Graft Versus Host Disease Treatment Market Size

Graft-versus-Host Disease Treatment Market Analysis

The Graft Versus Host disease treatment market is projected to register a CAGR of 8.4% during the forecast period.

The COVID-19 pandemic had a significant impact on the market's growth rate. Graft-versus-Host disease (GvHD) is a condition that occurs in people who have received allogeneic transplantation. The donor immune cells attack the recipient's body organs and cause a "cytokine storm." A cytokine storm refers to the overproduction of inflammatory cytokines, which may result in local organ damage. As per a review published in Nature in April 2021, a similar condition occurs during the incidence of COVID-19, where the immune system of the infected individual produces increased levels of inflammatory cytokines, resulting in organ failure. Thus, the severity of the GvHD increases when the patient is affected by COVID-19. The increase in complications posed a serious challenge to the healthcare system globally during the COVID-19 pandemic phase. Thus, there was a surge in demand for Graft-versus-Host disease treatment products to combat the further complications that developed due to COVID-19. In addition, the market growth is stabilizing in the current scenario post-COVID-19 as the worldwide restrictions eased down and disease screening services resumed.

The increasing rate of bone marrow or hematopoietic stem cell treatment, the growing incidence of acute GvHD, and the increasing number of pipeline drugs are likely to propel the market growth throughout the analysis period. For instance, as per a report published by StatPearls Publishing in October 2021, it was found that the incidence of acute GvHD was found to be about 50% for patients receiving HCT from Human Leukocyte Antigen (HLA) matched siblings, and the range was even higher in unmatched donors. The incidence of chronic GvHD was found to be in the range of 6-80%. Additionally, according to an article published by Elsevier in June 2021, in the United States, 42% of the patients had developed cGvHD within three years of allogenic HCT; 66% of those affected by cGvHD were found to have acute GvHD prior. The refractory nature of cGvHD is expected to propel the growth of the GvHD treatment market.

High investments in R&D capabilities by industry players and governments are anticipated to create lucrative opportunities in the market. For instance, in June 2021, Equillium Inc. reported the completion of an End-of-Phase 1 meeting with the US FDA for itolizumab in the first-line treatment of patients with acute graft-versus-host disease (aGvHD). Thus, the positive outcome of such clinical trials will likely lead to new treatments, which will be expected to boost the market's growth over the forecast period.

Thus, owing to the abovementioned factors, the market is anticipated to project growth over the forecast period. However, the high cost of GvHD treatment is expected to limit the growth of the market.