Market Size of Global Downstream Processing Industry
| Study Period | 2019 - 2029 |
| Base Year For Estimation | 2023 |
| CAGR | 13.80 % |
| Fastest Growing Market | Asia Pacific |
| Largest Market | North America |
| Market Concentration | High |
Major Players
*Disclaimer: Major Players sorted in no particular order |
Need a report that reflects how COVID-19 has impacted this market and its growth?
Downstream Processing Market Analysis
The Downstream Processing Market is expected to witness a CAGR of 13.8% during the forecast period (2022 - 2027).
The initial phase of the pandemic has had a substantial impact on the growth of the single-use bioprocessing market owing to the significant decline in manufacturing processes and restricted demand and supply of drugs. With the increasing number of COVID-19 cases, the demand for effective drugs and vaccines were increased which has increased the adoption of downstream processing systems and technology by biopharmaceutical companies due to fewer chances of contamination and reduced sterilization tests between the batches. This impacted the market growth during the pandemic.
The factors attributing to the market growth are the increasing demand for the biotechnology sector globally, rising research and development expenditure in biopharmaceutical companies, and an increase in the prominence of contract manufacturing companies.
With the increasing pharmaceutical spending on research and development, adoption of various business strategies, and advanced technology, downstream processing is being increasingly adopted in the biopharmaceutical industry, boosting market growth over the forecast period. According to the data published by the Congressional Budget Office, in 2021, it has been observed that pharmaceutical industries have spent nearly USD 200 billion on research and development in 2020 globally compared to USD 83 million in 2019. Thus, the increasing investment in research and development by the companies further increases the capabilities of the company to adopt innovative bioprocess technologies, resulting in the adoption of continuous downstream processing systems for multicomponent separations, perfusion chromatography systems, high-throughput process development, and high-resolution membrane systems, thereby increasing market growth.
Several advantages offered by downstream processing, such as high efficiency, reduce costs, and generally dominated by chromatographic separations and membrane filtrations are also contributing to the market growth.
Also, the rising utilization of filters in assessing viral inactivation is expected to increase the market growth. For instance, according to an article published in May 2020, titled 'Approaches to Purification, Analysis, and Characterization of Antibody-Based Therapeutics', it has been observed that the final two steps of downstream processing for antibodies often involve the two fundamental biopharmaceutical production technologies of virus filtration and ultrafiltration. Additionally, with current developments like continuous processing and increased monoclonal antibody (mAb) concentrations, virus filters have developed to better meet the needs of the biopharmaceutical industry. Furthermore, as per the same source, parvovirus-retentive filters are now utilized for the development of new mAb processes. Thus, the increased usage of virus filters in the production of antibodies and related biotherapeutics and recent advances in the use of filters is expected to increase the demand for downstream processing which in turn is anticipated to boost the market growth.
However, the high cost of instruments and purification bottleneck are expected to restrain the market growth over the forecast period.
