Global HER-2 Negative Breast Cancer Market Size

HER-2 Negative Breast Cancer Market Analysis

The Global HER-2 Negative Breast Cancer Market size is estimated at USD 15.03 billion in 2024, and is expected to reach USD 23.32 billion by 2029, growing at a CAGR of 9.17% during the forecast period (2024-2029).

The emergence of the COVID-19 pandemic had an adverse effect on the world economy and healthcare system. The lockdown all over the globe has affected the supply chain of pharmaceuticals, medical devices, and biotechnological products largely. On the other hand, research and development have come into focus and all the government agencies and healthcare players come forward to support the development of diagnostics and treatment methods for COVID-19. For instance, according to the study titled 'Impact of the COVID-19 Pandemic on the Diagnosis and Surgery of Breast Cancer: A Multi-Institutional Study' published in the Journal of Breast Cancer in December 2021, at the start of the COVID-19 pandemic, more patients had advanced and aggressive kinds of breast cancer, including HER-2 positive and HER-2 negative disease. In South Korea, the number of breast cancer diagnoses decreased by 9.9% by 2020. Most routine preventative actions, including active screening programs, have been decreased. Furthermore, breast cancer screening has dropped by 89.2%. Thus, this is expected to negatively impact breast cancer drug manufacturers, as their demand has reduced significantly due to the decline in diagnosis. Thus, restricting the chemotherapy used in HER-2 negative cancer with covid-19 infection, hampered the market growth. However, the utilization of specific therapeutic medicines used in the treatment of HER-2-negative cancer has increased. COVID-19 has had sightly negative impact on market growth, while it has slightly delayed the rate of growth of the global HER-2 negative breast cancer market throughout the forecast period.

Furthermore, the incidence and prevalence are growing rapidly due to lifestyle changes and certain factors increase the risk of breast cancer including increasing age, obesity, harmful use of alcohol, family history of breast cancer, history of radiation exposure, reproductive history (such as age that menstrual periods began and age at first pregnancy), tobacco use and postmenopausal hormone therapy. For instance, according to the National Institutes of Health data published in March 2022, HER-2 Negative cancer accounted for around 15-20% of the total breast cancer cases across the United States. It is anticipated that 287,850 new cases of female breast cancer would be diagnosed in 2022.

Additionally, as per the 2020 report of the Global Cancer Observatory (Globocan), breast cancer was the most prevalent form of cancer worldwide in 2020. About 2,261,419 new cases of breast cancer were diagnosed in 2020. The incidence of breast cancer cases is expected to increase from 2,261,419 in 2020 to 3,025,471 new cases by 2040. This data shows an increasing burden of breast cancer worldwide. Therefore, due to the increasing prevalence of breast cancer around the world, the HER-2-negative breast cancer market is expected to grow over the forecast period of the study.

A number of advanced targeted medicines for HER2-positive breast cancer are approved by the FDA. For instance, in August 2022, the Food and Drug Administration (FDA) approved Enhertu (fam-trastuzumab-deruxtecan-nxki), an IV infusion for the treatment of patients with unresectable (unable to be removed) or metastatic (spread to other regions of the body) HER2-breast cancer.

Additionally, rising clinical activity is likely to support the market growth. For instance, according to the ClinicalTrials.gov, updates in March 2022, ZB716 is in phase II development as monotherapy and in combination with palbociclib in patients with HER2-negative locally advanced or metastatic breast cancer, with a completion date of 2024. This is likely to opens up the growth horizons to the market studied.

However, the high cost of treatment and availability of alternative treatments are expected to restrict the growth of this market.