of the COVID-19 pandemic has created a favorable impact on the market as the countries and the major players are manufacturing huge amounts of ingredients to maintain the demand for the treatment of COVID 19.
The outbreak of COVID-19 has led drug manufacturers to redirect their models to focus on a larger pool of patients. For example, the US requested that hydroxychloroquine (HCQ) be imported from India as a treatment for coronavirus. The virus has also disrupted the drug supply chain in Canada and may cause problems for patients in the country. Canadian pharma majors expand their programs with countries other than China to gain access to new regions.
The key factors boosting the growth of the global active pharmaceutical ingredients market are the rising drug research and development activities for drug manufacturing, the rising importance of generics, and the increasing uptake of biopharmaceuticals. However, the unfavorable drug price control policies across various nations and high manufacturing costs are expected to hinder the growth of the market.
The increasing prevalence of chronic diseases is expected to increase the demand for drugs, which is expected to fuel the active pharmaceutical ingredients market growth in the near future. According to the World Health Organization (WHO), cardiovascular diseases are the leading cause of death globally, accounting for an estimated 17.9 million lives each year.
The Alzheimer's Association stated that around 5.8 million people in the United States were living with Alzheimer’s disease in 2018. This disease is the sixth-leading cause of death in the United States and is more prevalent among people above 65 years of age (and approximately 5.6 million patients fall in this age bracket). With the baby-boom generation reaching around 65 years of age, this number is expected to reach 14 million, worsening the situation over the forecast period. By 2050, a new case of the disease is expected to develop every 33 seconds.
Moreover, the launches of new drugs and biological products, acquisitions, collaborations, and regional expansions are some of the strategic initiatives to maintain stability in the market. This is likely to fuel the market growth in the near future. For instance, in 2020, Quartic.ai and Bright Path Labs collaborated to develop AI-based technology for continuous manufacturing of critical APIs that required for producing crucial small-molecule drugs.
The active pharmaceutical ingredients (API) market has traditionally been dominated by drugs, such as anti-infectives and the diabetes, cardiovascular, analgesics, and pain management drugs. However, as per the R&D trends, the demand is shifting toward the development of complex APIs used in novel formulations, targetting niche therapeutic areas.
The major factors limiting the market growth include drug price control policies across various countries, fierce competition among existing players, and stringent regulatory policies.
Scope of the Report
Active pharmaceutical ingredient (API) is a part of any drug that produces its effects. Some drugs, such as combination therapies, have multiple active ingredients to treat different symptoms or act in different ways. They are produced using highly technological industrial processes, both during the R&D and the commercial production phase. Active Pharmaceutical Ingredients (API) Market is segmented by Business Mode(Captive API, Merchant API), Synthesis Type (Synthetic, Biotech), Type of Drug (Generic, Branded), Application (Cardiology, Pulmonology, Oncology, Opthalmology, Neurology, Orthopedic, Other Applications), and Geography (North America, Europe, Asia-Pacific, Middle East and Africa, and South America). The market report also covers the estimated market sizes and trends for 17 different countries across major regions, globally. The report offers the value (in USD billion) for the above segments.
|By Business Mode|
|By Synthesis Type|
|By Type of Drug|
Key Market Trends
Cardiology is Expected to hold the Largest Market Share in the Application Category
Presently, the pulmonology segment is having a high peak in the growth due to the pandemic. As the pharma industry is at the lead of the combat against COVID-19 and has responded to this global challenge by guaranteeing the availability of medicines in spite of supply chain interruptions.
The API market, by application, cardiology segment holds a significant share, due to the vast population using various CVD drugs owing to the high prevalence of cardiovascular diseases. According to the European Society of Cardiology 2019 Statistics, cardiovascular diseases (CVD) remain the leading cause of mortality and a major cause of morbidity in Europe. Currently there are more than 6 million new cases of CVD in the EU and more than 11 million in Europe as a whole, every year. With almost 49 million people living with the disease in the EU, the cost to the EU economies is high at Euros 210 billion a year.
The oncology segment is also expected to grow significantly during the forecast period owing to the high prevalence of cancer in the last few decades, and the disease is expected to claim a more prevalent population during the forecast period. Market players are continously developing new APIs to cater the need in oncology segment globally. In December 2019, Dr Reddy's Laboratories launched Bortezomib for injection in the US market a generic version of Velcade of Millennium Pharmaceuticals. Bortezomib is used for the treatment of adult patients with multiple myeloma or with mantle cell lymphoma who have received at least one prior therapy.
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North America Dominates the Market and is Expected to continue its dominance through the Forecast Period
North America currently dominates the market for active pharmaceutical ingredients and is expected to continue its stronghold for a few more years. This region is expected to increase its market share in the future, owing to the increasing incidences of disease and rising aging population. The United States holds the majority of the market in the North American region.
With the drastic spread of COVID 19 in the country, the demand for the drugs and their ingredients increased forcing the country to export many APIs from different countries, and the local players also produced as per the demand. The majority of its API requirements are met through imports from the Asian Markets. The US trade statistics suggest that nearly 75% to 80% of the APIs imported to the United States are from China and India, as these countries have well-established manufacturing facilities and an abundant talent pool serving the pharmaceutical sector.
The recent political and trade policies implemented by the US government to increase import duties and taxes are expected to drive operational costs and increase the pricing pressure on the manufacturers. The FDA has also increased the application fees for new drug approvals and has increased the number of periodic inspections conducted on various off-shore contract manufacturing facilities to ensure the supply of high-quality products to the US market.
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The active pharmaceutical ingredients market is highly competitive, and consists of several major players; thus, indicating a fragmented market scenario. The API market has several manufacturers from China and India holding a dominant market position, due to their large manufacturing footprints. In Europe, Italy, Germany, and the United Kingdom are the key regions for API trade, due to the presence of a well-developed pharmaceutical and life sciences industry.
A majority of the APIs produced by reputed MNCs are used for captive production. However, few players have emerged as contract manufacturers with a diversified client base. Further, with increasing technological advancements and product innovation, mid-size and small-scale companies are increasing their market presence, by introducing new ingredients with competitive prices. Companies, like Teva, Pfizer, Aurobindo, Sun Pharmaceuticals, Novartis, Mylan, and Boehringer Ingelheim, hold substantial market shares in the active pharmaceutical ingredients market.
In August 2020, Pfizer Inc. announced a multi-year agreement with Gilead Sciences, Inc. to manufacture and supply Gilead’s investigational antiviral remdesivir supporting efforts to scale up the supply of the investigational treatment for COVID-19.
In April 2020, Boehringer Ingelheim acquired Northern Biologics. This acquisition broadened Boehringer Ingelheim’s oncology product portfolio.
Table of Contents
1.1 Study Deliverables
1.2 Study Assumptions
1.3 Scope of the Study
2. RESEARCH METHODOLOGY
3. EXECUTIVE SUMMARY
4. MARKET DYNAMICS
4.1 Market Overview
4.2 Market Drivers
4.2.1 Increasing Prevalence of Infectious, Genetic, Cardiovascular, and Other Chronic Disorders
4.2.2 Increasing Adoption of Biologicals and Biosimilars
4.2.3 Rising Prevalence of Cancer and Increasing Sophistication in Oncology Drug Research
4.3 Market Restraints
4.3.1 Drug Price Control Policies Across Various Countries
4.3.2 High Competition Between the API Manufacturers
4.3.3 Stringent Regulations
4.4 Industry Attractiveness Porter's Five Forces Analysis
4.4.1 Threat of New Entrants
4.4.2 Bargaining Power of Buyers/Consumers
4.4.3 Bargaining Power of Suppliers
4.4.4 Threat of Substitute Products
4.4.5 Intensity of Competitive Rivalry
5. MARKET SEGMENTATION
5.1 By Business Mode
5.1.1 Captive API
5.1.2 Merchant API
5.2 By Synthesis Type
5.3 By Type of Drug
5.4 By Application
5.4.7 Other Applications
5.5.1 North America
126.96.36.199 United States (By Business Mode, By Synthesis Type, By Type, and By Application)
188.8.131.52 Canada (By Business Mode, By Synthesis Type, By Type, and By Application)
184.108.40.206 Mexico (By Business Mode, By Synthesis Type, By Type, and By Application)
220.127.116.11 Germany (By Business Mode, By Synthesis Type, By Type, and By Application)
18.104.22.168 United Kingdom (By Business Mode, By Synthesis Type, By Type, and By Application)
22.214.171.124 France (By Business Mode, By Synthesis Type, By Type, and By Application)
126.96.36.199 Italy (By Business Mode, By Synthesis Type, By Type, and By Application)
188.8.131.52 Spain (By Business Mode, By Synthesis Type, By Type, and By Application)
184.108.40.206 Rest of Europe (By Business Mode, By Synthesis Type, By Type, and By Application)
220.127.116.11 China (By Business Mode, By Synthesis Type, By Type, and By Application)
18.104.22.168 Japan (By Business Mode, By Synthesis Type, By Type, and By Application)
22.214.171.124 India (By Business Mode, By Synthesis Type, By Type, and By Application)
126.96.36.199 Australia (By Business Mode, By Synthesis Type, By Type, and By Application)
188.8.131.52 South Korea (By Business Mode, By Synthesis Type, By Type, and By Application)
184.108.40.206 Rest of Asia-Pacific (By Business Mode, By Synthesis Type, By Type, and By Application)
5.5.4 Middle East and Africa
220.127.116.11 GCC (By Business Mode, By Synthesis Type, By Type, and By Application)
18.104.22.168 South Africa (By Business Mode, By Synthesis Type, By Type, and By Application)
22.214.171.124 Rest of Middle East and Africa (By Business Mode, By Synthesis Type, By Type, and By Application)
5.5.5 South America
126.96.36.199 Brazil (By Business Mode, By Synthesis Type, By Type, and By Application)
188.8.131.52 Argentina (By Business Mode, By Synthesis Type, By Type, and By Application)
184.108.40.206 Rest of South America (By Business Mode, By Synthesis Type, By Type, and By Application)
6. COMPETITIVE LANDSCAPE
*List Not Exhaustive
6.1 Company Profiles
6.1.1 Aurobindo Pharma
6.1.2 Teva Pharmaceutical Industries Ltd
6.1.3 Pfizer Inc.
6.1.4 Novartis AG
6.1.5 BASF SE
6.1.6 Boehringer Ingelheim GmbH
6.1.7 Dr. Reddy’s Laboratories Ltd
6.1.8 Lupin Ltd
6.1.9 Mylan NV
6.1.10 Sun Pharmaceutical Industries Ltd
6.1.12 Bristol Myers Squibb
6.1.13 Eli Lilly and Company
6.1.14 Merck & Co., Inc
6.1.15 Abbvie Inc.
7. MARKET OPPORTUNITIES AND FUTURE TRENDS
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Frequently Asked Questions
What is the study period of this market?
The Global Active Pharmaceutical Ingredients (API) Market market is studied from 2018 - 2026.
What is the growth rate of Global Active Pharmaceutical Ingredients (API) Market?
The Global Active Pharmaceutical Ingredients (API) Market is growing at a CAGR of 7.8% over the next 5 years.
Which region has highest growth rate in Global Active Pharmaceutical Ingredients (API) Market?
Asia Pacific is growing at the highest CAGR over 2021- 2026.
Which region has largest share in Global Active Pharmaceutical Ingredients (API) Market?
North America holds highest share in 2020.
Who are the key players in Global Active Pharmaceutical Ingredients (API) Market?
- Teva Pharmaceutical Industries Ltd
- Sun Pharmaceutical Industries Ltd
- Novartis AG
- Pfizer Inc.
- Mylan NV
Are the major companies operating in Global Active Pharmaceutical Ingredients (API) Market.